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Effect of nutritional supplement formula on catch-up growth in young children with nonorganic faltering growth: a prospective multicenter study

  • Shim, Jung Ok;Kim, Seung;Choe, Byung-Ho;Seo, Ji-Hyun;Yang, Hye Ran
    • Nutrition Research and Practice
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    • v.14 no.3
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    • pp.230-241
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    • 2020
  • BACKGROUND/OBJECTIVES: Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supplementation with a pediatric concentrated and balanced nutritional supplement formula on promoting growth and improving nutritional status in children with nonorganic faltering growth. SUBJECTS/METHODS: Children aged 12-36 months whose body weight-for-age was < 5th percentile on the Korean Growth Charts were enrolled. Children born premature or having organic diseases were excluded. Children were instructed to consume 400 mL of formula per day in addition to their regular diet for 6 months. Pediatricians and dietitians educated the parents and examined the subjects every 2 months. Anthropometric parameters were measured at baseline and at 2, 4, and 6 months, and laboratory tests were done at baseline and 6 months. The good consumption group included children who consumed ≥ 60% of the recommended dose of formula. RESULTS: Total 82 children completed the 6-month intervention. At baseline, there were no significant differences in all variables between the good consumption and poor consumption groups. Weight and weight z-scores were significantly improved in the good consumption group compared to the poor consumption group at the end of the intervention (P = 0.009, respectively). The good consumption group showed a significant trend for gaining weight (P < 0.05) and weight z-score (P < 0.05) compared to the poor consumption group during 6 months of formula intake. The concentration of blood urea nitrogen was significantly increased in the good consumption group (P = 0.001). CONCLUSIONS: Nutritional supplementation with a concentrated and balanced pediatric nutritional formula along with dietary education might be an effective approach to promote catch-up growth in children with nonorganic faltering growth.

Suitability of Sainfoin (Onobrychis viciifolia) Hay as a Supplement to Fresh Grass in Dairy Cows

  • Scharenberg, A.;Kreuzer, M.;Dohme, Frigga
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.7
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    • pp.1005-1015
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    • 2009
  • Two experiments were carried out to determine the utility of sainfoin hay, a temperate tanniferous forage legume, as a dietary supplement for grass-fed cows. The condensed tannins (CT) of sainfoin might counteract the typical metabolic ammonia load of cows in intensive grazing systems. Furthermore, the physical fibrousness of sainfoin might improve ruminal pH stability. In the preliminary experiment, the eating rate of non-lactating Holstein cows of two tanniferous hays, sainfoin and birdsfoot trefoil, was compared to that of a grass-clover hay after specific periods of time (n = 4). The eating rate of sainfoin was superior to that of the other forages. In the main experiment, designed as a replicated 3${\times}$3 Latin square, six ruminally-cannulated, lactating Red Holstein cows received grass, concentrate and either no supplementation, 3 kg/d of grass hay or 3 kg/d of sainfoin hay (n = 6). Measured intakes of the grass hay and the sainfoin hay were 2.0 and 1.5 kg DM, and two cows entirely refused to eat the sainfoin hay and had to be excluded from data analysis. Grass DMI was similar for cows supplemented with sainfoin hay and cows fed only grass whereas intake of concentrate was higher (p<0.01) for the latter treatment. Continuous measurement of ruminal pH showed that the minimum pH at night tended to be lower (p<0.10) with grass-only feeding compared to sainfoin supplementation, but pH did not decline below the threshold of subacute acidosis for a longer period of time. The slightly higher intake of nitrogen (N) for cows supplemented with sainfoin hay (413 g/d) compared to cows fed only grass (399 g/d) was accompanied by an increased (p<0.05) fecal N excretion and a tendency for an increased (p<0.10) urinary N excretion. Ruminal ammonia concentration, as well as plasma and milk urea, were not affected by sainfoin supplementation. In conclusion, the lack of positive effects typical for CT might be explained either by the limited CT content of this plant species (55 g/kg DM) or the relatively low proportion of sainfoin in the total diet or both. Moreover, due to the unexpected low grass quality, the general ammonia load might have been too low for CT to have an impact.

