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Hemiarthroplasty for Osteosarcoma of Proximal Tibia (근위 경골의 골육종에 시행한 반관절성형술)

  • Jeon, Dae-Geun;Cho, Wan-Hyeong;Kim, Jin-Wook-;Koh, Han-Sang
    • The Journal of the Korean bone and joint tumor society
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    • v.12 no.1
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    • pp.9-14
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    • 2006
  • Purpose: The proximal tibial sarcoma patients, especially in their growing ages have problems of reconstruction. This study is to devise a methodology which can circumvent this limitations. Materials and Methods: Four cases of proximal tibial osteosarcoma underwent hemiarthroplasty. The mean age was 13 years (11~15) with a mean follow-up of 64 months (47~89). The procedure consists of ultrahigh molecular weight polyethylene (UHMWPE) liner as an substitute for the joint surface and this piece was fixed to the remaining tibial bone stock with Ender nail and bone cement. Results: Final functional score was 23.5 (78.3% of control) by MSTS criteria. All the cases showed stable joint without pain. Hemiarthroplasty related complications were absent. By saving the femoral physis, expected leg length discrepancy could be minimized by this procedure. Conclusions: Hemiarthroplasty of proximal tibia can be an option in pediatric sarcoma patients.

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Effects of Ultra High Molecular Weight Poly-${\gamma}$-glutamic Acid from Bacillus subtilis (chungkookjang) on Corneal Wound Healing

  • Bae, Sun-Ryang;Park, Chung;Choi, Jae-Chul;Poo, Ha-Ryoung;Kim, Chul-Joong;Sung, Moon-Hee
    • Journal of Microbiology and Biotechnology
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    • v.20 no.4
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    • pp.803-808
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    • 2010
  • Poly-${\gamma}$-glutamic acid (${\gamma}$-PGA) is a natural edible polypeptide in which glutamate is polymerized via ${\gamma}$-amide linkages. First, we assessed the eye irritancy potential of ${\gamma}$-PGA in rabbits. Additionally, we studied the effects of ${\gamma}$-PGA on corneal wound healing, due to the anti-inflammatory properties and water retaining abilities of ${\gamma}$-PGA. In this study, the effects of ${\gamma}$-PGA on corneal wound healing after an alkali burn were evaluated. Thirty eyes wounded by alkali burning in 30 white rabbits were divided into three groups: group A was treated with 0.1% 5,000 kDa ${\gamma}$-PGA for 2 days; group B was treated with 0.1% hyaluronic acid; and group C was not treated, as a control. The area of corneal epithelial defect was examined at 12, 24, 30, 36, 42, and 48 h after corneal alkali wounding to determine initial wound healing. We found that ${\gamma}$-PGA promoted corneal wound healing, compared with controls, and showed similar effects to hyaluronic acid. These results indicate that ${\gamma}$-PGA stimulates corneal wound healing by an anti-inflammatory effect and enhancing cell migration and cell proliferation. ${\gamma}$-PGA is a promising biomaterial that may be a substitute for hyaluronic acid in corneal wound healing treatment.

Composition of Mineral Contents in Korean Cow무s Milk (우리나라 일부 우유의 무기질 함량 조성에 관한 연구)

