• 약학회지
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• 제41권3호
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• pp.381-388
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• 1997

Metabolism of DWP401, recombinant juman epidermal growth factor, was examined in vivo and in vitro in rats. When $^{125}I$-labeled DWP401 was administered at a dose of 50 ${\mu}g$/kg by i.v. injection. $^{125}I$-labeled DWP401 was rapidly degraded within 30 minytes above 93%. Thin layer chromatography analysis of urine collected for 24 hr after i.v. administration of $^{125}I$-labeled DWP401 showed ohly one spot on a X-ray film which was considered as diiodo-tyrosine. This result suggests tha $^{125}I$-labeled DWP401 was completely digested into free amino acids without any specific intermediate polypeptides. About 42.1% of the administered iodine was recovered in 24 hr. For in vitro degradation study, $^{125}I$-labeled DWP401 was added to plama and tissue homogenates of rats and incubated at $37^{\circ}C$. Almost 98% of the added radioactivity recovered from the protein fraction of the liver, kidey, small intestine, stomach and spleen decreased rapidly. For examplem the recovery rates of $^{125}I$-labeled DWP401 were 58.6, 63.2, 39.9, 52.9 and 66.8% after 4hrs of incubation in respective organ homogenates.

• 대한간호학회지
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• 제7권2호
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• pp.83-94
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• 1977

Diabetes Mellitus is a worldwide disease affecting millions of persons and appears to be on the increase in Korea. At the present time it can not be cured but can be controlled. To achieve control the patient must know about the disease. Education of the patient is an essential part of the management of the diabetic and is the responsibility of the nurse. The educational program must be adapted according to patient's knowledge and attitude about their diseases. Therefore, the opportunity to assess the knowledge and attitude of diabetics must provided. The objectives of this study were : 1. To describe the general characteristics of the study population. 2. To find out the characteries of experience of treatment. 3. To exams the knowledge and attitude of diabetics about the self-control. 4. To learn the influencing factors affecting the knowledge and attitude of diabetics about self - control. The study population defined and selected was 65 diabetics registered at the Diabetic Clinic of 5. hospital who visited the Diabetic Clinic from April 16, 1976 to May 14, 1976. The direct interview method was used. Statistical analysis of the data was X²- test. The following results were obtained : A. General characteristics of the study population : The respondent's average age was 50. 8 years old, sex ratio(male to female) revealed as 1 : 1.1, economic background was upper middle class, the most respondents had better than- average education, 75.4 Percents of the respondents lived in Seoul, 47. 2 percents were unemployed, the average size of family was 5.3 and 47.7 percents of respondents had religions. B. The characteristics of clinical experience : The average duration was 7.0 years, 46.1 percents of respondents had experience of hospitalization, 56.9 percents was taking oral drugs, 67.7 percents examined urine- sugar at home, 60.0 Percents had treat compilations and 20.0 percents had experience of coma. C. There was significant difference in the relationship : Between complications and durations of diabetes, hospitalization and therapeutic methods.

• 혜화의학회지
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• 제20권1호
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• pp.11-23
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• 2011

Systemic Lupus Erythematosus(SLE) is an autoimmune disease invading the skin, joint, kidney, intestinal membrane, neurosystem and other organs. SLE is an autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear antibodies(ANA), generation of circulating immune complexes, and activation of the complement system. In Korean medicine, lupus can be classified as acute arthritis, reddish butterfly erythema, asthenic disease, edema and so on. The cause and procedure of the diseases are flourishing noxious heat, excessive fire due to deficiency of yin, blood stasis due to stagnation of qi, internal movement of the liver-wind, congenital deficiency, exhausted vital-qi, which are treated by clearing away heat and cooling the blood, nourshing yin and extinguishing fire, treating flatulence and activating blood circulation, nourishing the blood to expel wind, invigorating the liver and kidney, invigorating qi and replenishing the blood. To experimentally examine the influence of Insam-Buja-Tang (Ginseng & Aconiti Extract, IBT) on the outbreak and development of lupus, lupus induce MRL/MpJ-Faslpr lupus-prone mice model was used. As IBT was orally administrated to a lupus model mouse, various tests such as the weight, urine protein, renal function, Lymph cell test of the spleen, Cytokine expression, histopathological analysis of kideny were performed to see the influence on the kidney and whether it work effectively on the immune function. The main purpose of this study is to evaluate the effect of IBT on MRL/MpJ-Faslpr lupus-prone mice model. The effect of IBT on MRL/MpJ-Faslpr lupus-prone mice that can have autoimmune disease similar to SLE in human was evaluated after IBT per oral in the present study.

