• 제목/요약/키워드: Use-dependence

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Neurobiological Effects of Methamphetamine Abuse on Neurotransmitters: A Review (흥분제(Psychostimulants)에 대한 신경생물학 측면의 고찰 -Methamphetamine 남용을 중심으로)

  • Lee Tae Kyung;Jon E. Grant;Kim, Suck Won;Oh Dong Yul
    • Journal of The Korean Society of Clinical Toxicology
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    • v.1 no.1
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    • pp.21-26
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    • 2003
  • Methamphetamine (MA) is a major drug of abuse in Korea. Currently preliminary evidence suggests that MA dependence may cause long-term neural damage in human. Repeated exposure to psychostimulants such as methamphetamine results in behavioral sensitization, a paradigm thought to be relevant to drug craving and addiction in human. Sensitization alters neural circuitry involved in normal processes of incentrive, motivation, and reward. However the precise mechanism of this behavioral sensitization has not yet been fully elucidated. Repeated use of high dose MA causes neurotoxicity which is characterized by a long-lasting depletion of striatal dopamine (DA) and tyrosin hydroxylase activity of DA, DA-transporter binding sites in the striatum. The loss of DA transporters correlates with memory problems and lack of motor coordination. DA fuels motivation and pleasure, but it' s also crucial for learning and movement. This selective review provides a summary of studies that assess the neurobiological mechanisms of MA.

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Preparation and characterization of proton exchange membranes in non-aqueous conduction (무수 전도성 양성자 교환막 제조 및 특성평가)

  • Park, Jin-Soo;Sekhon, S.S.;Baek, Ji-Suk;Yang, Tae-Hyun;Kim, Chang-Soo;Yim, Sung-Dae;Park, Gu-Gon
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.06a
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    • pp.282-285
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    • 2009
  • This study presents preparation and characterization of composite membranes based on ionic liquids. The ionic liquids act as water in sulfonated membranes. On the behalf of ionic conduction through ionic liquid inside the membranes, non-aqueous membranes showed Arrenhius dependence on temperature with no external humidification. It was implied that hopping mechanism of proton was dominant in the ionic liquid based membranes. In addition, small angle X-ray (SAXS) studies provided the information on morphology of ionic clusters formed by the interaction between sulfonic acid groups of the polymers and ionic liquids. The SAXS spectra showed matrix peaks, ionomer peaks and Prodo's law for Nafion based composite membranes and only matrix peaks for hydrocarbon based ones. However, ionic conductivity and atomic force microscopy (AFM) images showed the clear formation of ionic clusters of the hydrocarbon based composite membranes. It implies for ionic liquid based high temperature membranes that it is important to use sulfonated polymers as solid matrix of ionic liquid which can form clear ionic clusters in SAXS spectra.

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Determination of Specimen Geomery for Estimation of the Complex Modulus of Viscoelas the Materials by the Lumped Mass Model (집중질량 모형화에 의한 점탄성재료의 복소 탄성계수 산출을 위한 시편 크기 의 절정)

  • Kang, Gi-Ho;Shim, Song;Kim, Gwang-Jun
    • Journal of KSNVE
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    • v.1 no.2
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    • pp.121-128
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    • 1991
  • In order to use viscoelastic materials efficiently for noise and vibration control, or th qualify newly developed materials, knowledge of the Young' s modulus and loss factor is essemtial. These material properties, the so-called complex Young' s modulus, are frequently treated as dynamic charicteristics because of their dependence upon the frequency. Many techniques have been developed and verified for measuring complex Young' s modulus of viscoelastic materials. Among them, the impedance method is preferable in order to obtain the frequency information in detail. In this method, a cylindrical or prismatic specimen is excited into longitudinal harmonic vibration at one end, the other being fixed, and the resulting force is measured at the driving or fixed end. The amplitude ratio of the two signals and phase angle between them are then used to compute the material properties using various mathematical models. In this paper, the impedance method is investigated theoretically and experimentally. A way to determine the specimen geometry which is most appropriate for the identification of complex Young' s modulus using the lumped mass model is presented and discussed. Then experimental results supporting the theoretical predictions are presented.

