Archives of Pharmacal Research
- Volume 6 Issue 1
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- Pages.45-53
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- 1983
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Halolactonization reaction using N-haloimides
- Cook, Chae-Ho (College of Pharmacy, Seoul National University) ;
- Cho, Youn-Sang (College of Pharmacy, Seoul National University) ;
- Jew, Sang-sup (College of Pharmacy, Seoul National University) ;
- Suh, Young-Guh (College of Pharmacy, Seoul National University) ;
- Kang, Eung-Ku (College of Pharmacy, Seoul National University)
- Published : 1983.06.01
Abstract
Novel halactolactonizations using NBS (2), NIS(3), and NSP(4) in dry DMF were found to be the most reasonable and efficient procedures. The participation of X as the cylization initiator could be clarly rationalized by experimental results and the regioselectivities of formed halolactones were reasonably elucidated by weakly bridged carbonium ion intermediate.
Keywords
- N-chlorosuccinimide;
- N-bromosuccinimide;
- N-iodosuccinimide N-bromophthalimide;
- N-bromosaccharin haloactonization;
- bromolactonization;
- N,N-dimethylformamide