Effects of Probiotics on Antioxidant Biochemical Parameters and Antioxidant Enzymesin the Blood, Intestinal Mucosal Tissues and Liver of Broiler Chicks under High Ambient Temperature Conditions (고온기 생균제 급여가 육계의 혈액, 소장 점막 및 간 조직에서 항산화 생화학 지표 및 항산화 효소에 미치는 영향)

  • Kang-Min Seomoon;In-Surk Jang
    • Korean Journal of Poultry Science
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    • v.50 no.2
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    • pp.109-118
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    • 2023
  • Four-d-old broiler chicks were randomly assigned to 3 groups with 9 replicates (8 birds/cage) under high ambient temperature; birds fed a basal diet (CON), a basal diet supplemented with 0.25% of probiotic complex (LPB, 1 × 106 Lactobacillus plantarum, 1 × 106 Bacillus subtilis, and 1 × 106 Saccharomyces cerevisiae) and 0.5% probiotic complex (HPB). Immediately after 28-d feeding trial, 6 birds having average body weight per group were sacrificed for evaluating the effects of probiotics on antioxidant parameters in the serum, intestine, and liver of birds. As results, serum biochemical parameters of nitrogen components including total protein, albumin, urea nitrogen, and glutathione were unaffected by dietary probiotics. In addition, serum superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) activities, and lipid peroxidation (MDA) were not changed by dietary probiotic supplement in birds. In the intestinal mucosa, SOD activity in the HPB group significantly (P<0.05) increased compared with that in the CON and the LPB groups. Lipid peroxidation in the HPB group significantly (P<0.05) decreased compared with that in the CON group. However, there was no statistical difference in GPX, and GST activities in the intestinal mucosa among treatment groups. In the liver, the activities of SOD, GPX, and GST, and the level of MDA were unaffected by probiotic supplement. In conclusion, 0.5% of probiotics significantly increased SOD activity and decreased lipid peroxidation in the intestinal mucosa, suggesting that probiotic complex could be potential to improve the small intestinal antioxidant capacity of bird under high ambient temperature conditions.

A Comparative Study on Digestive Parameters in an Indigenous Fat-tailed and a Conventional Dorper Sheep Fed on Maize Stover Crop Residue

  • Mwenya, B.;Wollny, C.;Blummel, M.;Banda, J.;Takahashi, J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.4
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    • pp.529-533
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    • 2003
  • The intake, dry matter (DM) digestibility, total mean retention time (TMRT) and weight changes were investigated in four fat tailed and four Dorper sheep fed on a maize stover crop residue. Animals were subjected to five dietary treatments, which were: 90, 135 and $180g\;DM/kgBW^{0.75}/day$ of chopped maize stover offered with urea, and in subsequent dietary treatments $180g\;DM/kgBW^{0.75}/day$ of stover supplemented with either dried bean husks or poultry manure. Although not statistically different (p>0.05) fat tailed sheep had higher maize stover intake than the Dorper sheep when expressed per metabolic body weight. The DM intake and digestibility increased significantly (p<0.001) in both sheep breeds when the maize stover offer levels were increased from 90 to $135g/kgBW^{0.75}/day$. Dorper sheep had significantly (p<0.001) higher DM digestibility and longer total mean retention times for both the liquid and solid matter than the fat-tailed sheep. Fat-tailed sheep gained 4.75 kg while Dorper sheep gained 3.75 kg over the entire experimental period. The weight change per dietary treatment was affected by the amount of maize stover and the type and amount of supplement consumed. The higher DM digestibility and longer total mean retention time in Dorper sheep shows that the breed has adapted to utilize the low quality roughage diets. An indigenous fat tailed, has the potential to ingest high volumes of fibrous feed and has higher voluntary intakes relative to its body size. The two sheep breeds are a valuable genetic resource in sub Saharan Africa that is characterized by long dry season with no readily available and affordable conventional feeds for small ruminants.

Effects of Using Monensin and Different Levels of Crude Protein on Milk Production, Blood Metabolites and Digestion of Dairy Cows

  • Ghorbani, B.;Ghoorchi, T.;Amanlou, H.;Zerehdaran, S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.1
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    • pp.65-72
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    • 2011
  • Twenty-four Holstein dairy cows were used to evaluate the single and combined effects of different levels of crude protein (CP) and monensin treatment during early lactation on blood metabolites, milk yield and digestion of dairy cows. The experiment was designed as a completely randomized block with a $3{\times}2$ factorial arrangement of treatments. The factors were three concentrations of CP supplement (19.5, 21.4, and 23.4% of dry matter) and two levels of monensin (0 and 350 mg per cow per day). The experiment consisted of three phases and each phase was 3 wk in length. Monensin did not affect milk yield, lactose, solids-non-fat (SNF), blood glucose, triglyceride and DMI, but increased blood cholesterol, blood urea nitrogen (BUN), insulin and reduced blood ${\beta}$-hydroxybutyrate (BHBA), milk fat and protein percentage. Monensin premix significantly decreased rumen ammonia, but rumen pH and microbial protein synthesis were not affected by monensin treatment. Increasing dietary CP improved milk and protein production, but did not alter the other components of milk. Digestibility of NDF, ADF, CP were improved by increasing dietary CP. Increasing dietary CP from 19.5 to 21.4% had no significant effect on ruminal ammonia, but increasing CP to 23.4% significantly increased ruminal ammonia. There was a linear relationship between level of crude protein in the diet and volume of urine excretion. Microbial protein synthesis was affected by increasing CP level; in this way maximum protein synthesis was achieved at 23.4% CP.

