• Title/Summary/Keyword: Union

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The Clinicopathological and Prognostic Impact of 14-3-3 Protein Isoforms Expression in Human Cholangiocarcinoma by Immunohistochemistry

  • Wu, Qiao;Liu, Chang-Zheng;Tao, Lian-Yuan;Yu, Lan;Liu, Wei;Chen, Song-Sen;He, Xiao-Dong
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1253-1259
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    • 2012
  • The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic phenomena, such as cell cycle control, and apoptosis. However, their expression in cholangiocarcinoma has not been previously characterized. In this paper, immunohistochemistry using specific anti-14-3-3 monoclonal antibodies was performed on formalin-fixed;, paraffin embedded archival tissue from 86 patients of cholangiocarcinoma. We also examined the correlation between expression and survival rate and clinicopathologic factors such as tumor location, tumor size, pathologic differentiation, lymphatic permeation, lymph node metastasis, and tumor stage. Positive 14-3-3 proteins expression was observed for 6 isoforms (${\beta}$, ${\sigma}$, ${\gamma}$, ${\theta}$, ${\delta}$, ${\eta}$) of these proteins in 86 patients of cholangiocarcinoma. ${\beta}$ and ${\sigma}$ isoform immunoreactivity was correlated with lymph node metastasis, tumor stage and patients' survival rate. In addition, ${\delta}$ isoform immunoreactivity showed trends with tumor location, tumor size, pathologic differentiation and tumor stage, while the ${\theta}$ isoform was correlated with pathologic differentiation. These results indicated that upregulated expression of some isoforms of 14-3-3 may be a common mechanism for evading apoptosis in cholangiocarcinoma, so that targeting 14-3-3 may be a novel promising strategy for the treatment of this tumor.

An Analysis of the Effects of Unions on Wages for Female Workers (우리나라 노동조합이 여성근로자의 임금에 미치는 영향)

  • Shin, Woori;Song, Heonjae
    • Journal of Labour Economics
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    • v.39 no.3
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    • pp.99-124
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    • 2016
  • This study analyzed the effects of labor unions on the wages of Korean female workers using 'Korean Labor and Income Panel Study.' In the estimation we considered the self-selection bias due to the women's labor force participation decision and a plausible non-response bias from not answering the question about the company size in terms of number of employees. By fixed effect estimation we found that labor unions in Korea do not increase the wages of both the female union workers and non-union workers who work at a company in which a union is organized comparing to female workers who work at company without a union. This results indicates that female workers who work in the company with labor union tend to have unobserved characteristics that are positively correlated with both wages and the probability to enter the company with labor union. We also came to the conclusion that there is no free-rider effects of non-union workers.

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A Case Study about Non-regular Worker's Labor Dispute : Focusing on the Labor Dispute about Subcontract Company of Hynix Semiconductor Co. (비정규직 노사분규 사례 연구 : 하이닉스 사내하청 노사분규를 중심으로)

  • Yoon, Chan-Seong;Kim, Jung-Hoon;Lee, Hye-Jin
    • The Journal of the Korea Contents Association
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    • v.10 no.4
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    • pp.386-396
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    • 2010
  • The purpose of this study is to examine the non-regular labor dispute from beginning to the ends, thus, give guidance for future similar labor disputes. As a result of this study, firstly, subcontract company union negotiated with their companies, but after their companies was shut up, the union demanded negotiation with Hynix Co.(Hynix Co. contracted with union member's companies about cleaning job etc for every year). However, Hynix rejected the union's demand, because Hynix Co. do not have the legal obligation to negotiate with subcontract company union. Secondly, union members was to in unemployment and for the employment & negotiation with Hynix Co. they did illegal actions against Hynix Co. Thirdly, there was tried many efforts by NGO & government authorities etc to settle the disputes, and mediated, arbitrated by private expert(Certified Public Labor Attorney) Finally, both parties(that is Hynix Co. and subcontract company union) negotiated each other and settled the dispute without employment.

