• Journal of dental hygiene science
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• v.19 no.2
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• pp.141-146
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• 2019

Background: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival. Lysophosphatidic acid (LPA) is a bioactive lipid mediator that promotes various cellular processes, including cell survival, proliferation, metastasis, and invasion. Signal transducer and activator of transcription (STATs) are transcription factors that mediate gene expression. Among the seven types of STATs in mammals, STAT3 is involved in invasion and metastasis of numerous tumors. However, little is known about the role of STAT3 in oral tumor invasion. In the present study, we hypothesized that STAT3 mediates LPA-induced oral cancer invasion. Methods: Immunoblotting was performed to analyze LPA-induced STAT3 activation. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was performed to assess the survival rates of YD-10B cells. STAT3 levels in LPA-treated oral tumor cells were evaluated by performing in vitro invasion assay. Results: To the best of our knowledge, this is the first study to demonstrate that LPA enhances STAT3 phosphorylation in oral cancer. In addition, treatment with WP1066, a selective inhibitor of STAT3, at a concentration that does not cause severe reduction in cell viability, significantly attenuated LPA-induced YD-10B cancer cell invasion. Conclusion: The results suggested that LPA induces oral tumor cells with greater invasive potential via STAT3 activation. Our findings provided important insights into the mechanisms underlying mouth neoplasms.

• Journal of the Korean Society of Tobacco Science
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• v.29 no.2
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• pp.140-145
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• 2007

Acrylamide has been found in many foods. Acrylamide in foodstuffs were analyzed by a GC/MS after bromination of acrylamide or by a LC/MS for underivatized acylamide. Time consuming and laborious clean up procedures is applied for the purification of the extract, in these methods. In this study, a simple and fast method without clean up step for the analysis of acrylamide in mainstream cigarette smoke was developed by using liquid chromatography-tandem mass spectrometry (LC/MS/MS) and the effects of tobacco leaf constituents on acrylamide content was observed. The analysis of acrylamide in mainstream cigarette smoke started to collect TPM (total particulate matter) from smoking and to extract by 0.1 % acetic acid solution and then to detect by liquid chromatography tandem mass spectrometry using electrospray in the positive mode. The recovery of acrylamide in 2R4F reference cigarette was 98 % and the reproducibility was 2.5 % and the limit of detection was 1.6 ng/mL. Reducing sugars and amino acids are considered to be main precursors of acrylamide in foodstuffs. Cut tobacco contain substantial amounts of reducing sugars and amino acid which may be explained the occurrence of acrylamide in mainstream cigarette smoke. The effects of reducing sugars and total nitrogen studied in an experiment with a various tobacco types. This result indicated that reducing sugars are not limiting factor for acrylamide formation, but the level of acrylamide in cigarette smoke was significantly correlated with the total nitrogen contents.

• Journal of East-West Nursing Research
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• v.5 no.1
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• pp.50-64
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• 2000

The purpose of this study was to investigate the correlation of family support, self-esteem and life-satisfaction in homeless persons and to provide basic data to help them attain a better quality of life. From Jul. 1 to Oct. 10, 2000, 235 homeless persons, registered at the noninstitutionalized homeless and institutionalized homeless in Seoul, were accepted as subjects for the study. The instruments used for this study were a Family support scale of Park, Jee Won, life-satisfaction scale of Wood, Wylie & Sheafer and Rosenberg's Self-esteem Scale. The reliability of the scales were tested by Cronbach's Alpha. The collected data Were analyzed by the SPSS program using unpaired t-test and Pearson's Correlation Coefficients. The results were as follows : 1. There Was a statistically significant difference in the level of demographic between family support groups : age(t=2.74, P=.001), education background(f=5.48, P=.001), connection of family (t=2.29, P=.05), present illness(t=2.04, P=.05). 2. There Was a statistically significant difference in the level of demographic between self-esteem groups : education background(t=3.24, P=.05), connect of family (t=3.38, P=.001), types of disease(t=2.12, P=.05), job related to income (t=2.12, P=.05). 3. There Was a statistically significant difference in the level of demographic between life-satisfaction groups : education background(t=3.39, P=.05), connect of family(t=2.10, P=.01), smoking(t=2.38, P=.01), disease(t=1.92, P=.05), emotion states(t= 6.12, P=.001). 4. There was a positive correlation between family support and self-esteem for the homeless and it was statistically significant (r=.267, p=.001). 5. There was a positive correlation between family support and life-satisfaction for the homeless and it was statistically significant(r=.299, p=.001). 6. There was a positive correlation between life-satisfaction and self-esteem for the homeless and it was statistically significant(r=.179, p=.01).