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The Concentration Distribution and Temperature Dependence of Hexachlorocyclohexane in Rural Atmosphere (교외지역에서 대기 중 Hexachlorocyclohexane의 농도분포 및 온도 의존성)

  • 최민규;여현구;김태욱;천만영;선우영
    • Journal of Korean Society for Atmospheric Environment
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    • v.18 no.3
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    • pp.183-192
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    • 2002
  • Concentrations of $\alpha$- and ${\gamma}$-hexachlorocyclohexane (HCH) were measured in ambient air samples at a two week intervals between July 1999 and February 2000 at Ansung, Kyonggi province. Their concentration levels averaged at 78 ($\alpha$-HCH) and 18 pg/m$^3$(${\gamma}$-HCH). Although the use of HCHs was ceased in South Korea since 1979, their residues are still present in air even after nearly 20 years. Given the composition of the two main HCH pesticide formulation (technical HCH antral lindane), the $\alpha$/${\gamma}$-HCH ratio in air is a useful indicator on the regional scale. The moderately low $\alpha$/${\gamma}$-HCH ration in this study indicates previous usage of both technical HCH and lindane. The relationship of temperature with gas-phase partial pressures was also examined using the Clausius-Clapeyron equation. Slopes generated by linear regression analysis between partial pressure (In P) and 1/T were considerably steep thor HCHs. It is thus suggested that their concentrations are controlled by re-volatilization processes from surfaces in the local surroundings of the sampling site.

A Study of Design factors for Increasing Energy Production in Small Hydro power with Using Long Pipe (장대관로를 이용한 소수력 발전량 향상을 위한 설계요소에 관한 연구)

  • Kim, Hyun-Han;Kim, Kwang-Ho
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.63 no.8
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    • pp.1134-1139
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    • 2014
  • Recently the need for renewable energy development is expanding due to the global climate change, the environmental issues and the limited fossil energy resources. Dependence of energy on overseas is high in Korea. To resolve the environmental problems and to improve the energy independence rate, the development of renewable energy is more required. The small hydro power, one of the renewable energy resources, has been developing and operating from a long time ago. If we are new developing a small hydro power with the use existing dams and reservoirs, we will design the length of inlet pipe and the diameter suitable for it. However, in case of using the existing water supply pipe which had been designed suitable for water service, the designer has to review and check that the pipe is suitable for operating a generator. In this paper, the design of small hydro power using the existing long pipe of water supply, we suggest the optimum way to reduce the water hammer in pipe which causes the unsteady flow during the load-shutdown of generator, the generator operation plan for the stable supply of water and the design factor of determining the generator capacity through the analysis between discharge and head-loss.

Accurate Representation of Light-intensity Information by the Neural Activities of Independently Firing Retinal Ganglion Cells

  • Ryu, Sang-Baek;Ye, Jang-Hee;Kim, Chi-Hyun;Goo, Yong-Sook;Kim, Kyung-Hwan
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.3
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    • pp.221-227
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    • 2009
  • For successful restoration of visual function by a visual neural prosthesis such as retinal implant, electrical stimulation should evoke neural responses so that the informat.ion on visual input is properly represented. A stimulation strategy, which means a method for generating stimulation waveforms based on visual input, should be developed for this purpose. We proposed to use the decoding of visual input from retinal ganglion cell (RGC) responses for the evaluation of stimulus encoding strategy. This is based on the assumption that reliable encoding of visual information in RGC responses is required to enable successful visual perception. The main purpose of this study was to determine the influence of inter-dependence among stimulated RGCs activities on decoding accuracy. Light intensity variations were decoded from multiunit RGC spike trains using an optimal linear filter. More accurate decoding was possible when different types of RGCs were used together as input. Decoding accuracy was enhanced with independently firing RGCs compared to synchronously firing RGCs. This implies that stimulation of independently-firing RGCs and RGCs of different types may be beneficial for visual function restoration by retinal prosthesis.

HI LINEWIDTHS, ROTATION VELOCITIES AND THE TULLY-FISHER RELATION

  • Rhee, Myung-Hyun;Broeils, Adrick H.
    • Journal of Astronomy and Space Sciences
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    • v.22 no.2
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    • pp.89-112
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    • 2005
  • We determine the rotation velocities of 108 spiral and irregular galaxies (XV-Sample) from first-order rotation curves from position-velocity maps, based on short 21-cm observations with the Westerbork Synthesis Radio Telescope (WSRT). To test the usual random motion corrections, we compare the global HI linewidths and the rotation velocities, obtained from kinematical fits to two-dimensional velocity fields for a sample of 28 galaxies (RC-Sample), and find that the most frequently used correction formulae (Tully & Fouque 1985) are not very satisfactory. The rotation velocity parameter (the random-motion corrected HI linewidth: W?), derived with these corrections, may be statistically equal to two times the true rotation velocity, but in individual cases the differences can be large. We analyse, for both RC- and XV-Samples, the dependence of the slope of, and scatter in the Tully-Fisher relation on the definition of the rotation velocity parameters- For the RC-Sample, we find that the scatter in the Tully-Fisher relation can be reduced considerably when the rotation velocities derived from rotation curves are used instead of the random-motion corrected global H I linewidths. No such reduction in the scatter is seen for XV-Sample. We conclude that the reduction of the scatter in the Tully-Fisher relation seems to be related to the use of two-dimensional velocity information: accurate rotation velocity and kinematical inclination.

