• Journal of Marine Bioscience and Biotechnology
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• v.6 no.2
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• pp.62-67
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• 2014

In this study, we investigated the bioactive substances of the Alcalase hydrolysate obtained from fishery processing by-products in Jeju by measuring bioactivities including radical scavenging acitivty, cytoprotective activity against 2,2-azobis-(2-amidino-propane) dihydrochloride (AAPH), and ACE inhibitory activity. This study is important because of utilization of unused fishery processing by-products in Jeju. The Alcalase hydrolysate was prepared through the hot water extraction and enzymatic hydrolysis, and then further separation of the Alcalase hydrolysate was performed by ultrafiltration using 10 kDa molecular weight cut-off membrane. The Alcalase hydrolysate showed the relatively higher DPPH and peroxyl radical scavenging activity ($IC_{50}$ value; 1.30 mg/ml and 0.888 mg/ml, respectively). Also, the Alcalase hydrolysate showed the ACE inhibitory activity with 1.87 mg/ml of $IC_{50}$ value. These biological activities are increased over 1.2 or 2.5 times through the ultrafiltration of the Alcalase hydrolysate. Therefore, the Alcalase hydrolysate obtained from fishery processing by-products in Jeju and the different molecular weight fractions should be given consideration for food and cosmetics ingredient. Furthermore, this research on the utility of fishery processing by-products might be a useful tool into the industry.

• Journal of Mushroom
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• v.16 no.4
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• pp.331-333
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• 2018

The incorporation of Shiitake culture into sawdust is a widely utilized technique that can assist in reducing the cost and time consumption associated with oak cultivation. In sawdust cultivation, browning of the surface mycelia is an important stage with respect to the utility and longevity of the sawdust media. Surface browning forms a protective coating on the substrate, which can inhibit the invasion of pathogens and suppress water evaporation. Several different light sources (red LED, white LED, blue LED, and fluorescent light) were used and the intensity of illumination was carefully controlled (1.5, 10.5, $20.5{\mu}mol/m^2s$ for LEDs and 10, 100, 300 lux for the fluorescent light) to induce browning. The light sources were regulated via a 1 h on/off cycle in a controlled room environment at a temperature of $20^{\circ}C$, 60% humidity, and 1200 ppm $CO_2$ concentration for 60days. The browning effect varied depending on the source and the intensity of illumination. This effect was most effectively induced at $1.5{\mu}mol/m^2s$ for the red and blue LEDs. All light sources induced less browning at the highest intensity of illumination. This indicates that intensity values higher than $20.5{\mu}mol/m^2s$ in the case of the LEDs and 300 lux for the fluorescent light are not effective. After harvesting of the fruit bodies, we measured the weight, length, and width of the pileus and stipe in addition to their chromaticity and hardness. Treatment with $1.5{\mu}mol/m^2s$ blue LED produced the best harvest with the highest average chromaticity, weight (21.2 g), stipe length (30.8 mm), and hardness (377.9 g), with a fine length and width of the pileus.

• Journal of radiological science and technology
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• v.46 no.6
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• pp.543-551
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• 2023

In this study, the aim was to assess the shielding performance of different 3D printing materials, specifically those produced using FDM, SLA, and CJP methods, with a focus on their application as shielding devices in clinical settings. Additionally, the weight of lead shielding materials can evoke reluctance in pediatric patients undergoing X-ray imaging. A total of 12 materials were printed using their respective 3D printers. These materials were then subjected to X-ray testing using diagnostic X-ray equipment and an exposure meter. The goal was to evaluate their shielding capabilities in comparison to 1 mm lead. The results of this evaluation revealed that VisiJet PXL-Pastel, produced using the CJP method, exhibited the highest shielding performance. Therefore, VisiJet PXL-Pastel by CJP method was selected for the creation of a shielding device designed for pediatric reproductive organs. Subsequent tests demonstrated that both the newly created shielding device and conventional lead shielding equipment achieved the same maximum shielding rate at 50 kVp. Specifically, the shielding rate for the 3D printed device was measured at 84.53%, while the conventional lead shielding equipment, categorized as Apron1 (85.74%), Apron2 (99.98%), and Apron3 (99.04%), demonstrated similar performance. In conclusion, the CJP-produced VisiJet PXL-Pastel material showcased excellent radiation shielding capabilities, allowing for anatomical observations of the target organs and their surrounding structures in X-ray images. Furthermore, its lower weight in comparison to traditional lead shielding materials makes it a clinically practical and useful choice, particularly for pediatric applications.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.26 no.6
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• pp.346-354
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• 2023

