• Title/Summary/Keyword: University Archives

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A New Phenylpropanoid Glucoside from the Fruits of Illicium verum

  • Lee, Sung-Won;Li, Gao;Lee, Kyong-Sun;Song, Dong-Keun;Son, Jong-Keun
    • Archives of Pharmacal Research
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    • v.26 no.8
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    • pp.591-593
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    • 2003
  • One new phenylpropanoid glucoside (3), along with one known phenylpropanoid (1), and one known alkyl glucoside (2) were isolated from the fruits of Illicium verum and their chemical structures were elucidated on the basis of spectroscopic studies.

Halolactonization reaction using N-haloimides

  • Cook, Chae-Ho;Cho, Youn-Sang;Jew, Sang-sup;Suh, Young-Guh;Kang, Eung-Ku
    • Archives of Pharmacal Research
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    • v.6 no.1
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    • pp.45-53
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    • 1983
  • Novel halactolactonizations using NBS (2), NIS(3), and NSP(4) in dry DMF were found to be the most reasonable and efficient procedures. The participation of X as the cylization initiator could be clarly rationalized by experimental results and the regioselectivities of formed halolactones were reasonably elucidated by weakly bridged carbonium ion intermediate.

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Phenolic Compounds on the Leaves of Betula Platyphylla var. latifolia

  • Lee, Min-Won;Takashi Tanaka;Gen-Ichiro Nonaka;Hahn, Dug-Ryoung
    • Archives of Pharmacal Research
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    • v.15 no.3
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    • pp.211-214
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    • 1992
  • Chemical examination of Betula platyphylla var. latifolia afforded a novel diarylheptanoid named betulateraol, together with a phenylpropanoid (3, 4'-dihydroxypropio-phenone), flavan-3-ol [(+)-catechin] and its glycosides [(+)-catechin 5-O-$\beta$-glucopyranoside, (+)-catechin 7-0-$\beta$-D-glucopyranoside] and two proanthocyanidins (procyanidins B-1 and B-3).

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Synthesis of 2,5Bis(2'-piperidymethyl)piperidine and Related Compounds

  • Hammouda, Metwally;Kandeel, Ex-el-Din;Hamama, Wafaa;Afsah, Elsayed
    • Archives of Pharmacal Research
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    • v.16 no.1
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    • pp.68-70
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    • 1993
  • The triketones 3-6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-mannich base (1) or (2). Schmidt reaction of the tricketones 3-6 afforded the corresponding trcyclic lactames 7-10 respectively. reduction of 7 and 9 gave compounds 11 and 12 respectively.

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A Rubrofusarin Gentiobioside Isomer from Roasted Cassia tora

  • Lee, Hee-Jung;Jung, Jee-Hyung;Kang, Sam-Sick;Choi, Jae-Sue
    • Archives of Pharmacal Research
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    • v.20 no.5
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    • pp.513-515
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    • 1997
  • From the roasted seeds of Cassia tora L., a new naphthopyrone glycoside was isolated and characterized as 10-[${\beta}$-D-glucopyranosyl-$(1{\rightarrow}6)-O-{\beta}-D-$glucopyranosyl)oxy]-5-hydrox y-8-methoxy-2-methyl-4H-naphtho[1, 2-b]pyran-4-one(isorubrofusarin gentiobioside). Along with isorubrofusarin gentiobioside, alaternin and adenosine were isolated and identified.

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Synthesis of novel Heterocycles Through Reaction of Indolin-2-one Derivatives with Active Methylene and Amino Reagents

  • Abdel-Latif, F.F.;Ahmed, E.Kh.;Mekheimer, R.;Mashaly, M.M.
    • Archives of Pharmacal Research
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    • v.20 no.5
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    • pp.507-509
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    • 1997
  • Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.

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The absolute configuration of ketoprofen

  • Kim, Jin-Woong;Jew, Sang-Sup;Cho, Youn-Sang;Cook, Chae-Ho
    • Archives of Pharmacal Research
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    • v.10 no.1
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    • pp.25-28
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    • 1987
  • (+)-Ketoprofen was obtained form resolution with (S) (+)-2-amino-1-butanol and its absolute configuration was determined to be (S) by chemical correlation with (S) (+)-ethyl hydratropate using Beckmann rearrangement as a key step.

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Effects of some organophosphate pesticides on the murine immune system following subchronic exposure 1

  • Moon, Chang-Kiu;Yun, Yeo-Pyo;Lee, Soo-Hwan;Lee, Young-Soon
    • Archives of Pharmacal Research
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    • v.9 no.3
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    • pp.175-181
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    • 1986
  • Four technical grade organophosphate pesticides (Fenitrothion, Fenthion, Dizninon and EPN) were investigated for their effects on the murine immune function. Among the immunotoxicological assay parameters of NIEHS, humoral immune parameter and pathotoxicological indicators were examined in this study. Subchronic exposure of rodents to these pesticides resulted in marked suppression of humoral immune function and moderate histological changes of lymphoid organ any significant alterations of clinical status.

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