• The Journal of Korean Society for School & Community Health Education
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• v.11 no.1
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• pp.117-134
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• 2010

Background & Objectives: Recently, problems such as in-school violence of teenagers, gang fight, habitual drinking, smoking, running away from home and group isolation can be regarded as the most fundamental causes of teenagers' deviation. It is said that such fundamental causes are originated from their home, the base for the psychological and behavioral development. Methods: In this study, the data for 3,188 students studying in the 3rd grade at middle school, which have been obtained from the second year survey for the panel of the 2nd grade students in 2004 by to Korea Youth Panel Survey, have been used for the analysis of the study. Results: According to the result of the study, there seems to be no difference between two genders for differences of average values. Regarding the analysis of correlation coefficients between such related variables as domestic violence, self-control, self-worth, self-trust and family relationship (sociability), and teenagers' deviation, When variables increase, teenagers' deviation decreases. Regarding the relationship between domestic violence and teenagers' deviation, physical violence is more related than lingual violence. The relationship between self-control and teenagers' deviation is the highest. By studying the deviation of teenagers exposed to domestic violence and carrying out the regression analysis, physical violence influences, teenagers' deviation was greater. As self-control, self-worth and family relationship(sociability) increase, teenagers' deviation decreases. Regarding the analytic results of this study, the experience of domestic violence seems to influence teenagers' deviation greatly. Among various types of domestic violence, physical violence is analyzed to influence teenagers' deviation greatly. Self-control, self-worth and family relationship(sociability) increase, teenagers' deviation decreases. Conclusions: In order to prevent teenagers' deviation and decrease the second conviction rate, it is necessary to provide a method of decreasing the domestic violence. It is necessary for schools and local communities to provide social support for teenagers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup1
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• pp.79-84
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• 2016

Graphic health warnings (GHW) on tobacco packages have proven to be effective in increasing quit attempts among smokers and reducing initial smoking among adolescents. This research aimed to examine the relative importance of different attributes of graphic health warnings on tobacco packages in Viet Nam. A discrete choice experimental (DCE) design was applied with a conditional logit model. In addition, a ranking method was used to list from the least to the most dreadful GHW labels. With the results from DCE model, graphic type was shown to be the most important attribute, followed by cost and coverage area of GHW. The least important attribute was position of the GHW. Among 5 graphic types (internal lung cancer image, external damaged teeth, abstract image, human suffering image and text), the image of lung cancer was found to have the strongest influence on both smokers and non-smokers. With ranking method, the image of throat cancer and heart diseases were considered the most dreadful images. GHWs should be designed with these attributes in mind, to maximise influence on purchase among both smokers and non-smokers.

• Journal of the Korean Institute of Landscape Architecture
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• v.40 no.3
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• pp.60-68
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• 2012

The purpose of this research is to identify green roofs based on how to utilize the diverse space. This research also aims to discover the correlation between the use of the green roof and the overall level of the public's health condition, through which it is intended to grasp the health effects by means of the space of the green roof. The current use patterns of the green roof have been identified generally to have more than 60% accessibility, less than 30 minutes of short-tenn use, relaxation or removing stress, enjoy the view of the surrounding, smoking, walking and exercise. It will be highly effective to furnish facilities and plants for tree planting, and to get financial maintenance & management subsidy for the purpose of revitalizing the green roof. It is expected that if the green roof is created in educational institutes, hospitals and shopping centers, where the current level of health conditions is generally low, it will contribute in promoting the city dwellers' health benefits. In addition, the physical environmental renovation through establishing the green roof will bring about producing a healthy city because the emotional health benefits also will make a positive impact upon physical health.

