• Journal of Korean Tunnelling and Underground Space Association
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• v.10 no.3
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• pp.269-282
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• 2008

In general, the effects of steel ribs are not considered in the numerical analysis of tunnel design. However, attempts have been increased recently to consider these effects in the analysis of shallow tunnels in soft ground, based on the fact that the steel ribs embedded in the shotcrete take a role to support some portion of the redistributed load due to excavation. In such analyses, the steel ribs can be considered in four different methods: (1) a conventional method where the steel ribs are not considered, (2) a method using the equivalent composite cross section in which the bending moment of shotcrete is not considered, (3) a method using the equivalent composite cross section in which both the compressive stress and the bending moment for the shotcrete and steel rib are considered, and (4) a method using beam elements for the shotcrete and the steel rib, respectively. These methods are adopted in the numerical analysis using FLAC 2D to investigate stresses of both the shotcrete and the steel rib. The overall results show that the analyses are more practical and economical when the effects of steel rib are considered fer the methods (2), (3), and (4). Since the results of those analyses considering steel rib capacity may be different according to the ground condition, it will be necessary to consider the appropriate method among them in accordance with design conditions.

• Wind and Structures
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• v.31 no.2
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• pp.143-152
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• 2020

The wind design of buildings is typically based on strength provisions under ultimate loads. This is unlike the ductility-based approach used in seismic design, which allows inelastic actions to take place in the structure under extreme seismic events. This research investigates the application of a similar concept in wind engineering. In seismic design, the elastic forces resulting from an extreme event of high return period are reduced by a load reduction factor chosen by the designer and accordingly a certain ductility capacity needs to be achieved by the structure. Two reasons have triggered the investigation of this ductility-based concept under wind loads. Firstly, there is a trend in the design codes to increase the return period used in wind design approaching the large return period used in seismic design. Secondly, the structure always possesses a certain level of ductility that the wind design does not benefit from. Many technical issues arise when applying a ductility-based approach under wind loads. The use of reduced design loads will lead to the design of a more flexible structure with larger natural periods. While this might be beneficial for seismic response, it is not necessarily the case for the wind response, where increasing the flexibility is expected to increase the fluctuating response. This particular issue is examined by considering a case study of a sixty-five-story high-rise building previously tested at the Boundary Layer Wind Tunnel Laboratory at the University of Western Ontario using a pressure model. A three-dimensional finite element model is developed for the building. The wind pressures from the tested rigid model are applied to the finite element model and a time history dynamic analysis is conducted. The time history variation of the straining actions on various structure elements of the building are evaluated and decomposed into mean, background and fluctuating components. A reduction factor is applied to the fluctuating components and a modified time history response of the straining actions is calculated. The building components are redesigned under this set of reduced straining actions and its fundamental period is then evaluated. A new set of loads is calculated based on the modified period and is compared to the set of loads associated with the original structure. This is followed by non-linear static pushover analysis conducted individually on each shear wall module after redesigning these walls. The ductility demand of shear walls with reduced cross sections is assessed to justify the application of the load reduction factor "R".

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1699-1702
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• 2014

Objective: To evaluate clinical efficacy of a dose escalating schedule of paclitaxel concurrent with radiotherapy in treating patients with locally advanced non-small cell lung (NSCLC). Methods: Patients with locally advanced NSCLC were treated with conventional fractionated radiotherapy or three dimensional conformal radiotherapy (3 DCRT), concurrently with a dose escalating schedule of paclitaxel. All patients were divided into three groups, A with paclitaxel $30mg/m^2$, B with paclitaxel $60mg/m^2$ and C with paclitaxel $90mg/m^2$. Paclitaxel was repeated every week for a total of 4 or 6 weeks. Results: Among 109 patients, response rates were 68.8%, 71.1% and 71.8% (p>0.05) for group A (n=32), B (n=38), and C (n=39) respectively. Accordingly, disease control rates were 81.3%, 81.6% and 82.1% (p>0.05). Progression-free survival time was $8.0{\pm}5.0$ months, $11.6{\pm}6.1$ months, and $14.8{\pm}7.9$ months (p<0.05), respectively. Overall survival time was $15.4{\pm}7.6$ months, $18.2{\pm}8.0$ months, and $22.0{\pm}7.6$ months (p<0.05), one-year survival rates were 62.5%, 73.1% and 90.0% (p>0.05) and two-year survival rates were 31.3%, 38.5% and 50.0% (p<0.05). Main side-effects were bone marrow suppression, radiation related esophagitis and gastrointestinal reaction. Conclusion: In treating patients with NSCLC, concurrent chemoradiotherapy with paclitaxel improves early response compared with conventional fractionated radiotherapy or 3 DCRT. The survival rate was improved with the addition of paclitaxel, but there was an increase in adverse reactions when the dose of paclitaxel was increased.

