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Acetylation of Retinoblastoma Like Protein2 (Rb2/p130) in Tumor Tissues

  • Khan, Z.N.;Sabir, M.;Kayani, M.A.;Saeed, M.
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2255-2258
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    • 2013
  • The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.

A Study of Protective Gear Provision Improvement for Preventing an Accidental Fall in Construction Field of Educational Facilities (교육시설 공사현장의 추락예방 보호구 지급개선에 관한 연구)

  • Lee, Kyoung-Hun;Kim, Jung-Ho
    • The Journal of Sustainable Design and Educational Environment Research
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    • v.13 no.2
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    • pp.26-34
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    • 2014
  • Recently, a series of massive earthquakes have been occurred northeast Asia and there has also been constant sensible earthquakes in South Korea. Particularly, after diagnosing educational facilities with Sichuan earthquake momentum, remodeling construction of old educational facilities and buildings which were not designed not to resist earthquake are actively underway. Remodeling construction sites, however, are mostly small construction sites which consist of less than 30 full-time laborers, where a number of deaths from a fall occur by improper uses of protective gear. Therefore, to reduce the disaster from a fall caused by inadequate uses of protective gear in domestic small construction sites such as those for remodeling, this study conducts research into ways of decreasing accident rates by suggesting providing and administering protective gear as a national project so that donning protective gear is activated.

A Development of Feature-based Wire Harness Drawing System (특징형상 기반 자동차 전장도면설계 시스템 개발 연구)

  • 이상준;이수홍
    • Korean Journal of Computational Design and Engineering
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    • v.1 no.3
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    • pp.177-188
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    • 1996
  • An approach to providing computational support with an expert shell is discussed with the scope of an industrial wire harness design, especially at a manufacturing stage. Key issues include the development of an architecture that supports a frequent design change among engineers associated with different parts of the wiring design process and the development of hierarchical representations that capture the different characteristics (e.g., connectivity, configuration) of the harnesses. The abstraction of design information results in features, while the abstraction of drawing elements leads to the definition of objects. These abstractions are essential for efficient transactions among people and computer tools in a domain that involves numerous interacting constraints. In this paper the strategy for the problem decomposition, the definition of features, and the ways in which features are shared by various operations and design changes, are discussed. We conclude with a discussion of some of the issues raised by the project and the steps underway to address them.

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Development of DNA Barcode Database and Identification System of Forest Mushrooms in Korea

  • Han, Sang-Kuk;Jo, Jong Won;Kim, Chang Sun;Kwag, Young-Nam;Sung, Gi-Ho
    • 한국균학회소식:학술대회논문집
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    • 2014.05a
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    • pp.17-17
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    • 2014
  • Over five thousand higher fungal specimens were collected from 32 forest areas of Chungcheong and Gyeongsang province from 2012 to 2013. We obtained 513 strains and 3,120 ITS sequences. Mushrooms were first identified with macro- and micro-scopic characters, and their identification was confirmed on the basis of ITS sequences. Voucher specimens were designated for each species found in Korea. Construction of DNA barcoding Database is currently underway with sequences of 409 species. During the development of the database, some new species were recognized, along with several Korean new records. When the system has been completed, it will provide essential molecular information for metagenomic and phylogenetic researches for higher fungi.

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Fronthaul Technology Trends for 5G Mobile Communications (5G 이동통신을 위한 프론트홀 기술 동향)

  • Oh, D.S.;Lyu, D.S.;Lee, H.
    • Electronics and Telecommunications Trends
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    • v.32 no.5
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    • pp.97-106
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    • 2017
  • The introduction of new access technologies in 5G radio networks has had a considerable impact on the design of transport networks. Research activities are underway on new transport technologies in both the wireless and optical domains to support 5G transport. This paper provides an overview of the concept and requirements of a fronthaul. We also discuss the research activities of a new fronthaul interface for future 5G networks, a 5G integrated fronthaul/backhaul transport network (5G-Crosshaul), a next-generation fronthaul interface (NGFI), a mobile xhaul network (MXN), and a next-generation mobile fronthaul architecture with multi-IF carrier transmission scheme.

Trends in 5G Radio Access Network Technologies Based on mmWave (mmWave 기반 5G RAN 기술 동향)

  • Lee, N.S.;Park, M.H.;Choi, Y.S.
    • Electronics and Telecommunications Trends
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    • v.32 no.5
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    • pp.85-96
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    • 2017
  • The research, design, and development of wireless access technologies using the new 6 to 100GHz band mmWave are actively underway in order to address the frequency shortage problem in the sub-6GHz band and accommodate the 5G technical requirements, such as the increased transmission capacity. Technical elements to efficiently overcome the problems caused by mmWave signal characteristics, support an effective interworking with a conventional communication service, and ensure smooth mobility between mmWave base stations and existing base stations are also being investigated. This paper discusses the technical solutions for an mmWave-based 5G RAN configuration and their considerations under various operational scenarios.

