• Archives of Pharmacal Research
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• v.26 no.3
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• pp.197-201
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• 2003

Novel $\beta$-hydroxy propenamides as analogues of the active metabolite of leflunomide (A 771726) were synthesized and evaluated for their inhibitory activity on dihydroorotate dehydrogenase (DHODH) in an investigation into their immunosuppressive activity. Compounds 2a, 3a, and 3h were approximately 4-40 times more potent than leflunomide in their activity while they were-less active than A 771726.

• Archives of Pharmacal Research
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• v.12 no.4
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• pp.236-238
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• 1989

The anti-microbial and anti-inflammatory activities of the constituents from Atractylodes rhizomes were evaluated. Atracylone showed anti-microbial activity. Atractylone and attractylenolide I possessed considerable anti-inflammatory activity utilizing rat cotton pellet granuloma bioassay.

• Archives of Pharmacal Research
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• v.14 no.3
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• pp.282-283
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• 1991

Stable intergeneric hybrids involving allodiploid were obtained through protoplast fusion and nuclear transfer between the auxotrophic mutans of two basidiomycetes. Ganoderma lucidum and Corolus versicolor.

• Archives of Pharmacal Research
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• v.14 no.1
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• pp.78-80
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• 1991

Ten 1,2,4-thiadiazolidines were synthesized and screened for their anti-inflammatory and analgesic activities. Butyl isothiocyanate was used as a starting material. Several compounds showed significant anti-inflammatory and analgesic activities. The unsubstituted and o-methyl, p-acetoxy and o-chloro substituted compounds were found to be more potent anti-inflammatory and analgesic agents than the other compounds.

• Archives of Pharmacal Research
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• v.2 no.2
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• pp.127-131
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• 1979

The extracts of sixty Korean plants were evaluated for their biological activities such as antitumor activities against Sarcoma 180, Leukemia SN-36 and Ehrlich ascites carcinoma, antimicrobial activities and behavioral observation in mice. The results are tabulate.

• Archives of Pharmacal Research
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• v.9 no.1
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• pp.25-28
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• 1986

Twenty nine substituted thiaxanthone derivatives were synthesized for schistosomicidal evaluation. The compounds, 1-morpholino-4-methyl-6-nitrothiaxanthone and 1-(2-diethyl-aminoethyl-amino)-4 methyl-6-nitrothiaxanthone dipicrate were found to possess promising schistosomicidal activity against Schistosoma mansoni in mice.

• Archives of Pharmacal Research
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• v.15 no.1
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• pp.73-77
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• 1992

From the roots of Angelica dahurica Bentham et Hooker (Umbelliferae), five coumarin glucosides together with adenosine have been isolated and identified as nodakenin, 3'-hydroxymarmesinin, tert-O-$\beta$-D-glucopyranosyl-byakangelicin, sec-O-$\beta$-D-glucopyranosyl-byakangelicin and scopolin. This is the first report of the occurrence of these compounds in this plant.

• Archives of Pharmacal Research
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• v.17 no.4
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• pp.249-255
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• 1994

An efficient synthetic method for 11-deoxyanthracycline AB synthons is described. A verstile key intemediate vinyl bromide 3 was prepared from 5- methodxy-1-tetralone in three steps, and then was converted to the allylic alcohols 4 and 8 which, in tum, fumished highly fuctionalized AB synthons 7 and 12, respectively, via sequential epoxidation-reduction-protection processes.

• Archives of Pharmacal Research
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• v.17 no.1
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• pp.36-38
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• 1994

A convenient route was reported for the synthesis of 3-anilino-4-arylazo-1-phenyl 1-2-pyrazolin-5-ones to improve their yields. The structures of the obtained products were supported by spctral data.

• Archives of Pharmacal Research
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• v.17 no.5
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• pp.323-326
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• 1994

Three new sesquiterpene lactone glucosides named dentatins A, B and C were isolated from lxeris dentata and the structures were elucidated as $3{\betha}, {\;}8{\betha}-dihydroxy-(1{\alpha}, 5{\alpha})guainan-10(14)-ene-6{\alpha}, {;\}12-olide-3-O-{\betha}-D-giucopyuranoside{\;}(1), {\;}3{\betha}, {\;}8{\betha}-dihydroxy-(1{\alpha}, {\;}5{\alpha})-guaian-4(15), {\;}10(14)-diene-6{\alpha}, {\;}12-plide-3-O-{\betha}-D-glucopyranoside{\;}(3)$, respectively, on the basis of spectral evidence.