  • 이영희;정문호
    • Journal of Environmental Health Sciences
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    • v.30 no.1
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    • pp.29-40
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    • 2004
  • This study was performed to investigate and assess the composition of mineral and macronutrient contents in Korean cow′s milk.48 individual farm raw milk, 10 plant raw milk and 29 market milk were collected from June to August in 2003. The minerals such as calcium(Ca), potassium(K), magnesium(Mg), sodium(Na), zinc(Zn), iron(Fe) and phosphorus(P) were determined by using atomic absorption spectrometer(AAS). The macronutrients such as fat, protein and lactose were tested by using IR spectrometer. The obtained analytical results of minerals(mg/100 g) and rnaetronutrients (%) are as follows:1. In case of raw cow′s milk ; Ca 113.56, K 144.09, Mg 10.86, Na 42.53, Zn 0.42, Fe 0.030, p 113.32, fat 3.85, protein 3.08, lactose 4.80,2. In case of market cow′s milk ; Ca 103.04, K 142.46, Mg 10.27, Na 43.21, Zn 0.40, Fe 0.034. p 97.30, fat 3.78, protein 3.05, lactose 4.70,3. In case of fortified market cow′s milk ; Ca 165.40, K 145.79, Mg 10.57. Na 42.55, Zn 0.57, Fe 0.414, p 94.68, fat 3.74, protein 3.08, lactose 4.68,4. In case of processed market cow′s milk ; Ca 134.72, K 142.74, Mg 10.33, Na 45.07, Zn 0.50, Fe 0.650, p 92.48, fat 3.72, protein 3.07, lactose 4.74. According to the group of market milk(milk, fortified market row′s milk, processed market cow′s milk), the mean concentration of Ca and Fe were significantly higher in fortified and processed milk than milk(p<0.05). There were no significant differences in macronutrient(fat, protein, lactose) and mineral contents between pasteurized milk and UHT(ultra high temperature) treated milk($\alpha$=0.05). The labeled "Nutritional Facts" of market milk were satisfied with "Labeling Standards for Livestock Products of Korea". The measured mean concentrations of Ca, Fe, Zn were generally higher than lower limit of labeled value(above 80% of labeled value). The mean concentration of sodium was lower than upper limit of labeled value(below 120% of labeled value).

A Novel Multiple Band Antenna Design Implementing Unbalanced Feed-Lines and Meandered Patch Options (비대칭 급전선로와 패치설계를 이용한 다중대역 안테나의 설계)

  • Jung, Jin-Woo;Roh, Hyoung-Hwan;Park, Jun-Seok;Cho, Hong-Goo
    • 한국정보통신설비학회:학술대회논문집
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    • 2007.08a
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    • pp.427-431
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    • 2007
  • Applications in present-day mobile communication systems particularly require miniaturized dimensions and low-profiles of antenna in order to meet the mobile units. Thus, size reductions and bandwidth enhancements are becoming crucial design considerations for practical applications of microstrip antennas. The motivation of further experiments have been stepped to follow those studies for achieving compact and broadband, even multiplied operation modes, which are greatly increased with much attentions recently. To obtain broadband, single-feed, circularly polarized characteristics of microstrip antennas, a design with feed-line ought to be a factor of two. Usually, diagonally balanced-line feeds with hybrid coupler are employed to attain circular polarizations. We firstly formulated DGS (Defected Ground Structures) based operation principles of the entire microstrip components and therefore were able to derive impedance variance of feed-lines. After verifying corresponding experimental results, we targeted the frequency bands of UHF RFID (Ultra High Frequency Radio Frequency IDentification) and approximately of 0.4-2.4GHz have exhibited remarkable two resonance amplitudes as a dual band antenna. Our secondary researches were aimed to design quad band microstrip antenna which represents four resonance characteristics within the identical frequency bands as well. Microstrip patch has been meandered to lengthen the electrical paths, and the other design criteria with respecting physical parameters including radiation patterns and impedance bandwidths measurements will be described for verification. Advisable applications of these antennas can be GSM850, GSM900, GPS (L1-1575 and L2-1227) and UMTS-2110 of cellular systems, which extremely desire multiband and minimum size.

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Performance Evaluation of Time Hopping Binary PPM Impulse Radio System for Indoor Multiple Access Communication (실내 다원접속 통신을 위한 TH Binary PPM IR 시스템의 성능 평가)

  • 이양선;강희조
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.6 no.7
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    • pp.1032-1037
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    • 2002
  • In this paper, derived monocycle pulse that application is possible within permission frequency band (3.1 ~ 10.6GHz) that establish in FCC. Also, PPM modulated TH IR system simulator is designed in AWGN environment. It is analyzed monocycle pulse specific property and system performance using simulator. Also, analyzed BER performances of IR system in multiple access interference environment using proposed parameters. According to result, application of possible pulse duration$(t_n)$ is very limited by 0.04~0.0326 ns in permission frequency range that establish in FCC. In the case of same pulse signal power, we could know that system performance changes by $N_s$ regardless of pulse duration. IR system that need high speed transmission more than 50 Mbps in multiple access interference environment could know that very serious performance decrease by multiple access Interference happens.

