• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.586-591
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• 2010

Chemokine and Growth Factor are major mediumtors of immuno-inflammatory pathway. The purpose of this study is to investigate whether productions of Chemokine and Growth Factor in lipopolysaccharide (LPS)-induced mouse macrophage RAW 264.7 cells are modulated by Gallic acid (GA), which is easily founded in tannin-containing natural materials such as red wine, green tea, grape juice, and Corni Fructus. Productions of Chemokine and Growth Factor were analyzed by High-throughput Multiplex Bead based Assay with Bio-plex Suspension Array System based on $xMAP^{(R)}$ (multi-analyte profiling beads) technology. At first, cell culture supernatant was obtained after treatment with LPS and GA for 24 hour. Then, the antibody-conjugated beads were added and incubated for 30 minutes. After incubation, detection antibody was added and incubated for 30 minutes. And Strepavidin-conjugated Phycoerythrin (SAPE) was added. After incubation for 30 minutes, the level of SAPE fluorescence was analyzed on Bio-plex Suspension Array System. Based on fluorescence intensity, concentrations of Chemokine and Growth Factor were determined. The results of the experiment are as follows. GA significantly inhibited the production of interferon-inducible protein (IP)-10, keratinocyte-derived chemokine(KC), and vascular endothelial growth factor (VEGF) in LPS-induced RAW 264.7 cells at the concentration of 25, 50, 100, 200 uM (p<0.05). GA significantly inhibited the production of monocyte chemoattractant protein-1(MCP-1) and macrophage-colony stimulating factor(M-CSF) in LPS-induced RAW 264.7 cells at the concentration of 50, 100, 200 uM (p<0.05). GA diminished the production of granulocyte macrophage-colony stimulating factor (GM-CSF) in LPS-induced RAW 264.7 cells. But GA did not show the inhibitory effect on the production of leukemia inhibitory factor (LIP) and macrophage inflammatory protein (MIP)-2 in LPS-induced RAW 264.7 cells. These results suggest that GA has the immuno-modulating activity related with its inhibitory effects on the production of IP-10, KC, MCP-1, VEGF, and M-CSF in LPS-induced macrophages.

• Journal of Microbiology and Biotechnology
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• v.30 no.4
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• pp.583-590
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• 2020

Deinococcus actinosclerus BM2^T (GenBank: KT448814) is a radio-resistant bacterium that is newly isolated from the soil of a rocky hillside in Seoul. As an extremophile, D. actinosclerus BM2^T may possess anti-inflammatory properties that may be beneficial to human health. In this study, we evaluated the anti-inflammatory effects of BM2U, an aqueous extract of D. actinosclerus BM2^T, on lipopolysaccharide (LPS)-mediated inflammatory responses in RAW264.7 macrophage cells. BM2U showed antioxidant capacity, as determined by the DPPH radical scavenging (IC₅₀ = 349.3 ㎍/ml) and ORAC (IC₅₀ = 50.24 ㎍/ml) assays. At 20 ㎍/ml, BM2U induced a significant increase in heme oxygenase-1 (HO-1) expression (p < 0.05). BM2U treatment (0.2-20 ㎍/ml) significantly suppressed LPS-induced increase in the mRNA expression of proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 (p < 0.05). BM2U treatment also suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are involved in the production of inflammatory mediators. BM2U treatment also inhibited the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs): JNK, ERK, and p-38 (p < 0.05). Collectively, BM2U exhibited anti-inflammatory potential that can be exploited in attenuating inflammatory responses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2769-2777
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• 2014

This research herein aims to assist maximizing performance of introduced systems by managing the acceptance factor of uTradeHub that is easily overlooked in the system installation process by trading companies aiming to install uTradeHub system in future by conducting the two following things: i) grasping factors affecting system usefulness and user satisfaction derived from uTradeHub acceptance factor, and ii) analyzing the effect relationship of system usefulness on user satisfaction at an inspection level of system usefulness and user satisfaction, since the uTradeHub system introduced for mid- and small-sized trading companies in export and import works in mid-2008. Proof analysis was conducted by using SPSS 19.0 statistic package on data of 112 effective responses collected through questionnaire surveys, whose results are as follows. First, the uTradeHub acceptance factors having a significant effect on system usefulness are relative advantage, easy of use, task adaptedness, support of CEO, maturity of IT infrastructures, and degree of education/training. Second, the uTradeHub acceptance factors having an effect on user satisfaction are relative advantages, task adaptedness, support of CEO, maturity of IT infrastructures, and degree of education/training. Third, system usefulness showed a significant effect on user satisfaction.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1803-1806
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• 2013

