• Clinical and Experimental Reproductive Medicine
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• 제36권1호
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• pp.63-70
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• 2009

목 적: 본 연구는 전향적 무작위 배정법 연구로 40세 이상의 불임여성의 자연주기에서 소량의 재조합난포자극호르몬을 이용한 최소자극법의 효과를 성선자극호르몬분비호르몬길항제 다회투여법과 비교 분석하고자 한다. 연구방법: 불임크리닉을 방문하였던 환자들 중 나이가 40세 이상인 75명 환자들을 대상으로 시행하였다. 연구군은 최소자극법으로 37명, 대조군은 성선자극호르몬분비호르몬길항제 다회투여법으로 38명의 환자들로 구성되었으며 모두 체외수정시술을 시행 받았다. 주기 취소율, 난포자극호르몬 종 사용량과 일수, 성숙난자의 수, 이식된 배아의 수, 배아이식 주기당 임신율, 착상율 등을 비교하였으며, 통계학적인 방법은 평균값의 비교를 위하여 Student's t-test를 이용하였고 분율의 비교를 위하여 ${\chi}^2$ 검정, Fisher's exact test를 사용하였으며, p값이 0.05 미만인 경우에 통계학적으로 유의하다고 판정하였다. 결 과: 두 군간의 대상 환자들의 기본적인 특성은 차이가 없었다. rhFSH의 투여기간과 총용량에서 연구군의 경우 4.5${\pm}$1.2일, 632.2${\pm}$123.7 IU로 대조군에서의 11.3${\pm}$2.7일, 3124.6${\pm}$452.1 IU에 비하여 통계학적으로 유의하게 낮은 값을 보였고, 주기 취소율은 연구군에서 16.2%, 대조군에서 5.3%로 통계적으로 유의성은 없었다. 회수된 난자의 수, 성숙한 제 2감수분열 중기 상태의 난자의 수 및 수정된 난자의 수, 양질의 배아수, 배아이식된 배아의 수에 있어서 대조군에 비해서 연구군에서 통계적으로 유의하게 낮았다. 배란유도를 시작한 주기당 임상적 임신율과 배아이식 주기당 임상적임신율은 연구군의 경우 각각 10.8%와 13.4%로 대조군에서 13.2%와 13.9%에 비하여 다소 낮긴 하였으나 통계학적으로 유의성은 없었다. 착상율, 자연유산율에서는 두 군간의 차이가 없었다. 결 론: 40세 이상의 고령 여성에서 체외수정술을 시행하고자 할 때 배란유도의 방법으로 GnRH antagonist와 성선자극호르몬을 이용한 최소자극법은 성선자극호르몬분비호르몬길항제 다회투여법과 비교하여 임신율이 감소하지 않으며 비용면에서 효율적이고 효과적인 방법이다.

• 대한물리의학회지
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• 제13권1호
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• pp.63-72
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• 2018

PURPOSE: The aim of this study was to compare the effect of whole body vibration stimulation on ankle instability, ankle range of motion, and balance ability in adult with chronic ankle instability. METHODS: Forty-five adult with chronic ankle instability were randomly equally allocated the I group (whole body vibration stimulated at 10 Hz), or the II group (20 Hz), or the III group (25 Hz). All the participants (male:13/female: 32, age: $26.64{\pm}3.14$) in this study received whole body vibration therapy for an additional 15 minutes after hot pack and ultrasound three times a week for four weeks. Outcome were measured before and after 4 weeks training. RESULTS: All the three groups showed significant differences in AII and CAIT after intervention (p<.05). I group showed the most significant difference (p<.05). All the three groups also showed significant increase in ankle dorsiflexion and plantar flexion after training (p<.05). I group showed greater increase than the other groups in ankle dorsiflexion (p<.05). The X-axis, Y-axis, and fluctuation speed were significantly decreased in the three groups (p<.05), but there was no significant difference between the three groups after the intervention. CONCLUSION: The findings suggest that the whole body vibration stimulation according to various frequencies is effective for improve ankle instability, ankle range of motion and balance ability in adult with chronic ankle instability. 10 Hz whole body vibration stimulation could help improve ankle instability and ankle range more effectively than other frequencies.