The Organization of the Archival Systems and Their Transformations in the first period of the Soviet UnionAn Essay for Reconstruction on the Classification System of Government-General of Chosun (소련 초기의 기록관리제도와 그 변화)

  • Cho, Ho-Yeon
    • The Korean Journal of Archival Studies
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    • no.10
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    • pp.324-370
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    • 2004
  • This paper aims to research the historical development of the archival systems in the Soviet Union from 1917 to the 1920's. The Russian revolution was the turning point not only for the political and social changes but for the archival administration in Russia, as it provided the new Soviet regime with the chances to reorganize the archival institutions under Bolshevik rule. However, we must not forget the fact that the Russian Archival Workers' Union had taken part in the organization of the archival systems together with the Bolshevik revolutionaries. The Soviet government intended to transform the decentralized and poorly organized archival systems in the prerevolutionary years into the centralized and bureaucratized ones. In this meaning, the decree signed be V. I. Lenin on 1 June 1918 was estimated as the real basis for the Soviet archival centralization. Lenin's archival decree of 1918 encompassed the entire national documentary legacy, which was gradually extended to all types and categories of manuscripts and archival records by successive legislation. The concept of state proprietorship of all documentary records was designated "Single State Archival Fond"(Edinyi Gosudarstvennyi arkhivnyi fond), which was renamed as "Archival Fond of the Russian Federation" after the collapse of the USSR. The independent state administrative agency, that is, "Main Administration of Archival Affairs"(Glavnoe upravlenie arkhivnym delom) was charged with the management of the entire "Single State Archival Fond". While the Soviet Union reorganized its archival systems in the twenties, the archival institutions became under the severe control of the government. For example, M. N. Pokrovskii, the well-known Marxist historian and the political leader, headed the organizational work of archives in the Soviet Union, which resulted in the exclusion of the prerevolutionary specialists from the archival field in the Soviet Union. However, the discussions over the concept of "the Archival Fond" by B. I. Anfilov helped to develop the archival theories in the USSR in the twenties. In conclusion, the Soviet Union, having emphasized the centralization of the archives, developed its archival systems from the early period, which were the basis of the systematic archival institutions in Russia.

An Exploratory Study on Group Bullying of Labor Union Members in Labor-Management Disputes (노사분규 사업장 내 노동조합 조합원의 집단따돌림에 관한 탐색적 연구)

  • An, Sung-Eun;Lee, Dong-Yeon;Chae, Jun-Ho
    • Journal of Digital Convergence
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    • v.17 no.9
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    • pp.31-37
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    • 2019
  • The results of this study showed that victim's job motivation, organizational distrust, nervousness, turnover intention, frustration, stress and resistance, powerlessness and alienation were similar to previous studies. I was overwhelmed by the negative force of the collective union and experienced anger in the reality that one individual could not resist or find a solution. In addition, psychological factors such as union members' fear of union bullying were found to have a positive effect on the union members who did not join the strike and those who did not join the strike. It is necessary to consider the question of whether the group bullying behavior is valid in that the union bullying behavior of the union is effective in achieving the purpose of the group.

Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis

  • Zhen Wang ;Xueheng Xie ;Mengchen Wang ;Meng Ding ;Shengliang Gu ;Xiaoyan Xing;Xiaobo Sun
    • Journal of Ginseng Research
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    • v.47 no.4
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    • pp.493-505
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    • 2023
  • In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related "ingredients-targets" network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

Security Treats about Union File System and Responce Methodology (유니온 파일시스템에 대한 보안 위협 및 대응 방법)

  • Han, Sung-Hwa
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.445-446
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    • 2021
  • Union file system is a technology that can be used as a single file system by integrating various files and directories. It has the advantage of maintaining the source file/directory used for integration, so it is used in many applications like container platform. When using the union file system, the user accesses the write-able layer, to which the security technology provided by the operating system can be applied. However, there is a disadvantage in that it is difficult to apply a separate security technology to the source file and directory used to create the union file system. In this study, we intend to propose an access control mechanism to deny security threats to source file/directory that may occur when using the union file system. In order to verify the effectiveness of the access control mechanism, it was confirmed that the access control mechanism proposed in this study can protect the source file/directory while maintaining the advantages of the union file system.

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