• Title/Summary/Keyword: University of Agriculture

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Vascular ring anomaly with a right patent ductus arteriosus and a left aortic arch in a juvenile cat

  • Aki Takeuchi ;Kazumi Shimada ;Lina Hamabe ;Tomohiko Yoshida;Yusuke Ozai ;Miki Hirose ;Aimi Yokoi ;Momoko Watanabe ;Ikki Mitsui ;Ryou Tanaka
    • Journal of Veterinary Science
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    • v.24 no.4
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    • pp.50.1-50.6
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    • 2023

  • This paper reports the clinical findings and surgical treatment of feline right patent ductus arteriosus (RPDA) with a left aortic arch. A two-month-old female Maine Coon was referred for an investigation of regurgitation after weaning. RPDA with a left aortic arch was diagnosed based on the echocardiographic and computed tomography (CT) findings. A right-fourth intercostal thoracotomy was found to be an appropriate approach to the duct. Preoperative diagnosis is crucial and diagnostic imaging, including radiography, echocardiography, and cardiac CT examination, is essential for determining if the aortic arch is right or left.

  • https://doi.org/10.4142/jvs.22290 인용 PDF

Sclareol Protects Staphylococcus aureus-Induced Lung Cell Injury via Inhibiting Alpha-Hemolysin Expression

  • Ouyang, Ping;Sun, Mao;He, Xuewen;Wang, Kaiyu;Yin, Zhongqiong;Fu, Hualin;Li, Yinglun;Geng, Yi;Shu, Gang;He, Changliang;Liang, Xiaoxia;Lai, Weiming;Li, Lixia;Zou, Yunfeng;Song, Xu;Yin, Lizi
    • Journal of Microbiology and Biotechnology
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    • v.27 no.1
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    • pp.19-25
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    • 2017

  • Staphylococcus aureus (S. aureus) is a common gram-positive bacterium that causes serious infections in humans and animals. With the continuous emergence of methicillin-resistant S. aureus (MRSA) strains, antibiotics have limited efficacy in treating MRSA infections. Accordingly, novel agents that act on new targets are desperately needed to combat these infections. S. aureus alpha-hemolysin plays an indispensable role in its pathogenicity. In this study, we demonstrate that sclareol, a fragrant chemical compound found in clary sage, can prominently decrease alpha-hemolysin secretion in S. aureus strain USA300 at sub-inhibitory concentrations. Hemolysis assays, western-blotting, and RT-PCR were used to detect the production of alpha-hemolysin in the culture supernatant. When USA300 was co-cultured with A549 epithelial cells, sclareol could protect the A549 cells at a final concentration of $8{\mu}g/ml$. The protective capability of sclareol against the USA300-mediated injury of A549 cells was further shown by cytotoxicity assays and live/dead analysis. In conclusion, sclareol was shown to inhibit the production of S. aureus alpha-hemolysin. Sclareol has potential for development as a new agent to treat S. aureus infections.

  • https://doi.org/10.4014/jmb.1606.06039 인용 PDF KSCI