• Archives of Pharmacal Research
• /
• v.27 no.6
• /
• pp.633-639
• /
• 2004

The expression of therapeutic transgenes in recombinant adenoviral vectors is a major cause of toxicity in dividing cancer cells as well as non dividing normal cells. To solve the problem of toxicity to normal cells, we have reported on a recombinant adenoviral vector system （AdLP-） in which the expression of the transgene is directed by the tumor-specific L-plastin promoter （LP） （Chung et al., 1999）. The object of this study was to generate a recombinant adenoviral vector system which would generate tumor cell specific expression of cytosine deaminase （CD） gene. We report the construction of a replication-incompetent adenoviral vector in which CD is driven by the L-plastin promoter （AdLPCD）. Infection of 293 cells by AdLPCD generated the functional CD protein as measured by HPLC analysis for the conversion of 5-Fluorocy-tosine （5-FC） to 5-Fluorouracil （5-FU）. HPLC analysis in conjunction with counting radioactivity for ［6-$^3$H］-5FC and ［6-$^3$H］-5FU demonstrated vector dose-dependent conversion of 5-FC to 5-FU in AdLPCD infected ovarian cancer cells. The results from present and previous studies（Peng et al., 2001； Akbulut et al., 2003） suggest that the use of the AdLPCD／5-FC system may be of value in the treatment of cancer including microscopic ovarian cancer in the peritoneal cavity.

• Journal of Advanced Navigation Technology
• /
• v.13 no.3
• /
• pp.399-405
• /
• 2009

This paper proposes a design of attenuator based on meta-material structure and its application. The unit-cell attenuator based on the lossy transmission line consists of the CRLH(Composite Right/Left Handed) transmission line and PIN diodes to be controlled internal loss according to diode bias voltage to change resistance of diode. Also, to reduce the initial losses, there is used parallel connection of PIN diodes. To increase attenuations, it is connected a cascade unit-cell of attenuator with periodic structure. The attenuation quantities of unit-cell are about 10dB and phase variations are 15o maximum at 1.5 GHz ~ 2.5 GHz. Also, its application is represented a vector modulator.

• ETRI Journal
• /
• v.38 no.6
• /
• pp.1064-1073
• /
• 2016

An adaptive speech streaming method to improve the perceived speech quality of a software-based multipoint control unit (SW-based MCU) over IP networks is proposed. First, the proposed method predicts whether the speech packet to be transmitted is lost. To this end, the proposed method learns the pattern of packet losses in the IP network, and then predicts the loss of the packet to be transmitted over that IP network. The proposed method classifies the speech signal into different classes of silence, unvoiced, speech onset, or voiced frame. Based on the results of packet loss prediction and speech classification, the proposed method determines the proper amount and bitrate of redundant speech data (RSD) that are sent with primary speech data (PSD) in order to assist the speech decoder to restore the speech signals of lost packets. Specifically, when a packet is predicted to be lost, the amount and bitrate of the RSD must be increased through a reduction in the bitrate of the PSD. The effectiveness of the proposed method for learning the packet loss pattern and assigning a different speech coding rate is then demonstrated using a support vector machine and adaptive multirate-narrowband, respectively. The results show that as compared with conventional methods that restore lost speech signals, the proposed method remarkably improves the perceived speech quality of an SW-based MCU under various packet loss conditions in an IP network.

• Journal of the Korean Statistical Society
• /
• v.27 no.2
• /
• pp.165-187
• /
• 1998

Shin and Sarkar (1993, 1994) studied the problem of testing for a unit root in an AR(p) signal observed with MA(q) noise when the MA parameters are known. In this paper we consider the case when the MA parameters are unknown and to be estimated. Test statistics are defined using unit root parameter estimates based on three different estimation methods of Hannan and Rissanen (1982), Kohn (1979) and Shin and Sarkar (1995). An AR(p) process contaminated by MA(q) noise is a .estricted ARMA model, for which Shin and Sarkar (1995) derived an easy-to-compute Newton- Raphson estimator The two-stage estimation p.ocedu.e of Hannan and Rissanen (1982) is used to compute initial parameter estimates in implementing the iterative estimation methods of both Shin and Sarkar (1995) and Kohn (1979). In a simulation study we compare the relative performance of these unit root tests with respect to both size and power for p=q=1.

• Parasites, Hosts and Diseases
• /
• v.58 no.6
• /
• pp.627-634
• /
• 2020

Belitung district in Bangka-Belitung Province, Indonesia with a population of 0.27 million is endemic for Brugia malayi and 5 rounds of mass drug administration (MDA) were completed by 2010. Based on the results of 3 transmission assessment surveys (TAS), the district is declared as achieving elimination of lymphatic filariasis (LF) in 2017. The findings of an independent survey conducted by the National Institute of Health Research and Development (NIHRD) in the same year showed microfilaria (Mf) prevalence of 1.3% in this district. In 2019, NIHRD conducted microfilaria survey in 2 villages in Belitung district. Screening of 311 and 360 individuals in Lasar and Suak Gual villages showed Mf prevalence of 5.1% and 2.2% with mean Mf density of 120 and 354 mf/ml in the respective villages. Mf prevalence was significantly higher among farmers and fishermen compared to others and the gender specific difference was not significant. The results of a questionnaire based interview showed that 62.4% of the respondents reported to have participated in MDA in Lasar while it was 57.7% in Suak Gual village. About 42% of the Mf positive cases did not participate in MDA. Environmental surveys identified many swampy areas supporting the breeding of Mansonia vector species. Persistence of infection is evident and in the event of successful TAS3 it is necessary to monitor the situation and plan for focal MDA. Appropriate surveillance strategies including xenomonitoring in post-MDA situations need to be developed to prevent resurgence of infection. Possible role of animal reservoirs is discussed.

