• Archives of Pharmacal Research
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• 제22권6호
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• pp.542-548
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• 1999

The UL47 gene (b 60390-b 60388) located in the unique long region of the human cytomegalovirus (HCMV) AD169 strain genome was analyzed RNA mapping. Northern blot analysis showed that the UL47 gene was expressed at late times after infection (72 h postinfection). The 9.7-kb transcript was expressed in the infected cells but not in phosphonoformate-treated cells at 72 hpi, indicating that the UL47 gene was only expressed at late times after infection. To map the 5'-end and 3'-end of UL47 transcripts, primer at late times after infection. To map the 5'-end and 3'-end of UL47 transcripts, primer extension and RNase protection analysis were performed. Primer extension analysis revealed that the transcription initiation site of UL47 was located in 27 bp downstream (b 60323) of the TATA box motif. The sizes of UL47 ORF (approximately 2.9-kb) and UL48 ORF (approximately 6.7-kb) deduced from computer sequence analysis suggest that the expressed 9.7-kb transcript of UL47 uses the 3'-end polyadenylation signal of Ul48. The result of RNase protection determined that the 3'-end of UL47 RNA utilized the 3'-end polyadenylation signal of UL48, which is located in HCMV genome b 70082.

• KDI북한경제리뷰
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• 제23권9호
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• pp.23-47
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• 2021

• Journal of Yeungnam Medical Science
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• 제38권2호
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• pp.142-147
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• 2021

Background: This study was performed to investigate the association between cystographic anastomotic urinary leakage (UL) after retropubic radical prostatectomy (RRP) and early urinary incontinence (UI). Methods: The medical records of 53 patients who had undergone cystography after RRP at our institution between January 2015 and December 2018 were retrospectively analyzed. Cystography was performed 7 to 10 days after surgery. The duration of catheterization depended on the degree of UL, which was classified as mild, moderate, or severe. The study subjects were divided into the non-UL group and the UL group. Continence was defined as the use of no pads. The prostate was dissected in an antegrade fashion, and urethrovesical anastomosis was performed with a continuous suture. Results: Incontinence rates at 1 and 3 months postoperatively were significantly higher in the UL group than the non-UL group (83.3% vs. 52.2%, p=0.014 and 76.7% vs. 47.8%, p=0.030, respectively); however, those at 6 and 12 months were not significantly different (23.3% vs. 17.4%, p=0.597 and 4.3% vs. 10.0%, p=0.440, respectively). The severity of UL was not found to influence the duration of incontinence. The presence of cystographic anastomotic UL was found to be predictive of UI during the first 3 postoperative months (odds ratio, 3.3; p=0.045). Conclusion: The presence of anastomotic UL on cystography was associated with higher rates of UI in the early postoperative periods. However, incontinence rates in patients with or without anastomotic UL immediately after RRP equalized at 6 months and the severity of UL did not affect the duration of postoperative UI.

• Nuclear Engineering and Technology
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• 제55권8호
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• pp.2941-2951
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• 2023

The optimal minimum ECCD power is evaluated numerically for completely suppressing the 3/2 and 2/1 NTMs in the CFETR hybrid scenario. For two typical frequencies of ECCD sources launching from two upper launcher (UL) ports, f_ec = 210 GHz and 240 GHz with O1-mode, UL₁: (R_i, Z_i) = (8.47, 5.7) m and UL₂: (R_i, Z_i) = (8.2, 4.5) m, higher frequency of ECCD source launching from the UL₂ port is better than that low frequency counterpart from the UL₁ port. Using 240 GHz ECCD source launching from the UL₂ port, the minimum power required to fully suppress the two NTMs with precise ECCD alignment is 12.4 MW and 16.7 MW, respectively. When good alignment cannot be achieved, the results suggest that the misalignment should not exceed 0.02α, preferably 0.015α, corresponding to 4.4 cm and 3.3 cm. Considering engineering difficulty of high-frequency gyrotron sources, the optimal minimum ECCD power with the 210 GHz source launching from the UL₂ port is 17.9 MW and 20.6 MW for completely suppressing the 3/2 and 2/1 NTMs, respectively. In view of this, it is a good choice to select the 210 GHz ECCD source launching from the UL₂ port in the short and medium term.