Analysis of Gas Flow Behavior with Experiments for LPG releasing and 3D Mapping of Gas Sensor (LPG 누출 및 가스센서 3D Mapping을 통한 가스유동현상 분석)

  • Kim, Jeong Hwan;Lee, Min-Kyung;Kil, Seong-Hee;Lee, Jin-han;Jo, Young-do;Moon, Jong-Sam
    • Journal of the Korean Institute of Gas
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    • v.21 no.5
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    • pp.45-55
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    • 2017
  • Release and fire/explosion tests of flammable gas are extremely dangerous. Furthermore, it is difficult to select the site where the experiment can be performed. In these reasons, gas flow analysis(CFD) has been used as much as possible. However, with the opening of the Energy Safety Empirical Research Center in Yeongwol-gun, Gangwon-do in October 2016, it was possible to conduct releases and detection tests of small scale combustible gas as well as large scale / high pressure / ultra low temperature experiments. In this study, LPG leaked after the calibration and placement of the sensor, the sensor detected LPG and the data were visualized as a contour map. And the differences between the actual release(28s, max 3.7[m]) and the analysis were analyzed compared to the FLACS analyzed under the same conditions.

Bulk Micromachined Vibration Driven Electromagnetic Energy Harvesters for Self-sustainable Wireless Sensor Node Applications

  • Bang, Dong-Hyun;Park, Jae-Yeong
    • Journal of Electrical Engineering and Technology
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    • v.8 no.6
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    • pp.1320-1327
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    • 2013
  • In this paper, two different electromagnetic energy harvesters using bulk micromachined silicon spiral springs and Polydimethylsiloxane (PDMS) packaging technique have been fabricated, characterized, and compared to generate electrical energy from ultra-low ambient vibrations under 0.3g. The proposed energy harvesters were comprised of a highly miniaturized Neodymium Iron Boron (NdFeB) magnet, silicon spiral spring, multi-turned copper coil, and PDMS housing in order to improve the electrical output powers and reduce their sizes/volumes. When an external vibration moves directly the magnet mounted as a seismic mass at the center of the spiral spring, the mechanical energy of the moving mass is transformed to electrical energy through the 183 turns of solenoid copper coils. The silicon spiral springs were applied to generate high electrical output power by maximizing the deflection of the movable mass at the low level vibrations. The fabricated energy harvesters using these two different spiral springs exhibited the resonant frequencies of 36Hz and 63Hz and the optimal load resistances of $99{\Omega}$ and $55{\Omega}$, respectively. In particular, the energy harvester using the spiral spring with two links exhibited much better linearity characteristics than the one with four links. It generated $29.02{\mu}W$ of output power and 107.3mV of load voltage at the vibration acceleration of 0.3g. It also exhibited power density and normalized power density of $48.37{\mu}W{\cdot}cm-3$ and $537.41{\mu}W{\cdot}cm-3{\cdot}g-2$, respectively. The total volume of the fabricated energy harvesters was $1cm{\times}1cm{\times}0.6cm$ (height).