• 운동영양학회지
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• 제16권1호
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• pp.43-50
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• 2012

This study was designed to investigate the effect of vibratory stimulation on recovery of muscle function from delayed onset muscle soreness (DOMS). Volunteers performed 3 set of 70 % maximal voluntary eccentric muscle contraction and induced DOMS. volunteers were allocated to one of three treatment group after DOMS : group I (control), group II (ultrasound), group III (vibration). Maximal Voluntary Isometric Contraction (MVIC), Visual Analog Scale (VAS), Range Of Motion (ROM), Root Mean Square (RMS), Median frequency (MDF), Blood Serum Creatine Kinase (CK), Lactic dehydrogenase (LDH) were recorded at baseline, and 24, 48, 72 hours post-exercise. In MVIC measurement, there was a statistically significant difference in group III compared to group I (p < .05). In VAS measurements, there were a statistically significant difference in group II and III compared to group I (p < .05). In ROM measurement, there was a statistically difference in group II and III compared to group I (p < .05). In Muscle Volume with Ultrasonography measurement, there was no statistically significant difference in any groups (p > .05). In RMS and MDF measurement, there were a statistically significant difference in group II and III compared to group I (p < .05). In Blood samples of CK and LDH measurements, There were no statistically significant difference in any groups (p > .05). From the above result, Vibratory stimulation had a positive effect on recovery of muscle function from delayed onset muscle soreness. Further studies should be undertaken to ascertain the more effectiveness of vibratory stimulation and may be a promising treatment modality.

• 한국정보전자통신기술학회논문지
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• 제15권6호
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• pp.477-484
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• 2022

본 연구는 집속형초음파자극시스템의 카트리지부를 시료로 사용하여 의료기기 안전성 평가 기준인 GLP(Good Laboratory Practice)에 관한 시험 중 동물실험을 통한 피부 자극 시험 및 피부 감작성시험을 진행하였다. New Zealand White Rabbit 암컷 6마리를 이용하여 IACUC 승인 후 시험을 진행하였으며, 실험기간 동안 사망한 개체 수는 없었으며, 실험동물에서 어떤 이상 증상도 관찰되지 않았다. 극성, 비극성 자극 지수는 모두 '0.0'으로 나타났다. 또한, 피부감작성 평가의 경우 IACUC 승인을 통한 기니피그 30마리를 통하여 대조군 및 실험군으로 나누어 시험검체 및 공시험액을 별도의 희석 없이 용출액 자체를 사용하여 모든 유도 및 유발단계를 적용하였다. 실험결과대조동물의 피부반응 등급은 0등급이었으며, 시험동물의 피부반응에서 1등급 이상을 나타내는 동물은 없었다. 두 시험 결과에서 피부의 이상 증상은 발견되지 않았으며, 인체에 적용하여 환자를 치료할 경우 시험에 사용된 시험재료로부터 피부의 이상 증상이 생기는 질환 등은 나타나지 않는지에 관하여 안정성을 알아 보고자 하였다.

• Clinical and Experimental Reproductive Medicine
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• 제40권4호
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• pp.143-147
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• 2013

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.

• 한방재활의학과학회지
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• 제32권1호
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• pp.145-155
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• 2022

The purpose of this study is to evaluate the effectiveness of traditional Korean medicine treatment of cervical vertigo. Three patients were diagnosed as cervical vertigo with correlating symptoms of imbalance and dizziness with neck pain. The diagnosis of cervical vertigo is also dependent on excluding other vestibular disorders on the basis of history, examination, and vestibular function tests. They were treated by acupuncture, transcutaneous electrical nerve stimulation therapy and low-intensity pulsed ultrasound at acupoints and sympathetic ganglion chain of their cervical and upper thoracic region. The evaluation of clinical outcome was done by numeric rating scale (NRS), dizziness handicap inventory (DHI) and neck disability index (NDI), EuroQol-five dimensions questionnaire (EQ-5D) index. After the treatment, the value of their NRS, NDI, DHI was significantly decreased and their EQ-5D index was significantly increased. The traditional Korean medicine treatment at cervical and upper thoracic region could be an effective way to treat cervical vertigo.

