• Analytical Science and Technology
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• v.6 no.4
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• pp.395-399
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• 1993

Corynoxeine, rhynchophylline, isocorynoxeine, isorhychophylline were isolated from Uncaria hooks and determined by HPLC. Their contents were : isocorynoxeine 0.21%, isorhynchophylline 0.16%, corynoxeine 0.28%, rhynchophylline 0.23%, respectively. Corynoxeine and isocorynoxeine, rhynchophylline and isorhychophylline were interconverted each other by heat treatment.

• YAKHAK HOEJI
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• v.40 no.1
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• pp.36-40
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• 1996

Chemical constituents of Uncaria hooks were studied. Four compounds were isolated from the ether soluble fraction by chromatographic purification process. They were ident ified as isocorynoxeine-N-oxide, anti-isorhynchophylline-N-oxide, physcion and ursolic acid by spectral evidences. Their contents analyzed by HPLC or GC method were physcion 0.04%, ursolic acid 0.26%, isocorynoxeine-N-oxide 0.04% and anti-isorhynchophylline-N-oxide 0.03% respectively. Isocorynoxeine-N-oxide was not reported in nature so far.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.47-47
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• 1993

조구등(Uncaria Hooks)은 한방에서 고혈압, 동맥경화 및 편두통의 치료제로 널리 사용되는 셍약이다. 한방에서 조구등은 오래 달이면 약효가 감소하고 약 15분 정도 달이는 것이 가장 약효가 강하다고 알려져 있다. 본 연구는 이러한 조구등의 수치에 환한 연구의 일환으로 조구등으로부터 혈압 강하 성분을 관리하고 이들 성분이 생약을 달이는 과정에서 어떻게 변화하는지를 알아보고자 하였다.

• Natural Product Sciences
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• v.11 no.3
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• pp.145-149
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• 2005

A methanol soluble extract from the dried hooks and stems of Uncaria rhynchophylla showed a strong inhibitory activity against monoamine oxidase in mouse brain. Using a bioassay-guided purification of this extract, a known ${\beta}-carboline$ type alkaloid, harman (1), was obtained as an active constituent. In addition, five known indole alkaloids, isocorynoxeine (2), isorhynchophylline (3), corynoxeine (4), cadambine (5), and $3{\alpha}-dihydrocadambine$ (6), were isolated and found to be weakly active or inactive.