• Clinical Endoscopy
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• 제56권2호
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• pp.229-238
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• 2023

Background/Aims: Shear wave elastography (SWE) is used for liver fibrosis staging based on stiffness measurements. It can be performed using endoscopic ultrasound (EUS) or a transabdominal approach. Transabdominal accuracy can be limited in patients with obesity because of the thick abdomen. Theoretically, EUS-SWE overcomes this limitation by internally assessing the liver. We aimed to define the optimal technique for EUS-SWE for future research and clinical use and compare its accuracy with that of transabdominal SWE. Methods: Benchtop study: A standardized phantom model was used. The compared variables included the region of interest (ROI) size, depth, and orientation and transducer pressure. Porcine study: Phantom models with varying stiffness values were surgically implanted between the hepatic lobes. Results: For EUS-SWE, a larger ROI size of 1.5 cm and a smaller ROI depth of 1 cm demonstrated a significantly higher accuracy. For transabdominal SWE, the ROI size was nonadjustable, and the optimal ROI depth ranged from 2 to 4 cm. The transducer pressure and ROI orientation did not significantly affect the accuracy. There were no significant differences in the accuracy between transabdominal SWE and EUS-SWE in the animal model. The variability among the operators was more pronounced for the higher stiffness values. Small lesion measurements were accurate only when the ROI was entirely situated within the lesion. Conclusions: We defined the optimal viewing windows for EUS-SWE and transabdominal SWE. The accuracy was comparable in the non-obese porcine model. EUS-SWE may have a higher utility for evaluating small lesions than transabdominal SWE.

• 한국방사선학회논문지
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• 제11권4호
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• pp.221-225
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• 2017

초음파영상 진단장치의 성능을 평가할 때, 초음파장비에서 제공하는 음속변화 파라메타를 변화시킴에 따른 공간분해능의 변화를 알아보고자 하였다. 익산 소재 A기관에서 사용중인 초음파 진단장치에서 3.0 ~ 5.0 MHz 볼록형 탐촉자를 이용하여 초음파팬텀영상를 얻었다. N-365 다목적 초음파팬텀으로 종거리 측정정확도, 종 횡 해상도를 측정하였다. 같은 방법으로 초음파장치의 음속을1580 m/sec부터 1400 m/sec 까지 6단계로 변화시켜 측정 값의 차이가 있는지 image J 프로그램을 이용하여 반치폭을 측정하였다. 측정 결과, 횡측해상도는 속도변화에 따라 1.91 mm ~ 5.3 mm까지 측정되었으며, 음속 1420 m/sec 일 때 반치폭 1.91 mm로 가장 작게 측정되었다. 종측해상도는 1.03 mm ~ 1.14 mm까지 측정되었으며, 음속 1400 m/sec 일 때 반치폭 1.03 mm 로 가장 작게 측정되었다. 초음파장치의 음속이 느려질수록 종측정 길이가 짧아지는 상관관계를 보였다.

• 한국음향학회지
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• 제18권5호
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• pp.68-77
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• 1999

본 논문에서는 고강도 집속형 초음파의 주파수 특성(파형)에 따른 초음파 공동 현상을 억 제하는 효과를 살펴보았다. 본 연구에서는 세가지 파형, 즉, 정현파(1 MHz, 5 MPa), 주파수 변조파(10 ㎲ 동안 1 MHz에서 6 MHz까지 선형적으로 증가, 5 MPa), 비대칭 충격파(기 본 주파수 1 MHz, 양압 12 MPa, 음압 -4 MPa)를 고려하였다. 동일한 강도(833 W/㎠)를 가지는 각 초음파에 노출된 초기 반경이 1 ㎛인 물 속에 있는 공기 기포의 반응을Gilmore bubble dynamic model 및 Church's rectified gas diffusion equation을 이용하여 예측하였다. 기포 진동의 크기는, 정현파에 노출된 경우와 비교하여, 주파수 변조된 초음파의 경우 현저히 감소하였고, 비대칭 충격파의 경우 약간 감소함을 볼 수 있었다. 흥미롭게도 주파수 변조파에 대한 기포의 반응은 변조된 초음파의 주파수 성분이 기포의 공진 주파수(3 MHz) 이상에서는 거의 동일하게 유지되는 것으로 나타났다. 이 사실은 주파수 변조를 현재의 1 MHz부터 6 MHz까지에서 1 MHz부터 3 MHz까지로 줄여도 유사한 공동 억제 효과를 얻을 수 있음을 암시한다. 실용적으로, 비교적 좁은 밴드 폭을 가지는 범용 초음파 변환기를 이 용하여 초음파의 공동 현상 억제 효과를 얻기 위한 주파수 변조를 구현할 수 있음을 의미한다. 본 연구의 결과는 초음파의 적절한 주파수 성분 조절로 초음파의 공동 현상을 일정 수준 억제할 수 있음을 시사한다.

