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On the Chance of Mineral Content in Human Milk (수유기간의 경과에 따른 모유 중 무기질 함량 변화)

  • 전예숙
    • The Korean Journal of Food And Nutrition
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    • v.5 no.2
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    • pp.84-89
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    • 1992
  • Concentrations of major minerals(Ca, p, Na, K, Mg) and trace elements (Fe, Zn) were measured in human milk samples collected from 19 selected, healthy lactating women at 2~5 days, and at 4, 8 and 12 weeks postpartum. Decreases in the contents of m) or minerals and trace elements were found with the increase of time postpartum. Mean Ca contents of 2~5 days, 4 week, 8 week and 12 week in human milk were 243.02$\pm$50.90ug/ml, 295.0$\pm$65.70ug/ml, 295.0$\pm$41.50ug/ml, 349.90$\pm$83.50ug/ml, respectively And mean P contents of 2~5 days, 4 week, 8 week and 12 week in human milk were 134.70$\pm$49.4ug/ml, 134.90$\pm$19.70ug/ml, 117.60$\pm$18.90ug/ml, 130.60$\pm$28.20ug/ml, respectively. Ca/P of them were 1.81, 2.19, 2.20, 2.68, respectively. Mean Mg contents of them were 22.30$\pm$5.60ug/ml, 25.70$\pm$3.70ug/ml, 25.10$\pm$3.60ug/ml, 32.10$\pm$4.50ug/ml, respectively. And mean Na contents of them were 171.20$\pm$90.50ug/ml, 158.70$\pm$47.00ug/ml, 104.50$\pm$24.70ug/ml, 115.90$\pm$12.50ug/ml, respectively. Mean K contents of them were 506.10$\pm$156.10ug/ml, 520.90$\pm$55.00ug/ml, 370.10$\pm$29.00ug/ml, 468.40$\pm$75.70ug/ml, respectively. Na/K of them were 0.34, 0.30, 0.28, 0.25, respectively. Mean Fe contents of them were 2.80$\pm$1.80ug/ml, 2.70$\pm$0.40ug/ml, 2.60$\pm$0.40ug/ml, 2.10$\pm$0.10ug/ml, respectively. And mean Zn contents of them were 3.70$\pm$1.60ug/ml, 2.78$\pm$9.70ug/ml, 2.70$\pm$0.70ug/ml, 2.30$\pm$0.20ug/ml, respectively, These determinations will provide the basic information on the variability of major minerals and trace elements as lactation proceeds and on the composition of components between term and preterm milk.

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Studies on the Chemical Resistance of Phytopathogenic Bacteria II. Selective Effect of Chemical Resistance on the Rice Bacterial Leaf Blight Pathogen, Xanthomonas oryzae (Uyeda et Ishiyama) Dowson, to Agrepto (식물병원성 세균의 약제저항성에 관한 연구 II. 벼흰빛잎마름병균의 Agrepto에 대한 저항성의 선발효과)

  • Cho W. C.;Shim J. W.
    • Korean journal of applied entomology
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    • v.16 no.4 s.33
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    • pp.229-234
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    • 1977
  • The experiments were carried out to investigate the selection effects on the drug resistance to Agrepto in Xanthomonas oryzae, the causal bacteria of rice bacterial leaf blight. The results obtained were as follows. 1, The Agrepto was stable at the heat treatment of $105^{\circ}C$ for 20 minutes, when the drug was added in the media. 2. The local isolates of the bacteria, 75-6 and 75-9, showed the different resistante reaction, when they were selected by the Agrepto contained media which concentrations of 10r9/m1 and 100ug/ml. 3. The individuals shelving high degree of resistance, which can grow on the media contained 10,000ug/m1 of Agrepto, could selected by the concentrations as low as 10ug/ml and 100ug/m1, in one generation. 4. The highly resistant isolates which selected by 3-stepwise selections such as 100ug/ml, 3,000ug/ml and 10,000/ml plots, showed nearly normal growth at the media contained 100ug/ml of Agrepto 5. When the isolate 75-9 was selected at the 100ug/m1 of concentration, showed various degrees of resistance, indicating that the isolate may be composed of resistance groups that lower than 500ug/ml, between 500-1,000ug/ml and 1,000-3,000ug/ml, to the Agrept.

