• 가정간호학회지
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• 제22권2호
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• pp.291-299
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• 2015

Purpose: The purpose of this study was to examine the influences of sex-relatedl knowledge, sex-related attitude and knowledge of cervical cancer on knowledge of human papilloma virus (HPV) among female high school students. Methods: A cross-sectional descriptive study was conducted with a convenience sample of 545 second-grade female high school students of three different schools. Results: Knowledge of HPV was positively correlated with sex-related knowledge (r=.36, p<.001), sex-related attitude (r=.14 p=.001) and knowledge of cervical cancer (r=.62, p<.001). Significant predictors affecting knowledge of HPV among female high school students were knowledge of cervical cancer (${\beta}$=.57) and sex-related knowledge (${\beta}$=.11), explaining 39.6% of the variance in knowledge of cervical cancer among female high school students (F=178.34, p<.001). Conclusion: Based on the outcomes of this study, in order to improve knowledge of HPV among female high school students, school based sexual education linked to HPV and cervical cancer must be included in the curriculum.

• Journal of Yeungnam Medical Science
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• 제8권1호
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• pp.166-177
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• 1991

1986년 4월부터 1991년 3월까지 영남대학교 의과대학 부속병원에서 자궁 경부암으로 확진되어 수술후 방사선치료를 시행한 22명의 환자에서 방사선 선량 분포에 따른 치료성적은 다음과 같다. 1. 22명중 3명(13.6%)에서 골반이나 복부에 재발이 생겼으며 임상적 병기가 진행될수록, 외부조사선량이 적을수록 재발이 많았다. 2. 골반내 임파선 전이와 임파혈관 침범인 경우에 재발이 되었다. 3. 강내조사 선량이나 수술방법은 재발과 무관하였다. 4. 중대한 합병중은 임상적 병기가 앞설수록 외부조사 선량이나, 총조사 선량이 증가할수록 많이 발생하였다. 이상의 결과를 보면 본원 치료방사선과의 자궁 경부암의 수술후 방사선 치료원칙은 적절하며 재발방지와 합병증의 예방을 위한 세심한 주의와 항암제를 위시한 전신요법의 추가를 고려하여야 하겠다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2815-2819
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• 2014

Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydan Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4221-4227
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• 2012

Cancer of the uterine cervix is a worldwide menace taking innumerable womens' lives. The literature is vast and a large number of studies have been conducted in this field. Analyses have shown significant differences exist in terms of screening and HPV testing facilities among high income and low to middle income countries. In addition, acute lack of awareness and knowledge among the concerned population is particularly noted in rural areas of the low income countries. A detailed review of Indian case studies revealed that early age of marriage and childbirth, multiparity, poor personal hygiene and low socio-economic status among others are the principal risk factors for this disease. This review concludes that a two pronged strategy involving strong government and NGO action is necessary to minimize the occurrence of cervical cancer especially in low and medium income countries.

• Radiation Oncology Journal
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• 제12권3호
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• pp.369-376
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• 1994

This is a retrospective analysis of 64 patients who was treated with postoperative radiation therapy after radical hysterectomy and bilateral pelvic lymphadenectomy (53 patients) or total abdominal hysterectomy(11 patients) for uterine cervix cancer between May 1980 and September 1991 at the Department of Radiation Oncology, Kyung Hee University Hospital. Most patients were FIGO IB (31 Patients) and IIA (25 patients), and median period of follow-up was 5.1 years. Of these patients,24 received adjuvant whole pelvis irradiation of 6000 cGy and 40 received 5000-5500 cGy whole pelvis irradiation and/or intracavitary radiation (7 Patients). The actuarial overall and relapse free 5 year survival rate were $71.0\%$, $68.3\%$ respectively. The survival rates by stage were $79.1\%$ in stage I, and $61.2\%$ in stage II. Treatment failure was noted in 18 of 64 patients ($28.1\%$), Iocoregional failure in 8 ($12.5\%$), distant metastasis in 8 ($12.5\%$), paraaortic node metastasis in 1 and one patient and concurrent locoregional and distant metastasis. The univariate analysis of prognostic factors affecting to overall survival rate represented lymph node status, the number and site of metastatic lymph node, parametrial invasion, the thichness of cervical wall invasion, and size of cancer mass. Histology, vessel invasion, endometrial extension, hemoglobin level. resection margin status, age, radiation dose were not significant prognostic factors. Complication relating to operation and postoperative radiation were variable according to radiation therapy method: 6000 cGy RT group 8/24($33.3\%$), 5000-5500 cGy+ICR 3/7 ($42.9\%$), 5000-5500 cGy external RT only group 3/33 ($9.1\%$). In conclusion, the results suggest that postoperative radiotherapy is necessary in high risk patients for locoregional control and improving survival rate, and higher dose does not improve results but only increases complication.