• 성인간호학회지
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• 제16권3호
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• pp.398-408
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• 2004

Purpose: The purpose of this study was to identify the frequency of urinary incontinence and lower urinary symptoms, to identify lifestyle and sexual matters for UI of adult women in an urban area. Method: The sample consisted of 364 educated women from a women's health education program in a public health center. For data collection, the Bristol Female Lower Urinary Tract Symptoms Questionnaire developed by Jackson, et. al.(1996) and the demographic questionnaire were used. For data analysis, SAS 8.2 program was used. Result: The results were as follows: 1. the prevalence rate of UI was 73.63%. 45.88% of them were stress incontinence and 27.75% of them were urge incontinence. 2. Remarkable differences were found between the type of UI and LUTS in the case of urgency($x^2=42.0585$, P<0.001), unexplained incontinence($x^2=59.0585$, P<0.001), noctural incontinence($x^2=18.8080$, P<0.001) and catetherization($x^2=10.7207$, P= 0.004), burning sense($x^2=27.7400$, P<0.001). 3. Remarkable differences were found between the type of UI and lifestyle matters in the cases as follows fluid intake restriction($x^2=31.0532$, P=0.008), interference in physical activity($x^2=36.7481$, P=0.001), interference in relation with others($x^2=22.2729$, P=0.034). 4. Remarkable differences were found between the type of UI and sexual matters with difficulty of sexual intercourse($x^2=16.1898$, P=0.002), and urine leakage during sexual intercourse($x^2=17.9752$, P=0.001). Conclusion: Based on the results, developing and carrying out an adequate UI care and education program is needed.

• Journal of Korean Biological Nursing Science
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• 제3권2호
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• pp.51-61
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• 2001

This study was done to investigate the effect of the first experience of the clinical experience for psychiatric nursing on urinary $Na^+$, $Cl^-$, $K^+$, $Ca^{++}$ of the nursing students. We analyzed the urine of 36 students on curriculum who were students of D college in K city. The data were analyzed with SAS Statistical analysis was performed by using paired t-test, GLM. The second day group increased 18.56 at 8AM, 31.90 at 4PM in case of $Na^+$(p=0.004). The second day group increased 27.61 at 8AM, 45.53 at 4PM in a case of $Cl^-$(p=0.009). The first day group increased 2.62 at 8AM, 7.09 at 4PM in case of $K^+$(p=0.018). The second day group increased 3.69 at 8AM, 5.19 at 4PM in a case of $K^+$(p=0.013). The second day group increased 20.65 at 8AM, 14.07 at 4PM in a case of $Ca^{++}$(p=0.033). There was a significant difference in $Na^+$ according to group at 8AM(F=4.17, p=0.024) and 4PM(F=3.58, p=0.040). There was a significant difference in $Cl^-$ according to group at 8AM(F=4.38, p=0.020) and 4PM(F=6.29, p=0.003). There was a significant difference in $K^+$ according to group at 8AM(F=5.03, p=0.012). In conclusion, $Na^+$, $Cl^-$, $K^+$, $Ca^{++}$ may be used as a indicator of the amount of stress to improve the educational environment for the students.

