• Clinics in Shoulder and Elbow
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• v.15 no.1
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• pp.16-24
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• 2012

Purpose: This study was designed to investigate the rate of incidence, location and the clinical value of the rotator cuff retear by analyzing MRI scans, which was taken after an arthroscopic rotator cuff repair. Materials and Methods: This study included a total of 109 patients, who underwent a shoulder MRI scan after an average of 10.6 months later from the arthroscopic rotator cuff repair. We only defined the 'retear' when the Sugaya type IV and V was observed in the sagittal section of the MRI. The location of the retear was divided into the medial and lateral areas by the site, which was 1 cm medial to the anchor insertion. We investigated the incidence rate and the location of the retear, in terms of the age, sex, initial tear size and the suture method. Also, we compared the functional score of the retear group and the non-retear group, after an average of 13.9 months follow-up. Results: There were 38 of the 109 patients that showed the rotator cuff retear. Of these patients, 25 were male patients, and 13 were female patients. Of the 38 patients with the rotator cuff retear, 21 patients were included in the <3 cm retear group, and 17 were included in the ${\geqq}3$ cm retear group. At the end of the follow up period, all 109 patients showed a statistical significant improvement in the shoulder functional score. Conclusion: According to the follow up of the MRI scan, which was taken after the rotator cuff repair, the retear rate reached 34.9 %, and there were no significant differences on the age and the suture method. More rotator cuff retear occurred in male patients, and the initial tear size was positively correlated with the incidence rate of the rotator cuff retear. Also, the retear was more frequently observed at the medial side. That is because when the suture was performed, excessive tension was loaded on the medial side of the suture site.

• Tuberculosis and Respiratory Diseases
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• v.65 no.6
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• pp.476-486
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• 2008

Background: TRAIL (TNF-related apoptosis inducing ligand) is a newly identified member of the TNF gene family which appears to have tumor-selective cytotoxicity due to the distinct decoy receptor system. TRAIL has direct access to caspase machinery and induces apoptosis regardless of p53 phenotype. Therefore, TRAIL has a therapeutic potential in lung cancer which frequently harbors p53 mutation in more than 50% of cases. However, it was shown that TRAIL also could activates $NF-{\kappa}B$ in some cell lines which might inhibit TRAIL-induced apoptosis. This study was designed to investigate whether TRAIL can activate $NF-{\kappa}B$ in lung cancer cell lines relatively resistant to TRAIL-induced apoptosis and inhibition of $NF-{\kappa}B$ activation using proteasome inhibitor MG132 which blocks $I{\kappa}B{\alpha}$ degradation can sensitize lung cancer cells to TRAIL-induced apoptosis. Methods: A549 (wt p53) and NCI-H1299 (null p53) lung cancer cells were used and cell viability test was done by MTT assay. Apoptosis was confirmed with Annexin V assay followed by FACS analysis. To study $NF-{\kappa}B$-dependent transcriptional activation, a luciferase reporter gene assay was used after making A549 and NCI-H1299 cells stably transfected with IgG ${\kappa}-NF-{\kappa}B$ luciferase construct. To investigate DNA binding of $NF-{\kappa}B$ activated by TRAIL, electromobility shift assay was used and supershift assay was done using anti-p65 antibody. Western blot was done for the study of $I{\kappa}B{\alpha}$ degradation. Results: A549 and NCI-H1299 cells were relatively resistant to TRAIL-induced apoptosis showing only 20~30% cell death even at the concentration 100 ng/ml, but MG132 ($3{\mu}M$) pre-treatment 1 hour prior to TRAIL addition greatly increased cell death more than 80%. Luciferase assay showed TRAIL-induced $NF-{\kappa}B$ transcriptional activity in both cell lines. Electromobility shift assay demonstrated DNA binding complex of $NF-{\kappa}B$ activated by TRAIL and supershift with p65 antibody. $I{\kappa}B{\alpha}$ degradation was proven by western blot. MG132 completely blocked both TRAIL-induced $NF-{\kappa}B$ dependent luciferase activity and DNA binding of $NF-{\kappa}B$. Conclusion: This results suggest that inhibition of $NF-{\kappa}B$ can be a potentially useful strategy to enhance TRAIL-induced tumor cell killing in lung cancer.

