• Journal of Internet Computing and Services
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• v.15 no.1
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• pp.29-43
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• 2014

The development of NGS technologies, such as scientific workflows, has reduced the time required for decoding DNA sequences. Although the automated technologies change the genome sequence analysis environment, limited computing resources still pose problems for the analysis. Most scientific workflow systems are pre-built platforms and are highly complex because a lot of the functions are implemented into one system platform. It is also difficult to apply components of pre-built systems to a new system in the cloud environment. Cloud computing technologies can be applied to the systems to reduce analysis time and enable simultaneous analysis of massive DNA sequence data. Web service techniques are also introduced for improving the interoperability between DNA sequence analysis systems. The workflow-based middleware, which supports Web services, DBMS, and cloud computing, is proposed in this paper for expecting to reduceanalysis time and aiding lightweight virtual instances. It uses DBMS for managing the pipeline status and supporting the creation of lightweight virtual instances in the cloud environment. Also, the RESTful Web services with simple URI and XML contents are applied for improving the interoperability. The performance test of the system needs to be conducted by comparing results other developed DNA analysis services at the stabilization stage.

• The Journal of the Acoustical Society of Korea
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• v.23 no.6
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• pp.437-445
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• 2004

In this paper. we describe a novel method for transforming audio contents according to user's preference on sound field. Sound field effect technologies. which transform or simulate acoustic environments as user's preference, are very important for enlarging the reality of acoustic scene. However huge amount of computational power is required to process sound field effect in real time. so it is hard to implement this functionality at the portable audio devices such as MP3 player. In this paper, we propose an efficient method for providing sound field effect to audio contents independent of terminal's computational power through processing this functionality at the server using user's sound field preference, which is transfered from terminal side. To describe sound field preference, user can use perceptual acoustic parameters as well as the URI address of room impulse response signal. In addition, a novel fast convolution method is presented to implement a sound field effect engine as a result of convoluting with a room impulse response signal at the realtime application. and verified to be applicable to real-time applications through experiments. To verify the evidence of benefit of proposed method we performed two subjective listening tests about sound field descrimitive ability and preference on sound field processed sounds. The results showed that the proposed sound field preference can be applicable to the public.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.1
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• pp.40-46
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• 2017

Shipping activities have become possible in the Arctic Ocean due to melting ice by global warming. An increasing number of vessels are passing through the Arctic Ocean consequently bringing concerns of ship-iceberg collisions. Thus, most classification societies have implemented regulations to determine requirements for ice strengthening in ship structures. This paper presents the simulation results of an ice-strengthened polar class ship after an iceberg collision. The ice-strengthened polar class ship was created in accordance with the Unified Requirements for a Polar-Ship (IACS URI). An elastic-perfect plastic ice model was adopted for this simulation with a spherical shape. A Tsai-Wu yield surface was also used for the ice model. Collision simulations were conducted under the commercial code LS-DYNA 971. Hull deformations on the ice-strengthened foreship structure and collision interaction forces have been analysed in this paper. A normal-strength ship structure in an iceberg collision was also simulated to present comparison results. Distinct differences in structural strength against ice impact forces were shown between the ice-strengthened and normal-strength ship structures in the simulation results. About 1.8 m depth of hull deformation was found on the normal ship, whereas 1.0 m depth of hull deformation was left on the ice-strengthened polar class ship.

• Journal of the Korea Society of Computer and Information
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• v.15 no.12
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• pp.67-73
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• 2010

In SIP(Session Initiation Protocol) environment, the presence event notification operation makes presence service user to recognize presence information status changes of the other party. In conventional method, the user should send each SIP SUBSCRIBE message containing the address of the other party to the presence server. Furthermore each presence subscription requires refresh messages, and the amount of notification messages from the other party becomes large. These facts increases network traffic and the load of presence server. In this paper, to solve these problems a new presence list service has been suggested. It uses a presence list consists of URI of the other party and make it possible to subscribe by using one SUBSCRIBE message. So this method decreases the amount of SUBSCRIBE messages and refresh messages, and it also decreases the amount processing event notification messages from the subscribed the other party. And to increase the efficiency, a presence filtering method which enables to include some parts of selected presence information into the notification message body has been also suggested. The implemented system can reduce SIP message related network traffic and message processing time of the presence server. The performance of this proposed system has been evaluated by experiments, and the results showed decreasing of server processing time.

• BMB Reports
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• v.42 no.9
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• pp.552-560
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• 2009

Cyclooxygenases (COX-1 and COX-2) are ER-resident proteins that catalyze the committed step in prostanoid synthesis. COX-1 is constitutively expressed in many mammalian cells, whereas COX-2 is usually expressed inducibly and transiently. Abnormal expression of COX-2 has been implicated in the pathogenesis of chronic inflammation and various cancers; therefore, it is subject to tight and complex regulation. Differences in regulation of the COX enzymes at the posttranscriptional and posttranslational levels also contribute significantly to their distinct patterns of expression. Rapid degradation of COX-2 mRNA has been attributed to AU-rich elements (AREs) at its 3’UTR. Recently, microRNAs that can selectively repress COX-2 protein synthesis have been identified. The mature forms of these COX proteins are very similar in structure except that COX-2 has a unique 19-amino acid (19-aa) segment located near the C-terminus. This C-terminal 19-aa cassette plays an important role in mediation of the entry of COX-2 into the ER-associated degradation (ERAD) system, which transports ER proteins to the cytoplasm for degradation by the 26S proteasome. A second pathway for COX-2 protein degradation is initiated after the enzyme undergoes suicide inactivation following cyclooxygenase catalysis. Here, we discuss these molecular determinants of COX-2 expression in detail.

