• 한국측량학회지
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• 제26권3호
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• pp.241-253
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• 2008

최근 u-City, uECO-City와 같은 유비쿼터스(ubiquitous) 개념이 도입된 도시계획의 새로운 패러다임이 등장하면서 도심지역에 대한 고품질의 3차원 지형공간정보에 대한 필요성이 대두되고 있다. 정사영상(orthophoto)은 고도의 전문기술자가 아니더라도 개인용 컴퓨터를 이용하여 수치지도에 비해 손쉽게 적은 비용과 시간으로도 제작할 수 있으며, 지형지물의 상호위치관계가 지형도와 동일함에 따라 정사사진을 통해 직접적으로 거리, 각도 지형지물의 수평 및 수직위치좌표, 면적 등의 정보를 얻을 수 있다. 그리고 영상으로 표현됨으로 시각적 효과가 양호함으로 지형의 세세한 부분까지도 판독이 용이하여 수치지도에 비해 효과적으로 정보를 인식할 수 있는 장점을 가지고 있어 다양한 분야에서 제작 및 활용이 이루어지고 있다. 이에 본 연구에서는 도심지역의 실감정사 사진 제작을 위한 정밀 DSM 생성 방안을 제시하고, 정사사진의 기하학적 보정과 방사적 보정시 최적 변수값을 실험을 통해 규명함으로써, 도심지역의 최적 실감정사사진 제작 방안을 제시하였다. 또한 정립된 최적 생성 방안으로 생성된 실감정사영상 및 정밀 DSM을 이용해 3차원 도시모델을 제작하여 활용성을 검토하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권6호
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• pp.797-803
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• 2017

Objective: Effects of nitrogen supplementation associated with different levels of starch on voluntary intake, digestibility, and rumen and metabolic characteristics of cattle fed low-quality tropical forage (Brachiaria decumbens hay, 7.4% crude protein, CP) were evaluated using ruminal and abomasal cannulated steers. Methods: Five European${\times}$Zebu young bulls (186 kg body weight, BW) were distributed according to a $5{\times}5$ Latin square. The following treatments were evaluated: control, supplementation with 300 g CP/d (0:1), supplementation with 300 g starch/d and 300 g CP/d (1:1), supplementation with 600 g starch/d and 300 g CP/d (2:1), and supplementation with 900 g starch/d and 300 g CP/d (3:1). A mixture of nitrogenous compounds provided 1/3 from true protein (casein) and 2/3 from non-protein nitrogen (mixture of urea and ammonium sulphate, 9:1) was used as the nitrogen supplement. In order to supply energy a unique source of corn starch was used. Results: Supplements increased (p<0.05) dry matter intake, but did not affect (p>0.05) forage intake. There was a cubic effect (p<0.05) of starch on voluntary intake. This was attributed to the highest forage intake (g/kg BW) when using the 2:1 starch:CP ratio. Supplements increased (p<0.05) organic matter (OM) digestibility, but did not affect (p>0.05) neutral detergent fibre corrected for ash and protein (NDFap) digestibility. There was a positive linear effect (p<0.05) of the amount of starch supplemented on OM digestibility. Total NDFap digestibility was not affected (p>0.05) by the amount of supplemental starch. Ruminal ammonia nitrogen concentrations were higher (p<0.05) in supplemented animals, however, a negative linear effect (p<0.05) of amount of starch was observed. Supplements increased (p<0.05) the nitrogen balance (NB) and efficiency of nitrogen utilization. These effects were attributed to increased body anabolism, supported by higher (p<0.05) serum concentration of insulin-like growth factor 1. Increasing the amount of starch tended (p<0.06) to linearly increase the NB. In spite of this, there was a highest NB value for the 2:1 starch:CP ratio amongst the treatments with supplementation. Conclusion: Nitrogen supplementation in cattle fed low-quality tropical forage increases nitrogen retention in the animal's body. An additional supply of starch increases nitrogen retention by increasing energy availability for both rumen and animal metabolism.