Purpose: Carbohydrate antigen (CA) 242 is inversely related to prognosis in many cancers. However, few data regarding CA 242 in esophageal cancer (EC) are available. The aim of this study was to determine the prognostic value of CA 242 and propose an optimum cut-off point in predicting survival difference in patients with esophageal squamous cell carcinoma (ESCC). Methods: A retrospective analysis was conducted of 192 cases. A receiver operating characteristic (ROC) curve for survival prediction was plotted to verify the optimum cuf-off point. Univariate and multivariate analyses were performed to evaluate prognostic parameters for survival. Results: The positive rate for CA 242 was 7.3% (14/192). The ROC curve for survival prediction gave an optimum cut-off of 2.15 (U/ml). Patients with CA 242 ${\leq}$ 2.15 U/ml had significantly better 5-year survival than patients with CA 242 >2.15 U/ml (45.4% versus 22.6%; P=0.003). Multivariate analysis showed that differentiation (P=0.033), CA 242 (P=0.017), T grade (P=0.004) and N staging (P<0.001) were independent prognostic factors. Conclusions: Preoperative CA 242 is a predictive factor for long-term survival in ESCC, especially in nodal-negative patients. We conclude that 2.15 U/ml may be the optimum cuf-off point for CA 242 in predicting survival in ESCC.

• Ocean and Polar Research
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• v.25 no.spc3
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• pp.353-360
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• 2003

Estimation of undrained shear strength $(S_u)$ of clayey soils from piezocone penetration test (CPTu), which has widely been known as one of very promising in situ test methods, requires piezocone factors. Empirical correlations are generally utilized to derive piezocone factors, but previous studies on the empirical piezocone factors are site-specific and in some cases need engineering characteristics, which should be obtained from additional laboratory tests. In this study, empirical cone factors were evaluated by comparing 6 CPTu results at Shihwa region in Korea with reference $S_u$ values obtained from field vane test (FVT). From previous CPTu results of other regions in Korea as well as the results herein, the correlations between piezocone factor, $N_{kT}$ and CPTu results were investigated and three simplified evaluation methods of $S_u$ using only CPTu results were presented. The $S_u$ values estimated by $(q_T-{\sigma}_v)/{\sigma}'_v$ method shows better matches with those obtained from laboratory tests for marine clays at Shihwa region.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1997.11a
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• pp.60-63
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• 1997

Dieletric ailed piezoelectric properties of Pb[$Zr_{0.45}$/ $Ti_{0.5-x}$/L $u_{x}$ (M $n_{1}$3//S $b_{2}$3)$_{0.05}$] $O_3$(0$\leq$x $\leq$0.03) were investigated. The partial substitution of $Ti^{4+}$ by a L $u^{3+}$ permitted improvement of the piezoelectric constant( $d_{33}$ ), electromechanical coupling factor ( $k_{p}$ ) and dielectric constant($\varepsilon$$_{33}$ /Sup T/). The dielectric loss(tan $\delta$ ) increased and mechanical quality factor(Qm) decreased with an increase of x were observed. A new piezoelectric material for actuator application was developed at x=0.02 with $d_{33}$ =370$\times$10$^{-2}$ /C/N, $k_{p}$ =58.5%, $\varepsilon$$_{33}$ $^{T}$ =1321, $Q_{m}$ =714 and tan $\delta$ =0.98%.%..%.%.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.34 no.3
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• pp.87-93
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• 2018

Ground source heat pump(GSHP) system is one of the high efficiency heat source systems which utilizes the constant geothermal energy of a underground water or soil. However, the design of conventional GSHP system in the domestic market is dependent on the experience of the designer and the installer, and it causes increase of initial installation cost or degradation of system performance. Therefore, it is necessary to develop a guideline and the optimal design method to maintain stable performance of the system and reduce installation cost. In this study, in order to optimize the GSHP system, design factors according to ground heat exchanger(GHX) type have been examine by simulation tool. Furthermore, the design factors and the correlation of a single U-tube and a double U-tube were analyzed quantitatively through sensitivity analysis. Results indicated that, the length of the ground heat exchanger was greatly influenced by grout thermal conductivity for single U-tube and pipe spacing for double U-tube.

• Bulletin of the Korean Mathematical Society
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• v.42 no.3
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• pp.501-507
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• 2005

A Boolean matrix with rank 1 is factored as a left factor and a right factor. The perimeter of a rank-1 Boolean matrix is defined as the number of nonzero entries in the left factor and the right factor of the given matrix. We obtain new characterizations of rank preservers, in terms of perimeter, of Boolean matrices.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2007.10a
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• pp.296-299
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• 2007

The focus of this study is to estimate the stiffness factor of the separator plate of MCFC (Molten Carbonate Fuel Cell) at the elevated temperature. The process factors affecting the stiffness of the separator plate were chosen to determine the most important factor using the finite element analysis with the Taguchi method. The most influential factor, picked out by the ANOYA, turned out the pitch in the separator plate.

• Journal of the Korean Statistical Society
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• v.12 no.1
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• pp.36-45
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• 1983

After every decennial census in the U.S., national surveys such as the Consumer Expenditures surveys are redesigned. The redesigned samples will be multi-stage systematic samples. Many sampling schemes have been proposed for comparison which requires the estimation and variance estiamtion formula. This paper deals with the surveys redesign research which concerns the sample design within the Primary Sampling Unit (PSU). In constructing the estimators it deals with the problem of which first stage inflation factor to use. The expected value of the proposed estimators is also derived.