• Health Policy and Management
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• v.17 no.1
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• pp.75-93
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• 2007

This research purposed to analyse the diversity of the long-term care system based on the dependency/independency of the aged. For this purpose, we divided the long-term care systems to three components; form of benefit, generosity of benefit and delivery system. Form of benefit is whether the benefit is cash or in-kind, and the generosity of benefit is related to the level and coverage of benefit. The last concerned to focus on provider and user selection. According to this, we tried to make an ideal type of long-term care in the perspective of citizenship and consumerism. As a result, we established four types of long-term care system; active citizen type, passive citizen type, latent citizen type, and family dependent type. And we investigated Austria, Sweden, Germany and Korea for each type empirically.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2005.11a
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• pp.373-376
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• 2005

본 연구에서는 뇌의 반응과 말초신경계의 변화를 통하여 유머와 기쁨의 긍정적인 정서의 구분이 가능한가를 밝히고자 하였다. fMRI와 말초신경계 반응 측정 실험 각각을 수행하는 동안, 유머와 기쁨정서를 유발하는 동영상 자극(2분)이 제시되었고, 실험이 끝난 후 심리적인 평가도 함께 수행되었다. fURI 실험은 boxcar design으로 한 session 내에 두 block으로 구성되었다. 말초신경계 반응실험에서는 안정상태와 정서상태에서의 피부전기 반응을 측정하였다. fMRI 결과, 유머자극과 기쁨자극 제시 시 공통적으로 precentral Cortex, temporal Cortex, precuneus 가 활성화 되었고, 유머자극은 기쁨자극에 비하여 우측 middle temporal cortex, 우측 inferior frontal cortex, 좌측 middle frontal cortex 에서 큰 활성화를 보였다. 피부전기 반응(EDA) 분석 결과 두 정서 모두 안정상태에 비하여 유의하게 증가하였고, 유머자극은 기쁨자극에 비하여 피부전도수준(SCL)과 피부전도반응의 수(NSCR)에서 유의하게 증가하는 것으로 나타났다.

• Journal of the Korean Society for Library and Information Science
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• v.44 no.1
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• pp.181-198
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• 2010

In this paper, the necessity calling for a paradigm shift in information organization is summarized: an attempt is being made to move from a web of documents to a web of data. In this, the principles used to make a universal library network, as part of the semantic web, or linked data, are described. Popular RDF vocabularies are also briefly introduced emphasizing FRBR and RDA vocabularies. Some library-related linked data projects are also summarized, describing the steps necessary to make a library catalogue available as linked data, as well as a rationale for doing so. Lastly, proposed models for a universal library network focusing on linked data are suggested. Some implications for the use of library applications for linked data, among others, are also presented.

• Journal of Chest Surgery
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• v.15 no.2
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• pp.243-249
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• 1982

A persistent left superior vena cava draining into the left atrium associated with atresia of the coronary sinus-ostium, ASD, and PDA is a rare congenital anomaly. The patient was a 4 year-old female whose complaints were frequent URI and exertional dyspnea. The congenital heart anomaly was suspected at 2 months of her age. Chest films showed cardiomegaly [C-T ratio, 75%]. EKG, Echocardiography, cardiac catheterization and angiocardiography were performed. Open heart surgery was done under impression of LV-RA shunt, bilateral superior vena cavae, and ASD. At the time of operation, huge LA and RA, inferior vena caval defect of a secundum type ASD [1.5 x 3cm in diameter], absence of innominate vein, atresia of the coronary sinus-ostium, and persistent LSVC draining into LA were noted. Direct suture closure of ASD and ligation of LSVC were done. The patient`s postoperative course was somewhat eventful: systolic murmur at apex remained. Four months after the operation, congestive heart failure attacked a few times. PDA that was overlooked at the time of open heart surgery was detected through postoperative cardiac catheterization in.4 months later. Emergent operation for closure of PDA was performed on the day of recatheterization. After that, patient`s heart failure was easily controlled without any notable problem.

• Journal of Chest Surgery
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• v.15 no.2
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• pp.250-253
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• 1982

A persistent left superior vena cava draining into the left atrium associated with atresia of the coronary sinus-ostium, ASD, and PDA is a rare congenital anomaly. The patient was a 4 year-old female whose complaints were frequent URI and exertional dyspnea. The congenital heart anomaly was suspected at 2 months of her age. Chest films showed cardiomegaly [C-T ratio, 75%]. EKG, Echocardiography, cardiac catheterization and angiocardiography were performed. Open heart surgery was done under impression of LV-RA shunt, bilateral superior vena cavae, and ASD. At the time of operation, huge LA and RA, inferior vena caval defect of a secundum type ASD [1.5 x 3cm in diameter], absence of innominate vein, atresia of the coronary sinus-ostium, and persistent LSVC draining into LA were noted. Direct suture closure of ASD and ligation of LSVC were done. The patient`s postoperative course was somewhat eventful: systolic murmur at apex remained. Four months after the operation, congestive heart failure attacked a few times. PDA that was overlooked at the time of open heart surgery was detected through postoperative cardiac catheterization in.4 months later. Emergent operation for closure of PDA was performed on the day of recatheterization. After that, patient`s heart failure was easily controlled without any notable problem.