• 대한소아치과학회지
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• 제30권2호
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• pp.298-307
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• 2003

측모두부방사선 사진은 임상적으로 쉽게 드러나지 않은 치아와 골격간의 상세한 관계를 나타내주며, 이것을 계측 분석하는 다양한 방법들이 소개되어 임상에 적용되고 있다. 이 중 Kim's analysis는 수직피개(overbite)의 지표로 ODI(Overbite Depth Indicator), 전후방적 부조화의 지표로 APDI(Anteroposterior Dysplasia Indicator). 그리고 이들의 합인CF(Combination Factor)를 제시하였다. 또 CF에 상하악의 절치각과 안모의 돌출도를 고려하여 EI(Extraction Index)를 산출하였다. 이러한 분석법에 이용되는 각 계측치들이 정상교합자와 III급 부정교합자에서 어떻게 분포하며 어떤 차이를 보이는가를 조사하기 위해 본 연구를 시행하였다. 골격이 조화로우며 안모가 단정한 7세부터 9세의 정상교합자와 동일한 연령의 III급 부정교합자 141명의 아동을 대상으로 하여 Kim's analysis에 이용되는 계측항목들을 통계적으로 분석하여 다음과 같은 결과를 얻었다. 1. 정상교합자와 III급부정교합자의 비교에서 ODI, APDI, IIA, UL은 유의한 차이를 보였으나, CF와 EI는 통계적인 유의차가 없었다(P<0.01). 2. 정상교합자에서 ODI, APDI, IIA의 평균은 각각 72.63, 80.47, 121.37이었다. 3. III급 부정교합자 ODI, APDI, IIA의 평균은 각각 64.46, 87.31, 129.80이었다. 4. ODI와 APDI의 Pearson 상관계수는 -0.576으로 역상관관계를 나타내었다. 5. EI와 다른 계측치들간의 상관관계는 CF(0.777), LL(-0.607), UL(-0.588), IIA(0.485), APDI(0.444), ODI(0.304)의 순서였다. 이것은 발치분석을 하는데 있어 상순과 하순의 돌출도가 가장 민감하게 반영된다는 것을 암시한다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 춘계학술대회 논문집 센서 박막재료 반도체재료 기술교육
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• pp.47-50
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• 2002

The displacemant current measuring system used for detecting the dynamic behavior of monolayers at the air-water interface is described. It basically consists of a film balance, a pair of electrodes connected to each other through a sensitive ammeter. Here, one electrode is suspended in air and the other electrode is placed in the water. With Maxwell-displacement-current-measuring method, the phase transitons of $Poly-{\gamma}-benzyl_{L}$ -glutamate (PBLG) and $Poly-{\gamma}-benzyl_{D}$-glutamate(PBDG) on a water surface were detected. Measured surface pressure, displacement current and dipole moment of monolayers of PBLG and PBDG on the water surface. Also, we measured that compression velocity (30, 40, 50[mm/min]) when the sample spread volume was about 370[ul]-400[ul] and displacement current that occur when differed temperature. From the result, it is known that current is generated in the range of high surface pressures as compression velocity become faster and increase of temperature.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권6호
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• pp.457-463
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• 2011