• Journal of IKEEE
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• v.11 no.4
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• pp.272-278
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• 2007

In this paper, we report on the 2D (two-dimensional) simulation result of the DC (direct current) electrical and thermal characteristics of AlGaN/GaN HEMTs (high electron mobility transistors) grown on Si substrate, in comparison with those grown on sapphire and SiC (silicon carbide) substrate, respectively. In general, the electrical properties of HEMT are affected by electron mobility and thermal conductivity, which depend on substrate material. For this reason, the substrates of GaN-based HEMT have been widely studied today. The simulation results are compared and studied by applying general Drift-Diffusion and thermal model altering temperature as 300, 400 and 500 K, respectively. With setting T=300 K and $V_{GS}$=1 V, the $I_{D,max}$ (drain saturation current) were 189 mA/mm for sapphire, 293 mA/mm for SiC, and 258 mA/mm for Si, respectively. In addition, $G_{m,max}$ (maximum transfer conductance) of sapphire, SiC, Si was 38, 50, 31 mS/mm, respectively, at T=500 K.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.38 no.9
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• pp.634-642
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• 2001

We calculate the facet reflectivity of buried channel waveguides and ridge waveguides as a function of the waveguide width for various thicknesses using the angular spectrum method and the two dimensional field profiles obtained by the variational method (VM) and the effective index method (EIM). The variation of the reflectivity of buried channel waveguides as a function of the waveguide width is large, while that of ridge waveguides is very small. The accuracy of the field profiles necessary for the calculation of the facet reflectivity using the angular spectrum method greatly affects that of the facet reflectivity. The difference between the exact reflectivity and that using EIM increases as the waveguide width and thickness decreases due to the inaccuracy of the field profiles obtained by EIM. However, the difference between the exact reflectivity and that using VM is smaller than that using EIM regardless of waveguide width and thickness. The difference between the facet reflectivities u sing EIM and VM is small in the area where the EIM works very well.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.1
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• pp.17-29
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• 2003

This paper preliminarily investigates the effectiveness of various control systems, such as passive, active, semiactive and hybrid control, for seismic protection of cable-stayed bridges by examining the ASCE first generation benchmark problem for a cable-stayed bridge. This benchm.0.00000ark problem considers the cable-stayed bridge that is scheduled for completion in Missouri, USA In 2003. Seismic considerations were strongly considered in the design of this bridge due to location of the bridge and its critical role as a principal crossing of the Mississippi River. Based on detailed drawings of this cable-stayed bridge, a three-dimensional linearized evaluation model has been developed to represent the complex behavior of the bridge. A set of eighteen evaluation criteria has been developed to evaluate the capability of each control system. In this study, four passive control systems, one active control system, two semiactive control systems and three hybrid control systems are considered. Numerical simulation results show that all the control systems are effective in reducing the responses of the benchmark cable-stayed bridge under the historical earthquakes. To get good performance, however, the passive control systems need quite large control forces compared to other control systems. The simulation results also demonstrate that the passive, semiactive and hybrid control systems are robust to the stiffness uncertainty of the structure. Therefore, the semiactive and hybrid control systems are more appropriate in real applications for full-scale civil infrastructures.

• Archives of Pharmacal Research
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• v.29 no.3
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• pp.224-234
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• 2006

We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-kB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic agents against the SK-MEL-28 human melanoma cell line.

