• 분석과학
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• 제19권5호
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• pp.433-440
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• 2006

본 연구에서는 톨루엔, 크실렌, 스티렌 등의 폭로에 대한 측정지표로써 체내에서 대사되어 뇨로 배설되는 마뇨산, 메틸마뇨산, 만델산과 페닐글리옥실산에 대한 신속한 동시분석법을 개발하였다. 일반 충전형 ODS 칼럼과 달리 빠른 유속에서도 고분리능을 구현할 수 있는 monolithic 칼럼을 사용하였고, 이동상으로는 ion-pairing reagent인 tetrabutylammonium bromide 5.5 g과 potassium phosphate monobasic 1.5 g을 증류수 1 L에 녹인 후, 메탄올 0.6 L와 혼합하여 조제한 것을 사용하였으며, 유속 2.4 mL/min에서 분석한 결과, 6종의 유기용매 대사체들을 2.5분 이내에 검출하였다. 일정 농도 범위 내에서 6종 화합물 모두 검량선의 상관계수($r^2$)가 0.9993 이상으로 양호한 직선성을 나타내었다. 각 화합물별로 5가지 농도에 대하여 하루에 5번 반복 실험하여 구한 일내 정밀성 %C.V.와 정확성은 0.01~7.32%, 83.9~116.3%이고 5일간 반복 실험하여 구한 일간 정밀성 %C.V.는 0.01~7.16%이다. 본 분석법은 뇨 중 유기용매 대사체의 분석에 필요한 충분한 감도와 특이성, 직선성, 정확성 및 정밀성을 가지며, 한국산업안전공단 산하 산업안전보건연구원 직업병연구센터의 정도관리 소변시료를 분석 비교하여 그 신뢰성을 확보하였다.

• 한국환경보건학회지
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• 제47권2호
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• pp.131-143
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• 2021

Objectives: This study aims to investigate the atmospheric concentration of polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) and the urinary concentration of biomarkers in residents near the Shinpyeong·Jangrim Industrial Complex to compare them with those of residents in a control area. Methods: Hazardous air pollutants (PAHs and VOCs) were measured in an exposure area (two sites) and a control area (one site). Urine samples were collected from residents near the industrial complex (184 persons) and residents in the control area (181 persons). Multiple linear regression analysis was used to identify which factors affected the concentration of PAHs and VOCs metabolites. Results: The average atmospheric concentration of PAHs in Shinpyeong-dong and Jangrim-dong was 0.45 and 0.59 ppb for pyrene, 0.15 and 0.16 ppb for benzo[a]pyrene, and 0.29 and 0.35 ppb for dibenz[a,h]anthracene. The average atmospheric concentration of VOCs was 1.10 and 0.99 ppb for benzene, 8.22 and 11.30 ppb for toluene, and 1.91 and 3.05 ppb for ethylbenzene, respectively. The concentrations of PAHs and VOCs in residents near the Shinpyeong·Jangrim Industrial Complex were higher than those of residents in the control area. Geometric means of urinary 2-hydroxyfluorene, 1-hydroxypyrene, methylhippuric acid, and mandelic acid concentrations were 0.45, 0.22, 391.51, and 201.36 ㎍/g creatinine, respectively. Those levels were all significantly higher than those in the control area (p<0.05). In addition, as a result of multiple regression analysis, even after adjusting for potential confounding factors such as gender and smoking, the concentration of metabolites in urine was high in residents near the Shinpyeong·Jangrim Industrial Complex. Conclusion: The results of this study show the possibility of human exposure to VOCs in residents near the Shinpyeong·Jangrim Industrial Complex. Therefore, continuous monitoring of the local community is required for the management of environmental pollutant emissions.