Cryogenic Mechanical Characteristics of Laminated Plywood for LNG Carrier Insulation System (LNG운반선 방열시스템에 적용되는 적층형 플라이우드의 극저온 기계적 특성 분석)

  • Kim, Jeong-Hyeon;Park, Doo-Hwan;Choi, Sung-Woong;Lee, Jae-Myung
    • Journal of Ocean Engineering and Technology
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    • v.31 no.3
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    • pp.241-247
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    • 2017
  • Plywood, which is created by bonding an odd number of thin veneers perpendicular to the grain orientation of an adjacent layer, was developed to supplement the weak points such as contraction and expansion of conventional wood materials. With structural merits such as strength, durability, and good absorption against impact loads, plywood has been adopted as a structural material in the insulation system of a membrane type liquefied natural gas (LNG) carrier. In the present study, as an attempt to resolve recent failure problems with plywood in an LNG insulation system, conventional PF (phenolic-formaldehyde) resin plywood and its alternative MUF (melamine-urea-formaldehyde) resin bonded plywood were investigated by performing material bending tests at ambient ($20^{\circ}C$) and cryogenic ($-163^{\circ}C$) temperatures to understand the resin and grain effects on the mechanical behavior of the plywood. In addition, the failure characteristics of the plywood were investigated with regard to the grain orientation and testing temperature.

The Effects of Vitamin C on Biological, Biochemical and Economical Characteristics of the Silkworm, Bombyx mori L.

  • Etebari, Kayvan;Ebadi, Rahim;Matindoost, Leila
    • International Journal of Industrial Entomology and Biomaterials
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    • v.8 no.1
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    • pp.81-87
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    • 2004
  • In order to investigate the effects of supplementary nutrients on silkworms, Bombyx mori, an experiment was conducted with ascorbic acid treatments. Dietary supplements of ascorbic acid 1, 2 and 3% were fed to silkworm larvae through 1st to 5th instar, The larvae were fed by mulberry loaves of Kokoso variety and the supplementary loaves were used once a day. These treatments resulted in a significant increase of biological parameters such as larval weight, the rate of food consumption and the approximate digestibility of the food. But the economical parameters such as cocoon weight and cocoon shell weight didnt show considerable difference compared to control. Dietary supplement of 2% ascorbic acid increased the larval weight by 7.8% and reached to 1.065g, which had the highest weight increase in the fourth day of 4th instar larvae. The percentage of daily weight increase in this group of larvae (79.01%) had significant difference compared with other treatments. The nutritional efficiency index in this group of larvae was better than others. Also the abundance of biochemical macromolecules such as glucose, cholesterol, triacylglycerol and urea in haemolymph of larvae fed by 2% ascorbic acid increased to become 29.75 (mg/㎗), 24 (mg/㎗), 75.4(mg/㎗) and 32.1(mg/㎗) respectively. But protein contents of haemolymph of larvae in each treatment were not significantly different. Since all the results achieved were not considerable either statistically or economically, this method could not be recommended to improve the sericultural parameters.

Effect of Indigenous Herbs on Growth, Blood Metabolites and Carcass Characteristics in the Late Fattening Period of Hanwoo Steers

  • Kim, D.H.;Kim, K.H.;Nam, I.S.;Lee, S.S.;Choi, C.W.;Kim, W.Y.;Kwon, E.G.;Lee, K.Y.;Lee, M.J.;Oh, Y.K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.11
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    • pp.1562-1568
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    • 2013
  • This study was conducted to evaluate the effects of indigenous herbal supplements on growth, blood metabolites and carcass characteristics in the late fattening period of Hanwoo steers. In a 6 month feeding trial, thirty Hanwoo steers ($647{\pm}32$ kg) were allotted to one of 5 treatment groups, control (basal diet contained lasalocid), licorice, clove, turmeric and silymarin, with six steers per pen. All groups received ad libitum concentrate and 1 kg rice straw/animal/d throughout the feeding trial. Blood samples were collected at the beginning, middle, and the end of the experiment and the steers were slaughtered at the end. Blood glucose, triglyceride, total protein, and albumin concentrations were higher in the turmeric treatment compared with other treatments. Blood urea nitrogen and creatinine concentrations were highest (p<0.003 and p = 0.071, respectively) in steers treated with silymarin. Alanine aminotransferase activity was lower (p<0.06) for licorice and silymarin compared with the control group. There were no alterations in serum aspartate aminotransferase and gamma glutamyltransferase activities as a consequence of herb treatments (p = 0.203 and 0.135, respectively). Final body weight, body weight gain, average dairy gain and dry matter intake were not significantly different among treatments. Yield grade, marbling score and quality grade were higher for silymarin group than those of the control group (p<0.05). Therefore, the results suggest that silymarin can be used an effective dietary supplement as an alternative to antibiotic feed additive and a productivity enhancer, providing safe and more consumer acceptable alternative to synthetic compounds during the late fattening period of steers.