• 대한약침학회지
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• 제19권2호
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• pp.129-136
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• 2016

Objectives: The crude extracts of Scutellaria barbata D. Don (SB) have traditionally demonstrated inhibitory effects on numerous human cancers both in vitro and in vivo. Gastric cancer is one of the most common types of cancer on world. The authors investigated the effects of an ethanol extract of Scutellaria barbata D. Don (ESB) on the growth and survival of MKN-45 cells (a human gastric adenocarcinoma cell line). Methods: The MKN-45 cells were treated with different concentrations of ESB, and cell death was examined using an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Analyses of sub-G1 peaks, caspase-3 and -9 activities, and mitochondrial membrane depolarizations were conducted to determine the anti-cancer effects of SB on MKN-45 cells. Also, intracellular reactive oxygen species (ROS) generation was investigated. Results: ESB inhibited the growth of MKN-45 cells, caused cell cycle arrest, and increased the sub-G1 population. In addition, ESB markedly increased mitochondrial membrane depolarization and the activities of caspase-3 and -9. ESB exerted anti-proliferative effects on MKN-45 cells by modulating the mitogen-activated protein kinase (MAPK) signaling pathway and by increasing the generation of ROS. Furthermore, combinations of anti-cancer drugs plus ESB suppressed cell growth more than treatments with an agent or ESB, and this was especially true for cisplatin, etoposide, and doxorubicin. Conclusion: ESB has a dose-dependent cytotoxic effect on MKN-45 cells and this is closely associated with the induction of apoptosis. ESB-induced apoptosis is mediated by mitochondria-, caspase- and MAPK dependent pathways. In addition, ESB enhances ROS generation and increases the chemosensitivity of MKN-45 cells. These results suggest that treatment with ESB can inhibit the proliferation and promote the apoptosis of human gastric adenocarcinoma cells by modulating the caspase-, MAPK- and ROS-dependent pathway.

• 경영과정보연구
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• 제32권1호
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• pp.1-18
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• 2013

기업의 R&D 노력과 혁신에 관한 선행연구들은 주로 R&D 노력이 혁신에 어떠한 영향을 미치는지에 관한 분석에 집중하였는데, 이들 연구의 핵심결과는 일관적인 실증분석의 결과를 가져다주지 못하였다. 또한 기업의 혁신을 강화하기 위한 정부의 정책지원은 기업혁신을 창출시키기 위한 중요한 요소로써 간주되어 왔음에도 불구하고 정부정책지원이 기업의 R&D 노력이 혁신으로 이어지는데 있어서의 역할을 규명한 연구는 극히 드문 실정이다. 실제로 대부분의 정부정책지원에 관한 연구 역시 혁신에 직접적인 효과성이 있는지에 관한 연구에 편중되어 왔다. 본 연구는 과학기술정책연구원(STEPI)에서 조사한 2008년 제조업 기업의 기술혁신활동조사표(2008년도)를 이용하여 R&D가 기업의 혁신에 미치는 영향 및 그러한 관계에서 정부정책지원의 조절효과를 규명하려고 시도하였다. 실증분석의 결과는 R&D는 혁신에 긍정적인 영향을 미치는 것으로 나타났으며, R&D와 혁신간 관계에서 정부정책지원의 조절효과를 분석한 결과 역시 긍정적으로 나타났다. 이는 기업의 정부정책지원을 많이 받을수록 R&D와 혁신 간의 긍정적 관계가 더 높아진다는 것을 의미하는 것으로 정부정책지원의 긍정적 조절효과가 존재하고 있음을 보여준다. 따라서 기업에 필요한 혁신은 기업의 R&D 노력으로 달성될 수 있는데 R&D 노력이 보다 효율적으로 혁신과 연계되기 위해서는 정부정책지원이 필요가 있음을 시사하고 있다.

