• Molecules and Cells
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• 제40권4호
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• pp.271-279
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• 2017

Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal development of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localization studies in cultured cells. Knockdown of ranbp9 resulted in retinal dysplasia with defective proliferation of retinal cells, downregulation of neuronal differentiation marker huC, elevation of neural proliferation marker her4, and alteration of cell cycle marker p57kip2. Expression of the $M{\ddot{u}}ller$ glial cell marker glutamine synthase was also affected in knockdown morphants. Our results suggest that Mind bomb-binding partner RanBP9 plays a role during retinal cell development of zebrafish embryogenesis.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1997년도 추계학술대회 논문집
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• pp.120-126
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• 1997

This paper examines the crack growth behavior of 7075-T651 aluminum alloy under high-low block loading condition. The cantilever beam type specimen with a chevron notch is used in this study. The crack growth and closure are investgated by compliance method. The applied initial stress ratios are R=-0.5, R=0.0 and R=0.25 Crack length($\alpha$), effective stress intensity factor range(ΔKeff), ratio of effective stress intensity factor range(U) and crack growth rate(d$\alpha$/dN) etc. are inspected fracture mechanics estimate.

• 대한후두음성언어의학회지
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• 제8권1호
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• pp.65-68
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• 1997

The mutational falsetto is failure to change from the higher pitched voice of preadolescence to the lower pitched voice of adolescence and adulthood. The one of characteristic findings is contraction of suprahyoid muscles. The large majority of young men with inappropriately high voice have excellent voice therapy prognosis. We have experienced one case of mutational falsetto treated with botulinum toxin injection on suprahyoid muscles. His suprahyoid muscles are contracted markedly simultaneously with each phonation. fundamental frequency$(F_0)$ of his vowel phonation was 332Hz. Extensive voice therapy including manual compression of thyroid notch was ineffective. Forty units of Botox$^{\circledR}$ was injected under the EMG-guidance(20U bilaterally). At seven days post-injection, his voice changed lower than before and at 40 days after procedure, his $F_0$ was 126Hz.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1996년도 추계학술대회 논문
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• pp.194-197
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• 1996

The high-strength aluminum alloy 7075-T651 was used to observe the fatigue-crack-propagation behavior for the various stress ratios with constant amplitude loading and thus to predict the fatigue life. With a chevron notch in the specimen the fatigue-crack-propagation behavior of through crack was investigated. Crack propagation behavior of through crack in the depth direction and crack growth of weldments were experimentally studied. Base material heat affected zone and weld material were considered in the fracture of weldments. The change of crack-propagation length with respect to several parameters such as stress intensity factor range(ΔK) effective stress intensity factor range(ΔKeff)ration of effective stress intensity factor range(U) stress intensity factor of crack opening point(K op) maximum stress intensity factor(K max) and number of cycles(Nf)was determined. The crack length of through crack of weldments was 2.4mm and the remaining part was a base material. The experiment was accomplished by making the crack propagate near the base material.

• 한국표면공학회지
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• 제24권1호
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• pp.16-16
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• 1991

Generally brittle eta phase produced during TiC deposition has a effect on the TRS (transverse rupture strength ; thoughness). Therefore it is necessary to reduce eta(η), phase for the improvement of tool life. At this experiment some properties (TRS, bonding strength, tool life, eta phase)have been investigated by inserting TiN or TiCN underlayer between TiC layer and substrate. The results obtained were as follows; 1. by inserting underlayer eta phase were decreased and TRS was increased, but the bonding strength was decreased. 2. the diffusion of W, Co from the substrate was hindered by the underlayer. 3. TiC layer with TiCN underlayer had the finsest grain size. 4. by inserting underlayer (TiCN or TiN) the tool life was improved and especially notch and crater wear resistance was greatly improved.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2013년도 전력전자학술대회 논문집
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• pp.130-131
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• 2013

In this paper, it suggests offset compensation method of output current in single phase PV-BES system which is connected with grid. The algorithm applied removes grid's frequency ingredient using a notch filter and it extracts only DC offset current. It can reduce problems as saturation of power transformer cause by DC current when it is indoctrinated to grid.

