• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1989년도 한국자동제어학술회의논문집; Seoul, Korea; 27-28 Oct. 1989
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• pp.813-818
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• 1989

A two compartmented autoclave reactor for the polymerization of low density polyethylene is analyzed with respect to the effects of heat transfer and operation variables. Each compartment being considered as a completely mixed cell, two CSTRs model is proposed. The system shows various multiplicity features of steady state and periodic oscillatory motions. Heat removal efficiency and initiator supplement appear to have significant effect on the conversion of monomer with the temperature properly maintained, which should be taken into account in the reactor design.

• 대한수의학회지
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• 제37권2호
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• pp.321-330
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• 1997

Enrofloxacin is one of the second-generation quinolones which have been widely used to treat bacterial infections in various species including chicken, pig, horse and cattle. The objective of the present study was to describe the serum bactericidal activity(SBA) of enrofloxacin, its pharmacokinetic behaviors after intramuscular or intravenous administration to Korean native goats in the dose rate of 5mg/kg b.w. The results obtained through this study were as follows : 1. Sera collected from both sexes of Korean native goats administered 5mg/kg i.v. or i.m. showed potent antibacterial activities up to the 12 hours by way of the serum bactericidal activity. 2. Concentrations of enrofloxacin in the biological samples were measured by high-performance liquid chromatography(HPLC) so as to study pharmacokinetic characteristics. For detection of enrofloxacin, 10% TCA was optimal for protein precipitation and the mobile phase was 0.01M citric acid/methanol/acetonitrile(7/2/1, pH 3.5) with solid phase being the $C_{18}$ reversephase column and detection wavelength being 278nm. The limit of detection of enrofloxacin on HPLC was $0.05{\mu}g/ml$. 3. Pharmacokinetic profile of enrofloxacin administered 5mg/kg i.v. in Korean native goats was best described by two-compartment open model and that administered i.m. the same rate by one-compartment model. There were no sex differences in pharmacokineticl parameters. In conclusion, enrofloxacin showed potent in vivo antibacterial activity and excellent pharmacokinetic properties in Korean native goats, hence it may be used as a potential antibacterial in the veterinary clinical settings.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.557-561
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• 2014

In this work, Altair Engineering's vibroacoustic modeling approach is used to simulate the acoustic signature of a simplified automobile in a wind tunnel. The modeling approach relies on a two step procedure involving simulation and extraction of acoustic sources using a high fidelity Computational Fluid Dynamics (CFD) simulation followed by propagation of the acoustic energy within the structure and passenger compartment using a structural dynamics solver. The tools necessary to complete this process are contained within Altair's HyperWorks CAE software suite. The CFD simulations are performed using AcuSolve and the structural simulations are performed using OptiStruct. This vibroacoustics simulation methodology relies on calculation of the acoustic sources from the flow solution computed by AcuSolve. The sources are based on Lighthill's analogy and are sampled directly on the acoustic mesh. Once the acoustic sources have been computed, they are transformed into the frequency domain using a Fast Fourier Transform (FFT) with advanced sampling and are subsequently used in the structural acoustics model. Although this approach does require the CFD solver to have knowledge of the acoustic simulation domain a priori, it avoids modeling errors introduced by evaluation of the acoustic source terms using dissimilar meshes and numerical methods. The aforementioned modeling approach is demonstrated on the Hyundai Simplified Model (HSM) geometry in this work. This geometry contains flow features that are representative of the dominant noise sources in a typical automobile design; namely vortex shedding from the passenger compartment A-pillar and bluff body shedding from the side view mirrors. The geometry also contains a thick poroelastic material on the interior that acts to reduce the acoustic noise. This material is modeled using a Biot material formulation during the structural acoustic simulation. Successful prediction of the acoustic noise within the HSM geometry serves to validate the vibroacoustic modeling approach for automotive applications.

