• Communications of the Korean Institute of Information Scientists and Engineers
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• v.33 no.2
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• pp.42-51
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• 2015

• Asian Journal of Innovation and Policy
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• v.5 no.2
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• pp.146-184
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• 2016

This paper analyzes the major comparisons and contrasts in entrepreneurship among technology-based university alumni over multiple decades from Tsinghua University in China and the Massachusetts Institute of Technology in the United States. In doing so, we ask two related research questions: (1) Who enters entrepreneurship and with what types of ideas and founding teams? (2) How do the innovation and other firm performance outcomes compare? We find that the sources of venture ideas and the composition of founding teams differ as well as the initial capital levels and revenues. This research provides a step toward a better understanding of high-tech entrepreneurship in developing vs. developed institutional environments. Furthermore, while MIT and Tsinghua University are unique in the programs they offer and in their historical cultures of entrepreneurship, both Tsinghua University and MIT provide benchmarks by which other institutions can gauge their alumni entrepreneurs and the types of ventures that they create.

• Molecules and Cells
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• v.27 no.1
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• pp.39-45
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• 2009

Ligand-dependent or independent oligomerization of receptor protein tyrosine kinase (RPTK) is often an essential step for receptor activation and intracellular signaling. The novel oncogene with kinase-domain (NOK) is a unique RPTK that almost completely lacks an ectodomain, expresses intracellularly and activates constitutively. However, it is unknown whether NOK can form oligomer or what function oligomerization would have. In this study, two NOK deletion mutants were generated by either removing the ectodomain ($NOK{\Delta}ECD$) or including the endodomain (NOK-ICD). Co-immunoprecipitation demonstrated that the transmembrane (TM) domain of NOK was essential for its intermolecular interaction. The results further showed that NOK aggregated more closely as lower order oligomers (the dimer- and trimer-sized) than either deletion mutant did since NOK could be crosslinked by both Sulfo-EGS and formaldehyde, whereas either deletion mutant was only sensitive to Sulfo-EGS. Removing the NOK TM domain (NOK-ICD) not only markedly promoted higher order oligomerization, but also altered the subcellular localization of NOK and dramatically elevated the NOK-mediated constitutive activation of extracellular signal-regulated kinase (ERK). Moreover, NOK-ICD but not NOK or $NOK{\Delta}ECD$ was co-localized with the upstream signaling molecule RAS on cell membrane. Thus, TM-mediated intermolecular contacting may be mainly responsible for the constitutive activation of NOK and contribute to the autoinhibitory effect on RAS/MAPK signaling.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.10a
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• pp.49-51
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• 2005

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.55.6-55
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• 2002

Huafei Liao is a graduate student of the Automation department in Tsinghua University, China. His research involves computer-aided process planning, 3D CAD/CAM, virtual reality, and feature recognition.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.3095-3105
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• 2022

Solid Microencapsulated Fuel (SMF) is a type of solid fuel rod design that disperses TRISO coated fuel particles directly into a kind of matrix. SMF is expected to provide improved performance because of the elimination of cladding tube and associated failure mechanisms. This study focused on the neutronics and some of the fuel cycle characteristics of SMF by using OpenMC. Two kinds of SMFs have been designed and evaluated - fuel particles dispersed into a silicon carbide matrix and fuel particles dispersed into a zirconium matrix. A 7×7 fuel assembly with increased rod diameter transformed from the standard NHR200-II 9×9 array was also introduced to increase the heavy metal inventory. A preliminary study of two kinds of burnable poisons (Erbia & Gadolinia) in two forms (BISO and QUADRISO particles) was also included. This study found that SMF requires about 12% enriched UN TRISO particles to match the cycle length of standard fuel when loaded in NHR200-II, which is about 7% for SMF with increased rod diameter. Feedback coefficients are less negative through the life of SMF than the reference. And it is estimated that the average center temperature of fuel kernel at fuel rod centerline is about 60 K below that of reference in this paper.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4379-4397
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• 2017

Three different improvements of the Velocity-based model were proposed in a minimal velocity-based pedestrian model. The improvements of the models are based on the different agent forms. The different representations of the agent lead to different results, in this paper, we simulated the pedestrian movements in some typical scenes by using different agent forms, and the agent forms included the circles with different radiuses, the ellipse and the multi-circle stand for one pedestrian. We have proposed a novel model of pedestrian dynamics to optimize the simulation. Our model specifies the pedestrian behavior using a dynamic ellipse, which is parameterized by their velocity and can improve the simulaton accuracy. We found a representation of the pedestrian much closer to the reality. The phenomena of the self-organization can be observable in the improved models.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09b
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• pp.973-975
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• 2005

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09b
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• pp.1359-1360
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• 2005

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.205-206
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• 2003