• 한국식품영양과학회지
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• 제37권10호
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• pp.1264-1270
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• 2008

곡류분말의 위생화 및 물성 개선을 위해 고선량 감마선 조사 기술의 이용 가능성이 높아짐에 따라 이들의 안전성을 확보할 목적으로 30 kGy 고선량 감마선 조사 곡류분말을 대상으로 3개월간 독성 평가를 실시하였다. 30 kGy로 조사한 곡류분말을 3개월간 암수 랫트에 경구 투여한 후 독성을 평가한 결과, 시험기간 동안 시험 물질 투여에 의한 임상 증상이나 폐사 동물은 나타나지 않았으며 체중 변화, 사료 섭취량 및 주요 장기 무게도 대조군에 비해 차이를 보이지않았다. 혈액학적 검사, 혈청학적 검사 및 뇨 검사에서도 모든 시험군은 정상적인 수치를 나타내었다. 병리조직학적 검사에서 간, 신장, 비장 및 위 조직 모두 정상적인 구조를 유지하고 있었으며, 염증, 괴사 등의 유의할만한 병적 변화도 관찰되지 않았다. 따라서 고선량 조사 곡류분말(30 kGy)을 3개월간 암 수 랫트에 5,000 mg/kg까지 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 나타났다.

• 대한간호학회지
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• 제24권3호
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• pp.345-363
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• 1994

This study attempted to identify important problems of the factors related to the indwelling catheter with closed drainage and to enhance recognization of Urinary Tract Infection management to protect patients with indwelling catheter from UTI. We selected the 58 patients with indwelling catheter with closed drainage from md-surg. intensive care units, and general neurological and neurosurgical ward, in one hospital in Pusan, Korea from May 30 to October 15, 1993. Patients were examined by urinary analysis before inserting catheter and then by urine cultures three times. The obtained data was analized using an SPSS /PC$^{+}$ The statistical analyses employed here was the frequency, percentage and x$^2$-tests. 1. Analyses for Indwelling Catheter induced UTI and infection rates were found to be presented in patients related to the factors of being on antibiotic drugs (x$^2$=14.105, p=.000) and the duration of the indwelling catheter(x$^2$=58.0, p=.000), both of which were found to affect the UTI. 2. UTI rates according to the duration of the in-dwelling catheter were high 8.6％ for the 2nd day, 27.6 for the 4th day, and 36.2% for the 7th day, and as the duration for the indwelling catheter was longer, UTI rates were higher. 3. The UTI rates according to the duration of the indwelling catheter related re factors, on the 7th day, were high-52.0% for women, 37.0% for more than 50 years in ages, 30.0% for patients under sur-gery, 33.3% for altered mental states outsides the alert, 76.7% for patients not given antibiotic drugs, 36.4% for less than 3500cc of fluids intakes, it was found that these affected to increase the UTI. 4. Causative organisms of UTI were found ; E.Coli appears the most than all other isolated organisms in women and Klebsiella and Pseudomonas in men. For antibiotic susceptibility of causative organisms, all causative organisms were found to be susceptible to Sul -cefoperazone, Trim-prim, and unasyn and Pseudomonas mostly net susceptible.e.

• 한국의상디자인학회지
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• 제16권3호
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• pp.61-73
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• 2014

