• 한국보건간호학회지
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• 제1권1호
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• pp.17-31
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• 1987

This study was carried out for the age 60years over who are attending a villa house for the aged during day time. The purpose of this study was to measure occurance rate of Diabetes by self cognitiveness about their disease of Diabetes; by result of urine test tape test and a questionaire study and self-care behavior about Diabetes. The results of the study are summarized as follow: 1. General Characteristics of the suryeyed. The population studied consisted of 143 males and 256 females comprising $73.9\%$ of the total population registered at the elderly villa house at the time of the study. The mean age group of the study was 70-79 years; educational level $77.2\%$ was below than primary education. 2. The results of Diabetes study. The number of cases who were self-recognized about their Diabetes were 19; 8 males and 11 females. The number of urine sugar positive cases was 35; 19 males and 16 females. The consistency rate of positive urine sugar test was $93.5\%$ An average degree of the results of knowledge test about Diabetes was 1. 4 point. When the correct 1 item was given 1 point for the 6 item of questions. Among 19 cases of self-recognized disease group an average degree of the knowledge test results was 2. 3 point and among the 35 cases of the urine test positive group an average degree of the knowledge test results was 1. 7 point. The average degree of self -care behavior about Diabetes was 1. 6 point when measued 3 point scale on the self-care behavior for the 7 item of questions.

• Journal of Preventive Medicine and Public Health
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• 제28권1호
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• pp.225-243
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• 1995

Benzidine Industry in Korea has started after Japan has banned its production in early 1970's, and it has been in operation in Korea for over 20 years. However, it is not known yet whether any bladder cancer has developed from benzidine exposure. This study was done to screen benzidine-exposed workers for bladder cancer, and to examine the feasibility of employing screening test at the workplace. All the workplaces that manufacture or use benzidine for more than 20 years in Korea have been covered in this study, and they include 2 benzidine manufacturing factories, 5 benzidine using factories, as well as 2 benzidine free factories as an outside control. In total, 516 workers were screened with urine stick test and urine cytology test for the evidence of hematuria and abnormal urothelial cells. Each worker was also asked about risk factors and symptoms of bladder cancer including past medical history, smoking, medication and occupational history Benzidine in the air was measured by personal and area sampling. Out of 516 screened workers, 84(16.3%) workers showed positive hematuria in urine stick test, and 7(1.4%) workers showed degenerative cells in urine cytology tests. Those workers with abnormal urine test results who have been exposed to benzidine fo more than 10 years were further screened, and, in total, 23 workers were examined with intra-venous pyelography and cystoscopy. None of those screened had any evidence of bladder cancer When workers with only past hematuria history were included in the positive hematuria group, 96(18.5%) had positive hematuria. On the multiple logistic regression analysis, positive hematuria was significantly associated with benzidine exposure, history of other occupations with elevated bladder cancer risk, pyuria and glycosuria. The association got stronger as direct benzidine exposure was accounted through individual task analysis, and as exposure duration was accounted with tenure analysis. For those with benzidine exposure with more than 10 years of tenure, the odds of having positive hematuria was elevated 2.14(95%C.I is 1.08 to 4.25) times more than for those without exposure. Even though bladder cancer was not detected for several limitations including short observation period, majority of studied workers with short latency, healthy worker effect, and low sensitivity of single screening test in a cross-sectional study, the study results suggest that hematuria screening is a feasible and very useful test for bladder cancer screening among benzidine exposed workers.

• 한국보건간호학회지
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• 제2권2호
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• pp.99-116
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• 1988

