• 한방재활의학과학회지
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• 제32권1호
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• pp.1-19
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• 2022

Objectives This study aims to evaluate the wound healing effects of oral administered hot water extracts of Korean black ginseng (KBG). Methods 40 C57BL/6 mice were divided into five groups; normal, control, vitamin E 200 mg/kg, KBG 100 mg/kg, KBG 200 mg/kg, each n=8. Skin wounds were made in the back of all mice except normal group using biopsy punches. Wounds were observed on days 7 and 14 after injury. The anti-oxidant and inflammatory protein levels were evaluated using western blotting. Skin tissue was analyzed by hematoxylin & eosin and Masson's trichrome staining method. Results KBG significantly accelerated reducing wound area. KBG significantly decreased myeloperoxidase activity. KBG significantly decreased oxidative stress factors such as NADPH oxidase-4 and p22^phox and increased antioxidant enzymes including nuclear factor erythroid 2-related factor2, kelch-like ECH-associated protein-1, heme oxygenase-1, superoxide dismutase, catalase and glutathione peroxidase-1/2. Moreover, KBG significantly decreased inflammation factors including nuclear factor-κB, phosphorylated inhibitor of κBα, cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-α and interleukin (IL)-6 and increased anti-inflammation cytokine such as IL-4 and IL-10. In addition, KBG significantly increased tight junction proteins including claudin-1, claudin-3, claudin-4. In histopathologic, KBG made the epithelium thin and uniform, and accelerated the remodeling of collagen. Conclusions The results suggest that KBG has healing effects on skin wound in mice by anti-inflammatory and antioxidant activity.

• 한국학교보건학회지
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• 제35권3호
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• pp.143-151
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• 2022

Purpose: The purpose of this study was to examine the effects of being aware of the physical and psychosocial environment of the school on subjective feeling of happiness in Korean middle and high school students. Methods: The data of "Health and lifestyle Survey (2019)" conducted by the National Youth Policy Institute were analyzed after receiving approval though the website. A total of 5,311 middle and high school students were included in the analysis. Descriptive statistics, t-test, one-way ANOVA, pearson correlation, and multiple regression analysis were executed using SAS 9.4. Results: The mean score of subjective feeling of happiness was 6.92±0.56 out of 10. From the univariate analysis, the more positive the perception of the physical school environment was, such as classrooms, restrooms, exercise facilities, catering facilities, health facilities, other school facilities and school uniform, the higher the subjective feeling of happiness was (p for all <.001). In addition, the psychosocial environment of the school was significantly related to the happiness of adolescents (p<.001). After controlling for gender, school level, school grade, socio-economic status, and stress, positive perception of classrooms (B=0.04, p<.001), catering facilities (B=0.01, p=.021), health facilities (B=0.08, p<.001), and the psychosocial environment of the school (B=0.18, p<.001) was significantly associated with happiness of the students. Conclusion: Positive perception of the school environment was found to increase happiness in adolescents. Therefore, efforts should be made to make classrooms, catering facilities, and health facilities a pleasant space as well as to create a school atmosphere that values health.

• Smart Structures and Systems
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• 제29권3호
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• pp.445-455
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• 2022

Steel anchor bolts are installed in concrete using a variety of methods. One of the most common methods of anchor bolt installation is using epoxy resin as an infill material injected into the drilled hole to act as a bonding material between the steel bolt and the surrounding concrete. Typical design standards assume uniform stress distribution along the length of the anchor bolt accompanied with single crack leading to pull-out failure. Experimental evidence has shown that the steel anchor bolts fail owing to the multiple failure patterns, hence these design assumptions are not realistic. In this regard, the presented research work details the analytical model that takes into consideration multiple micro cracks in the infill material induced via impact loading. The impact loading from the Schmidt hammer is used to evaluate the bond condition bond condition of anchor bolt and the epoxy material. The added advantage of the presented analytical model is that it is able to take into account the various type of end conditions of the anchor bolts such as bent or U-shaped anchors. Through sensitivity analysis the optimum stiffness and shear strength properties of the epoxy infill material is achieved, which have shown to achieve lower displacement coupled with reduced damage to the surrounding concrete. The accuracy of the presented model is confirmed by comparing the simulated deformational responses with the experimental evidence. From the comparison it was found that the model was successful in simulating the experimental results. The proposed model can be adopted by professionals interested in predicting and controlling the deformational response of anchor bolts.