Introduction: This study evaluate the soft tissue changes to the upper lip and nose after Le Fort I maxillary posterosuperior rotational movement. Materials and Methods: Twenty Skeletal class III patients, who had undergone bimaxillary surgery with a maxillary Le Fort I osteotomy and bilateral sagittal split ramus osteotomy, were included in the study. The surgical plan for maxilla was posterosuperior rotational movement, with the rotation center in the anterior nasal spine (ANS) of maxilla. Soft and hard tissue changes were measured by evaluating the lateral cephalograms obtained prior to surgery and at least 6 months after surgery. For cephalometric analysis, four hard tissue landmarks ANS, posterior nasal spine [PNS], A point, U1 tip), and five soft tissue landmarks (pronasale [Pn], subnasale [Sn], A' Point, upper lip [UL], stomion superius [StmS]) were marked. A paired t test, Pearson's correlation analysis and linear regression analysis were used to evaluate the soft and hard tissue changes and assess the correlation. A P value <0.05 was considered significant. Results: The U1 tip moved $2.52{\pm}1.54$ mm posteriorly in the horizontal plane (P<0.05). Among the soft tissue landmarks, Pn moved $0.97{\pm}1.1$ mm downward (P<0.05), UL moved $1.98{\pm}1.58$ mm posteriorly (P<0.05) and $1.18{\pm}1.85$ mm inferiorly (P<0.05), and StmS moved $1.68{\pm}1.48$ mm posteriorly (P<0.05) and $1.06{\pm}1.29$ mm inferiorly (P<0.05). The ratios of horizontal soft tissue movement to the hard tissue were 1:0.47 for the A point and A' point, and 1:0.74 for the U1 tip and UL. Vertically, the movement ratio between the A point and A' point was 1:0.38, between U1 tip and UL was 1:0.83, and between U1 tip and StmS was 1:0.79. Conclusion: Posterosuperior rotational movement of the maxilla in Le Fort I osteotomy results in posterior and inferior movement of UL. In addition, nasolabial angle was increased. Nasal tip and base of the nose showed a tendency to move downward and showed significant horizontal movement. The soft tissue changes in the upper lip and nasal area are believed to be induced by posterior movement at the UL area.

• 대한방사성의약품학회지
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• 제8권1호
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• pp.9-15
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• 2022

Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (⁴³Sc, ⁴⁴Sc) and therapy (⁴⁷Sc) in cancer theranostic approach. However, ⁴⁷Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of ⁴⁷Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of ⁴⁷Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced ⁴⁷Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using ⁴⁷Sc.

• 한국균학회지
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• 제43권2호
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• pp.99-103
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• 2015

제주도, 울릉도, 욕지도 등 우리나라 섬들과 계족산, 오서산, 백암산 등의 산에서 서식하는 야생화들에서 분리한 207 효모 균주들을 YPD 배지에 24시간 배양하여 각각의 무세포추출물과 배양상등액을 제조한 후 이들의 항산화활성과 Xanthine oxidase 저해활성 및 tyrosinase 저해활성을 측정하였다. 섬 지역 야생화들에서 분리한 Kuraishia capsulata UL40-2와 산 지역 야생화에서 분리한 Sporobolomyces ruberrimus 121-Z-3의 무세포추출물이 각각 46.4%와 48.3%의 비교적 높은 항통풍성 xanthine oxidase 저해활성을 보였다. 또한 Starmerella bombicola 80-J-1의 무세포추출물 역시 36.2%의 미백성 tyrosinase 저해활성을 보였다. 그 밖의 항산화활성과 tyrosinase 저해활성은 모든 분리효모들에서 없거나 30% 미만으로 미약하였다. 이들 가운데 xanthine oxidase 저해활성이 우수하였던 Kuraishia capsulate UL40-2와 Sporobolomyces ruberrimus 121-Z-3의 xanthine oxidase 저해제의 최적 생산 조건을 검토한 결과 두 효모 각각을 YPD에 접종하여 $30^{\circ}C$에서 24시간 배양하여 얻은 무세포추출물이 47.2%와 49.5%의 높은 xanthine oxidase 저해활성을 보였다.

• 대한조선학회논문집
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• 제47권2호
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• pp.210-224
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• 2010

The aim of the present study is to investigate the buckling strength of plates and stiffened panels with opening under transverse thrust and shear actions. It is observed that the existing design formulation for critical-buckling strength of plates are not valid for perforated plates, because the current design formulation trends can significantly overestimate or underestimate the load-carrying capacity of plates when plates have large opening and/or are thick. A series of eigen value and elastic.plastic large deflection finite element analyses are carried out with varying the aspect ratio of plate, the opening size and location on plate until and after the ultimate strength is reached. Based on the results obtained from the present study, closed-form design formulations for the elastic buckling strength of plates and stiffened panels with opening are derived. The derived design formulations are considered plasticity correction of the material and verified by experimental tests and results of nonlinear finite element computations.