• 약학회지
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• 제28권4호
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• pp.207-215
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• 1984

Effects of Ssang Wha Tang (SWT), a blended Chinease traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride+SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic paramiters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction ($f_p$) in Group II than that in Group I might also explain the increases of BSP clearance and Vdss in Group II compared to Group I. Assuming no changes in hepatic plasma flow(Q) in each group, hepatic intrinsic clearance($CL^h_{int}$) decreased in Group I did not recovered not at all in Group II. Therefore SWT seemed not to have any restoring effect of true hepaticfunction to biotransform and excrete BSP, and the apparent restoring effect of SWT might be due only to the replacement of BSP-plasma protein binding. Whether $f_p$ is actually higer in Group II than in Group I, and Q is constant in each group are being examined in our laboratory. The changes of Q, which might lead to another conculusions, also should be taken into consideration to clarify the apparent hepatorestoring effect of SWT.

• 대한수의학회지
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• 제35권3호
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• pp.471-480
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• 1995

The purpose of this experiment was to develop a simple and reliable HPLC method for the detection of ciprofloxacin in chicken serum and to provide a basic data on pharmacokinetic parameters after oral and intramuscular administration. The results obtained were as follows: 1. 0.2% meta-phosphoric acid: acetonitrile(7:3, v/v) solution had a high and regular recovery rates and was selected as an extraction solution. 2. The recovery rates of ciprofloxacin were 83-97% with the selected solution in chicken serum and the detection limit was 50ng/ml in serum. 3. Ka(abosorption rate constant) were 3.652 1/h in fasted group and 0.880 1/h in non-fasted group, and Ke (elimination rate constant) were 0.061 1/h and 0.133 1/h, respectively. 4. The highest concentration in serum after intramuscular injection was 840ng/ml within 15-30min and 160-324ng/ml in 1.1-3.2 hours after oral administration. 5. The time course of blood concentration fits well into a 2 compartment model. 6. On oral administration of ciprofloxacin with feed, ciprofloxacin was absorbed more slowly and the amount of absorbed was smaller than that of in fasted chickens. 7. Blood concentration of ciprofloxacin increased in a dose-dependent manner after intramusclular and oral administraiton.

• 한국환경과학회지
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• 제23권9호
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• pp.1609-1618
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• 2014

In this study, as a fundamental study for the remediation of the radionuclides-contaminated soil, the adsorption of cobalt, strontium, and cesium on natural soil and kaolin were experimently investigated and adsorption characteristics were evaluated by using several adsorption kinetic and isotherm models. The pseudo-first-order kinetic model (PFOM), pseudo-second-order kinetic model (PSOM), one-site mass transfer model (OSMTM), and two compartment first-order kinetic model (TCFOKM) were used to evaluate the kinetic data and the pseudo-second-order kinetic model was the best with good correlation. The adsorption equilibria of cobalt, strontium, and cesium on natural soil were fitted successfully by Redlich-Peterson and Sips models. For kaolin, the adsorption equilibria of cobalt, strontium, and cesium were fitted well by Redlich-Peterson, Freundlich, and Sips models, respectively. The amount of adsorbed radionuclides on natural soil and kaolin was in the order of cesium > strontium > cobalt. It is considered that these results could be useful to predicting the adsorption behaviors of radionuclides such as cobalt, strontium, and cesium in soil environments.

• 수산해양기술연구
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• 제52권2호
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• pp.88-95
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• 2016

Most grid sorting has been used to sort out flatfish in shrimp fisheries, while double grid systems have been tested to separate smaller shrimp. The escape of juvenile red seabream through separating panels made with steel grids or large mesh tested for masking effects in a two-species system. Fish behavior was observed in a circulating water tank. The escape rate was 20% greater with the separating codends than with the normal codend in the single-species experiments. The rates in the two-species experiments were 30% or 20% greater than the single-species rates for the normal or separating codends, respectively. The seabream retention rates in the grid separator codend decreased as rockfish retention increased, possibly due to a threat effect. Conversely, the retention rate of both species increased concurrently in the net separator, possibly due to a masking effect. The escape rates of juvenile red seabream varied by compartment in the mesh separating codend. These results suggest that grid separating codends can be used in the field as towed fishing gear to reduce juvenile catch.