• Tribology and Lubricants
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• 제37권6호
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• pp.224-231
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• 2021

Recently, the waterproofing performance of high-voltage connectors in automotive vehicles has attracted increased interest. In this study, an optimal cross-sectional shape was derived to obtain uniform contact pressure and strain by considering stress relaxation problems caused by initial tension when mounting a seal. A high strain of 52.1 was distributed in the round region, owing to excessive initial tension. The finite element method (FEM) analysis indicated that the strain corresponding to the optimal initial tensile was 11. We adopted six design factors to optimize the seal cross-section and three factors as the main design factors. An orthogonal arrangement table was prepared using Minitab. FEM analyses of 16 study models were conducted to determine the optimized model. The contact pressure of the optimization model is the most evenly distributed while satisfying the waterproof performance of 0.47 MPa. Compared to the initial model, the difference in strain decreases from 35.5% to 19.6%. Finally, the derived cross-sectional shape can reduce the strain of the round region by 33.8% and the differences in the contact pressure at the upper and lower surfaces by 42% and 76%, respectively.

• Advances in nano research
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• 제14권3호
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• pp.211-224
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• 2023

This work presents a modified analytical model for the bending behavior of axially functionally graded (AFG) carbon nanotubes reinforced composite (CNTRC) nanobeams. New higher order shear deformation beam theory is exploited to satisfy parabolic variation of shear through thickness direction and zero shears at the bottom and top surfaces.A Modified continuum nonlocal strain gradient theoryis employed to include the microstructure and the geometrical nano-size length scales. The extended rule of the mixture and the molecular dynamics simulations are exploited to evaluate the equivalent mechanical properties of FG-CNTRC beams. Carbon nanotubes reinforcements are distributed axially through the beam length direction with a new power graded function with two parameters. The equilibrium equations are derived with associated nonclassical boundary conditions, and Navier's procedure are used to solve the obtained differential equation and get the response of nanobeam under uniform, linear, or sinusoidal mechanical loadings. Numerical results are carried out to investigate the impact of inhomogeneity parameters, geometrical parameters, loadings type, nonlocal and length scale parameters on deflections and stresses of the AFG CNTRC nanobeams. The proposed model can be used in the design and analysis of MEMS and NEMS systems fabricated from carbon nanotubes reinforced composite nanobeam.

• Animal Bioscience
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• 제36권4호
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• pp.601-608
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• 2023

Objective: This study was conducted to investigate the effects of energy and protein levels in the diet of Hanwoo heifers on growth response and animal behavior. Methods: Forty heifers were randomly allocated into three experimental groups according to the target daily weight gain in 8 pens (T-0.2, 2 replications; T-0.4 and -0.6, 3 replications) based on similar body weight (BW) and age in months. The target average daily gain (ADG) was set at 0.2 (T-0.2), 0.4 (T-0.4), and 0.6 kg/d (T-0.6), and feed was based on National Institute of Animal Science (NIAS, 2017). In order to minimize hunger stress of T-0.2 and -0.4, the feeding ratio of rice straw was set to 55%, 50%, and 45% for T-0.2, -0.4 and T-0.6, respectively, so that the dry matter (DM) intake for all treatment groups was uniform but the energy and protein levels in the diet were adjusted differently. A total of 6 items (lying, standing, eating, rumination, walking and drinking) of animal behavior were analyzed. Results: During the whole period of the experiment, the ADG of the T-0.2, -0.4 and -0.6 treatments were 0.48, 0.56, and 0.65 kg/d (p<0.05), respectively, showing higher gain than the predicted value, especially for the low target ADG group. Based on these results, regression equations for the total digestible nutrient (TDN) and crude protein (CP) requirements were derived. No behavioral differences were found according to the energy and protein levels in the diet because the DM intake was kept constant by adjusting the roughage and concentration ratio. However, eating time was longer (p<0.05) at T-0.2 than T-0.6 during the whole day. Conclusion: Through this study, it was possible to derive regression equations for predicting TDN and CP requirements according to the target ADG and BW.