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Sensitivity of Staphylococcus aureus Isolated From Bovine Udders to Various Chemotherapeutic Agents (유우유방원(乳牛乳房源) Staphylococcus aureus 의 각종 화학요법제(化學療法劑)에 대한 감수성시험(感受性試驗))

  • Han, H.R.;Chung, G.T.
    • Korean Journal of Veterinary Research
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    • v.12 no.1
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    • pp.85-89
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    • 1972
  • The minimum inhibitory concentration (MIC) of five chemotherapeutic agents (penicillin, streptomycin, tetracycline, oxytetracycline and furazolidone) was measured for 126 strains of Staphylococcus aureus isolated from the udder of dairy cattle. The results obtained were as follows: 1. The MIC of penicillin, streptomycin, tetracycline, oxytetracycline and furazolidone ranged from 0.03 to 32 ug/ml, 0.06 to 128 ug/ml, 0.06 to 128 ug/ml, 1.0 to 512 ug/ml, and 0.06 to 32 ug/ml, respectively. The most frequent MIC of the above drugs were; penicillin 0.5ug/ml, streptomycin 1.0ug/ml, tetracycline 0.5ug/ml, oxytetracycline 4.0ug/ml, and furazolidone 2.0ug/ml. 2. The number of strains resistant to penicillin. streptomycin, tetracycline and oxytetracycline were 89(70.6), 9(7.1%), 10(7.9%), and 26(20.6%), respectively. Twenty-eight (29.2%) strains showed multiple resistance to more than two antibiotics tested.

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Trace Metal Contents in Urine of School Children around the Industrial Park Area (일부 공단주변 국민학생의 요중 중금속 함량에 관한 연구)

  • Hwang, In-Dam;Son, Wi-Ik
    • 산업보건소식
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    • no.48
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    • pp.9-18
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    • 1987
  • The results of this study which had been investigated to analyse heavy metal levels and to compare lead, cadmium, copper and zinc concentration in urine of children who lived around the industrial area and the agricultural area. Samples were collected and analyzed from September to December 1986 from 7-9 years old children living in Seoul (4 7 cases), lri ( 64 cases) industrial area and Chinan (56 cases) agricultural area. The summarized results were as follows: 1) The concentrations of lead were Seoul 28.7 $\pm$17.7 ug/l, lri 25.3 $\pm$7.5 ug/l and Chinan 19.3 $\pm$5.2 ug/l 2) The concentrations of cadmium were Seoul 1.5 $\pm$0.8 ug/l, Iri 1.4 $\pm$0.5 ug/l and chinan 0.9 $\pm$0.3 ug/l 3) The concentrations of copper were Seoul 12.8 $\pm$7.0 ug/l, Iri 10.5 $\pm$8.4 ug/l and Chinan 10.0 $\pm$4.5 ug/l 4) The concentrations of zinc were Seoul 383 $\pm$279 ug/l, Iri 329 $\pm$133 ug/l and Chinan 267 $\pm$181 ug/l 5) In lead, cadmium and zinc concentration of children, there were statistical difference between the industrial area and the agricultural area 6) There were no indicated significantly levels by the Sex

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Studies on Benzo(a)pyrene of the Suspended Particulate in Atmosphere of Seoul City (서울시(市) 대기중(大氣中) 유해(有害) 부유분진(浮遊粉塵) 성분(成分)에 관(關)한 조사연구(調査硏究) -부유분진중(浮遊粉塵中)의 Benzo(a)pyrene에 관(關)하여-)