This study examined the effect of Health Education on the aged. One of the Study objectives was to improve knowledge. attitude and self-care practice about diabetes of the aged who have responded positive in the urine sugar test. The other study objective was to find out factors influencing knowledge. attitude and self-care practice about diabetes. and the relationship among the three variables. The subjects, consisting of 45 positive responders in the urine sugar test, were selected from the elderly who attend elderly citizen center in southern part of Seoul Then they were divided into an experimental and a control group. The study design was set to compare the pre and post test data between the experimental and the control group with the measures of results from Health Education services including nursing care intervention programs on the aged diabetics. The first data collection was carried out in August. 1986 through questionaires and urine sugar testing. The second data collection was done in September, 1987 through the same methods. The results of the study are summarized as follows; 1. General characteristics of the subjects The experimental group has 9 females and 14 males and the control group has 12 females and 10 males. As for the educational level, more than half of the subjects in both group had completed at least 6 years of education. And there was no significant difference in urine sugar levels between the two groups. 2. The effect of Health Education on the extent of change in knowledge, attitude and self-care practice about diabetes was found to be significant. The first hypothesis that knowledge, attitude and self-care practice about diabetes in the aged will be unchanged by Health Education. was rejected by increased the three variables and decreased urine suger level in the experimental group. The second hypothesis that knowledge, attitude and self-care practice about diabetes wouldn't be concerned with each other, was rejected. That is. the three variables and urine sugar levels showed a significant positive relationship with each other but diabetic knowledge to urine sugar level had an insignificant positive relationship. The third hypothesis that the amount of learning Health Education will have no relationships with knowledge. attitude and self-care practice about diabetes. was rejected. That is, the more number of times an elderly person participated in Health Education. they increased their diabetic knowledge. attitude and self-care practice and decreased their urine sugar level. 3. Except for Health Education, an other factor influencing diabetic knowledge was educational level. And an other factor influencing the diabetic attitude was experience of the diagnosis of diabetes. 4. Except for Health Education. the other factors influencing self-care practice were experience of the diagnasis of diabetes, sex and experience of the hospitalization for diabetes. But factors influencing urine sugar level weren't found. Although the results seem to be plausible, this study is not without its problems. In paticular, the sample used is limited in its scope and size. So, more empirical work needs to be done for other diseases as well as diabetes before any general conclusions are to be made.

• 분석과학
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• 제33권1호
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• pp.23-32
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• 2020

Methamphetamine (MA) is the most common and available drug of abuse in Korea and its primary metabolite is amphetamine (AP). Detection of AP derivatives, such as MA, AP, phentermine (PT), MDA, MDMA, and MDEA by the use of immunoassay screening is not reliable and accurate due to cross-reactivity and insufficient specificity/sensitivity. Therefore, the analytical process accepted by most urine drug-testing programs employs the two-step method with an initial screening test followed by a more specific confirmatory test if the specimen screens positive. In this study, a gas chromatography-mass spectrometric (GC-MS) method was developed and validated for confirmation of MA and AP in human urine. Urine sample (500 µL) was added with N-isopropylbenzylamine as internal standard and ethyl chloroformate as a derivatization reagent, and then extracted with 200 µL of ethyl acetate. Extracted samples were analysed with GC-MS in the SIM/ Scan mode, which were screened by Cobas c311 analyzer (Roche/Hitachi) to evaluate the efficiency as well as the compatibility of the GC-MS method. Qualitative method validation requirements for selectivity, limit of detection (LOD), precision, accuracy, and specificity/sensitivity were examined. These parameters were estimated on the basis of the most intense and characteristic ions in mass spectra of target compounds. Precision and accuracy were less than 5.2 % (RSD) and ±14.0 % (bias), respectively. The LODs were 3 ng/mL for MA and 1.5 ng/mL for AP. At the screening immunoassay had a sensitivity of 100% and a specificity of 95.1 % versus GC-MS for confirmatory testing. The applicability of the method was tested by the analysis of spiked urine and abusers' urine samples.

• Journal of Biosystems Engineering
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• 제33권5호
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• pp.340-347
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• 2008

Dipstick urinalysis is used as a routine test for a screening test of UTI (urinary tract infection) in primary practice because urine dipstick test is simple. The result of dipstick urinalysis brings medical professionals to make a microscopic examination and urine culture for exact UTI diagnosis, therefore it is emphasized on a role of screening test. The objective of this study was to the classification between UTI patients and normal subjects using hybrid neural network classifier with enhanced clustering performance in urine dipstick screening test. In order to propose a classifier, we made a hybrid neural network which combines with RBF layer, summation & normalization layer and L VQ artificial neural network layer. For the demonstration of proposed hybrid neural network, we compared proposed classifier with various artificial neural networks such as back-propagation, RBFNN and PNN method. As a result, classification performance of proposed classifier was able to classify 95.81% of the normal subjects and 83.87% of the UTI patients, total average 90.72% according to validation dataset. The proposed classifier confirms better performance than other classifiers. Therefore the application of such a proposed classifier expect to utilize telemedicine to classify between UTI patients and normal subjects in the future.

