• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4927-4930
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• 2012

Background: Many observational studies have assessed the possible association between occupational cooking and uveal melanoma risk, but reported results are controversial. Our goal was to evaluate the association between occupational cooking and uveal melanoma risk by conducting a meta-analysis of observational studies. Methods: PubMed, EMBASE, and Web of Science were searched through June 2012 to identify all eligible studies. The pooled odds ratio (OR) with its 95% confidence interval (95%CI) was used to evaluate this association. Either a fixed- or a random-effects model were used to calculate pooled ORs. Results: Five case-control studies involving a total of 1,199 cases and 6,927 controls were included in the meta-analysis. Overall, occupational cooking was associated with an increased risk of uveal melanoma (OR: 1.81, 95%CI 1.33-2.46, P < 0.001). Subgroup analysis by gender suggested occupational cooking was associated with increased risk of uveal melanoma in both men (OR: 2.16, 95%CI 1.06-4.40, P = 0.034) and women (OR: 1.92, 95%CI 1.19-3.10, P = 0.008). Conclusion: This meta-analysis suggests that occupational cooking is associated with an increased risk of uveal melanoma in both men and women.

• 한국임상수의학회지
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• 제37권5호
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• pp.282-285
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• 2020

A 14-year-old neutered-male Shih-Tzu was referred for glaucoma and hyphema accompanied by systemic hypertension. After topical corticosteroid and antiglaucoma medications, the left eye (OS) progressed phthisically, but ocular hypertension redevelop one-year-and-seven-months later. Suspected limbal melanoma developed in peripheral cornea/limbal sclera with heavily pigmented cornea OS. Ultrasound biomicroscopy and ocular ultrasonography differentiated ciliary body origin-heterogeneous mass from limbal mass. Persistent hyphema and pigmented cornea might obscure intraocular lesion and advanced diagnostic methods played a crucial role. Unlike the generally benign limbal melanoma, aggressive treatment was recommended for uveal tumor. Histopathology of enucleated OS confirmed malignant uveal melanoma with chronic hypertensive vasculopathy.

• 대한방사선치료학회지
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• 제9권1호
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• pp.50-55
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• 1997

The optimal management of uveal melanoma is still a matter of controversy. To determine the effect of Gamma Knife surgery for patients with uveal malanoma. the authors reviewed the results of 5 patients underwent Gamma Knife sugery between Sep. 1993 and Dec. 1996. The mean age was 60.7 years ranging from 42.5 to 76.5 years. Median follow-up was 13.29 months and the patient with follow up period more than 6 months was 4. The mean tumor volume was $3442 mm^3$(mean diameter 15.3 mm) and all patients were irradiated with a mean maximum dose of 74Gy(range $60\~80\;Gy$), using the $50\%$ isodose. After Gamma Knife surgery. one pateint showed complete disapperance in tumor size with follow-up 32 months, one enucleation due to progression, and 2 no interval change. In regard to vision, one patient blind. one enucleation, and 2 patients had no interval change. According to our experiences, Gamma Knife surgery for uveal melanoma be able to achieve local tumor control, spare the eyeball, and have possibility of save vision.

• Journal of Korean Neurosurgical Society
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• 제30권5호
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• pp.652-656
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• 2001

Uveal melanoma is uncommon but life-threatening intraocular malignancy and has been treated by irradiation, local excision and enucleation. Gamma-Knife radiosurgery allows a high dose of radiation to be delivered to an intracranial target with a very high spatial accuracy and has been used for the treatment of ocular melanomas. We have treated two cases of uveal melanoma between October 1994 and December 1999. They include one man and one woman(34, 62 years, respectively). They were followed up for 12 momths. Mean maximal dose was 65Gy. In one case, the tumor disappeared 7 months after gamma-knife radiosurgery. In another case, multiple tumors (uveal, suprasellar and cerebellar tumor) had decreased in size. These results show that single and high dose gamma-knife radiosurgery is may be an option in the local control of uveal melanoma which can spare the eyeball and vision.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5281-5285
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• 2016

Background: Brachytherapy is the most commonly used conservative treatment for the uveal melanoma. The aim of this study was to evaluate therapeutic results of Ruthenium-106 plaque brachytherapy in the management of localized uveal melanoma cases. Methods: We reviewed retrospectively the clinical records of all patients treated in our department for an uveal melanoma, undergoing Ruthenium-106 plaque brachytherapy, from January 1996 to December 2015. We focused on clinical features, therapeutic characteristics, local and distant tumor control and side effects. Results: Nineteen patients were enrolled in our study. Mean age was 56.2 years (28-79) and the sex ratio was 1.37:1 males to females. Diagnosis was made on the basis of ophthalmological clinical examination, angiography, ultrasound and/or magnetic resonance. Median tumor diameter was 9.7 mm (6-13) and median thickness 4.4 mm (2.5-8). The dose of Ruthenium-106 plaque brachytherapy prescribed to the apex of each tumor was 70 Gy in all cases. The median radiation dose to the sclera surface was 226.4 Gy (range: 179.6-342.3) and the median total application time 115.2 hours (range: 27 to 237). After a median follow-up of 61.5 months, local control was achieved in 17 patients (89%): 16 demonstrated a partial tumor response and 1 tumor stabilization. Two patients suffered local progression leading to enucleation, one dying of hepatic metastasis. Radiation-induced complications were cataracts in 3 cases and vitreal hemorrhage in 2. Conclusion: Ruthenium-106 plaque brachytherapy is an efficient treatment for localized uveal melanoma, offering good local control with low toxicity.