• Toxicological Research
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• 제32권3호
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• pp.177-193
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• 2016

After more than half of century since the Warburg effect was described, this atypical metabolism has been standing true for almost every type of cancer, exhibiting higher glycolysis and lactate metabolism and defective mitochondrial ATP production. This phenomenon had attracted many scientists to the problem of elucidating the mechanism of, and reason for, this effect. Several models based on oncogenic studies have been proposed, such as the accumulation of mitochondrial gene mutations, the switch from oxidative phosphorylation respiration to glycolysis, the enhancement of lactate metabolism, and the alteration of glycolytic genes. Whether the Warburg phenomenon is the consequence of genetic dysregulation in cancer or the cause of cancer remains unknown. Moreover, the exact reasons and physiological values of this peculiar metabolism in cancer remain unclear. Although there are some pharmacological compounds, such as 2-deoxy-D-glucose, dichloroacetic acid, and 3-bromopyruvate, therapeutic strategies, including diet, have been developed based on targeting the Warburg effect. In this review, we will revisit the Warburg effect to determine how much scientists currently understand about this phenomenon and how we can treat the cancer based on targeting metabolism.

• 한국식생활문화학회지
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• 제38권6호
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• pp.434-441
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• 2023

This study investigated quality characteristics and antioxidant activity of beetroots after blanching. Beetroots were blanched in distilled water, 2% NaCl water, and 2% citric acid water at 100℃ for 3 minutes (the blanched group). The moisture content was highest in the control (CON) at 91.30% (p<0.05), and cooking loss was lowest in the water-blanched beetroot (BW) at 5.39% (p<0.01). Chromaticity decreased after blanching compared to CON (p<0.001). Total polyphenol contents (TPC) and total flavonoid contents (TFC) decreased after blanching, and as a result of comparing the True retention (TR) of the blanching treatment group, BW had the highest with TPC TR 91.22% and TFC TR 70.51%. DPPH and ABTS+radical scavenging activities were highest in the CON, and in the blanching group BW was highest scavenging activity. The total number of microorganisms in the CON group was 2.97 log CFU/g, whereas no microorganisms were detected in the blanched groups. Therefore, this study, blanching in water without additives is the most appropriate method for preserving physiologically active substances and nutrients in beetroots and inhibiting microbial growth.

• Asian-Australasian Journal of Animal Sciences
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• 제15권11호
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• pp.1634-1638
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• 2002

Quantification of endogenous amino acid loss at the terminal ileum is an essential means for calculation of the true amino acid digestibility of a feedstuff. Since nitrogen appeared in the determined diet or not could shift the results very much, also, none of digestibility markers could be recovered with 100% rate at the terminal ileum, the objectives of the present study were: (1) to determine endogenous amino acid losses when fed either a casein diet or a protein-free diet and (2) to examine the reliability of chromic oxide or acid insoluble ash in the protein-free diet. Six ileal-cannulated pigs ($65{\pm}1.85 kg$ BW) with a simple T-cannula in the terminal ileum were used in a replicated $3{\times}3$ Latin square designed trial, after allowed a 14 d recuperation period. Each test period ran for 12 days comprised of a 10 d adjustment period and a 2 d collection period. The endogenous AA losses of His, Ile, Lys, Cys, Thr, Val, Trp, Asp, Glu, and Ser from pigs fed the casein diet were significantly higher than those of the protein-free diet (p<0.05). No significant difference was found in the amount of endogenous amino acid loss when determined with the different markers in the protein-free diet (p>0.05). These data suggest that endogenous amino acid loss could be underestimated when a protein-free diet is used. A direct effect of dietary peptides on the endogenous amino acid loss was found when the casein diet was fed. Our results also indicate that acid insoluble ash can be used as an inert marker as an alternative to chromic oxide when measuring endogenous amino acid loss.

