• Title/Summary/Keyword: U-Capability

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Targeting Orthotopic Glioma in Mice with Genetically Engineered Salmonella typhimurium

  • Wen, Min;Jung, Shin;Moon, Kyung-Sub;Jiang, Shen Nan;Li, Song-Yuan;Min, Jung-Joon
    • Journal of Korean Neurosurgical Society
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    • v.55 no.3
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    • pp.131-135
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    • 2014
  • Objective : With the growing interests of bacteria as a targeting vector for cancer treatment, diverse genetically engineered Salmonella has been reported to be capable of targeting primary or metastatic tumor regions after intravenous injection into mouse tumor models. The purpose of this study was to investigate the capability of the genetically engineered Salmonella typhimurium (S. typhimurium) to access the glioma xenograft, which was monitored in mouse brain tumor models using optical bioluminescence imaging technique. Methods : U87 malignant glioma cells (U87-MG) stably transfected with firefly luciferase (Fluc) were implanted into BALB/cAnN nude mice by stereotactic injection into the striatum. After tumor formation, attenuated S. typhimurium expressing bacterial luciferase (Lux) was injected into the tail vein. Bioluminescence signals from transfected cells or bacteria were monitored using a cooled charge-coupled device camera to identify the tumor location or to trace the bacterial migration. Immunofluorescence staining was also performed in frozen sections of mouse glioma xenograft. Results : The injected S. typhimurium exclusively localized in the glioma xenograft region of U87-MG-bearing mouse. Immunofluorescence staining also demonstrated the accumulation of S. typhimurium in the brain tumors. Conclusion : The present study demonstrated that S. typhimurium can target glioma xenograft, and may provide a potentially therapeutic probe for glioma.

Determination of Source Contribution Based on Aerosol Number and Mass Concentration in the Seoul Subway Stations (분진의 개수농도 및 질량농도에 입각한 서울시 지하철 역사 내 오염원의 기여도 결정)

  • 최형욱;황인조;김신도;김동술
    • Journal of Korean Society for Atmospheric Environment
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    • v.20 no.1
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    • pp.17-31
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    • 2004
  • The subway play an important part in serious traffic problems. However, because subway system is a closed environment, many serious air pollution problems occurred in subway stations and injured passenger's health. Therefor, it is a necessary to identify sources and to estimate pollutant sources in order to protect passenger's health and to keep clean subway environment. The purpose of this study was to analyze a air quality in the subway stations and to apply a new receptor methodology for quantitatively estimate of PM10 sources. In this study, the size distributions of particulate matters has been measured by using Aerosizer LD (U.S.A., API, Inc.). It's real time measurement capability of time-of-flight technique offers a significant advantage of user convenience and air pollution management. Also, the mass concentrations of PM 10 has been measured by using mini-vol portable sampler (U.S.A., Airmetrics Co.). The sampling performed in Seoul subway stations during the period of February 2000 and April 2000. The number distribution data used in this study consisted of 26 raw data sets in the Jongno-sam-ga station. Correlation Analysis can be used in subway stations for source separation and identification. Then, number contribution from each source is determined by the particle number balance (PNB). The mass concentration data used in this study consisted of 31 raw data in the 8 different stations. The mass contributions of PM10 sources in the concourse by using PMF/CMB model.

Aging and Scientific Performance: An Empirical Study on Korean University Researchers

  • Chung, Sungchul
    • STI Policy Review
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    • v.6 no.2
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    • pp.1-23
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    • 2015
  • This study aims to contribute to the debate over the age-productivity relationships in scientific and technological research. For this purpose, we conducted an empirical experiment employing a time-series cross-section dataset derived from the KRI of the NRF containing data on individual researchers of fifty major universities in Korea covering the period of 2008-2013. This study has found that: (1) there exists an inverse U-shaped age-productivity relationship at the level of individual researchers; (2) the impact of the average age of a research group on the productivity of individual researchers varies across fields; (3) male and female researchers move along different age-productivity curves; and (4) the inverse U-shaped age-productivity relationship also holds at the level of organizations. The results suggest that the aging of researchers in Korea will soon reach the stage where serious losses in research productivity become a reality. Yet, it is not so clear whether the observed decline in the performance of older researchers is due to declining cognitive capability, which is an unavoidable result of aging, or to declining motivation, which results from an institutional system that discourages older researchers' research activities (such as reduced access to research opportunities or mandatory retirement). What is clear is that it is inevitable for the Korean science system to change the current seniority- and age-based organizational system into one of higher adaptability.