• Journal of Trauma and Injury
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• 제20권2호
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• pp.130-137
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• 2007

Purpose: Ultrasound is of proven accuracy in abdominal and thoracic trauma and may be useful for diagnosing extremity injury in situations where radiography is not available, such as disasters and military and space applications. However, the diagnosis of fractures is suggested by history and physical examination and is typically confirmed with radiography. As a alternative to radiography, we prospectively evaluated the utility of extremity ultrasound performed by trained residents of emergency medicine (EM) one patient with wrist and ankle extremity injuries. Methods: Initially, residents of EM performed physical examinations for fractures. The emergency ultrasound (EM US) was performed by trained residents, who used a portable ultrasound device with a 10- to 5-MHz linear transducer, on suspected patients before radiography examination. The results of emergency ultrasound and radiography and the final diagnosis were recorded, and correlation among them were determined by using Kappa s test Results: Thirty-nine patients were enrolled in our study. The average age was $36.6\;{\pm}\;19.3$ years. There were radius Fx. (n=21), radius-ulna Fx. (n=1), ulna Fx. (n=1), and contusion (n=2) injuries among the wrist injury and lat.-med. malleolar Fx. (n=13), lat. malleolar Fx. (n=6), and med. malleolar Fx. (n=3) injuries among the ankle injury. Comparing EM US with radiography, we found the sensitivity, specificity, positive predictive value, and negative predictive value of EM US for Fx. diagnosis to be 100%, 66.7%, 97.3%, 100% and those of radiography to be 97.2%, 100%, 100%, and 75%, respectively. Kappa s test for a correlation between the Fx. diagnosis of EM US and the final diagnosis of Fx was performed, and Kappa's value was 0.787 (P = 0.004).Conclusion: EM US for Fx. can be performed quickly and accurately by EM residents with excellent accuracy in remote locations such as disaster areas and in military and aerospace applications. EM US was as useful as radiography in our study and had a high correlation to the final diagnosis of Fx. Therefore, ultrasound should performed on patients with extremity injury to determine whether extremity evaluation should be added to the FAST (focused abdominal sonography trauma) examination.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.250-257
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• 2007

Functional gastrointestinal disorders affect millions of people of all age regardless of race and sex. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. The aim is, therefore, to develop a diagnostic method for the functional gastrointestinal disorders based on quantitative measurement of the rigidity of the gastrointestinal tract well using ultrasound technique. For this purpose, a preliminary ultrasound diagnostic system was developed and verified through phantom tests. The system consisted of transmitter, ultrasonic transducer, receiver, TGC, and CPLD, and verified via a phantom test. For the phantom test, ten soft-tissue specimens were harvested from porcine. Five of them were then treated chemically to mimic a rigid condition of gastrointestinal tract well, which was induced by functional gastrointestinal disorders. Additionally, the specimens were tested mechanically to identify if the mimic was reasonable. The customized ultrasound system was finally verified through application to human subjects with/without functional gastrointestinal disorders(Normal and Patient Groups). It was identified from the mechanical test that the chemically treated specimens were more rigid than normalspecimen. This finding was favorably compared with the result obtained from the phantom test. The phantom test also showed that ultrasound system well described the specimen geometric characteristics and detected an alteration in the specimens. The maximum amplitude of the ultrasonic reflective signal in the rigid specimens $(0.2{\pm}0.1Vp-p)$ at the interface between the fat and muscle layers was explicitly higher than that in the normal specimens $(0.1{\pm}0.0Vp-p)$ (p<0.05). Clinical tests using our customized ultrasound system for human subject showed that the maximum amplitudes of the ultrasonic reflective signals nea. to the gastrointestinal tract well for the patient group$(2.6{\pm}0.3Vp-p)$ were generally higher than those in normal group$(0.1{\pm}0.2Vp-p)$ (p<0.05). These results suggest that newly designed diagnostic system based on ultrasound technique may diagnose enough the functional gastrointestinal disorders.