Carcass Characteristics, Chemical Composition and Fatty Acid Profile of the Longissimus Muscle of Bulls (Bos taurus indicus vs. Bos taurus taurus) Finished in Pasture Systems

  • do Prado, Ivanor Nunes;Aricetti, Juliana Aparecida;Rotta, Polyana Pizzi;do Prado, Rodolpho Martin;Perotto, Daniel;Visentainer, Jesui Vergilio;Matsushita, Makoto
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.10
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    • pp.1449-1457
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    • 2008
  • This experiment was carried out to evaluate the carcass characteristics, chemical composition and fatty acid profile of the Longissimus muscle (LM) of three cattle genetic groups (Purunã, PUR, 11; 1/2 Purunã vs. 1/2 British, PUB, 6 and 1/2 Charolais vs. 1/2 Caracu, CHC, 10) finished in pasture systems. The field work took place at the Lapa Research Farm of the Agronomic Institute of Paraná, in the city of Lapa, south Brazil. The animals were fed during the winter with corn silage, cottonseed meal, cracked corn, urea, limestone and mineral salts as sources of protein, as well as an energy supplement, in pasture systems of Brachiaria decumbens Stapf. The animal groups were slaughtered at 20 months of age, at 50122.6 kg live weight. CHC bulls had higher (p<0.05) final weight than PUR and PUB bulls. Hot carcass weight was similar (p>0.10) between PUR and PUB. Hot carcass dressing percentage was higher (p<0.05) for PUB bulls than for PUR and CHC bulls. On the other hand, hot carcass dressing percentage was similar (p>0.05) between PUR and CHC bulls. Fat thickness was similar (p>0.10) among all genetic groups. However, the Longissimus area of CHC bulls was greater (p<0.05) than in PUR and PUB genetic groups. The genetic groups did not affect (p>0.10) the marbling of Longissimus. There was no observed difference (p>0.10) in moisture, ash, crude protein and total cholesterol contents among the three genetic groups. On the other hand, the total lipid percentage was higher (p<0.05) for the PUB genetic group in comparison with PUR and CHC. CLA percentage was highest for PUR animals. However, total CLA amounts were not altered by the different genetic groups.

Change of Blood Magnesium Level in Diabetes Patients Undergoing Off-pump Coronary Artery Bypass Grafting

  • Seo, Si-Young;Moon, Seong-Min;Hyun, Kyung-Yae;Kim, Chong-Rak;Choi, Seok-Cheol
    • Biomedical Science Letters
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    • v.15 no.3
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    • pp.207-215
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    • 2009
  • We carried out this study to investigate differences of physiological variables between patients with (DM group) and without type II diabetes mellitus (Non-DM group) undergoing off-pump coronary artery bypass grafting (OPCABG). Postoperative $Mg^{++}$ and $Ca^{++}$ levels were lower, whereas $Na^+$ level was higher in DM group than those in Non-DM group. ICU (intensive care unit) stay time in DM group was longer than that of Non-DM group. Postoperative platelet counts tended to decrease, whereas C-reactive protein (CRP) and cardiac troponin-I (cTNI) levels tended to increase in DM group compared with Non-DM group. Postoperative albumin level was lower, while blood urea nitrogen (BUN) and creatinine levels were greater in DM group than those in Non-DM group. DM group had higher incidence of post-operative arrhythmias than Non-DM group. These results reveal that type II DM patients undergoing OPCAB may have higher incidences of postoperative hypomagnesemia, hypocalcemia and arrhythmias, and increases of CRP, cTNI, BUN, and creatinine levels than in Non-DM patients undergoing OPCAB. The perioperative check and control (supplement) of $Mg^{++}$ levels should be considered in cardiovascular surgery combined with DM.

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