Urinary Incontinence is any leakage of urine against their will. It is not a life threatening illness but it causes negative effects both socially and psychologically. Based on many previous studies, 20-40% of adult female and 30% of men in their sixties have experienced symptoms of urinary incontinence. As the number of active aged people experiencing the symptoms increases, demand for specialized product is growing. The purpose of the study is to research the types and features of male disposable products for urinary incontinence on the market and to provide the basic data for improvement and development of better product. Products from 6 brands (Tena, Depend, Carnation, Keepers, Molimed, Abrimen) with high brand awareness both in online and offline were selected and analyzed. And product evaluation was carried out by male in their sixties with light symptom of urinary incontinence. The results are as follows. There are three types of male products for urinary incontinence: panties, diaper and pad. Among the 6 brands, the subject of analysis, only Depend from Yuhan Kimberly produces male panties while others make ones for unisex. There is no diaper product only for male, and Tena, Molimed, Abrimen have pad type products for male. Male panties from Depend emphasizes their design considering male's physical characteristics. Male pad is differentiated with female one by having different designs like triangular or pocket type which is more comforting to men. As a result of product evaluation, wearable panties similar to normal underwear were highly appreciated and satisfactory. Among various shapes of pads, 25cm long pad with wide width of front and narrow back was valued to be comfortable.

• Advances in pediatric surgery
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• 제4권1호
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• pp.16-26
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• 1998

Parenteral nutrition has been an essential part of postoperative care of neonates requiring major surgery who are unable to tolerate enteral feeding for long periods during the postoperative period. However, TPN via central venous catheters(central TPN), used in increasing trend, still presents significant morbidity. To find out whether TPN via peripheral veins(peripheral TPN) could be used as a viable alternative for postoperative parenteral nutrition in neonates, a clinical study was carried out by a retrospective analysis of 53 neonates subjected to peripheral TPN for more than 7 days after surgery. Operations consisted of procedures for esophageal atresia with tracheoesophageal fistula, gastroschisis and omphalocele. Surgery was performed at the Division of Pediatric Surgery, Department of Surgery, Hanyang University Hospitall, from 1983 to 1994. The mean total duration of TPN was 13.3 days (range; 7-58 days), the average daily total fluid intake was 117.6 ml/kg during TPN and 158.6 ml/kg during subsequent oral feeding. The average daily total calorie intake was 57.7 kcal/kg during full strength TPN and 101.3 kcal/kg during subsequent oral feeding. The mean urine output was maintained at 3.5 ml/kg/ hour during TPN and at 3.6 ml/kg/hour during subsequent oral feeding. The increment of body weight observed during TPN was 132 g in TEF, 53 g in gastroschisis and 3 g in omphalocele patients, while loss of body weight was not observed. The mortality rate was 5.7 %(3/53) and was related to the underlying congenital anomalies, not the TPN. The most common complication of peripheral TPN observed was laboratory findings suggestive of liver dysfunction in 23 cases(43.4 %) with no significant clinical symptom or signs in any case, transient pulmonary edema in one case, and generalized edema in one case. None of the major complications usually expected associated with central TPN were observed. The result of this study suggest that peripheral TPN can be used for adeguate postoperative nutritional support in neonates requiring 2 to 3 weeks of TPN.

• Journal of Korean Biological Nursing Science
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• 제9권2호
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• pp.135-142
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• 2007

Purpose: This study was conducted to investigate degree of stress level in CCU patients, and to give a baseline data in developing nursing intervention program to reduce the stress. Method: Subjects of this study were the 100 hospitalized patients of C University Hospital in Seoul City from February to December 2003. The collected data was analyzed by using the SAS program: t-test, Scheff$\acute{e}$ test, and ANOVA analysis were employed to find differences in stress level. Result: The highest stress factor was 'Concern', and next were 'Dependency & limitation', 'Uncertainty', 'Treatment procedure', 'Sleep disturbance', 'Environment' in order. The perceived stress level of CCU patients was 1.65 scores; the highest scored item was 'have to void urine and feces on the bed', next were 'have to use the toilet bowel lying on the bed' in order. The stress level according to characteristics of the subjects was significantly different with the marital status, the presence of religion, the hospitalized days, the economic status, and the admission experience. Conclusion: The stress level of patients in the coronary care unit was high in concern of a disease, family and economic state, in limitation and dependency, and in uncertainty about prognosis of a disease. Further researches are necessary to develop and apply the intervention method of reducing stress level of CCU patients. In addition studies on family members of CCU patients are also recommended.