  • Kwon, Sook-Pyo;Chung, Yong;Lim, Dong-Koo
    • Journal of Preventive Medicine and Public Health
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    • v.11 no.1
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    • pp.65-75
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    • 1978
  • This study was carried out to investigate air pollution by total suspended particulate(T.S.P.), benzene soluble matter and benzo(a) pyrene in Seoul city. The sampling areas were divided into commercial(Kwang Hwa Moon), indus-trial(Ku Ro Dong) and residensial area(Shin Chon). Sampling was undertaken by High Voulme Air Sampler for four seasons from January 1917 to November 1977. The T.S.P. was extracted with Soxhlet apparatus by benzene and benzo(a) pyrene was separated by column chromatography and thin layer chromatography. The concentrations of benzo(a) pyrene were measured by means of fluorophotometer, and following results were obtained. 1. Arithmetic average concentration for 1-day averaging time of total suspended particulate were $275.6ug/m^3$ in Kwang Hwa Moon, $325.9ug/m^3$ in Ku Ro Dong and $193.0ug/m^3$ in Shin Chon. 2. The seasonal variance of total suspended parti-culate at Ku Ro Dong and Shin Chon were $102.7ug/m^3\;99.6ug/m^3$ respectively and at Kwang Hwa Moon $39.9ug/m^3$. And the concentration of autumn is higher than of that spring at Ku Ro Dong and at Shin Chon, but at Kwang Hwa Moon, the seasonal variance is very little. 3. The concentrations of 50% frequency from geometric mean for 1-day averaging time were $264ug/m^3,\;300ug/m^3\;and\;178ug/m^3$ at Kwang Hwa Moon, Ku Ro Dong and Shin Chon. And geometric standard deviation were 1.27, 1.38 and 1.41 respectively. 4. The concentrations of benzene soluble mater were $26.9ug/m^3$ at Kwang Hwa Moon, $22.7ug/m^3$ at Ku Ro Dong and $15.5ug/m^3$ at Shin Chon, and the ratios to the T.S.P. were 9.8%(range 5.6-14.8%), 7.0%(range 2.4-14.4%) and 8.0%(range 5.5-22.1%) respectively. 5. The concentrations of benzo(a) pyrene were $8.5ug/m^3$ (range $0.8-29.9ug/m^3$) at Kwang Hwa Moon $10.9ug/m^3$(range $1.1-52.0ug/m^3$) at Ku Ro Dong and $5.8ug/m^3$(range $1.5-11.4ug/m^3$) at Shin Chon. 6. The results of this investigation were relatively high in compared with the recommended standards of suspended particulate in air of U.S. Environmental Protection Agency and observed levels of benzo(a)-pyrene in U.S. city.

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진행암환자에서 rh GM-CSF(recombinamt human granulocyte-macrophage colony stimulating factor)의 제 1 상 및 약동학 연구 평가를 위한 Protocol 개발 연구

  • 노재경;최진혁;노형근;김범수;한지숙;김병수
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.95-95
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    • 1993
  • 대상환자는 15예로, 14예에서 평가가능하였다. 남녀비는 8:6, 중앙연령 32세(10-70세)이었고, 대상질환은 악성골육종 7예, 악성임파종 2예, 위암2예, 폐암 2예, 그리고 자궁악성육종 1예였다. CSF 50 ug/$m^2$ 3예, 100 ug/$m^2$ 3예,150 ug/$m^2$ 3예, 250 ug/$m^2$ 3예,350 ug/$m^2$ 3예, 500 ug/$m^2$ 6예, 700 ug/$m^2$ 용량 3예에서 시행되었다. 1주기 시행한 환자는 7예, 2주기 5예, 3주기, 4주기 각각 1예씩이었다. 부작용은 50-150ug/$m^2$에서 WHO grade I의 발열, 전신쇠약, 식욕부진 등이 관찰되었으나 grade II이상의 부작용은 없었다. 250 ug/$m^2$ 이상의 용량에서도 grade II의 발열이 관찰되었을 뿐 다른 중증의 부작용은 관찰되지 않았다. 최고용량인 700 ug/$m^2$ 에서도 grade II의 발열외의 중한 부작용은 관찰되지 않았다. 각 용량에 따른 백혈구 증가율(%투여제2일/투여제1일)은 130-500% 이었다. 시행된 약동태는 CSF 투여 2-4 시간 후 최고치 (0.42-15.4 ng/ml)를 나타내고 투여 12시간까지 0.2-2 ng/ml의 농도로 지속되었다. 소변내 CSF 배설량은 총투여량의 1% 미만이었다. CSF중화항체는 전예에서 검출되지 않았다.