• Journal of the Korean Institute of Landscape Architecture
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• v.38 no.4
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• pp.11-24
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• 2010

The main focus of this research is the establishment of a systemic evaluation model based on objective evaluation indices, which are drawn to assess the experiencing of nature and recreational value at the level of the district unit. First of all, as a result of a literature review, a total of 10 indices can be drawn including vegetation structure, pavement rate, and hemeroby to evaluate an assessment of natural experiences and recreational value. Also, as a result of expert survey analysis, all evaluation index items were above 4.4, which is a high importance average. Hemeroby and unique landscape factor items in particular were above 5.8, which is very high. In addition, as a result of implementing a factor analysis to classify evaluation indices according to characteristics, three factors arise: 'landscape structure and quality of natural experience', 'typical availability', and 'quality of aesthetic and visual sense.' Based on the above survey analysis results, the 'quality of aesthetic and visual sense' was the highest, at 3.510. The classification 'landscape structure and quality of natural experience' was the lowest, at 3.035. A systemic value evaluation model was established by comprehensively analyzing these results. To verify the validity of the evaluation model drawn, real sites are selected and applied. First of all, as a result of a biotope types classification of sites, biotope type groups are classified into a total of 13 including the stream biotope while its subordinate biotope types are classified into a total of 61 groups. Lastly, as a result of biotope value evaluation, which was a previously established evaluation model, there are a total of 16 types including vegetation-abundant natural rivers and small-scale woodlands near forests in grade I. There are 9 types in grade II, 8 in grade III, 8 in grade IV, 19 in the least-valuable grade V.

• The Korean Journal of Nuclear Medicine
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• v.33 no.1
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• pp.100-109
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• 1999

Purpose: Preamplifier and amplifier are very important parts for developing a portable counting or imaging gamma probe. They can be used for analyzing pulses containing energy and position information for the emitted radiations. The commercial Nuclear Instrument Modules (NIMs) can be used for processing these pulses. However, it may be improper to use NIMs in developing a portable gamma probe, because of its size and high price. The purpose of this study was to develop both preamplifier and amplifier and measure their performance characteristics. Materials and Methods: The preamplifier and amplifier were designed as a charge sensitive device and a capacitor resistor-resistor capacitor (CR-RC) electronic circuit, respectively, and they were mounted on a print circuit board (PCB). We acquired and analyzed energy spectra for Tc-99m and Cs-137 using both PCB and NIMs. Multichannel analyzer (Accuspec/A, Canberra Industries Inc., Meriden Connecticut, U.S.A) and scintillation detectors (EP-047(Bicron Saint-Gobain/Norton Industrial EP-047 (Ceramics Co., Ohio, U.S.A) with $2"{\times}2"$ NaI(T1) crystal and R1535 (Hamamatsu Photonics K.K., Electron Tube Center, Shizuoka-ken, Japan) with $1"{\times}1"$ NaI(T1) crystal were used for acquiring the energy spectra. Results: Using PCB, energy resolutions of EP-047 detectors for Tc-99m and Cs-137 were 12.92% and 5.01%, respectively, whereas R1535 showed 13.75% and 5.19% of energy resolution. Using the NIM devices, energy resolutions of EP-047 detector for Tc-99m and Cs-137 were measured as 14.6% and 7.58%, respectively. However, reliable energy spectrum of R1535 detector could not be acquired, since its photomultiplier tube (PMT) requires a specific type of preamplifier. Conclusion: We developed a special preamplifier and amplifier suitable for a small sized gamma probe that showed good energy resolutions independent of PMT types. The results indicate that the PCB can be used in developing both counting and imaging gamma probe.