Purpose: Approximately 30% of children with chronic liver disease (CLD) are malnourished. However, proper assessment of their nutritional status is difficult. The subjective global nutritional assessment (SGNA) is a comprehensive approach that uses nutrition-focused history and examination, followed by grading of malnourishment. We aimed to study the prevalence of malnutrition in children with CLD using the SGNA tool. Methods: This cross-sectional observational study included patients aged <18 years with CLD. Nutritional assessments were recorded using SGNA tool. Conventional anthropometric measurements were performed and corroborated with nutritional status using SGNA tool. Results: A total of 85 children with CLD and mean age of 62 months were enrolled in this study. The prevalence of malnourished children according to SGNA was 34%; 22% were moderately malnourished and 12% were severely malnourished. We found statistically significant differences in anthropometric parameters among the three groups. A moderate degree of agreement was found between SGNA and weight-for-age (W/A) (p=0.020), mid-upper arm circumference (MUAC) (p<0.001), and triceps skin-fold thickness (TSF)-for-age (p=0.029). Furthermore, a fair degree of agreement was found between height-for-age (H/A) (p=0.001) and weight-for-height (W/H) (p<0.001). The sensitivity of W/A for detecting malnutrition was 93%, H/A was 90%, MUAC was 86%, and TSF was 88%. The sensitivity was much lower for W/H and body mass index for age (55% for both). Conclusion: In our study, more than one-third of children with CLD were malnourished. Nutritional assessment using SGNA is a reliable method for evaluating nutritional status and is significantly correlated with common anthropometric measurements.

• BMB Reports
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• v.40 no.5
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• pp.670-677
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• 2007

Although polysaccharide is believed to play an important role in the medicinal effect of Dendrobium chrysotoxum Lindl (DCL), its role as an antioxidant and in anti-hyperglycemic induction was not reported. In this study, polysaccharide with molecular weight of approximately 150 kDa, herein named DCLP, was isolated from the stem of DCL, and its antioxidative, hypoglycemic and immune stimulating effects were evaluated using various in vitro and in vivo assay systems. DCLP inhibited hydroxyl radicals ($^{\cdot}$OH)-mediated deoxyribose degradation by scavenging hydroxyl radicals directly as well as by chelating iron ions. DCLP also showed dose-dependent scavenging activity on superoxide anions ($O_2^{{\cdot}-}$) and offered significant protection (p < 0.001) against glucose oxidase-mediated cytotoxicity in Jurkat cells. DCLP had immune stimulating effects, as evidenced by the DCLP-mediated increases in the level of DNA synthesis, viability, and cytokine secretion in mouse lymphocytes. Moreover, oral administration of DCLP produced a significant reduction in blood glucose level in alloxan-induced diabetic mice. These findings suggest that DCLP has a potential utility in treating patients who require enhanced antioxidation, immune function and/or hypoglycemic activity.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2004.05a
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• pp.45-50
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• 2004

In this study, we processed two procedures of application test of filler for special-purpose utility that are new application methods of aerated concrete and properties test of aerated concrete according to mixing ratio because we investigated the better use of aerated concrete as filler for fireproof safety and we proposed basic data about standardization of mixing of aerated concrete. We measured flow and volume change of aerated concrete. And if its volume doesn't change, we added measuring unit weight and compressive strength. To test application of aerated concrete as filler for fireproof safety, we filled up aerated concrete to fireproof safety according to suitable mixing ratio. Then we measured maximum temperature of inner part of fireproof safety in accordance with the standard test of fireproof. According to the results, aerated concrete as filler for fireproof safety could be possibly used. So when we make aerated concrete, we should consider using an adding agent as well as a foaming agent.