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항암화학요법제에 의하여 골수억제가 수반된 진행암환자에서 rh GM-CSF(recombinamt human granulocyte-macrophage colony stimulating factor)의 제 1 상 및 약동학 연구

  • 노재경;최진혁;노형근;김범수;한지숙;김병수
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.68-68
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    • 1993
  • 대상환자는 15예로, 14예에서 평가 가능하였다. 남녀비는 8:6, 중앙연령 32세(10-70세)이었고, 대상질환은 악성골육종 7예, 악성임파종 2예, 위암2예, 폐암 2예, 그리고 자궁악성육종 1예였다. CSF 50 ug/$m^2$ 3예, 100 ug/$m^2$ 3예,150 ug/$m^2$ 3예, 250 ug/$m^2$ 3예, 350 ug/$m^2$ 3예, 500 ug/$m^2$ 6예, 700 ug/$m^2$ 용량 3예에서 시행되었다. 1주기 시행한 환자는 7예, 2주기 5예, 3주기, 4주기 각각 1예씩이었다. 부작용은 50-150ug/$m^2$에서 WHO grade I의 발열, 전신쇠약, 식욕부진등이 관찰되었으나 grade II이상의 부작용은 없었다. 250 ug/$m^2$ 이상의 용량에서도 grade II의 발열이 관찰되었을 뿐 다른 중증의 부작용은 관찰되지 않았다. 최고용량인 700 ug/$m^2$ 에서도 grade II의 발열 외의 중한 부작용은 관찰되지 않았다. 각 용량에 따른 백혈구 증가율(%투여제2일/투여제1일)은 130-500% 이었다. 시행된 약동태는 CSF 투여 2-4 시간후 최고치 (0,42-15.4 ng/ml)를 나타내고 투여 12시간까지 0.2-2 ng/ml의 농도로 지속되었다. 소변내 CSF 배설량은 총투여량의 1% 미만이었다. CSF 중화항체는 전예에서 검출되지 않았다.

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A Study on the Discharge of Volatile Organic Compounds in Indoor Air of Newly-constructed Apartment Houses

  • Ryu, Jung-Min;Jang, Seong-Ki;Yang, Won-Ho;Cho, Tae-Jin;Son, Bu-Soon
    • Journal of Environmental Science International
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    • v.18 no.5
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    • pp.479-487
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    • 2009
  • Because of the building is made airtight, Indoor Air Quality(IAQ) is go from bad to worse. There are many source of indoor pollution in any home. These include irritation of the eyes, nose, and throat, headaches, dizziness, and fatigue. Such immediate effects are usually short-term and treatable. In this study was measured and analyzed VOCs exposure levels and characteristic of Indoor air pollutant from new apartments in Korea. VOCs were measured indoor pre-residential and residential in new apartment and analyzed GC/MS. The concentration levels of indoor respirable TVOC were found to be higher than those of outdoor TVOC for new apartments. Before occupation, the average indoor and outdoor concentrations were 1498.61 $ug/m^3$ and 468.38 $ug/m^3$, respectively. After being occupied, the average indoor and outdoor concentration were 847.04 $ug/m^3$ and 102.84, respectively. The concentrations of TVOC in new apartments before occupation were shown in the order of Toluene(328.12 $ug/m^3$) > m,p-Xylene(163.67 $ug/m^3$) > Ethy1benzene(80.70 $ug/m^3$>o-XYlene (67.04$ug/m^3$). In addition, the TVOCs concentrations after occupation were also found in the order of Toluene (272.28 $ug/m^3$) > m.p-Xylene(121.79 $ug/m^3$) > Ethylbenzene(53.92 $ug/m^3$)>O-Xylene(24.94 $ug/m^3$). As a result, the concentrations of VOCs in new apartment houses were shown to be affected by indoor environment according activity patterns. So new apartments need to be controled in indoor air quality so that the residents can have more comfortable and healthier living environment.

