• Proceedings of the PSK Conference
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• 2002.10a
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• pp.262.1-262.1
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• 2002

Uncoupling proteins (UCPs) are transmembrane proton transporters present in the mitochondria. In UCPs. UCP1 and UCP3 play an important role in adaptive thermogenesis by uncoupling mitochondrial oxidation of substrates from ATP synthesis. PPARg coactivator 1(PGC-1) regulates transcriptional activity of PPARg and other nuclear receptors and controls the expression of UCPs. (omitted)

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.35 no.6
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• pp.609-616
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• 2017

National Geographic Information Institute has established a plan that preoccupies UCPs (Unified Control Points) at 2~3km intervals in urban areas by considering the distance between existing UCPs by satellite images and aerial photographs in 2015. In this study, we discussed the method of selecting the locations of optimal UCPs by simulating GPS reception environment in candidate sites for UCPs using GIS. For this purpose, we selected new candidate sites for installing UCPs using satellite images and aerial photographs, and analyzed the GPS reception environment by calculating the visibility distance from buildings around UCPs using GIS skyline analysis. The number of and the arrangement of visible satellites that are capable of GPS satellite reception from the viewpoint of sky view were showed by GIS skyline analysis. Quality evaluation results of GPS observation data were compared with average PDOP calculated from hourly PDOP and TEQC in two points of Sungkyunkwan University during 8 hours. As a result of GPS reception environment using GIS, if the PDOP increases, the data acquisition rate is lowed, and the multipath error and the cycle slip are increased. Thus, this study verified that the quality of GPS observation data can be secured by constructing three-dimensional spatial information and simulating PDOP when preoccupying multiple UCPs using GIS.

• Biomedical Science Letters
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• v.18 no.4
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• pp.355-361
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• 2012

We investigated to verify whether the $PPAR{\alpha}$ agonist fenofibrate regulates adipose tissue metabolism and to determine the molecular mechanism involved in this regulation. After male mice (C57BL/6J) received a high fat diet with or without fenofibrate for 6 weeks, the effects of fenofibrate on not only adipose tissue weight, visceral adipocyte size, serum lipid and glucose levels, but also the expression of uncoupling proteins (UCPs). Mice given a fenofibrate-supplemented high fat diet showed reduced both visceral and subcutaneous adipose tissue weights versus high fat diet-fed animals. The size of visceral adipocytes was significantly decreased by fenofibrate treatment. The administration of fenofibrate resulted in decreased serum levels of triglycerides, free fatty acids, and glucose. Moreover, fenofibrate up-regulated mRNA levels of visceral adipose tissue UCP2 and skeletal muscle UCP3. Therefore, our results suggest that the increases in the expression of UCPs by fenofibrate seem to suppress diet-induced visceral adiposity as well as severe hypertriglyceridemia and hyperglycemia in male mice.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.32 no.5
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• pp.539-550
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• 2014

High resolution satellite images have to be oriented and geometrically processed from GCPs(Ground Control Points) to generate precise DEMs(Digital Elevation Models) and topographic maps. In Korea, thousands of national UCPS(Unified Control Points) are established and distributed all over the country by the Korean NGII(National Geographic Information Institute). For that reason, UCPs can be easily searched and downloaded by the national-control-point-record-issues system. Following the study, we suggested the sky-view and road-view from web-portals for searching and identifying UCPs on the images. To evaluate the usefulness of UCPs in RPCs(rational polynomial coefficients) adjustment of the high resolution satellite images, the one UCP, which of using simple the control point, has been applied to adjust the vendor-provided RPCs of the KOMPSAT-3 images. As a result, the positioning error of corrected RPCs was approximately one pixel and one meter. From this experiment, we conclude that the UCPs will be able to replace the survey GCPs for mapping with the satellite images or aerial images.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.2
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• pp.153-163
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• 2020