• 한국임상수의학회지
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• 제35권6호
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• pp.315-318
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• 2018

A 13-year-old spayed female Beagle dog was referred with high intraocular pressure, hyperemia, and exophthalmos of the left eye and underwent ultrasound, which revealed a mass in the ciliary body of the left eye. Magnetic resonance (MR) imaging was ordered to evaluate invasion of surrounding structures and metastasis to the brain via the optic nerve. On MR imaging, a single, well-defined, smoothly marginated, triangular-to-oval-shaped mass was found. The mass was hyperintense on T1-weighted images and hypointense on T2-weighted images, similar to a previous case of ocular melanoma. The mass originated from the ciliary body and extended from the anterior chamber to the posterior chamber. Slight enhancement was observed in the mass. There was no evidence of invasion into surrounding structures or the optic nerve, and no sign of metastasis to the brain. The mass was histopathologically diagnosed as benign uveal melanocytoma.

• 대한방사선치료학회:학술대회논문집
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• 대한방사선치료학회 1997년도 학술대회
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• pp.23-24
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• 1997

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2685-2686
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• 2013

• 한국임상수의학회지
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• 제35권5호
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• pp.233-236
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• 2018

A 13-year-old spayed female Beagle dog was referred with high intraocular pressure, hyperemia, and exophthalmos of the left eye and underwent ultrasound, which revealed a mass in the ciliary body of the left eye. Magnetic resonance (MR) imaging was ordered to evaluate invasion of surrounding structures and metastasis to the brain via the optic nerve. On MR imaging, a single, well-defined, smoothly marginated, triangular-to-oval-shaped mass was found. The mass was hyperintense on T1-weighted images and hypointense on T2-weighted images, similar to a previous case of ocular melanoma. The mass originated from the ciliary body and extended from the anterior chamber to the posterior chamber. Slight enhancement was observed in the mass. There was no evidence of invasion into surrounding structures or the optic nerve, and no sign of metastasis to the brain. The mass was histopathologically diagnosed as benign uveal melanocytoma.

• 한국의학물리학회지:의학물리
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• 제18권1호
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• pp.1-6
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• 2007

CCD 카메라가 부착된 head mounted display (HMD)를 이용하여 포도막 흑색종(uveal melanoma)을 치료하기 위해 외부 침투적 고정장치 없이 안구의 움직임을 감시할 수 있는 안구의 고정 및 감시장치를 제작하여 임상 사용 가능성을 확인하고자 하였다. 안구 고정 및 감시장지 시스템은 환자의 안구를 고정시키기 위해 환자의 초점을 일정하게 해 줄 수 있는 스크린이 달린 head mount display (HMD) 장치와 고정된 안구를 감시할 수 있게 HWD에 부착시킨 CCD 카메라, 그리고 환자의 머리를 고정시키는 마스크로 구성되어 있다. CCD 카메라가 부착되어 있는 HMD를 마스크 위에 부착하여, HMD의 스크린에서 보여주는 기준점을 환자가 주시하도록 하여 환자의 안구를 고정시킬 수 있었다. 본 연구는 4명의 지원자와 정위적 방사선수술을 시행하는 한 명의 포도막 흑색종 환자를 대상으로 하였다. 4명의 지원자에게서는 셋업에 따른 오차와 안구의 움직임을 분석하는 자료를 얻었고, 한 명의 환자에게서는 임상 사용의 가능성을 확인하였다. 환자는 HMD를 착용한 후 스크린에서 보여지는 기준점에 안구를 고정시킨 후, CT 촬영을 하였다. 방사선 수술기간 동안에도 치료 전에 치료계획을 위한 CT 촬영 시와 동일한 조건에서 매일 CT 촬영을 시행하였고, 이것을 치료계획을 위해 촬영한 CT 영상과 비교하여, 방사선 치료를 받는 기간 동안 수정체의 움직임을 비교하였다. 4명의 지원자의 자료에서 얻은 셋업에 따른 오차는 1mm 이내였으며, 안구의 움직임도 2mm 이내의 오차범위 내에 고정할 수 있었다. 본 연구에서 제작한 안구의 고정 및 감시장치는 외부 침투적 고정장치 없이 환자의 안구를 성공적으로 고정시켜 포도막 흑색종의 정위적 방사선수술을 시행할 수 있게 하였다. 이로써 자체 제작한 안구의 고정 및 감시장치의 임상 사용의 가능성을 확인하였다.