• 대한세포병리학회지
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• 제1권1호
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• pp.111-120
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• 1990

Small cell neuroendocrine carcinoma of the uterine cervix is a distinct subtype of cervical cancer that appears analogous to oat cell carcinoma and carcinoid tumors of the lung. It has been assumed to be derived from the neural crest via argyrophilic cells in the normal endocervix. We have recently encountered a case of small cell neuroendocrine carcinoma of the uterine cervix coexisting with adenocarcinoma which was argyrophil negative. A 66-year-old multiparous woman was admitted because of vaginal bleeding for 2 months. Cervicovaginal smear revealed several scattered clusters and sheets of monotonous small cells with some peripheral palisading in the background of hemorrhage and necrosis. Radical hysterectomy specimen revealed an ulcerofungating tumor on endocervical canal which was composed of two components. Major component of the tumor was made up of monomorphic population of small oval-shaped tumor cells arranged in sheets and partly in acinar structures or trabecular fashion. Other component was adenocarcinoma, endocervical well-differentiated type. Argyrophilia was present on the Grimelius stain and immunohistochemical studies revealed diffuse positivity to neuron-specific enolase and carcinoembryonic antigen. Electron microscopic examination showed clusters of small round to oval cells, which had a few well-formed desmosomes and several membrane-bound, dense-core neurosectetory granules.

• Journal of Preventive Medicine and Public Health
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• 제29권2호
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• pp.159-172
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• 1996

A hospital-based case-control study was carried out to investigate the risk factors of uterine cervical cancer in Korea. Information on a wide-range of life-styles, which might be related with uterine cervix cancer, has been routinely collected through a dual application of the self-administered questionnaire and the direct interview by a well-trained nurse at the Department of Gynecology, Seoul National University Hosiptal since 1992. The number of cervical cancer cases, histologically confirmed at the hospital, were 284. Included were 939 women as controls, who were free of past history of any malignancies. Adjusted odds ratio and 95% confidence limits were based on the unconditional logistic regression model. The multivariate logistic model was constructed under the consideration of biologic characteristics on the natural history of the malignancy. In the multivariate results, the uterine cervical cancer risk was higher in women of shorter height$(P_{trend}<0.05)$, less educated spouse$(P_{trend}<0.001)$(0.001), multiple marriages(adjusted OR=2,70, 95% C.I. $1.64\sim4.47$), ever had a family history (adjusted OR=2.14., 95% C.I. $1.18\sim3.89$), multiparity$(P_{trend}<0.001)$, and early age at first $(P_{trend}<0.001)$. These results strongly suggest that the uterine cervix cancer might be related to the reproductive factors, and probably with sexual behaviour of both women and men in Korea.

• 보험의학회지
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• 제19권
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• pp.81-86
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• 2000

• Radiation Oncology Journal
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• 제14권1호
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• pp.33-39
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• 1996

목적 : 초기 자궁경부암은 수술과 방사선치료 모두 가능하며 결과도 비슷하다고 알려져있다. 이에 근치적 방사선치료를 받은 초기 자궁경부암 환자의 생존율, 실패율, 부작용등을 다른 결과와 비교하기 위하여 후향적 분석을 시행하였다. 대상 및 방법 : 근치적 방사선치료를 시행한 자궁경부암 IB 48명과 IIA 32명을 대상으로 하였다. 1985년 11월 부터 1993년 5월 까지 등록된 환자들로 최소 추적기간은 2년이었다. 외부전골반 방사선치료를 40-50Gy 시행후 3가지 다른 1회 조사량으로 고선량 강내치료를 시행후, 추적조사하여 생존율, 실패양상과 합병증등을 분석하였다. 결과 : 5년 생존율과 5년 무병 생존율은 각각 $72.3\%,\; 72.8\%$였으며 예후인자는 병기 병소의 크기, 병리조직 (선암), 방사선치료의 반응이었다. 19명의 치료실패가 있었으며 대부분 24개월이내에 발생하였다. Grade 2이상의 만성합병증은 방광이 $8.8\%$, 직장이 $15\%$, 모두 $17.5\%$ 였으며 발생율과 심한 정도는 강내치료 1회 조사량과 총 선량에 유의한 상관관계가 있었다. 결론 : 초기 자궁암의 방사선치료는 수술의 결과와 비슷하였으며 예후가 나쁜환자는 결과가 안좋아서 더 적극적인 치료방법이 필요하며 만성 합병증을 줄이기 위해서는 적절한 질 packing 등으로 주위조직의 방사선 피폭량을 줄이고 고선량 강내치료시 적절한 1회 조사량의 선택이 필요한 것으로 생각된다.