After launching the GOCE (Gravity Field and Steady-State Ocean Circulation Explorer) which obtains high-frequency gravity signal using a gravity gradiometer, many research institutes are concentrating on the development of GGM (Global Geopotential Model) based on GOCE data and evaluating its precision. The precision of some GGMs was also evaluated in Korea. However, some studies dealt with GGMs constructed based on initial GOCE data or others applied a part of GNSS (Global Navigation Satellite System) / Leveling data on UCPs (Unified Control Points) for the precision evaluation. Now, GGMs which have a higher degree than EGM2008 (Earth Gravitational Model 2008) are available and UCPs were fully established at the end of 2019. Thus, EIGEN-6C4 (European Improved Gravity Field of the Earth by New techniques - 6C4), GECO (GOCE and EGM2008 Combined model), XGM2016 (Experimental Gravity Field Model 2016), SGG-UGM-1, XGM2019e_2159 were collected with EGM2008, and their precisions were assessed based on the GNSS/Leveling data on UCPs. Among GGMs, it was found that XGM2019e_2159 showed the minimum difference compared to a total of 5,313 points of GNSS/Leveling data. It is about a 1.5cm and 0.6cm level of improvement compare to EGM2008 and EIGEN-6C4. Especially, the local biases in the northern part of Gyeonggi-do, Jeju island shown in the EGM2008 was removed, so that both mean and standard deviation of the difference of XGM2019e_2159 to the GNSS/Leveling are homogeneous regardless of region (mountainous or plain area). NGA (National Geospatial-Intelligence Agency) is currently in progress in developing EGM2020 and XGM2019e_2159 is the experimentally published model of EGM2020. Therefore, it is expected that the improved GGM will be available shortly so that it is necessary to verify the precision of new GGMs consistently.

• Nutritional Sciences
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• v.7 no.2
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• pp.70-75
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• 2004

The objective of this study was to examine diet-induced changes in the expression of UCP2 mRNA in the liver and UCP3 mRNA in the skeletal muscle of mice fed a high-sucrose or high-fat diet. Male ICR mice, aged 4 weeks, were divided into three dietary groups and fed control (N) or modified AIN-76 high-sucrose (US) or high-fat (HF) diets for 12 weeks. The serum total cholesterol (TC) and LDL-cholesterol concentrations of the HF group were significantly higher than those of the N and HS groups. The hepatic TC and triglyceride contents of the HS and HF groups were also significantly higher than those of the N group. The HS diet group had higher serum leptin and insulin levels compared to those of the HF group. Hepatic UCP2 mRNA expression was significantly higher in the HS group than in the N group, but the level in the HF group did not differ from that of the N group. Muscular UCP3 mRNA level was significantly higher in the HF group and especially in the HS group than in N the group. We observed that two gene (UCP2, 3) levels exhibited a similar tendency. These results suggest that UCPs mRNA levels and energy expenditure may be altered or controlled by various dietary patterns. Further research is needed to elucidate the effects of diet on the regulation of many obesity-related genes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1407-1410
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• 2007

We designed to investigate the relationship the cold-hot theory of herbology and body temperature in experimental model. we prepared four kinds of oriental medicine, which consisted of two cold herbs, Daehwang and Seokgo, and two hot herbs, Buja and Padu. Decrease of body temperature by cold exposure for 12 hour was not inhibited by four herbs oral administration for two weeks. Thermogenesis in mammals is an essential physiological function to maintain the body temperature. Mitochondrial uncoupling proteins(UCPs), which have a potential to generate heat by uncoupling oxidative phosphorylation, apper to play a crucial role in thermogenesis. Therefore UCP is commonly recognized as a key molecule in metabolic thermogenesis and its dysfunction contributes to the development of obesity. In these experiments, Daehwang water extracts inhibited the UCP1 mRNA expression increase by cold exposure in brown adipose tissue. But other herbs did not significantly influence on UCPs mRNA expression in white adipose tissue and seleus muscle tissue. Based on this experiment, we will try to clarify the effects of Daehwang water extracts on UCP1 expression and function.