• Journal of Oral Medicine and Pain
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• 제42권3호
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• pp.53-61
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• 2017

Myogenous temporomandibular disorder is a collective term for pathologic conditions of the masticatory muscles, mainly characterized by pain and dysfunction associated with various pathophysiological processes. Among the subtypes of myogenous temporomandibular disorder, myofascial pain is one of the most common muscle disorders, characterized by the presence of trigger points (TrPs). Various modalities, such as ultrasound, manipulative therapy, spray-and-stretch technique, transcutaneous electrical nerve stimulation, injection/dry needling, and low-level laser therapy are used to inactivate TrPs. Needling/injection on the TrPs is one of the most common treatments for myofascial pain. Despite the evidence, there is continued controversy over defining the biological and clinical characteristics of TrPs and the efficacy of injection/dry needling. This review discusses the current concept of injection/needling to relieve TrPs.

• Journal of Chest Surgery
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• 제35권8호
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• pp.605-607
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• 2002

Harmonic Scalpel(Echicon Endo-Surgery Cincinnati, OH)은 초음파를 이용하여 근육자극이 전혀 없으며, 열이나 연기가 적게 나며, 지혈도 쉽고, 수술시야가 좋아서 수술에 많은 이점을 가지고 있다. 교착성 심막염 환자에서 심막절제술을 시행할 때 Harmonic Scalpel을 사용하여 도움이 되었기에 보고하는 바이다.

• 전기학회논문지
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• 제61권6호
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• pp.879-884
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• 2012

Photoacoustic Tomography (PAT) is a promising medical imaging modality by reason of its particularity. It combines optical imaging contrast of optical imaging with the spatial resolution of ultrasound imaging and can demonstrate change of biological feature in an image. For that reason, many studies are in progress to apply this technic for diagnosis. But, real-time PAT system is necessary to confirm a biological reaction induced by external stimulation immediately. Thus, we developed a real-time PAT system using linear array transducer and self-developed Data acquisition board (DAQ) resources, To evaluate the feasibility and performance of our proposed system, two type of phantom test were also performed. As a result of those experiments, the proposed system shows enough performance and confirm its usefulness.

• Journal of Oral Medicine and Pain
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• 제39권4호
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• pp.140-145
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• 2014

Purpose: Temporomandibular disorder (TMD) is one of the most common diseases causing chronic orofacial pain. Prolotherapy is called 'regenerative injection therapy' or 'growth factor stimulation injection', and it induces the functional reactivation of tissues such as ligaments and tendons. The aim of this study is to evaluate the efficacy of ultrasound-guided prolotherapy with platelet-rich plasma (PRP) for the patients who had the TMD symptoms, especially in temporomandibular joint (TMJ) pain, restricted mouth opening, and TMJ sound. Methods: Twenty-seven patients visited Chosun University Dental Hospital with the symptoms of pain, restricted mouth opening, and TMJ sound were included in this study. When the patients visited the hospital, we measured; the degree of pain, range of mouth opening (ROM), and TMJ sound, and grouped them according to their chief complaints. TMJ pain and ROM were measured both at the first visit and the fourth week after the PRP injection, and also evaluated the impact of the treatment on their daily activities. Results: After the treatment, the patients in the TMJ pain group showed some improvement (visual analogue scale [VAS] 5.6 to 3.6), and the patients in the restricted mouth opening group exhibited increased ROM (26 mm to 32 mm; p<0.05). On the other hand, the patients in the TMJ sound group had no improvement. Conclusions: PRP prolotherapy could be effective for the treatment of TMJ pain and restricted mouth opening. However, further studies are still necessary in terms of TMJ sound and longterm effect of PRP prolotherapy.