• The Journal of Industrial Distribution & Business
• /
• v.9 no.5
• /
• pp.63-72
• /
• 2018

Purpose - This work analyzes, in detail, the specification of vector error correction model (VECM) and thus examines the relationships and impact among seven economic variables for USA - balance on current account (BCA), index of stock (STOCK), gross domestic product (GDP), housing price indices (HOUSING), a measure of the money supply that includes total currency as well as large time deposits, institutional money market funds, short-term repurchase agreements and other larger liquid assets (M3), real rate of interest (IR_REAL) and household credits (LOAN). In particular, we search for the main explanatory variables that have an effect on stock and real estate market, respectively and investigate the causal and dynamic associations between them. Research design, data, and methodology - We perform the time series vector error correction model to infer the dynamic relationships among seven variables above. This work employs the conventional augmented Dickey-Fuller (ADF) and Phillips-Perron (PP) unit root techniques to test for stationarity among seven variables under consideration, and Johansen cointegration test to specify the order or the number of cointegration relationship. Granger causality test is exploited to inspect for causal relationship and, at the same time, impulse response function and variance decomposition analysis are checked for both short-run and long-run association among the seven variables by EViews 9.0. The underlying model was analyzed by using 108 realizations from Q1 1990 to Q4 2016 for USA. Results - The results show that all the seven variables for USA have one unit root and they are cointegrated with at most five and three cointegrating equation for USA. The vector error correction model expresses a long-run relationship among variables. Both IR_REAL and M3 may influence real estate market, and GDP does stock market in USA. On the other hand, GDP, IR_REAL, M3, STOCK and LOAN may be considered as causal factors to affect real estate market. Conclusions - The findings indicate that both stock market and real estate market can be modelled as vector error correction specification for USA. In addition, we can detect causal relationships among variables and compare dynamic differences between countries in terms of stock market and real estate market.

• Progress in Medical Physics
• /
• v.7 no.1
• /
• pp.53-64
• /
• 1996

Purpose: The purposes of this paper are to develop a theoretical basis that the beam directions should be considered when the mechanical accuracy of teletherapy machine is evaluated by the star pattern test, to develop methods using asymmetric field in length to simulate beam direction for the case that beam direction does not appear on film. Method: In evaluating mechanical rotational accuracy of the gantry of teletherapy unit by the star pattern test, the direction of radiation beams was considered. A star pattern using some narrow beams was made. Density profiles at 10cm far from estimated gantry axis on the star pattern were measured using an optical densitometer. On each profile, one coordimate of a beam axis was determined. A pair of coordinates on a beam axis form an equation of the axis. Assume that a unit vector equation omitted is with same direction as radiation beam and a vector equation omitted is a vector directing to the beam axis from the estimated gantry axis. Then, a vector product equation omitted ${\times}$ equation omitted is an area vector of which the absolute value is equal to the distance from the estimated gantry axis to the beam axis. The coordinate of gantry axis was obtained by using least-square method for the area vectors relative to the average of whole area vectors. For the axis, the maximum of absolute value of area vectors would be an accuracy of the gantry rotation axis. For the evaluation of mechanical accuracies of collimator and couch axes for which beam direction could not be depicted on a star pattern test film, narrow beams asymmetric in field length was used to simulate beam direction. Result: For a star test pattern to evaluate the mechanical accuracy of rotational axes of a telectherapy machine, the result considering beam direction was different from that ignoring beam direction. For the evaluation of mechanical accuracies of collimator and couch axes by means of a star pattern test, narrow asymmetric beams could simulate beam direction. Conclusion: When a star pattern test is used to evaluate the mechanical accuracy of a teletherapy unit, beam direction must be considered or simulated, and quantitatively evaluated.

• Smart Media Journal
• /
• v.10 no.1
• /
• pp.16-24
• /
• 2021

The exiting word embedding methodology such as word2vec represents words, which only occur in the raw training corpus, as a fixed-length vector into a continuous vector space, so when mapping the words incorporated in the raw training corpus into a fixed-length vector in morphologically rich language, out-of-vocabulary (OOV) problem often happens. Even for sentence embedding, when representing the meaning of a sentence as a fixed-length vector by synthesizing word vectors constituting a sentence, OOV words make it challenging to meaningfully represent a sentence into a fixed-length vector. In particular, since the agglutinative language, the Korean has a morphological characteristic to integrate lexical morpheme and grammatical morpheme, handling OOV words is an important factor in improving performance. In this paper, we propose parallel Tri-LSTM sentence embedding that is robust to the OOV problem by extending utilizing the morphological information of words into sentence-level. As a result of the sentiment analysis task with corpus in Korean, we empirically found that the character unit is better than the morpheme unit as an embedding unit for Korean sentence embedding. We achieved 86.17% accuracy on the sentiment analysis task with the parallel bidirectional Tri-LSTM sentence encoder.

• Communications of the Korean Mathematical Society
• /
• v.9 no.2
• /
• pp.415-418
• /
• 1994

Let G be a compact Lie group and let $S^1$ denote the unit circle in $R^2$ with the standard metric. Since every smooth compact Lie group action on $S^1$ is smoothly equivalent to a linear action (cf. [3J TH 2.0), we may think of $S^1$ with a smooth G-action as S(V) the unit circle of a real 2-dimensional orthogonal G-module V.(omitted)

• Proceedings of the Microbiological Society of Korea Conference
• /
• 2007.05a
• /
• pp.65-67
• /
• 2007