• Geophysics and Geophysical Exploration
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• v.4 no.4
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• pp.124-132
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• 2001

Electrical resistivity survey has been conducted for delineating geological fault structure in Kaekok-ri near Kyungju. In general, electrical resistivity survey has an advantage of searching buried faults and its traces compared with other geophysical survey methods. Distribution of electrical conductivity in the ground is influenced by the ratio of pores, groundwater and clay minerals. These properties are evidenced indirectly to explain for weathering condition, faults and fracture Bones. Thus the electrical resistivity survey can be an effective method to find buried faults. We have carried out two dimensional (2-D) interpretation by means of smoothness-constrained least-squares and finite element method. Field data used in this paper was acquired at Kaekok-ri, Wuedong-eup, Kyungju-si, where is Ulsan Fault and is close to the region in which debatable quaternary fault traces were found recently. The dipole-dipole array resistivity survey which could show the 2-D subsurface electrical resistivity structure, was carried out in the area with three lines. The results showed good property of fault, fracture zone and fault traces which we estimated were congruous with the results. Through this study, 2-D electrical resistivity survey interpretation for fault is useful to apply.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.4
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• pp.215-223
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• 2010

A seasonal circulation patterns in the Chinju Bay (CB) were suggested from the observed data at two channels of the Noryang Channel (NC) and the Daebang Channel (DC) during the period from 2005 to 2008. The water circulation in the CB is mainly controlled through the NC and the DC. In winter, tidal current at the surface layer of the NC flows from the Kwangyang Bay (KB) eastward into the CB, whereas the current at the bottom layer flows from the CB westward into the KB. In summer, tidal current at the surface layer of the NC goes from the CB westward into the KB. The flow system at the NC shows the typical pattern of thermohaline circulation. In spring, tidal current at the surface layer of the eastern part of the DC flows out into southeastern open ocean. However, in summer, the current in the western part of the DC flows into the CB through the DC. Also, the velocity in the western part of DC is 50~70 cm/sec stronger than that in the eastern part. To obtain better understanding on the seasonal circulation pattern in the NC and the DC, additionally the detailed studies on the field measurements and three dimensional numerical modeling are needed.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.124-124
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• 2017

Cadmium (Cd) is of particular concern because of its widespread occurrence and high toxicity and may cause serious morpho-physiological and molecular abnormalities in in plants. The present study was performed to explore Cd-induced morpho-physiological alterations and their potentiality associated mechanisms in Sorghum bicolor leaves at the protein level. Ten-day-old sorghum seedlings were exposed to different concentrations (0, 100, and $150{\mu}M$) of $CdCl_2$, and different morpho-physiological responses were recorded. The effects of Cd exposure on protein expression patterns in S. bicolor were investigated using two-dimensional gel electrophoresis (2-DE) in samples derived from the leaves of both control and Cd-treated seedlings. The observed morphological changes revealed that the plants treated with Cd displayed dramatically altered shoot lengths, fresh weights, and relative water content. In addition, the concentration of Cd was markedly increased by treatment with Cd, and the amount of Cd taken up by the shoots was significantly and directly correlated with the applied level of Cd. Using the 2-DE method, a total of 33 differentially expressed protein spots were analyzed using MALDI-TOF/TOF MS. Of these, treatment with Cd resulted in significant increases in 15 proteins and decreases in 18 proteins. Significant changes were absorbed in the levels of proteins known to be involved in carbohydrate metabolism, transcriptional regulation, translation and stress responses. Proteomic results revealed that Cd stress had an inhibitory effect on carbon fixation, ATP production and the regulation of protein synthesis. In addition, the up-regulation of glutathione S-transferase and cytochrome P450 may play a significant role in Cd-related toxicity and stress responses. Our study provides insights into the integrated molecular mechanisms involved in response to Cd and the effects of Cd on the growth and physiological characteristics of sorghum seedlings. The upregulation of these stress-related genes may be candidates for further research and use in genetic manipulation of sorghum tolerance to Cd stress.