Bioequivalence Assessment of Nabumetone Tablets in Healthy Korean Volunteers

  • Park, Moon-Hee;Shin, In-Chul
    • Biomolecules & Therapeutics
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    • v.15 no.2
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    • pp.118-122
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    • 2007
  • This study was performed to evaluate the bioequivalency between the Osmetone$^{TM}$ Tablet (Myeongmoon Pharm. Co., Ltd.) as a test formulation and the Relafen$^{TM}$ Tablet (Handok Pharm. Co., Ltd.) as a reference formulation. Twenty-four healthy male volunteers were administered the formulations by the randomized Latin square crossover design, and the plasma samples were determined by a high performance liquid chromatography (HPLC) with Ultra-Violet (UV) detector. AUC$_t$, C$_{max}$ and T$_{max}$ were obtained from the time-plasma concentration curves, and log-transformed AUC$_t$ and C$_{max}$ and log-untransformed T$_{max}$ values for two formulations were compared by statistical tests and analysis of variation. AUC$_t$ was determined to be 897.8${\pm}$431.1 ug.hr/ml for the reference formulation and 902.3${\pm}$408.4 ug.hr/ml for the test formulation. The mean values of C$_{max}$ for the reference and test formulations were 24.2${\pm}$8.9 and 24.0${\pm}$9.5 ug/ml, respectively. The AUC$_t$ and C$_{max}$ ratios of the reference Relafen$^{TM}$ Tablet to the test Osmetone$^{TM}$ Tablet were +5.01% and -0.83%, respectively, showing that the mean differences were satisfied the acceptance criteria within 20%. The results from analysis of variance for logtransformed AUC$_t$ and C$_{max}$ indicated that sequence effects between groups were not exerted and 90% confidence limits of the mean differences for AUC$_t$ and C$_{max}$ were located in ranges from log 0.80 to log 1.25, satisfying the acceptance criteria of the KFDA bioequivalence. The Osmetone$^{TM}$ Tablet as the test formulation was considered to be bioequivalant to the Relafen$^{TM}$ Tablet used as its reference formulation, based on AUC$_t$ and C$_{max}$ values.

Internal Defect Position Analysis of a Multi-Layer Chip Using Lock-in Infrared Microscopy (위상잠금 적외선 현미경 관찰법을 이용한 다층구조 칩의 내부결함 위치 분석)

  • Kim, Seon-Jin;Lee, Kye-Sung;Hur, Hwan;Lee, Haksun;Bae, Hyun-Cheol;Choi, Kwang-Seong;Kim, Ghiseok;Kim, Geon-Hee
    • Journal of the Korean Society for Nondestructive Testing
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    • v.35 no.3
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    • pp.200-205
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    • 2015
  • An ultra-precise infrared microscope consisting of a high-resolution infrared objective lens and infrared sensors is utilized successfully to obtain location information on the plane and depth of local heat sources causing defects in a semiconductor device. In this study, multi-layer semiconductor chips are analyzed for the positional information of heat sources by using a lock-in infrared microscope. Optimal conditions such as focal position, integration time, current and lock-in frequency for measuring the accurate depth of the heat sources are studied by lock-in thermography. The location indicated by the results of the depth estimate, according to the change in distance between the infrared objective lens and the specimen is analyzed under these optimal conditions.

Vibration Characteristic Analysis of an Annular Cylindrical PWR Fuel Rod according to the Cross-sectional Dimensions and the Span Length (가압경수로용 환형 실린더 연료봉의 단면치수와 스팬길이에 따른 진동특성해석)

  • Lee, Kang-Hee;Kim, Jae-Yong;Lee, Yung-Ho;Yoon, Kyung-Ho;Kim, Hyung-Kyu
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2007.05a
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    • pp.197-201
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    • 2007
  • Vibration characteristics of an annular cylindrical fuel rod, which was proposed as a candidate design of fuel's cross section for the ultra-high burnup nuclear fuel, according to the cross-sectional dimensions and the number of supports or the span length were analytically studied. Finite element(FE) modeling for the annular cross sectional fuel was based on the methodology, that have been proven by the test verification, for the conventional PWR nuclear fuel rod. A commercial FEA code, ABAQUS, was used for the FE modeling and analysis. A planar beam element (B21) that uses a linear interpolation was used for the fuel rod and a linear spring element for the spring and dimple of the SG. Natural frequencies and mode shape were calculated according to the preliminary design candidates for the fuel's cross sectional dimension and the number of span. From the analysis results, the design scheme of the annular fuel compatible to the present PWR nuclear reactor core was discussed in terms of the number of supports and fuel's cross section.

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