• Archives of Pharmacal Research
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• v.22 no.6
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• pp.542-548
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• 1999

The UL47 gene (b 60390-b 60388) located in the unique long region of the human cytomegalovirus (HCMV) AD169 strain genome was analyzed RNA mapping. Northern blot analysis showed that the UL47 gene was expressed at late times after infection (72 h postinfection). The 9.7-kb transcript was expressed in the infected cells but not in phosphonoformate-treated cells at 72 hpi, indicating that the UL47 gene was only expressed at late times after infection. To map the 5'-end and 3'-end of UL47 transcripts, primer at late times after infection. To map the 5'-end and 3'-end of UL47 transcripts, primer extension and RNase protection analysis were performed. Primer extension analysis revealed that the transcription initiation site of UL47 was located in 27 bp downstream (b 60323) of the TATA box motif. The sizes of UL47 ORF (approximately 2.9-kb) and UL48 ORF (approximately 6.7-kb) deduced from computer sequence analysis suggest that the expressed 9.7-kb transcript of UL47 uses the 3'-end polyadenylation signal of Ul48. The result of RNase protection determined that the 3'-end of UL47 RNA utilized the 3'-end polyadenylation signal of UL48, which is located in HCMV genome b 70082.

• KDI북한경제리뷰
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• v.23 no.9
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• pp.23-47
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• 2021

• Journal of Yeungnam Medical Science
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• v.38 no.2
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• pp.142-147
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• 2021

Background: This study was performed to investigate the association between cystographic anastomotic urinary leakage (UL) after retropubic radical prostatectomy (RRP) and early urinary incontinence (UI). Methods: The medical records of 53 patients who had undergone cystography after RRP at our institution between January 2015 and December 2018 were retrospectively analyzed. Cystography was performed 7 to 10 days after surgery. The duration of catheterization depended on the degree of UL, which was classified as mild, moderate, or severe. The study subjects were divided into the non-UL group and the UL group. Continence was defined as the use of no pads. The prostate was dissected in an antegrade fashion, and urethrovesical anastomosis was performed with a continuous suture. Results: Incontinence rates at 1 and 3 months postoperatively were significantly higher in the UL group than the non-UL group (83.3% vs. 52.2%, p=0.014 and 76.7% vs. 47.8%, p=0.030, respectively); however, those at 6 and 12 months were not significantly different (23.3% vs. 17.4%, p=0.597 and 4.3% vs. 10.0%, p=0.440, respectively). The severity of UL was not found to influence the duration of incontinence. The presence of cystographic anastomotic UL was found to be predictive of UI during the first 3 postoperative months (odds ratio, 3.3; p=0.045). Conclusion: The presence of anastomotic UL on cystography was associated with higher rates of UI in the early postoperative periods. However, incontinence rates in patients with or without anastomotic UL immediately after RRP equalized at 6 months and the severity of UL did not affect the duration of postoperative UI.

• Nuclear Engineering and Technology
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• v.55 no.8
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• pp.2941-2951
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• 2023

The optimal minimum ECCD power is evaluated numerically for completely suppressing the 3/2 and 2/1 NTMs in the CFETR hybrid scenario. For two typical frequencies of ECCD sources launching from two upper launcher (UL) ports, f_ec = 210 GHz and 240 GHz with O1-mode, UL₁: (R_i, Z_i) = (8.47, 5.7) m and UL₂: (R_i, Z_i) = (8.2, 4.5) m, higher frequency of ECCD source launching from the UL₂ port is better than that low frequency counterpart from the UL₁ port. Using 240 GHz ECCD source launching from the UL₂ port, the minimum power required to fully suppress the two NTMs with precise ECCD alignment is 12.4 MW and 16.7 MW, respectively. When good alignment cannot be achieved, the results suggest that the misalignment should not exceed 0.02α, preferably 0.015α, corresponding to 4.4 cm and 3.3 cm. Considering engineering difficulty of high-frequency gyrotron sources, the optimal minimum ECCD power with the 210 GHz source launching from the UL₂ port is 17.9 MW and 20.6 MW for completely suppressing the 3/2 and 2/1 NTMs, respectively. In view of this, it is a good choice to select the 210 GHz ECCD source launching from the UL₂ port in the short and medium term.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.2
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• pp.298-307
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• 2003

The purpose of this study was to investigate the distribution and differences of the cephalometric measurements between normal occlusion and the class III malocclusion. Kim's analysis was achieved and compared on both the 141 elementary school students with proper profile and normal occlusion and the class III malocclusion group at the age of 7 to 9, in Gwang-ju area and the results were as follows; 1. The ODI, APDI, IIA, UL showed statistically significant differences between normal occlusion and class III malocclusion(p<0.01). But, no significant difference existed in both CF and EI. 2. The mean value of ODI was 72.62, APDI 80.47 IIA 121.37 in normal occlusion. 3. The mean value of ODI was 64.45, APDI 87.31 IIA 129.89 in class III malocclusion. 4. ODI decreased as APDI increased, and the correlation coefficient was -0.576 in both normal occlusion and class III malocclusion. 5. The correlation coefficient related to EI was CF 0.777, LL -0.670, UL -0.588, IIA 0.485. It means that UL and LL were very sensitively reflected on EI.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.05b
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• pp.47-50
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• 2002