• Structural Engineering and Mechanics
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• 제86권1호
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• pp.1-16
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• 2023

The free vibration of temperature-dependent functionally graded plates (FGPs) resting on a viscoelastic foundation is investigated in this paper using a newly developed simple first-order shear deformation theory (FSDT). Unlike other first order shear deformation (FSDT) theories, the proposed model contains only four variables' unknowns in which the transverse shear stress and strain follow a parabolic distribution along the plates' thickness, and they vanish at the top and bottom surfaces of the plate by considering a new shape function. For this reason, the present theory requires no shear correction factor. Linear steady-state thermal loads and power-law material properties are supposed to be graded across the plate's thickness. Uniform, linear, non-linear, and sinusoidal thermal rises are applied at the two surfaces for simply supported FGP. Hamilton's principle and Navier's approach are utilized to develop motion equations and analytical solutions. The developed theory shows progress in predicting the frequencies of temperature-dependent FGP. Numerical research is conducted to explain the effect of the power law index, temperature fields, and damping coefficient on the dynamic behavior of temperature-dependent FGPs. It can be concluded that the equation and transformation of the proposed model are as simple as the FSDT.

• 터널과지하공간
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• 제33권2호
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• pp.83-94
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• 2023

원통형 시료의 측면에 일정하게 구속압이 적용되는 통상적인 삼축시험 셀과는 달리, GREAT 셀은 독립적으로 제어되는 8쌍의 측면 가압장치들을 이용하여 차등적으로 구속압을 가할 수 있고, 이를 통해 다양한 크기와 방향의 수평 응력장을 생성시킬 수 있다. 본 연구의 선행 논문에서는 다양한 역학적 재하 조건에서 GREAT 셀 시험을 수치해석적으로 모사하고, 원주변형률에 대한 수치해석 및 실험측정 결과를 비교하여 적용된 수치모델의 적정성을 분석하였다. 본 연구에서는 역학적 재하 조건과 유체흐름 조건을 함께 고려하여 균열이 포함된 인공시료에 대한 GREAT 셀 시험을 수치모사하였다. 값이 알려지지 않은 균열면의 역학적 물성을 다양하게 설정하여 시료의 거동(원주변형률)에 대한 수치해석과 실험 결과를 비교하였으며, 균열면의 특정 역학적 조건에서 실험결과와 잘 일치하는 것으로 검토되었다. 추가적으로 유체흐름 조건이 시료의 역학적 거동에 미치는 영향을 분석하였다.

• Coupled systems mechanics
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• 제12권3호
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• pp.199-220
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• 2023

This article presents a new analytical model to study the effect of porosity on the shear correction factors (SCFs) of functionally graded porous beams (FGPB). For this analysis, uneven and logarithmic-uneven porosity functions are adopted to be distributed through the thickness of the FGP beams. Critical to the application of this theory is a determination of the correction factor, which appears as a coefficient in the expression for the transverse shear stress resultant; to compensate for the assumption that the shear strain is uniform through the depth of the cross-section. Using the energy equivalence principle, a general expression is derived from the static SCFs in FGPB. The resulting expression is consistent with the variationally derived results of Reissner's analysis when the latter are reduced from the two-dimensional case (plate) to the one-dimensional one (beam). A convenient algebraic form of the solution is presented and new study cases are given to illustrate the applicability of the present formulation. Numerical results are presented to illustrate the effect of the porosity distribution on the (SCFs) for various FGPBs. Further, the law of changing the mechanical properties of FG beams without porosity and the SCFare numerically validated by comparison with some available results.

• Geomechanics and Engineering
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• 제34권3호
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• pp.233-250
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• 2023

This paper investigates the flexural analysis of isotropic, transversely isotropic, and laminated composite plates using a new higher-order normal and shear deformation theory. In the present theory, only five unknown functions are involved compared to six or more unknowns used in the other similar theories. The developed theory does not need a shear correction factor. It can satisfy the zero traction boundary conditions on the top and the bottom surfaces of the plate as well as account for sufficient distribution of the transverse shear strains. The thickness stretching effect is considered in the computation. A simply supported was considered on all edges of the plate. The plate is subjected to uniform and sinusoidal distributed load in the static analysis. Laminated composite, isotropic, and transversely isotropic plates are considered. The governing equations are obtained utilizing the virtual work principle. The differential equations are solved via Navier's procedure. The results obtained from the developed theory are compared with other higher-order theories considered in the previous studies and 3D elasticity solutions. The results showed that the proposed theory accurately and effectively predicts the bidirectional bending responses of laminated composite plates. Several parametric studies are presented to illustrate the various parameters influencing the static response of the laminated composite plates.