Reforms of Social Security System : Social Assistance Programmes in the U.K. (영국 사회보장제도의 개혁 : 사회부조(Social Assistance)를 중심으로)

  • Shin, Dong-Myeon
    • Korean Journal of Social Welfare
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    • v.46
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    • pp.178-209
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    • 2001
  • This paper aims to provide a critical assesment of Conservatives's and new Labour's social assistance reforms in the U.K. and their differential impacts on low income groups. During the period of 18 years in power, the Conservative governments enforced benefit recipients being capable of work to be out of benefits and to get into work. They employed not only 'carrots' to encourage beneficiaries being capable of work to have full-time work, but also 'sticks' to discourage them to depend on benefits. The reforms under the Conservative governments were closer to the workfare model. The new Labour government has continued to emphasize work regarding social security reform. It has raised 'from welfare to work' as the main reform objective. However, it has not necessarily focused on 'carrots and sticks' in order to get beneficiaries into work. Instead, the new Labour government has put its priority regarding social assistance reform on human capital development in order to develop the capability of beneficiaries for work. Britain under the new Labour government seems to be moving from workfare to activation model. These differentials between the Conservative governments and the new Labour government regarding social assistance reforms bring about the different policy outcomes. Under the Conservative government, social assistance programmes were prone to strengthen the state's control over benefit recipients and to increase stigma to them. Punitive, demeaning, stigmatising programmes of work and unending job search activities harm the bases of self-respect. On the contrary, the activation programmes under the new Labour government has contributed positively to both socially significant participation and autonomy of beneficiaries.

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A Study on the Plan for the Masterpiece Tourism Assets of Traditional Cultural Resources Based on the Ubiquitous IT (U - 정보기술에 기반한 전통문화자원의 명품 관광자산화 방안)

  • Kim, Chang Su;Lee, Sung Ho;Park, Joon Ho;Park, Gyeong Won
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.8 no.2
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    • pp.145-160
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    • 2012
  • The globe-trotting trend has been converted from tourism for the simple purposes of sightseeing and enjoyment to a form of learning and practicing the more specialized contents by directly participation. Traditional cultural resources have sufficient potential as culture and tourism assets that fit this kind of trend. Therefore, building proper tourist resources for their application has become a very urgent and important matter. To make masterpiece tourism packages through combined services of traditional cultural resources, it is necessary for operators to ponder diverse methods that can be used to develop various experience programs and conserve traditional cultural properties by continuously generating profits. The major results of this research are as follows. Firstly, this study proposes plans for unified tourist information and combined services of traditional cultural resources based on ubiquitous IT. Secondly, it is ascertained that the organization of combined operational consultative groups and the improvement of operator' capability are required to execute combined services of traditional cultural resources. Thirdly, we propose business plans to generate profits in both product aspect and network aspect.

RFID-based Supply Chain Process Mining for Imported Beef

  • Kang, Yong-Shin;Lee, Kyounghun;Lee, Yong-Han;Chung, Ku-Young
    • Food Science of Animal Resources
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    • v.33 no.4
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    • pp.463-473
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    • 2013
  • Through the development of efficient data collecting technologies like RFID, and inter-enterprise collaboration platforms such as web services, companies which participate in supply chains can acquire visibility over the whole supply chain, and can make decisions to optimize the overall supply chain networks and processes, based on the extracted knowledge from historical data collected by the visibility system. Although not currently active, the MeatWatch system has been developed, and is used in part for this purpose, in the imported beef distribution network in Korea. However, the imported beef distribution network is too complicated to analyze its various aspects using ordinary process analysis approaches. In this paper, we suggest a novel approach, called RFID-based supply chain process mining, to automatically discover and analyze the overall supply chain processes from the distributed RFID event data, without any prior knowledge. The proposed approach was implemented and validated, by using a case study of the imported beef distribution network in Korea. Specifically we demonstrated that the proposed approach can be successfully applied to discover supply chain networks from the distributed event data, to simplify the supply chain networks, and to analyze anomaly of the distribution networks. Such novel process mining functionalities can reinforce the capability of traceability services like MeatWatch in the future.

U.S. Navy next generation Aegis Ships and AMDR(Air & Missile Defense Radar) (미 해군의 차기 이지스함과 AMDR)

  • Kim, Soo-hong;Kim, Young-ho;Park, Tae-yong
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.462-464
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    • 2015
  • Since the first Aegis Cruiser USS Ticonderoga was constructed, Arleigh Burke class destroyers are being mass constructed as U.S. Naval capital surface ships and consistently improved the performance. In recent years, the newest aegis combat system, Baseline 9, was deployed. Aegis BMD, aegis ships which have BMD capability, is participated BMDS(Ballistic Missile Defense System) as a sea based BMD. And AN/SPY-1D will be replaced by AMDR(Air & Missile Defense Radar), advanced anti-air radar system to defend effectively against increased ballistic missiles threat from DDG-51 Flight III. In this paper, development status and technical characteristics of each type of aegis ships are researched and characteristics of AMDR are surveyed and described.