The displacemant current measuring system used for detecting the dynamic behavior of monolayers at the air-water interface is described. It basically consists of a film balance, a pair of electrodes connected to each other through a sensitive ammeter. Here, one electrode is suspended in air and the other electrode is placed in the water. With Maxwell-displacement-current-measuring method, the phase transitons of $Poly-{\gamma}-benzyl_{L}$ -glutamate (PBLG) and $Poly-{\gamma}-benzyl_{D}$-glutamate(PBDG) on a water surface were detected. Measured surface pressure, displacement current and dipole moment of monolayers of PBLG and PBDG on the water surface. Also, we measured that compression velocity (30, 40, 50[mm/min]) when the sample spread volume was about 370[ul]-400[ul] and displacement current that occur when differed temperature. From the result, it is known that current is generated in the range of high surface pressures as compression velocity become faster and increase of temperature.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.37 no.6
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• pp.457-463
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• 2011

Introduction: This study evaluate the soft tissue changes to the upper lip and nose after Le Fort I maxillary posterosuperior rotational movement. Materials and Methods: Twenty Skeletal class III patients, who had undergone bimaxillary surgery with a maxillary Le Fort I osteotomy and bilateral sagittal split ramus osteotomy, were included in the study. The surgical plan for maxilla was posterosuperior rotational movement, with the rotation center in the anterior nasal spine (ANS) of maxilla. Soft and hard tissue changes were measured by evaluating the lateral cephalograms obtained prior to surgery and at least 6 months after surgery. For cephalometric analysis, four hard tissue landmarks ANS, posterior nasal spine [PNS], A point, U1 tip), and five soft tissue landmarks (pronasale [Pn], subnasale [Sn], A' Point, upper lip [UL], stomion superius [StmS]) were marked. A paired t test, Pearson's correlation analysis and linear regression analysis were used to evaluate the soft and hard tissue changes and assess the correlation. A P value <0.05 was considered significant. Results: The U1 tip moved $2.52{\pm}1.54$ mm posteriorly in the horizontal plane (P<0.05). Among the soft tissue landmarks, Pn moved $0.97{\pm}1.1$ mm downward (P<0.05), UL moved $1.98{\pm}1.58$ mm posteriorly (P<0.05) and $1.18{\pm}1.85$ mm inferiorly (P<0.05), and StmS moved $1.68{\pm}1.48$ mm posteriorly (P<0.05) and $1.06{\pm}1.29$ mm inferiorly (P<0.05). The ratios of horizontal soft tissue movement to the hard tissue were 1:0.47 for the A point and A' point, and 1:0.74 for the U1 tip and UL. Vertically, the movement ratio between the A point and A' point was 1:0.38, between U1 tip and UL was 1:0.83, and between U1 tip and StmS was 1:0.79. Conclusion: Posterosuperior rotational movement of the maxilla in Le Fort I osteotomy results in posterior and inferior movement of UL. In addition, nasolabial angle was increased. Nasal tip and base of the nose showed a tendency to move downward and showed significant horizontal movement. The soft tissue changes in the upper lip and nasal area are believed to be induced by posterior movement at the UL area.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.1
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• pp.9-15
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• 2022

Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (⁴³Sc, ⁴⁴Sc) and therapy (⁴⁷Sc) in cancer theranostic approach. However, ⁴⁷Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of ⁴⁷Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of ⁴⁷Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced ⁴⁷Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using ⁴⁷Sc.

• The Korean Journal of Mycology
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• v.43 no.2
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• pp.99-103
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• 2015

We prepared supernatants and cell-free extracts of yeasts isolated from wild flowers in Korea, and their antioxidant activity and inhibitory activities of xanthine oxidase and tyrosinase were investigated. Among them, cell-free extracts of Kuraishia capsulata UL40-2 and Sporobolomyces ruberrimus 121-Z-3 showed significantly high xanthine oxidase inhibitory activity of 46.4% and 48.3%, respectively. Starmerella bombicola 80-J-1 also showed tyrosinase inhibitory activity of 36.2% in the cell-free extract. Other antioxidant activities and tyrosinase inhibitory activities were not detected or were below 20%. Maximal production of the xanthine oxidase inhibitors were observed when Kuraishia capsulate UL40-2 and Sporobolomyces ruberrimus 121-Z-3 were cultured in the yeast extract-peptone-dextrose media at $30^{\circ}C$ for 24 hour, respectively.

• Journal of the Society of Naval Architects of Korea
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• v.47 no.2
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• pp.210-224
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• 2010

The aim of the present study is to investigate the buckling strength of plates and stiffened panels with opening under transverse thrust and shear actions. It is observed that the existing design formulation for critical-buckling strength of plates are not valid for perforated plates, because the current design formulation trends can significantly overestimate or underestimate the load-carrying capacity of plates when plates have large opening and/or are thick. A series of eigen value and elastic.plastic large deflection finite element analyses are carried out with varying the aspect ratio of plate, the opening size and location on plate until and after the ultimate strength is reached. Based on the results obtained from the present study, closed-form design formulations for the elastic buckling strength of plates and stiffened panels with opening are derived. The derived design formulations are considered plasticity correction of the material and verified by experimental tests and results of nonlinear finite element computations.