• Radiation Oncology Journal
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• 제12권3호
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• pp.387-392
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• 1994

Purpose : This study was done to confirm the reference point variation according to variation in applicator configuration in each fractioation of HDR ICR. Materials and Methods : We analyzed the treatment planning of HDRICR for 33 uterine cervical cancer patients treated in department of therapeutic radiology from January 1992 to February 1992. Analysis was done with respect to three view points-Interfractionation A point variation, interfractionation bladder and rectum dose ratio variation, interfractionation treatment volume variation. Interfractionation A point variation was defined as difference between maximum and minimum distance from fixed rectal point to A point in each patient. Interfractionation bladder and rectum dose ratio variation was defined as difference between maximum and minimum dose ratio of bladder or rectum to A point dose in each patient, Interfractionation treatment volume variation was defined as difference between miximum and minimum treatment volume which absorbed over the described dose-that is, 350 cGy or 400 cGy-in each patient. Results The mean of distance from rectum to A point was 4.44cm, and the mean of interfractionation distance variation was 1.14 cm in right side,1.09 cm in left side. The mean of bladder and rectum dose ratio was $63.8\%$ and $63.1\%$ and the mean of interfractionation variation was $14.9\%$ and $15.8\%$ respectively. With fixed planning administration of same planning to all fractionations as in first fractionation planning-mean of bladder and rectum dose ratio was $64.9\%$ and $72.3\%$.and the mean of interfraction variation was $28.1\%$ and $48.1\%$ reapectively. The mean of treatment volume was $84.15cm^3$ and the interfractionation variation was $21.47cm^2$. Conclusion : From these data, it was confirmed that there should be adapted planning for every fractionation ,and that confirmation device installed in ICR room would reduce the interfractionation variation due to more stable applicator configuration.

• 한국정보통신학회논문지
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• 제13권8호
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• pp.1699-1704
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• 2009

자궁경부암은 다른 암과 달리 전암(前癌) 단계가 존재하므로 조기 발견할 경우에 생존율이 높다. 그러나 의사나 병리학자가 하루에 검진할 수 있는 양은 제한되어 있다. 따라서 본 논문에서는 세포 도말 검사에 사용되는 자궁 경부진 세포에서 핵을 추출하는 방법을 제안한다. 조기 자궁 경부 세포진 영상에서 핵의 추출은 영상의 배경 그리고 핵과 세포질 영역의 구분이 중요하기 때문에 Lighting Compensation을 적용하여 영상을 보정하고, 명암도의 분포가 가장 작은 B채널에서 $3{\times}3$ 마스크를 이용하여 잡음을 제거한다. 잡음이 제거된 영상을 이진화하고 Grassfire 알고리즘을 적용하여 세포 객체를 추출한다. 추출된 세포 객체 중에서 군집화된 세포 영역에 대해서는 R 채널의 명암도 값을 반복 이진화에 적용하여 핵 영역을 추출한다. 실제 진단 세포학에서 사용하는 자금경부 세포진 400 배율 영상을 대상으로 실험한 결과, 45개의 세포 영역 중에서 40개의 핵이 추출되었다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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• pp.118-118
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• 2006

• 대한세포병리학회지
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• 제12권1호
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• pp.31-37
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• 2001

Whlie cytologic characteristics of squamous dysplasia, carcinoma in situ, and invasive squamous cell carcinoma of the uterine cervix are well documented, relatively few studios have dealt with the cellular features of microinvasive carcinoma. In order to describe the cellular characteristics of microinvasive squamous cell carcinoma, we retrospectively reviewed 45 cervovaginal smears(15 carcinoma in situ, 15 microinvasive cancer, 15 invasive cancer) which were confirmed by histologic examination of specimens obtained by hysterectomy at the Seoul National University Hospital during S years from 1995 to 1999. The cytologic features about tumor diathesis, inflammatory background, ceil arrangement, anisonucleosis, nuclear membrane irregularity, nuclear chromatin pattern, and nucleoli were observed. The cytologlc characteristics of microinvasive squamous cell carcinoma of the uterine cervix are syncytial pattern, mild tumor diathesis, the irregularity of nuclear membrane, irregularly distributed nuclear chromatin, and occurrence of micronucleoli. But, correlation between the depth of Invasion and the cytologic feature had limited value.

• 여성건강간호학회지
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• 제29권4호
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• pp.317-327
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• 2023

Purpose: This study investigated the influence of cervical cancer knowledge, human papillomavirus (HPV) knowledge, self-efficacy, and uncertainty on the intention to engage in cervical cancer preventive behavior in HPV-infected women. Methods: This descriptive correlational study was conducted among 129 adult women aged 20 to 65 years who received positive HPV results at a general hospital in Changwon, Korea. The dataset was analyzed using descriptive statistics, the independent t-test, analysis of variance, the Pearson correlation coefficient, and multiple regression. Results: The mean score for the intention to engage in cervical cancer preventive behavior was high (4.43±0.65). This intention was significantly different according to age at first sexual intercourse (F=7.38, p=.001), HPV type (F=4.79, p=.010), vaccination (t=3.19, p=.002), and condom use (t=3.03, p=.003). The intention to engage in cervical cancer preventive behavior showed significant, weak-to-moderate positive correlations with HPV knowledge (r=.22, p=.012) and self-efficacy (r=.42, p<.001). Self-efficacy (β=.46, p<.001), first sexual intercourse at <20 years (β=.45, p<.001), first sexual intercourse at 20-24 years (β=.29, p=. 018), HPV high- and low-risk group infection (β=.26, p=.019), HPV high-risk group infection (β=.26, p=.026), and vaccination (β=.21, p=.007) significantly influenced the intention to engage in cervical cancer preventive behavior. These variables explained 34.6% of variance in intention. Conclusion: Study findings support the need to develop a program that effectively conveys accurate information about cervical cancer prevention to HPV-infected women and helps them enhance self-efficacy to boost the intention to engage in cervical cancer preventive behavior.