• Journal of Integrative Natural Science
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• v.4 no.1
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• pp.23-30
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• 2011

Multidrug resistance (MDR) is one of the main obstacles in the chemotherapy of cancer. MDR is associated with the over expression of P-glycoprotein (P-gp), resulting in increased efflux of chemotherapy from cancer cells. Inhibiting P-gp as a method to reverse MDR in cancer patients has been studied extensively, but the results have generally been disappointing. First-generation agents were limited by unacceptable toxicity, whereas second-generation agents had better tolerability but were confounded by unpredictable pharmacokinetic interactions and interactions with other transporter proteins. Third-generation inhibitors have high potency and specificity for P-gp. Furthermore, pharmacokinetic studies to date have shown no appreciable impact on drug metabolism and no clinically significant drug interactions with common chemotherapy agents. Third-generation P-gp inhibitors have shown promise in clinical trials. The continued development of these agents may establish the true therapeutic potential of P-gp-mediated MDR reversal.

• Steel and Composite Structures
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• v.12 no.4
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• pp.325-350
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• 2012

Concrete filled steel hollow structural sections (CFSs) are an efficient, sustainable, and attractive option for both ambient temperature and fire resistance design of columns in multi-storey buildings and are becoming increasingly common in modern construction practice around the world. Whilst the design of these sections at ambient temperatures is reasonably well understood, and models to predict the strength and failure modes of these elements at ambient temperatures correlate well with observations from tests, this appears not to be true in the case of fire resistant design. This paper reviews available data from furnace tests on CFS columns and assesses the statistical confidence in available fire resistance design models/approaches used in North America and Europe. This is done using a meta-analysis comparing the available experimental data from large-scale standard fire tests performed around the world against fire resistance predictions from design codes. It is shown that available design approaches carry a very large uncertainty of prediction, suggesting that they fail to properly account for fundamental aspects of the underlying thermal response and/or structural mechanics during fire. Current North American fire resistance design approaches for CFS columns are shown to be considerably less conservative, on average, than those used in Europe.

• The Journal of Natural Sciences
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• v.7
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• pp.91-101
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• 1995

To establish the simple and practical test method of estimating resistance of rice varieties against rice leafblight, trials were made to correlate among the four test methods such as true resistance test,secondaryinfection test, secondary epidemic test and field test. The results obtained through the experiment on 25 ricevarieties and 3 pathogenic isolates designated to HB9O11, HB9022 and HB9033 can be summarized asfollows. 1 .Based on the results of true resistance test, 25 rice varieties can be classified into four groups:1 )Samgang variety group ;resistant to HB9011, 13 varieties, 2)Pungsan variety group ; resistant to HB9011 and HB9022, 5 varieties, 3)Samgang variety group ; resistant to all three isolates, 2 varieties, 4)Unbongvariety group: sensitive to all three isolates, 12 varieties. 2. The responses of rice varieties to isolates showed some discrepancies among on the test methods. These examples were found in 3 varieties including Yeongdeog varieties to HB9011, 3 varieties including Taebaeg variety to HB9022 and Taebaek vaieties to HB9033. 3. Correlation coefficiences between the secondary infection test and the secondary epidemic test for HB9011, HB9022 and HB9033 were 0.972, 0.894 and 0.919, respectively. It suggests that the two methods are not significantly different so that one of the two methods are not significantly different so that one of the two methods can be omitted from resistant test without affecting the result. 4. Between the true resistance test and the field test at the disease common area, there were no significant correlations. Unbong, Chucheong and Yeongdeog varieties are appeared as resistant varieties in the true resistant test, but their responses in the field test were different and appeared as sensitive varieties. 5. The disease index was used to express theresults from four test methods. The disease index was calculated as the sum of each numerical values of theresults from the four test methods by giving the same weights(0 to 25)to each test method. If the disease index for certain variety is less than 15, then the variety is considered to be resistant. 4 varieties such as Seohae, Hwajin, Yeongdeog and Pungsan varieties-disease indices were less than 15 were selected as field resistance varieties.

• Journal of the Korean Society of Safety
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• v.5 no.3
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• pp.3-7
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• 1990

This study is conducted to experiment on the performance test for 20 types of Filter-integrated Half-masks which could not only protect workers exposed to dusty environment, but also improve workability. Results and conclusions are as follows ： 1) Respirators that removal efficiency of aerosols is 95 percent or more are 11 kinds(55%), and those who are 99.9 percent or more are 4 kinds(20%). Respirators that inhalation resistance is 4 mm in water or less are 13 kinds(65%), and those who are 6 mm in water or less are 17 kinds(85%). Respirators that efficiency of cumulative inhalation resistance is 100 percent or less are 11 kinds(55%) . 2) Respirators that resistance of moisture inhalation is 6 mm in water or less are 11 kinds(55%). and those who are 10 mm in water or less are 13 kinds(65cio), Respira'tors that ratio of removal efficiency for aerosols between dry and wet conditions is 95 percent or more are 9 kinds(45%). 3) Respirators which are not only 95 percent or more for removal efficiency of aersosls and 6 mm in water or less for inhalation resistance, but also 200 percent or less for efficiency of cumulative inhalation resistance, are 8 kinds(40％). Respirators which are not only 99.9 percent or more for removal efficiency and 6 mm in water or less for inhalation resistance, but also 100 percent or less for efficiency of cumulative inhalation resistance, are 3 kinds(15%). Respirators which are not only 95 percent or more for removal efficiency of aerosols and 6 mm in water or less for inhalation resistance, but also 200 percent or less for efficiency of cumulative inhalation resistance and 10 mm in water or less for resistance of moisture inhalation, are 6 kinds(30％) . 4) As standard rrlodel of artificial human head which would be perhaps different from the true one Is used to experiment fitness test, leakage rate is shown to be more or less high. However, artificial human head shall be accurately examined and follow-up studt. would be conducted in the future.