• Economic and Environmental Geology
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• v.40 no.5
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• pp.675-689
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• 2007

Kilauea volcano's summit area was formed by continuous ind/or sporadic eruption activities for several hundreds years. In this study, we mainly focused on the trace elements characteristics through systematic sample rocks erupted from 1790 to September of 1982. Under the microscope it can be observed some main minerals such as olivine, clinopyroxene. and plagioclase with minor opaque minerals including Cr-spinel and ilmenite. Zr, V, Y, Ti elements show incompatible activities with MgO while Ni, Cr, Co elements show highly compatible properties. Elements like as Ba, Rb, Th, Sr, Nd are highly incompatible to show positive trends with $K_2O$. In the REE diagram LREE is more enriched than HREE suggesting typical Oceanic Island Basalt(OIB) type. It can be suggested that Sr have an effect on the fractionation of plagioclase from the kink in the $K_2O$ variation diagram. Y/Ho ratio diagram shows there was no fluids effect in the historical Kilauea volcano but Zr/Hf ratio diagram shows a significant difference between Kilauea lavas and PuuOo lavas. There are distinctive changes of trace element contents showing in particular abrupt changes of temporal variations between 1924 and 1954. Moreover, PuuOo lavas which had been erupted since 1983 follow these decreasing trends of trace element variation. Therefore, it is strongly suggested that these abrupt changes of trace elements trends result from the huge collapse geological event which formed Halemaumau crater in 1924 causing contamination effects of crustal contents into magma chamber and from the changes of parental magma composition injected into Kilauea volcano's summit magma reservoir.

• Korean Journal of Ecology and Environment
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• v.39 no.4 s.118
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• pp.450-461
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• 2006

In this study, sorption kinetics of lead (Pb) and cadmium (Cd) onto coastal sediments were investigated at pH 5.5 using laboratory batch adsorbers. Four different models: one-site mass transfer model (OSMTM), pseudo-first-order kinetic model (PFOKM) ,pseudo-second-order kinetic model (PSOKM) and two compartment first-order kinetic model (TCFOKM) were used to analyze the sorption kinetics. As expected from the number of model parameters involved, the three-parameter TCFOKM was better than the two-parameter OSMTM, PFOKM and PSOKM in describing sorption kinetics of Pb and Cd onto sediments. Most sorption of Pb and Cd was rapidly completed within the first three hours, followed by slow sorption in the subsequent period of sorption. All models predicted that the sorbed amount at the apparent sorption ($q_{e,s}$) equilibria increased as the CEC and surface area of the sediments increased, regardless of initial spiking concentration ($C_0$) and heavy metal and the sediment type. The sorption rate constant ($k_s,\;hr^{-1}$) in OSMTM also increased as the CEC and BET surface area increased. The rate constant of pseudo-first-order sorption ($k_{p1,s},\;hr^{-1}$) in PFOKM were not correlated with sediment characteristics. The results of PSOKM analysis showed that the rate constant of pseudo-second-order sorption ($k_{p2,s},\;g\;mmol^{-1}\;hr^{-1}$) and the initial sorption rate ($v_{o,s},\;mg\;g^{-1}\;hr^{-1}$) were not correlated with sediment characteristics. The fast sorption fraction ($f_{1,s}$) in TCFOKM increased as CEC and BET surface increased regardless of initial aqueous phase concentrations. The sorption rate constant of fast fraction ($k_{1,s}=10^{0.1}-10^{1.0}\;hr^{-1}$) was much greater than that of slow sorption fraction ($k_{2,s}=10^{-2}-10^{-4}\;hr^{-1}$) respectively.

• Korean Journal of Food Science and Technology
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• v.35 no.1
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• pp.103-110
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• 2003

Stable production of fermented kanjang containing 1.8% (v/v) ethanol was obtained within four days using traditional kanjang containing 4% added glucose in packed-bed bioreactor systems filled with immobilized Zygosaccharomyces rouxii and Candida versatilis on porous alumina ceramic bead carrier at $28{\pm}0.5^{\circ}C$ and aeration rate of 0.05 vvm. Specific rates of alcohol production for Z. rouxii and C. versatilis were 0.0033 and 0.0031/day, respectively, and those of glucose consumption were both -0.0087/day in the batch type of alcoholic fermentation. In semi-continuous alcoholic fermentation at a dilution rate of 0.25/day, specific rates of alcohol production for Z. rouxii and C. versatilis were 0.0045 and 0.0029/day, and those of glucose consumption were -0.01 and -0.008/day, respectively, using identical bioreactor system. Similar specific rates of alcohol production were observed both in the batch or semi-continuous process and in the continuous one at the dilution rate of 0.25/day. Sensory characteristics of all alcoholic-fermented kanjang by Z. rouxii, C. versatilis, and a mixture of both yeasts (2:1, w/w) were shown to be significantly superior to those of home-made kanjang as revealed through organoleptic evaluation tests (p<0.05).