• Korean Journal of Remote Sensing
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• v.30 no.6
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• pp.829-837
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• 2014

The KOMPSAT-3 can acquire panchromatic stereo image with 0.7 m spatial resolution, and provides Rational Polynomial Coefficient (RPC). In order to determine ground coordinate using the provides RPC, which include interior-exterior orientation errors, its adjustment is needed by using the Ground Control Point (GCP). Several thousands of national Unified Control Points (UCPs) are established and overall distributed in the country by the Korean National Geographic Information Institute (NGII). UCPs therefore can be easily searched and downloaded by the national-control-point-record-issues system. This paper introduced the point-extraction method and the distance-bearing method to detect of UCPs. As results, the distance-bearing method was better detected through the experiment. RPC adjustment using this method was compared with that by only one UCP and GCPs using GPS. The proposed method was more accurate than the other method in the horizontal. As demonstrated in this paper, the proposed UCPs detection method could be replaced GPS surveying for RPC adjustment.

• Journal of Microbiology and Biotechnology
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• v.15 no.4
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• pp.823-830
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• 2005

This study was undertaken to evaluate the effect of bacteria-derived $\beta$-glucan fiber on serum lipids, adiposity and uncoupling protein (UCP) expression in rats. In order to induce obesity, Sprague-Dawley weanling male rats were allowed free access to AIN-76A diet until 4 weeks of age, and fed high-fat diet (beef tallow, $40\%$ of calories as fat) for 6 weeks until 10 weeks of age. Rats were then fed with $0\%$ thigh- fat control group), $1\%$, or $5\%$ bacterial ~-glucan supplemented high-fat diets (w/w) for another 6 weeks. For comparison, normal control group was fed with AIN-76 diet $11.7\%$ fat). Supplementation with bacterial $\beta$-glucan resulted in a significant reduction of high-fat-induced white fat (i.e., visceral and peritoneal fat) development, adipocyte hypertrophy, and development of hyperinsulinemia and hyperleptinemia. Serum triglyceride, total cholesterol, and free fatty acid levels were greatly reduced, but, HDL-cholesterol concentrations were increased by bacterial $\beta$-glucan supplementation. Serum leptin level was lower in the $\beta$-glucan groups than in the high-fat group. The expression of UCPs (UCP1, UCP2, and UCP3) in brown adipose tissue (BAT) were significantly increased by $5\%$ bacterial $\beta$-glucan-containing diet. This study suggests that the anti-obesity effect of $5\%$ bacterial $\beta$-glucan is attributed to upregulation of UCPs and inefficient energy utilization.

• Journal of Korean Medicine for Obesity Research
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• v.6 no.1
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• pp.81-92
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• 2006

Objectives : Recent studies have provided some clues with regard to the relationship existing between uncoupling proteins (UCPs) and blood pressure in animal experiments. In an attempt to determine the genetic polymorphisms of UCPs that are associated with blood pressure in humans, we have analyzed genetic polymorphisms in members of the UCP family, including UCP1, UCP2 and UCP3. Methods : In this study, we assessed the association between UCP genotypes and systolic blood pressure (SBP) and diastolic blood pressure (DBP), in a population comprised of 832 Korean female subjects, using a general linear model, which was adjusted for both age and BMI. Results : Among 14 SNPs and the haplotypes constructed from them, haplotype3 of UCP1 (UCP1-ht3) evidenced significant associations with SBP (P=0.0053) and DBP (P=0.0130). However, this haplotype was not significantly associated with obesity phenotypes, including BMI or fat mass (P>0.05), thereby suggesting that its association with blood pressure was not mediated by obesity phenotypes. Conclusions : The source of variations in SBP were determined to occur in the following order: BMI (12.8 %), age (1.2 %) and UCP1-ht3 (1.1 %). Although BMI appears to exert greater effects on blood pressure, the UCP1-ht3 genotype was also found to exert a significant effect.