1 |
Elison, G. B. and Hitchings G. H., Azathioprine. Handb. Exp. Pharmacol., 38, 404-425 (1975)
|
2 |
Kuo, E. A., Hambleton, P. T., Kay, D. P., Evans, P. L., Matharu, S. S., Little, E., McDowall, N., Jones, C. B., Hedgecock, C. J. R., Yea, C. M., Chan, A. W. E., Hairsine, P. W., Ager, I. R., Tully, W. R., Williamson, R. A., and Westwood, R., Synthesis, structure-activity relationship, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4-(trifluoromethyl)phenyl] propenamide and related compounds. J. Med. Chem., 39, 4608-4621 (1996).Η⨀ ?ὁ⸀ Ā볬蒱뷬ꂜ냪떬谀 ᔀ 墱䙀ᔮ쀾﷿䙇侖邝垐浇 䦍䙁 ?ὁ 혹❁Ȁ ܀ ἀЀĀ ?ὁ墱䙀ᔮ쀾 ?ὁ﷿䙇샣ʗ⨀ Ā Ā 侖邝垐浇ʗ⨀ ᔀ Ȁ ﷿䙇äʗ⨀ Ā 侖邝垐浇⃤ʗ⨀ ᔀ 袛얖⨀ 䃣ʗ⨀ Ȁ ﷿䙇胣ʗ⨀ Ā Ā 侖邝垐浇ꃣʗ⨀ ᔀ Ȁ ⸀ 볬蒱뷬ꂜ냪떬谀 ⸀ 볬蒱뷬ꂜ냪떬谀 ⸀ 볬蒱뷬ꂜ냪떬谀 돐샡ʗ⨀ 〽 ʗ⨀ 处 돀ᢰʗ⨀ ⁊ 렼 ʗ⨀ 돐 éʗ⨀ 僠ʗ⨀
DOI
ScienceOn
|
3 |
Papageorgiou, C., Zurini, M., Weber, H.-P., and Borer, X., Leflunomides bioactive metabolite has the minimal structural requirement for the efficient inhibition of human dihydroorotate dehydrogenase. Bioorg. Chem., 25, 233-238 (1997)
DOI
ScienceOn
|
4 |
Sanders, S. and Harisdangkul, V., Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. Am. J. Med. Sci., 323, 190-193 (2002)
DOI
ScienceOn
|
5 |
Skolik, S. A., Palestine, A. G., Blaese, R. M. Nussenblatt, R. B., and Hess, R. A., Treatment of experimental autoimmune uveitis in the rat with systemic succinylacetone. Clin. Immunol. Immunopathol., 49, 63-71 (1988)
DOI
ScienceOn
|
6 |
Shaw, L. M., Kaplan, B., and Kaufman, D., Toxic effects of immunosuppressive drugs: mechanism and strategies for controlling them. Clin. Chem., 42, 1316-1321 (1996)
PUBMED
|
7 |
Knecht, W., Bergjohann, U., Gonski, S., Kirschbaum, B., and Lffler, M., Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovius vector system, and kinetic investigation of the purified enzyme. Eur. J. Biochem., 240, 292-301 (1996)
DOI
PUBMED
ScienceOn
|
8 |
Tschudy, D. P., Hess, R., Frykholm, B., and Blaese, R. M., Immunosuppressive activity of succinylacetone. J. Lab. Clin. Med., 99, 526-532 (1981)
|
9 |
Fidler, J. M., Chang, T. G., Bauer, R., Young, J. D., and Vitt, C. R., Suppression of graft-versus-host disease by succinylacetone in a rat allogeneic bone marrow transplantation model. Transplantation, 55, 367-373 (1993)
DOI
PUBMED
ScienceOn
|
10 |
Bertolini, G., Aquino, M., Biffi, M., dAtri, G., Di Pierro, F., Ferrario, F., Mascagni, P., Somenzi, F., Zaliani, A., and Leoni, F., A new rational hypothesis for the pharmacophore of the active metabolite of leflunomide, a potent immunosuppressive drug. J. Med. Chem., 40, 2011-2016 (1997)
DOI
ScienceOn
|
11 |
Hess, R. A., Tschudy, D. P., and Blaese, R. M., Immunosuppression by succinylacetone: II. prevention of graft-vs-host disease. J. Immunol., 139, 2845-2849 (1987)
PUBMED
|
12 |
Jones, M. E., Pyrimidine nucleotide biosynthesis in animals, genes, enzymes, and regulation of UMP biosynthesis. Annu, Rev. Biochem., 49, 253-256 (1980)
DOI
PUBMED
ScienceOn
|
13 |
Davis, J. F., Cain, G. A., Pitts, W. J., Magolda, R. L., and Copeland, R. A., The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry, 35, 1270-1273 (1996)
DOI
ScienceOn
|
14 |
Knecht, W. and Lffler, M., Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazole and cinchoninic acid derivatives. Biochem. Pharmacol., 56, 1259-1264 (1998)
DOI
PUBMED
ScienceOn
|
15 |
Tanaka, H., Kuroda, A., Marusawa, H., Hatanaka, H., Kino, T., Goto, T., Hashimoto, M., and Taga, T., Structure of FK506: a novel immunosuppressants isolated from Streptomyces. J. Am. Chem. Soc., 109, 5031-5033 (1987)
DOI
|
16 |
Perico, N. and Remuzzi, G., Prevention of transplant rejection current treatment guidelines and future developments. Drugs, 54, 533-570 (1997)
DOI
ScienceOn
|
17 |
Lindblad, B., Lindstedt, S., and Steen, G., On the enzyme defects in hereditary tyrosinemia. Proc. Natl. Acad. Sci. USA, 74, 4641-4645 (1977)
DOI
ScienceOn
|
18 |
Borel, J. F., History of cyclosporin A and its significance in immunology. In cyclosporin A, Borel, J. F., Ed.; Elsevier Biochemical Press: Amsterdam, 1982, pp 5-17
|