• Radiation Oncology Journal
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• 제7권2호
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• pp.259-267
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• 1989

Forty one patients with para-aortic node metastases from carcinoma of the uterine cervix treated with radiotherapy at Department of Radiation Oncology, Yonsei University, College of Medicine from January 1982 to December 1987 were retrospectively analyzed. Eleven patients were diagnosed at the time of diagnosis of carcinoma of the cervix (early diagnosis) and 30 patients were diagnosed during follow up period after definitive radiotherapy of primary site (late diagnosis). The most important factors affecting the survival in this study were time of diagnosis and dose of irradiation. Overall 5 year actuarial survival rate of 41 patients was $25.7\%$. Five year survival rate for early diagnosis was $60.3\%$, but late diagnosis was $16.9\%$. And survival rate for high dose (over 4000 cGy) radiation group and low dose radiation group were $42.2\%\;and\;8.9\%$ respectively The most leading cause of death was para-aortic node failure, so early diagnosis and maximum palliation with full dose radiotherapy (over 4000 cGy) is necessary to improve the survival and the quality of life.

• Radiation Oncology Journal
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• 제31권4호
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• pp.216-221
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• 2013

Purpose: The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Materials and Methods: Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. Results: The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Conclusion: Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1519-1523
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• 2015

Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical smears were HPV positive. There was increasing trend of high-risk-HPV positivity (HR HPV 16 and 18), from 20% in benign cytology (NILM) to 42.9 % in LSIL, 71.41% in HSIL and 100% in SCC. There was highly significant association of HPV infection with cervical lesion ($x^2=144.0$, p<0.01) and also with type specific HPV prevalence ($x^2=7.761^*$, p<0.05).

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7761-7762
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• 2013

Alternative strategies such as visual inspection of cervix with acetic acid, are real time, economical and easily implemented methods for cervical cancer screening. However, variable sensitivity and specificity have been observed in various community based studies. The possible reasons could include variation in man power training, light source used for visualization, and preparation of diluted (4-5%) acetic acid and its storage. A standardized protocol for training, teaching material (easy to understand in the local language) for trainees, supervision and reinforcement by intermittent and supplementary training to check the quality of their observation, a standard protocol for preparation dilute acetic acid and its storage and a standard good light source (equivalent to day light) are needed to minimize the variation in sensitivity and specificity of VIA in community settings.

• 대한영상의학회지
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• 제85권2호
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• pp.445-450
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• 2024

자궁 경부암의 위 전이는 매우 드물며, 소수의 증례만이 영문 문헌에서 보고되었다. 자궁경부 위형 점액샘암종은 드문 아형의 점액샘암종이다. 위형 점액샘암종은 진행성 암에서 발견되는 공격적인 암이지만, 위로의 전이는 보고된 바 없다. 저자들은 61세 여성의 자궁경부 위형 점액샘암종이 위 날문방에 전이된 증례를 보고하며 위 전이 및 자궁경부 점액샘암종의 영상의학적 소견을 서술하고자 한다. 위 전이는 조영증강이 잘되지 않는 점막 하 종괴로 보였다. 점액샘암종은 조영증강이 잘되지 않는 침윤성 종괴로 보였다. 확산강조영상에서는 경도의 고신호강도를 보였고 겉보기확산계수 지도에서는 낮은 값을 보였다. 이 사례는 매우 드물며 진단이 어렵지만, 자궁경부암의 유형이 사람유두종바이러스 비의존 위형 점액샘암종이며 동시에 위의 점막 하 병변이 발견된 경우, 우리 사례와 유사한 패턴의 전이 가능성을 고려할 수 있다.

• Radiation Oncology Journal
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• 제10권2호
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• pp.227-236
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• 1992

1979년 3월부터 1986년 12월까지 과거에 아무런 치료를 받지 않은 자궁경부암 IIB병기 환자 232명을 서울대학병원 치료방사선과에서 치료하였다. 대상 환자들은 FlGO 방식으로 병기가 결정되었으며, 대다수의 환자에게 골반 외부 방사선 조사 및 강내 조사가 병용되어 치료되었다. 이학적 검사소견, 혈액 검사소견, 내과적 질환의 과거력, 조직학적 소견 및 복부-골반 전산화단층촬영 소견등의 치료전 인자들이 분석되었으며 이들 인자들의 5년 국소 치료율, 5년 무병 생존율 및 5년 생존율 등에 대한 잠재적인 예후적 유의성을 밝히기 위해 단변수분석과 다변량분석을 시행하였다. 조직학적 소견, 자궁내진시 자궁방결합조직의 침윤, 전산화단층촬영상 대동맥 임파절의 전이등이 자궁경부암 IIB 병기에서 예후적 유의성을 갖는 것으로 판명되었다.