Effect of Fermented Artemisiae Argyi Folium on Human Hepatoma Cell Line HepG2 Activity (발효 애엽(艾葉) 추출물이 인간 간암세포주 HepG2 활성에 미치는 영향)

  • Han, Hyo-Sang
    • The Korea Journal of Herbology
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    • v.28 no.3
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    • pp.107-113
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    • 2013
  • Objective : The purpose of this study was to investigate the effect of fermented Artemisiae Argyi Folium(AAF) on some activities of human hepatoma cell, HepG2. Method : To investigate the effect of fermented Artemisiae Argyi Folium(AAF) activity on the human hepatoma cells, AAF extracts was fermented by Lactobacillus pentosus K34(AFL) and Sacchromyces cerevisiae STV89(AFS). And the effects of AFL or AFS on the activities of HepG2 cell, such as cell viability, nitric oxide(NO) production and reactive oxygen species(ROS) production, were tested. Result : Human Hepatoma Cells were incubated each for 3 hours and 24 hours. Human Hepatoma Cells treated with the extract was measured with MTT assay. Then AFL was found to be non-toxic at concentrations of 10 ug/mL(3h), 100 ug/mL(24h) or more. AFS was the same result at concentrations of more than 10 ug/mL. The extract increased ROS generation in Human Hepatoma Cells. AFL increased at concentrations of 100 ug/mL more (3h, also 10 ug/mL more) and 50 ug/mL(24h) and AFS increased both 50 ug/mL. In point of NO generation, AFL inhibited at concentrations of 10 ug/mL(3h) and 100 ug/mL(24h) more (3h, also 10 ug/mL more) and AFS also inhibited 50 ug/mL or more. Conclusion : AFL and AFS, obtained from Artemisiae Argyi Folium extracts by fermentation, reduced the NO production and increased ROS production in HepG2 cell, without cytotoxicity on HepG2 cell. The results suggested that AFL and AFS increased the immunological effects of Artemisiae Argyi Folium extracts.

The critical period in Korean EFL contexts and UG (한국인 EFL 학습자의 결정적 시기와 보편문법)

  • Hahn, Hye-Ryeong
    • English Language & Literature Teaching
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    • no.6
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    • pp.219-239
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    • 2000
  • There has been a growing enthusiasm in Korea for the early education of English as a foreign language (EFL). The present study examined the validity of the Critical Period Hypothesis in terms of the Universal Grammar (UG), in three different types of learning contexts - first language (L1), second language (SL), and foreign language (FL) learning contexts. While previous research findings in L1 and SL learning contexts suggest that UG principles and parameters are accessible to language learners only for the early years of lifetime, this article argues that their results - and even the methods - cannot be applied to EFL settings and that independent studies on the EFL context are, required. It also proposes the recent UG notion of functional categories as the most appropriate subject in the discussion of Korean EFL learners' access to UG. Findings on foreign language contexts, including the author's own, strongly indicate that UG is not sensitive to learners' starting ages in FL settings. If young children in FL contexts cannot develop their interlanguage grammar based on UG, the existing teaching methods for young children should be revised.

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