• 기본간호학회지
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• 제2권2호
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• pp.131-137
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• 1995

Improving validity and reliability is the important components of clinical laboratory tests. And the quality control of the test should be started with the accurate collection of specimen. Urinalysis is one of the useful and common tests in diseases diagnosis and determining the process of medical treatment. Since urinalysis is requested routinely in hospital setting, the importance of the quality control for urine specimen is often ignored. To improve the validity of urinalysis, a clinical trial was done on the method of collecting urine specimen. The result was as follows : 1. The rate of presumtive UTI(urinary tract infection) was decreased in 21.6% with experiment method for collecting urine specimen. 2. The rate of presumtive UTI in female patients was decreased in 43.2% with the experiment method. 3. The rate of negative urine culture was decreased in 6.6% with the experiment method.

• 공업화학
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• 제5권6호
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• pp.975-980
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• 1994

소변 속에 함유되어 있는 글루코우즈의 농도를 측정하기 위한 폴리우레탄 진단막의 제조과정과 조성조건들에 대해 조사하였다. 요당과 반응한 후 진단막에 나타난 색의 민감도와 안정성도를 증가시키기 위해서는 막 제조과정의 교반조건 및 교반용기, 그리고 사용되어지는 용매의 혼합비율이 아주 중요한 요소들로 작용됨을 알 수 있었다. 실질적으로 이러한 폴리우레탄을 이용해 얻어진 소변용 진단스트립을 사용하면 글루코우즈 농도가 30mg/dL에서 500mg/dL까지에서 색의 분리가 잘 이루어지므로, 이러한 농도 사이에서 요당의 정량적인 측정이 가능하여졌다.

• 대한유전성대사질환학회지
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• 제1권1호
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• pp.18-22
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• 2001

Renal colic, hematuria, dysuria and stone passage were developed in younger brother (4 year 6 month old boy). But the elder sister (6 year old girl)had no specific symptoms and signs. The identification of the disease was proved by cyanide nitroprusside test and amino acid analysis of urine. In our patients the chromatographic amino acid patterns of urine showed remarkably increased excretion of cystine, ornithine, lysine, and arginine. They are managed by adequate hydration with Shohl solution for rendering the urine more alkaline, and alpha-mercaptopropionylglycine (Thiola).

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.214.1-214.1
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• 2003

Metabonomic analysis using Liquid Chromatography-Mass Spectrometry (LC-MS) was employed to test the feasibility to predict chemical-induced toxicity. Time-dependent metabolic variations were evaluated in rats treated with the model hepatotoxin, ${\alpha}$- naphthylisothiocyanate (ANIT). Urine samples of ANIT treated group and control group were collected up to 7 days postdose. Urine samples were analyzed by gradient HPLC combined with electrospray mass spectrometry. The chromatographic results were data-reduced and analyzed using principal component analysis to show the time dependent biochemical variations induced by ANIT toxicity. (omitted)

• 보건교육건강증진학회지
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• 제27권2호
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• pp.95-108
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• 2010

Objectives: The Purpose was to investigate the effects of the '5&6 smoking cessation program' and '5 days smoking cessation program' on the high school student's perception, urine cotinine, and smoking behaviors. Methods: This study was designed using nonequivalent control group pretest-posttest. The '5&6 smoking cessation program' was applied to the experimental group 1(28 students). The '5 days smoking cessation program' was applied to the experimental group 2(19 students). Control group was 53 students. Data was analyzed using descriptive statistics, $X^2$-test, Fisher's exact test, Independent-sample t-test, Paired t-test, ANOVA, Wilcoxon signed ranks test, Cronbach's coefficient alpha. Results: The '5&6 program' was significantly increased on smoking self-efficacy, stage of smoking cessation behavior change, Cons. for smoking and significantly decreased on daily smoking amount, urine cotinine level than control group. The '5 days program' was significantly decreased on urine cotinine level and Pros. for smoking than control group. The '5&6 program' was significantly increased on stage of smoking cessation behavior change than '5 days program'. Conclusion: This study showed that the '5&6 program and the '5 days program' are effective in adolescent's smoking cessation behaviors.