• 치과방사선
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• 제21권1호
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• pp.7-13
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• 1991

하악절흔 내측 함요는 하악골의 하악절흔 전, 내, 하방에 함몰된 양상으로 나타나는 정상 해부학적 구조물이다. 이 구조물에 대한 해부학적 중요성이나, 발생이 선천적인가 아니면 출생 후 발생되는 것인가에 대하여는 알려져 있지 않다. Langlais는 하악절흔내측함요는 파노라마 방사선사진상에서 절흔, 또는 소공 모양의 방사선투과상으로 나타난다고 하였지만 이는 하악사측방향 촬영상 등에서도 나타날 수 있는 해부학적 구조물이다. 파노라마 방사선사진에서는 익상판, 연구개, 기도, 그외 다른 조직 등의 중첩으로 인하여, 이 구조물의 발견 빈도가 낮아진다. 저자는 78개의 하악골에서의 발생빈도, 위치, 크기 등을 조사하고, 이를 파노라마 방사선사진촬영하여 그 발생 빈도를 조사하였으며, 치과환자 500명의 파노라마 방사선사진에서의 발생 빈도도 알아보았다. 1. 하악골에서의 발생빈도는 62%였다(편측성 28%, 양측성 33%). 2. 하악골의 파노라마 방사선사진상의 발생빈도는 33%였다(편측성 14%, 양측성 19%). 3. 하악절흔내측함요의 중심 위치는 하악절흔 하방 6.0㎜, 전방 3.8㎜였다. 4. 크기는 수직 7.8㎜, 수평 8.3㎜이였다. 5 치과환자들의 파노라마 방사선사진상에서의 발생 빈도는 24%였다(편측성 18%, 양측성 7%).

• 대한기계학회논문집A
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• 제26권9호
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• pp.1746-1752
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• 2002

Fatigue fracture in machine components is produced by surface micro-crack from stress concentration area such as notch and material defect. It is difficult to predict the remaining fatigue lift of mechanical components because the surface micro-crack on critical area initiates and grows with statistical distribution. Plane bending fatigue tests were carried out on the plain specimen of Al 2024-T3 and the initiation and growth behavior of surface micro cracks were observed. The statistical distribution of surface length of multiple micro cracks and their maximum length were investigated. The maximum surface crack length distributions were analyzed on the basis of the statistics of extremes in order to examine the prediction of remaining life.

• 한국생산제조학회지
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• 제26권2호
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• pp.151-157
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• 2017

Hydraulic equipment have been traditionally used for constructing machines with high power density and durability. In particular, pumps and motors are considered essential equipment, and are consistently investigated to find suitable methods for optimal utilization of their characteristics. A kinematic analysis of a swash-plate-type piston motor model using the hydraulic analysis program SimulationX$^{(R)}$ to model a nine-piston motor and simulate a swash-plate angle with a low-pulsation and high-efficiency performance of the motor has been provided in this paper. Finally, along with the theoretical consideration of the stroke, the effect of changing strokes and notch shape (V, U, non-type) on the pulsation is simulated to analyze and determine the effects of reduction in pulsation. The optimal swash-plate angle and stroke thus obtained will reduce the trial and error in future design.

• 대한치과기공학회지
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• 제21권1호
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• pp.55-65
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• 1999

So far, I Conducted an examination with focus on the type, characteristic, and test methods of impact test. which is a type of mechanical that evaluate materials. As mentioned previously, in testing soldering strength of soldering is the load when the object under experiment is broken down with the result of flexibility test or peel test. In this method, a hevay load is necessary until alloy of parent metal is bended, if the alloy of the parent metal has a large mechanical quality(peel strength or resisting power). Once the alloy of the parent metal is bended, however, it tends to come into pieces abruply form the part where soldered. Therefore, a metal has a high breakdown value if the degree of strength of its parent metal is high even if the result of measurement indicates otherwise. Thus, the result of the test did not correspond to the clinical result. Therefore, this study concludes as the following from a test of strength of soldering by mean of conducting an impact test, which is a type of mechanical evaluation methods : 1. Among various impact tests, a charpy thpe is more appropriate than the izod type in testing strength of soldering. 2. As far as test piece is concerned, to use subsized impact test piece is appropriate in the impact test in that it does not have notch. 3. In the matter of analysis, it is appropriate to measure absorbing energy which results from rupture of test piece.