Method for Exposing Capability and Functionality of Mobile Network (이동통신 서비스 개방 기술 동향)

  • Bahg, Y.J.;Na, J.H.
    • Electronics and Telecommunications Trends
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    • v.33 no.1
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    • pp.111-122
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    • 2018
  • In this review, several new technologies considered when providing an open service environment in a mobile communication network are described. Recently, 3GPP developed some standards related to IoT services for opening a service platform in an SCS environment based on the OSA concept in a 3GPP LTE system. Similarly, the development of a new framework is underway to allow a plurality of services to commonly use an API environment in which a service provider or client accesses a 5G mobile communication system. Extending the existing LTE SCEF concept, the standardization of the northbound API is applied in the 5G CAPIF environment. Therefore, it is possible to construct a framework that facilitates access from outside, and takes advantage of the common management of various open service environments. An open service platform environment is expected to play an important role in transforming a network with simple connectivity services into a variety of new service markets, or into a service environment that can create added value.

The Necessity and Future Challenges of Science, Technology, Society and Humanities Fusion Research in Korea

  • Song, Wichin
    • STI Policy Review
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    • v.1 no.4
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    • pp.29-39
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    • 2010
  • Science, technology, society and humanities (STSH) fusion research is aimed at creating new research areas and methods that can resolve complicated issues in society that cannot be solved by a single academic discipline. This study identifies initiatives that can promote STSH fusion research in Korea. We review the definition and characteristics of STSH fusion research to analyze the necessity of STSH fusion research with a focus on the structural changes in the S&T environment. The emergence and diffusion of generic technologies, transition to post catch-up innovation mode, and the evolution of policy to the third generation innovation policy are identified as notable changes. This paper briefly reviews the status of fusion research underway and presents initiatives to promote STSH fusion research.

Clinical Year in Review of Interstitial Lung Diseases: Focused on Idiopathic Interstitial Pneumonia (사이질 폐병의 최신지견: 특발사이질 폐렴을 중심으로)

  • Lee, Won-Yeon
    • Tuberculosis and Respiratory Diseases
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    • v.67 no.4
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    • pp.275-280
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    • 2009
  • Interstitial lung disease (ILD) is a group of diseases characterized by pulmonary interstitial inflammation. Finally the inflammation results in pulmonary fibrosis and impairment of oxygen transportation. The causes of idiopathic interstitial pneumonia (IIP) are unknown. Diagnosis of IIP is not easy, especially distinguising between nonspecific interstitial pneumonia and usual interstitial pneumonia (UIP). First line treatments of IIP include corticosteroids and immune modulators, which have limited effect. Currently, several drugs are being researched to prevent and treat fibrosis. Newer drugs that may useful to treat pulmonary fibrosis include endothelin receptor antagonist, recombinant soluble TNF receptor antagonist, and cotrimoxazole. The causes of IIP are largely unknown, treatment is not specific, and prognosis is poor. Recent studies are underway to investigate the pathogenesis and treatment of IIP and pulmonary fibrosis. As the pathogenesis of IIP is elucidated, better treatments will emerge.

Analysis of Three-Dimensional Natural Convection Using a Holographic Interferometric Tomography (홀로그래피 간섭 토모그래피를 이용한 3 차원 자연대류 해석)

  • Shim, Dong-Sik;Lee, Soo-Man;Kang, Bo-Seon;Cha, Dong-Jin;Joo, Won-Jong
    • Proceedings of the KSME Conference
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    • 2001.06d
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    • pp.497-502
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    • 2001
  • Three-dimensional natural convection from a discrete flush-mounted circular heat source on the bottom of a cubic enclosure was studied by using a holographic interferometric tomography. The heat source was located at the off-center of the bottom plate so that three-dimensional temperature field can be achieved. A set of multidirectional holographic interferogram was recorded by employing a double-reference beam, double-exposure holographic technique in order to eventually reconstruct the temperature fields. The recorded interferometric data appear good enough to be further processed to extract optical pathlength data from them and finally reconstruct the temperature fields. A complete analysis of the temperature fields including the field reconstructions and comparison with thermocouple measurements is underway and will be reported shortly.

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