• 방사성폐기물학회지
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• 제4권4호
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• pp.365-372
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• 2006

[ $^{137}C_s$ ]의 토양침적으로 인한 농작물 오염 평가를 위한 동적격실모델이 제시되었다 토양침투(percolation), 쟁기질에 의한 토양혼합(soil mixing), 뿌리흡수(plant uptake), 용출(leaching to a deep soil), 토양고착(fixation to a clay mineral)이 모델에서 고려된 $^{137}C_s$의 주요 이동경로이며 $^{137}C_s$의 토양이동에 대한 토양특성(pH, 점토함량, 유기물함량, 이온교환성 K 농도)의 영향을 반영하기 위하여 Absalom 모델을 적용하였다. 모델의 검증을 위해 다른 토양특성을 가진 17종류의 논토양에서 2년 연속 벼를 재배하면서 수행한 $^{137}C_s$ 모의침적실험으로부터 구한 벼에 대한 $^{137}C_s$ 전이계수를 모델에 의한 예측치와 비교하였다. 측정된 벼의 $^{137}C_s$ 전이계수는 pH와 점토함량 변화에는 뚜렷한 경향을 보여주지 않았으나, 유기물함량의 증가 또는 이온교환성 K 농도의 감소에 따라 다소 증가하는 경향을 보여주었다. 측정된 전이계수는 모델에 의한 예측치와 대체적으로 유사한 값을 가졌다.

• 대한조선학회논문집
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• 제60권4호
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• pp.222-230
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• 2023

In the present work, the scale effect on the Boil-Off Rate (BOR) was investigated based on an analytical method to systematically evaluate the thermal performance of a Liquefied Natural Gas (LNG) Cargo Containment System (CCS). A two-dimensional thermal resistance network model was developed to accurately estimate the heat ingress into the CCS from the outside. The analysis was performed for the KC-1 LNG membrane tank under the IGC and USCG design conditions. The ballast compartment of both the LNG tank and cofferdam was divided into six sections and a thermal resistance network model was made for each section. To check the validity of the developed model, the analysis results were compared with those from existing literature. It was shown that the BOR values under the IGC and USCG design conditions were agreed well with previous numerical results with a maximum error of 1.03% and 0.60%, respectively. A SDR, the scale factor of the LNG CCS was introduced and the BOR, air temperature of the ballast compartment, and the surface temperature of the inner hull were obtained to examine the influence of the SDR on the thermal performance. Finally, a correlation for the BOR was proposed, which could be expressed as a simple formula inversely proportional to the SDR. The proposed correlation could be utilized for predicting the BOR of a full-scale LNG tank based on the BOR measurement data of lab-scale model tanks.

• IMMUNE NETWORK
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• 제1권3호
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• pp.196-202
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• 2001

Backgorund: WEHI-231 B cell line is a representative model for $IgM^+$ mature B cells. To understand the signaling differences between mature and immature B cells, we compared the responsiveness of WEHI-231 and Bal 17 B cell lines to BCR cross-linking. Methods: The extents of tyrosine phosphorylation, ligand-induced internalization, and activation-induced cell death upon BCR cross-linking were compared in two cell lines. Results: Despite a higher expression of BCR, cross-linking of BCR on WEHI-231 cell evoked a weaker level of tyrosine phosphorylation and BCR endocytosis than Bal 17 cells. Furthermore, the endocytosed BCR could not enter the lysosomal compartment and stayed as peripheral spots in WEHI-231 cells. Conclusion: WEHI-231 cell showed preferred BCR-mediated signaling pathways leading to a reduced capability of antigen presentation as well as the enhanced apoptosis in comparision with Bal 17 cells. These results might reflect the signaling differences between mature and immature B cells.