Toward Transparent Virtual Coupling for Haptic Interaction during Contact Tasks (컨택트 작업 시 햅틱 인터렉션의 투명성 향상을 위한 Virtual Coupling 기법의 설계)

  • Kim, Myungsin;Lee, Dongjun
    • The Journal of Korea Robotics Society
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    • v.8 no.3
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    • pp.186-196
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    • 2013
  • Since its introduction (e.g., [4, 6]), virtual coupling technique has been de facto way to connect a haptic device with a virtual proxy for haptic rendering and control. However, because of the single dependence on spring-damper feedback action, this virtual coupling suffers from the degraded transparency particularly during contact tasks when large device/proxy-forces are involved. In this paper, we propose a novel virtual coupling technique, which, by utilizing passive decomposition, reduces device-proxy position deviation even during the contact tasks while also scaling down (or up) the apparent inertia of the coordinated device-proxy. By doing so, we can significantly improve transparency between multiple degree of freedom (possibly nonlinear) haptic device and virtual proxy. In other to use passive decomposition, disturbance observer of [3] is adopted to estimate human force with some dead-zone modification to avoid "winding-up" force estimation in the presence of device torque saturation. Some preliminary experimental results are also given to illustrate efficacy of the proposed technique.

Texture Images Segmentation by Combination of Moment & Homogeneity Features (모멘트와 동차성 특징 결합에 의한 텍스쳐 영상 분할)

  • Mo, Moon-Jung;Lim, Jong-Seok;Lee, Woo-Beom;Kim, Wook-Hyun
    • The Transactions of the Korea Information Processing Society
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    • v.7 no.11
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    • pp.3592-3602
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    • 2000
  • Image processing consist of image analysis and classification. The one is extracting of feature value in the image. The other is segimentationof image that have same properiv. A novel approach for the analysis and classification of tezture images based on statistical texture prunitive estraction are proposed. In this approach, feature vector extracting is based on stalisucal method using apatial dependence of grey level and use general lexture proerty. In is advantageous that not effiected on structure and type of lexture. These components describe the amount of roughness and softness of texture images Two leatures. Moment and Homogeneity, are componted from GLCM(gray level co-occurrence matrices) of the lexture promitive to charactenize statisical properties of the image. We show the successful experimental results by considerationof these two components fro the analysis and classificationto regular and irregular texture images.

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Room Temperature Preparation of Electrolytic Silicon Thin Film as an Anode in Rechargeable Lithium Battery (실리콘 상온 전해 도금 박막 제조 및 전기화학적 특성 평가)

  • Kim, Eun-Ji;Shin, Heon-Cheol
    • Korean Journal of Materials Research
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    • v.22 no.1
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    • pp.8-15
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    • 2012
  • Silicon-based thin film was prepared at room temperature by an electrochemical deposition method and a feasibility study was conducted for its use as an anode material in a rechargeable lithium battery. The growth of the electrodeposits was mainly concentrated on the surface defects of the Cu substrate while that growth was trivial on the defect-free surface region. Intentional formation of random defects on the substrate by chemical etching led to uniform formation of deposits throughout the surface. The morphology of the electrodeposits reflected first the roughened surface of the substrate, but it became flattened as the deposition time increased, due primarily to the concentration of reduction current on the convex region of the deposits. The electrodeposits proved to be amorphous and to contain chlorine and carbon, together with silicon, indicating that the electrolyte is captured in the deposits during the fabrication process. The silicon in the deposits readily reacted with lithium, but thick deposits resulted in significant reaction overvoltage. The charge efficiency of oxidation (lithiation) to reduction (delithiation) was higher in the relatively thick deposit. This abnormal behavior needs to clarified in view of the thickness dependence of the internal residual stress and the relaxation tendency of the reaction-induced stress due to the porous structure of the deposits and the deposit components other than silicon.