• 한국정보통신설비학회:학술대회논문집
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• 2005.08a
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• pp.259-262
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• 2005

Ground resistance measurement is an elementary technique for the evaluation of grounding system. There are main environmental factors to consider for correct measurement but the problem is that it is practically most cases to measure ground resistance unable to know the factors. This paper presents a methodology toward true value of resistance in the unknown circumstances, utilizing the defined term 'variation rate' of potential difference curve appearing in the distance to a current probe as in the three point fall-of-potential method which comprises the characteristics of environmental factors. This methodology is a induced result from the previous demostrated studies.

• Proceedings of the KIEE Conference
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• 1998.07b
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• pp.423-425
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• 1998

In this paper, a novel Programmable Signal Conditioner(PSC) for Thermo Couple(T/C) without variable-resistance is proposed. It is fabricated by using a fully digitalized error-correction and calibration algorithm. In signal processing of T/C, since the output voltage of T/C is nonlinear and its level is very low, the circuitry become very complicated to reduce the converting error and identify the true thermal voltage signal. The newly proposed PSC has compensation and calibration algorithm not using variable resistor. Moreover structure can be very simple and it has highly precise output characteristics.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.45 no.1
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• pp.59-70
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• 2000

In nature, plant diseases, insects and parasites (hereafter called as "pest") must be co-survived. The most common expression of co-survival of a host crop to the pest can be tolerance. With tolerance, chemical uses can be minimized and it protects environment and sustains host productivity and the minimum pest survival. Tolerance can be applicable in all living organisms including crop plants, lifestocks and even human beings. Tolerant system controls pest about 90 to 95% (this pest control system often be called as horizontal or partial resistance), while the use of chemicals or selection of high resistance controls pest 100% (the most expression of this control system is vertical resistance or true resistance). Controlling or eliminating the pests by either chemicals or vertical resistance create new problems in nature and destroy the co-survial balance of pest and host. Controlling pests through tolerance can only permit co-survive of pests and hosts. Tolerance is durable and environmentally-friend. Crop cultivars based on tolerance system are different from those developed by genetically modified organism (GMO) system. The former stabilizes genetic balance of a pest and a host crop in nature while the latter destabilizes the genetic balance due to 100% control. For three decades, the author has implemented the tolerance system in breeding maize cultivars against various pests in both tropical and temperate environments. Parasitic weed Striga species known as the greatest biological problem in agriculture has even been controlled through this system. The final effect of the tolerance can be an integrated genetic pest management (IGPM) without any chemical uses and it makes co-survival of pests in nature.in nature.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.15 no.2
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• pp.97-104
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• 2001

The effects of the position of potential probe on the measurements of the ground resistance in the fa11-of-potential method are described. The ground resistance is theoretically calculated by applying the 61.8[%] rule, and then the potential probe is located on the straight line between the grounding electrode to be measured and the current probe. However, sometimes the grounding electrode to be measured and the measuring potential and current probes in on-site test might not be arranged on the straight line with adequate distance because there are building, roadblock construction and other establishments. Provided that the grounding electrode to be measured and the measuring potential probes are out of position on the straight line, the measurement of the ground resistance classically falls into an error and the measured ground resistance should be corrected. In this work, measurements were focused on the grounding electrode system made by the ground rods of 2.4 m long. The measuring error was increased with increasing the angle which is made by the 3-points of the grounding electrode to be measured, the potential anti current probes, and it was a negative. That is, all of the measured ground resistances ware less than the true ground resistance.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.444-445
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• 2006

The proposed site selection for transmission system construction is applied by KEPCO's regulation of the site selection criteria and it is confirmed through the deliberation of site selection committee and talking with local authority, by means of study on Present status and site survey, to verify impediment of national land use and development plan. Therefore, it is true that KEPCO has difficulty in timely completion of power facility construction because of civil appeals due to insufficiently evaluate resistance factor of stakeholder and stubborn resistance of inhabitants. This paper describes the PEES(power effect estimation system) which contributed to timely completion of transmission system construction to solve the above difficulty by utilizing IT(Information Technology) such as GIS(Geographic Information System) and LiDAR for the proposed site section. PIES evaluates project impacts on commencement of construction and finds out counter measures then makes public construction information after prediction and analysis of stakeholder's resistance factor.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.7
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• pp.41-48
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• 2009

Grounding impedance depends on the frequency of current flowing into a grounding system lightning in particular has a broad frequency spectrum from some tens of Hz to a few MHz. So the grounding impedance related to transient currents such as lightning should be measured. In this paper, the grounding impedances of vertically-driven ground rods of 10, 30 and 48[m] long are measured and analyzed as functions of the frequency of injected current and the feeding point. As a result, the longer the ground rod is, the lower the steady-state ground resistance is. However the grounding impedance of a vertically-driven ground rod at a high frequency is significantly increased. It is not always true that low grounding impedance follows from a low steady-state ground resistance. It is important to evaluate the high frequency performance of grounding systems for protection against lightning.