• Annals of Occupational and Environmental Medicine
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• v.35
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• pp.14.1-14.10
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• 2023

Background: Shift work is known to cause changes in the circadian rhythm of the human body and adversely affect not only physical health but also mental health. Some studies have demonstrated the correlation between shift work and thyroid stimulating hormone (TSH), a hormone that changes according to the diurnal rhythm, but few studies have reported the different TSH levels according to the shift work type. This study aimed to investigate changes in TSH according to the shift work type. Methods: This study included 1,318 female workers who had a medical checkup at a university hospital in Changwon from 2015 to 2019. Shift work types were classified as non-shift work, regular 2 shifts, and irregular three shifts, and a TSH ≥ 4.2 mIU/L was defined as abnormal. A general linear model (GLM) was used to compare the TSH levels and the risk of subclinical hypothyroidism in each year, and a binary logistic analysis was performed using a generalized estimation equation (GEE) to compare the risk of subclinical hypothyroidism over the 5-year period. Results: Of the 1,318 participants included in this study, 363, 711, and 244 were non-shift, two-shift, and irregular three-shift workers, respectively. In the GEE analysis, after adjusting for age, body mass index, smoking, and alcohol consumption, the odds ratios (ORs) were 1.81 (95% confidence interval [CI]: 1.15-2.86; p = 0.011) in 2 shifts and 2.02 (95% CI: 1.23-3.32; p = 0.006) in irregular three shifts, compared to non-shift. Conclusions: Our results showed that shift work had a higher risk of subclinical hypothyroidism than non-shift work and that there was a significant difference in the risk of subclinical hypothyroidism according to the shift work type. These findings suggest that the shift work type can be considered in future thyroid function tests and evaluations.

• Journal of the Korea Convergence Society
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• v.11 no.8
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• pp.229-236
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• 2020

This study was conducted to identify the influence of the convergent lifestyles of the elderly consisting of physical exercise, smoking, drinking and social participation and the types of social participation on the risk of cognitive decline by using the 6th Korean Longitudinal Study of Ageing(KLoSA). Total 4,298 people aged 65 or older were included. Results show that all of lifestyle factors are significantly effected to prevent cognitive decline, social participation was derived as the most important explanatory variable to lower the risk of cognitive decline. In addition, participating in the religious groups, ascriptive groups, and expressive groups lowered the risk of cognitive decline. Therefore, active support at the community and policy for improving the convergent lifestyle of the elderly are needed.

• Health Policy and Management
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• v.29 no.2
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• pp.184-194
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• 2019

Background: The extent of coverage rate of the public health insurance is still insufficient to meet healthcare needs. Private health insurance (PHI) plays a role to supplement coverage level of national health insurance in Korea. It is expected that reduce unmet need healthcare. This study was aimed to identify relationship between PHI type and the unmet healthcare need and its associated factors. Methods: Data were obtained from the 2014 Korea Health Panel Survey using nationally representative sample was analyzed. Respondents were 8,667 who were adults over 20 years covered by PHI but have not changed their contract. According to the enrollment form, PHI was classified into three types: fixed-benefit, indemnity, and mixed-type. To identify factors associated with unmet needs, multiple logistic regression conducted using the Andersen model factors, which are predisposing factors, enabling factors, and need factors. Results: Our analysis found that subjects who had PHI with mixed-type were less likely to experience unmet health care needs compared than those who did not have it (odds ratio, 0.80; 95% confidence interval, 0.66-0.98). As a result of analyzing what affected their unmet healthcare needs, the significant factors associated with unmet medical need were gender, marital status, residence in a metropolitan area, low household income, economic activity participation, self-employed insured, physically disabled, low subjective health status, and health-risk factors such as current smoking and drinking. Conclusion: The results of this study suggest that having PHI may reduce experience of unmet healthcare needs. Findings unmet healthcare needs factors according to various subjects may be useful in consideration of setting policies for improving accessibility to healthcare in Korea.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.219-225
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• 2017

This article examined the condition of medical service utilization and the usage degree for the disabled in Korea, and analyzed factors affecting medical service utilization. This paper offers data for improving the health of disabled Korea residents and for enhancing medical service utilization. We analyzed data for disabled residents aged 19 from the 6th Korea National Health and Nutrition Examination Survey. Results found significant effects depending on gender, age, average monthly income, types of disorders, disability rating, and status of smoking. Concerning gender, men had a higher probability of lacking medical treatment compared with women, had increased probability of having a disability, and smokers had a higher probability of lacking treatment compared with nonsmokers. Therefore, for resolving medically untreated disabled Korean residents, government needs to improve the policy system and to managethe inequality of handicapped welfare work.