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Ubiquitous u-Health System using RFID & ZigBee (RFID와 ZigBee를 이용한 유비쿼터스 u-Health 시스템 구현)

  • Kim Jin-Tai;Kwon Youngmi
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.43 no.1 s.343
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    • pp.79-88
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    • 2006
  • In this paper, we designed and implemented ubiquitous u-Health system using RFE and ZigBee. We made a wireless protocol Kit which combines RFE Tag recognition and ZigBee data communication capability. The software is designed and developed on the TinyOS. Wireless communication technologies which hold multi-protocol stacks with RFID and result in the wireless ubiquitous world could be Bluetooth, ZigBee, 802.11x WLAN and so on. The environments that the suggested u-Health system may be used is un-manned nursing, which would be utilized in dense sensor networks such as a hospital. The the size of devices with RFID and ZigBee will be so smaller and smaller as a bracelet, a wrist watch and a ring. The combined wireless RFID-ZigBee system could be applied to applications which requires some actions corresponding to the collected (or sensed) information in WBAN(Wireless Body Area Network) and/or WPAN(Wireless Person Area Network). The proposed ubiquitous u-Health system displays some text-type alert message on LCD which is attached to the system or gives voice alert message to the adequate node users. RFE will be used as various combinations with other wireless technologies for some application-specific purposes.

A Review and Its Implications on School-based Crisis Response Team in the U.S. (미국의 학교기반 위기대응팀에 대한 고찰과 시사점)

  • Lee, Dong Hun;Jeong, Bo Young;Kang, Eun Jin;Myung, So Yeon
    • Korean Journal of Comparative Education
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    • v.27 no.1
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    • pp.1-28
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    • 2017
  • In this study, the school crisis response system and intervention are examined in the U.S. by reviewing Crisis Response Team(CRT) to give a direction for establishing and improving the school crisis response system in Korea. To do this, a literature review has been conducted focusing on domestic and foreign literature on the school - based crisis response system about the U.S. and Korea. The characteristics of the school-based CRT in the U.S. are as follows. First, in the U.S., the organizational structure and financial support for school - based crisis response has been stated by law so that the roles and responsibilities of region, district, school have been clearly defined. Second, in the event of a school crisis, the school have been shared the role of professional crisis response according to the Incident Command System and coordinates communication smoothly between each area of society through cooperation with CRT. Third, CRT prevents burnout by showing flexibility in team composition so that CRT members are not tired or overwhelmed by a crisis event, and focuses on strengthening the crisis capability of the school itself through cooperation between the school and CRT. Fourth, the school-based CRT in the U.S. conducts a step by step crisis intervention from prevention to prolonged post management. Based on these results, implications for the establishment and improvement of school-based crisis response system in Korea are discussed.

South Korea's strategy to cope with local provocations by nuclear armed North Korea (핵위협하 국지도발 대비 대응전략 발전방향)

  • Kim, Tae-Woo
    • Strategy21
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    • s.31
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    • pp.57-84
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    • 2013
  • North Korea's continuous threats and provocative behaviors have aggravated tension on the Korean peninsula particularly with the recent nuclear weapons test. South Korea's best way to cope with this situation is to maintain the balance among three policy directions: dialogue, sanctions, and deterrence. Among the three, I argue that deterrence should be prioritized. There are different sources of deterrence such as military power, economic power, and diplomatic clouts. States can build deterrence capability independently. Alternatively, they may do so through relations with other states including alliances, bilateral relations, or multilateral relations in the international community. What South Korea needs most urgently is to maintain deterrence against North Korea's local provocations through the enhancement of independent military capability particularly by addressing the asymmetric vulnerability between militaries of the South and the North. Most of all, the South Korean government should recognize the seriousness of the negative consequences that North Korea's 'Nuclear shadow strategy' would bring about for the inter-Korea relations and security situations in Northeast Asia. Based on this understanding, it should develop an 'assertive deterrence strategy' that emphasizes 'multi-purpose, multi-stage, and tailored deterrence whose main idea lies in punitive retaliation.' This deterrence strategy requires a flexible targeting policy and a variety of retaliatory measures capable of taking out all targets in North Korea. At the same time, the force structures of the army, the air force, and the navy should be improved in a way that maximizes their deterrence capability. For example, the army should work on expanding the guided missile command and the special forces command and reforming the reserve forces. The navy and the air force should increase striking capabilities including air-to-ground, ship-to-ground, and submarine-to-ground strikes to a great extent. The marine corps can enhance its deterrence capability by changing the force structure from the stationary defense-oriented one that would have to suffer some degree of troop attrition at the early stage of hostilities to the one that focuses on 'counteroffensive landing operations.' The government should continue efforts for defense reform in order to obtain these capabilities while building the 'Korean-style triad system' that consists of advanced air, ground, and surface/ subsurface weapon systems. Besides these measures, South Korea should start to acquire a minimum level of nuclear potential within the legal boundary that the international law defines. For this, South Korea should withdraw from the Nuclear Non-proliferation Treaty. Moreover, it should obtain the right to process and enrich uranium through changing the U.S.-South Korea nuclear cooperation treaty. Whether or not we should be armed with nuclear weapons should not be understood in terms of "all or nothing." We should consider an 'in-between' option as the Japanese case proves. With regard to the wartime OPCON transition, we need to re-consider the timing of the transition as an effort to demonstrate the costliness of North Korea's provocative behaviors. If impossible, South Korea should take measures to make the Strategic Alliance 2015 serve as a persisting deterrence system against North Korea. As the last point, all the following governments of South Korea should keep in mind that continuing reconciliatory efforts should always be pursued along with other security policies toward North Korea.

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