• Journal of Information Technology Application
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• v.1
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• pp.173-211
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• 1999

The task of classification permeates all walks of life, from business and economics to science and public policy. In this context, nonlinear techniques from artificial intelligence have often proven to be more effective than the methods of classical statistics. The objective of knowledge discovery and data mining is to support decision making through the effective use of information. The automated approach to knowledge discovery is especially useful when dealing with large data sets or complex relationships. For many applications, automated software may find subtle patterns which escape the notice of manual analysis, or whose complexity exceeds the cognitive capabilities of humans. This paper explores the utility of a collaborative learning approach involving integrated models in the preprocessing and postprocessing stages. For instance, a genetic algorithm effects feature-weight optimization in a preprocessing module. Moreover, an inductive tree, artificial neural network (ANN), and k-nearest neighbor (kNN) techniques serve as postprocessing modules. More specifically, the postprocessors act as second0order classifiers which determine the best first-order classifier on a case-by-case basis. In addition to the second-order models, a voting scheme is investigated as a simple, but efficient, postprocessing model. The first-order models consist of statistical and machine learning models such as logistic regression (logit), multivariate discriminant analysis (MDA), ANN, and kNN. The genetic algorithm, inductive decision tree, and voting scheme act as kernel modules for collaborative learning. These ideas are explored against the background of a practical application relating to financial fraud management which exemplifies a binary classification problem.

• Steel and Composite Structures
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• v.24 no.1
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• pp.93-112
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• 2017

Metaheuristic algorithms in general make use of uniform random numbers in their search for optimum designs. Levy Flight (LF) is a random walk consisting of a series of consecutive random steps. The use of LF instead of uniform random numbers improves the performance of metaheuristic algorithms. In this study, three discrete optimum design algorithms are developed for steel skeletal structures each of which is based on one of the recent metaheuristic algorithms. These are biogeography-based optimization (BBO), brain storm optimization (BSO), and artificial bee colony optimization (ABC) algorithms. The optimum design problem of steel skeletal structures is formulated considering LRFD-AISC code provisions and W-sections for frames members and pipe sections for truss members are selected from available section lists. The minimum weight of steel structures is taken as the objective function. The number of steel skeletal structures is designed by using the algorithms developed and effect of LF is investigated. It is noticed that use of LF results in up to 14% lighter optimum structures.

• Korean Journal of Human Ecology
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• v.22 no.1
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• pp.75-88
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• 2013

The purpose of this study was to investigate the effects of appearance instrumentality on body satisfaction and appearance management behaviors by adolescent' sex. The subjects were 750 adolescents in Daejeon and Chungnam province. The research method was a survey and the measuring instruments consisted of appearance instrumentality, body satisfaction, appearance management behaviors, and subjects' demographics attributions. The data were analyzed by Cronbach's ${\alpha}$, factor analysis, cluster analysis, ${\chi}^2$ test, and t-test, using SPSS statistical program. The results were as follows. First, 3 dimensions(the utility of interpersonal relationship, social achievement and sexual partnership) were emerged on appearance instrumentality, and adolescents were divided into 2 groups(unreceptive and receptive group) by appearance instrumentality. Second, appearance instrumentality had significant effects on female adolescents' body satisfaction; receptive group was more dissatisfied with their bodies, especially weight, hip, abdomen, and body shape than unreceptive group. However, it had no significant effects on male adolescents' body satisfaction. Third, appearance instrumentality had many significant effects on male and female adolescents' appearance management behaviors. Especially, female receptive group had higher intention to perform professional care by a sliming club, beauty salon, and dermatology, and face plastic surgery than unreceptive group.

• Journal of Yeungnam Medical Science
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• v.30 no.1
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• pp.4-9
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• 2013

Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations (e.g., POMC and NPY neurons) and activates several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway, which eventually translates into decreased food intake and increased energy expenditure. Leptin signal is inhibited by a feedback inhibitory pathway mediated by SOCS3. PTP1B involves another inhibitory pathway of leptin. Leptin potently promotes fat mass loss and body weight reduction in lean subjects. However, it is not widely used in the clinical field because of leptin resistance, which is a common feature of obesity characterized by hyperleptinemia and the failure of exogenous leptin administration to provide therapeutic benefit in rodents and humans. The potential mechanisms of leptin resistance include the following: 1) increases in circulating leptin-binding proteins, 2) reduced transport of leptin across the blood-brain barrier, 3) decreased leptin receptor-B (LRB), and/or 4) the provocation of processes that diminish cellular leptin signaling (inflammation, endoplasmic reticulum stress, feedback inhibition, etc.). Thus, interference of the cellular mechanisms that attenuate leptin signaling improves leptin action in cells and animal models, suggesting the potential utility of these processes as points of therapeutic intervention. Various experimental trials and compounds that improve leptin resistance are introduced in this paper.