• 대한의용생체공학회:의공학회지
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• 제40권2호
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• pp.39-47
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• 2019

Ultrasound sonication along with microbubble (MB) could enhance drug delivery to promote the absorption of anticancer drugs into cancers in a noninvasive and targeted manners. In this study, we verify the acute drug delivery enhancement (within an hour) of two representative focused ultrasound driven drug delivery enhancement methods (MB and Doxorubicin-coated Nanoparticle complex (MB-NP) based). Experiments were conducted using in vivo mouse model with MDA-MB-231 breast cancer cell line. Ultrasound generated by single-element 1 MHz focused ultrasound transducer was delivered in pulsed sonication consisted of 0.125 msec bursts at a pulse repetition frequency of 2 Hz for 20 seconds without a significant increase in local temperature (less than $0.1^{\circ}C$) or hemorrhage. Doxorubicin concentrations in tumors were improved by 1.97 times in the case of MB-NP, and 1.98 times by using Doxorubicin and MB separately. These results indicate anticancer drug delivery based on MB and MB-NP can significantly improve the effect of anticancer drugs delivered to tumors in a short time period by using low-intensity focused ultrasound.

• 대한전자공학회논문지
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• 제21권4호
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• pp.65-71
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• 1984

초음파 B스캔너의 경우 광대역 펄스를 사용하기 때문에 광학에서 사용되는 집속 계산식으로는 초음파 집속 시스템을 정확하게 설계할 수 없다. 본 연구에서는 초음파 다중소자에 광대역 펄스가 여기될 때 초음파의 전파모양을 정확하게 계산할 수 있늘 방법이 연구되었다. 계간된 초음차의 전파 모양을 이용하여 고해상력을 갖는 다이나믹 집속(dynamic focusing)시스템의 구동소자수, 집속치로 지연값 및 집속점 위치등을 설계하도록 하였다. 저잡음 스튀칭 특성을 갖는 다이나믹 집속 시스템을 구성하여 실험에 의해 3.5MHz선형소자로써 18cm의 깊이까지 2∼3mm의 해상도가 얻어짐을 확인하였다.

• Smart Structures and Systems
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• 제17권1호
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• pp.17-29
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• 2016

Ultrasonic tomography is a powerful tool for identifying defects within an object or structure. But practical application of ultrasonic tomography to solids is often limited by time consuming transducer coupling. Air-coupled ultrasonic measurements may eliminate the coupling problem and allow for more rapid data collection and tomographic image construction. This research aims to integrate recent developments in air-coupled ultrasonic measurements with current tomography reconstruction routines to improve testing capability. The goal is to identify low velocity inclusions (air-filled voids and notches) within solids using constructed velocity images. Finite element analysis is used to simulate the experiment in order to determine efficient data collection schemes. Comparable air-coupled ultrasonic signals are then collected through homogeneous and isotropic solid (PVC polymer) samples. Volumetric (void) and planar (notch) inclusions within the samples are identified in the constructed velocity tomograms for a variety of transducer configurations. Although there is some distortion of the inclusions, the experimentally obtained tomograms accurately indicate their size and location. Reconstruction error values, defined as misidentification of the inclusion size and position, were in the range of 1.5-1.7%. Part 2 of this paper set will describe the application of this imaging technique to concrete that contains inclusions.

• 제어로봇시스템학회논문지
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• 제13권11호
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• pp.1060-1066
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• 2007

When a high-energy ultrasound propagates through a solid body that contains a crack or a delamination, the two faces of the defect do not ordinarily vibrate in unison, and dissipative phenomena such as friction, rubbing and clapping between the faces will convert some of the vibrational energy to heat. By combining this heating effect with infrared imaging, one can detect a subsurface defect in material efficiently. In this paper a detection of the welding defect of thin SUS 304 plates using the UIR (ultrasonic infrared imaging) technology is described. A low frequency (20kHz) ultrasonic transducer was used to infuse the welded thin SUS 304 plates with a short pulse of sound for 280ms. The ultrasonic source has a maximum power of 2kW. The surface temperature of the area under inspection is imaged by a thermal infrared camera that is coupled to a fast frame grabber in a computer. The hot spots, which are a small area around the defect tip and heated up highly, are observed. From the sequence of the thermosonic images, the location of defective or inhomogeneous regions in the welded thin SUS 304 plates can be detected easily.

• Korea-Australia Rheology Journal
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• 제17권2호
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• pp.87-95
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• 2005

In this study, we performed RTD measurement at the die exit of co-rotating twin-screw extruder using a non-destructive ultrasonic device. The ultrasonic device was attached at slit die and was composed of a steel buffer rod and 10 MHz longitudinal piezoelectric ultrasonic transducer. This in-line ultrasonic monitoring method is based on the ultrasonic response of $CaCO_3$ filled in polymer. The RTD is evaluated by variation of ultrasonic attenuation with time caused by change of the tracer concentration during extrusion. The ultrasonic tracer, pellet type of compounded $CaCO_3$ in polymer was used in this study. The effects of tracer concentration on RTD and flow patterns were studied. Evaluation for the residence functions at different screw speeds, feeding rates and screw configurations were also carried out.