• 한국응용곤충학회지
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• 제38권1호
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• pp.29-33
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• 1999

총채벌레류의 포식성 천적으로 알려진 Orius strigicollis(Poppius)의 발육과 산란에 미치는 온도의 영향을 조사하기 위한 실험조건은 처리온도 15, 20, 25, $30^{\circ}C$, 상대습도 60~80%, 광주기 16L:8D로 조절하였으며, 먹이는 목화 진딧물을 급여하였다. 처리온도별 총산란수와 성충수명은 각각 39.1, 66.4, 68.5, 47.5개와 32.6, 26.5, 13.7, 9.0일이었으며, 알기간과 부화율은 각각 18.9, 8.6, 6.1, 3.4일과 70.6, 81.8, 80.0, 91.8%이었고, 약충의 발육기간과 생존율은 각각 45.6, 21.3, 11.6, 9.4일과 26.7, 43.3, 76.7, 46.7%였다. 발육영점온도는 알 $12.4^{\circ}C$, 약충 $11.4^{\circ}C$였고, 유효적산온도는 알 64.9일도, 약충 172.4일도이다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제23권1호
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• pp.25-29
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• 2018

The effect of soil grinding on total As and Pb concentrations determined by aqua regia method was examined. Among six field-collected, air-dried soil samples tested, soils A, B, C, and E were directly sieved through a $150-{\mu}m$ sieve without grinding and showed 2.18 to 3.03 times higher total As concentrations and 2.62 to 3.45 times higher total Pb concentrations than those of the soil samples prepared to allow all soil particles to pass through the $150-{\mu}m$ sieve by grinding. The reason can be ascribed to the fact that those soils contain fine particles (i.e., < $150{\mu}m$ in diameter) only 4.6 to 6.8% of the total soil weights. On the other hand, for D and F soils, fine particles smaller than $150{\mu}m$ accounted for 57 and 46%, respectively, so that the effect of grinding on As and Pb concentrations were relatively low (As: 1.15 and 1.23 times, Pb: 1.36 and 1.49 times, respectively). The result demonstrates that grinding prior to $150-{\mu}m$ sieving is necessary to ensure the homogeneity of soil samples and hence to obtain more accurate heavy metal concentrations in soils. This is especially true for soil samples with less fine soil particles and/or microaggregates (i.e., below $150{\mu}m$).

• Asian-Australasian Journal of Animal Sciences
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• 제27권1호
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• pp.69-76
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• 2014

This study was carried out to evaluate the relationship between threonine (Thr) efficiency and Thr dehydrogenase (TDG) activity as an indicator of Thr oxidation on chicks fed with levels of diets (CP [17.5% and 21.5%] and Thr [3.8 and 4.7 g/100 g CP]; glycine [Gly][0.64% and 0.98%] and true digestible Thr [dThr] [0.45% and 0.60%]). Calculation of the Thr efficiency was based on N-balance data and an exponential N-utilization model, and TDG activity was determined as accumulation of aminoacetone and Gly during incubation of hepatic mitochondria. This study found that in the liver of chicks who received a diet containing up to 0.79% Thr (4.7 g Thr/100 g of CP) in the 17.5% CP diet, no significant (p>0.05) effect on TDG activity was observed. However, significantly (p = 0.014) increased TDG activity was observed with a diet containing 21.5% CP (4.7 g Thr/100 g of CP) and the efficiency of Thr utilization showed a significant (p = 0.001) decrease, indicating the end of the Thr limiting range. No significant (p>0.05) effect on the total TDG activity and accumulation of Gly was observed with addition of Gly to a diet containing 0.45% dThr. In addition, addition of Gly to a diet containing 0.60% dThr also did not result in a change in accumulation of Gly. Due to an increase in accumulation of aminoacetone, an elevated effect on total TDG activity was also observed. No significant (p>0.05) reduction in the efficiency of Thr utilization was observed after addition of Gly at the level of 0.45% dThr. However, significantly (p<0.001) reduced efficiency of Thr utilization was observed after addition of Gly at the level of 0.60% dThr. Collectively, we found that TDG was stimulated not only by addition of Thr and protein to the diet, but also by addition of Gly, and efficiency of Thr utilization was favorably affected by addition of Gly at the level near to the optimal Thr concentration. In addition, no metabolic requirement of Gly through the TDG pathway was observed with almost the same accumulation of Gly and a slight increase in TDG activity by addition of Gly. Thus, our findings suggest that determination of TDG activity and parameter of efficiency of Thr utilization may be useful for evaluation of dietary Thr level.