• Korean Journal of Environment and Ecology
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• v.25 no.3
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• pp.358-364
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• 2011

To examine the possibility of natural regeneration of six Acer species in broadleaved mixed forest in Korean peninsula, samples of six Acer species' samaras were collected at several seed sources from September to October 2009 and 2010, and seed morphological characteristics and viability were studied using cutting method. Inflorescense type of Acer mandshuricum(AM), A. pseudosieboldianum(APS) and A. palmatum(AP) is corymb, that of A. pictum subsp. mono(APSM) and A. okamotoanum(AO) is flat-topped panicle, and that of A. ukurunduense(AU) is raceme. Number of seed-set per inflorescense proves the highest value 38.5 sets in AU and the lowest value 2.4 sets in APS. Diameter of the seeds proves highest value 13.5mm in AO, and the lowest value 4.7mm in APS. Angles between the wings proves the highest values $130.05^{\circ}$ in APS, and the lowest value $48.60^{\circ}$ in AU. Air dry weight of 20 seed-sets proves highest value 3,900mg, in AO, and the lowest value 404mg in AU. Viable seed ratio of AP proves 50%, and that of AU does 43.2%. Those of other four species ranges 8.6~22.2%. Considering postdispersal seed predators and disturbance of litter, viable seeds of APSM, AO, AM, and APS supplied in the natural forest in Korea might be insufficient for seedling establishment. This study showed that sound viable seed supply might be key factors of natural regeneration of major Acer species in Korea. The openings made by insect pests were observed on the seed-coat of APSM, AM, AU, and APS samara, and Bradybatus sharpi were observed in the samaras of APSM and AO. Further study on the seed insect fauna, pre- and post-dispersal seed viability, and annual variation on these factor should be needed.

• The Journal of the Petrological Society of Korea
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• v.26 no.3
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• pp.297-309
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• 2017

Jurassic granite from Geochang was analysed with respect to the characteristics of the rock cleavage. The comprehensive evaluation for rock cleavages was performed through the combination of the 16 parameters derived from the enlarged photomicrographs of the thin section and the spacing-cumulative frequency diagrams. The results of analysis for the representative values of these spacing parameters with respect to the rock cleavage are summarized as follows. First, the above parameters can be classified into group I (spacing frequency (N), total spacing ($1m{\geq}$), constant (a), exponent (${\lambda}$), slope of exponential straight line (${\theta}$), length of line (oa') and trigonometric ratios ($sin{\theta}$, $tan{\theta}$) and group II (mean spacing (Sm), difference value between mean spacing and median spacing (Sm-Sme), density (${\rho}$), lengths of lines (oa and aa'), area of a right-angled triangle (${\Delta}oaa^{\prime}$) and trigonometric ratio($cos{\theta}$). The values of the 8 parameters belonging to group I show an order of H(hardway, H1+H2)

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.4
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• pp.441-447
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• 2012

Purpose: This paper is about development and design of the 1x optical path relay adapter for the beam splitting prism by us the day & night scope. Methods: To product the day & night scope by using the beam splitting prism and the commercial zoom optical system with the C-mount lens barrel structure, the optical path relay adapter, which doesn't change the image size of the zoom optical system and can stretch the position of the image-forming surface, is needed. We could design the 1x optical path relay adapter by using the CodeV program in which the Lens Module mode is offered. Results: We could design the optical path relay adapter used in the day&night scope with the beam splitting prism, of which characteristics have the EFL of -56.0 mm, the magnification of +1.0x, the distance from the 1st lens surface to the last lens surface of about 20.4 mm. The resolution of this system is characterized by 30 lp/mm at 40% MTF. This is enough to accommodate the designed optical path relay adapter can overcome the resolution of the 3rd generation of image intesifier tubes. Conclusions: By designing and applying the optical path relay adapter of which optical characteristics have the EFL of -56.0 mm, the magnification of +1.0x, the distance from the 1st lens surface to the last lens surface of about 20.4 mm, and the resolution of 30 lp/mm at 40% MTF, we could develop the new type day&night scope consisting of the beam splitting, the commercial zoom optical system with the C-mount lens barrel structure, and the 3rd generation of image intesifier tubes.