• 통합자연과학논문집
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• 제4권1호
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• pp.23-30
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• 2011

Multidrug resistance (MDR) is one of the main obstacles in the chemotherapy of cancer. MDR is associated with the over expression of P-glycoprotein (P-gp), resulting in increased efflux of chemotherapy from cancer cells. Inhibiting P-gp as a method to reverse MDR in cancer patients has been studied extensively, but the results have generally been disappointing. First-generation agents were limited by unacceptable toxicity, whereas second-generation agents had better tolerability but were confounded by unpredictable pharmacokinetic interactions and interactions with other transporter proteins. Third-generation inhibitors have high potency and specificity for P-gp. Furthermore, pharmacokinetic studies to date have shown no appreciable impact on drug metabolism and no clinically significant drug interactions with common chemotherapy agents. Third-generation P-gp inhibitors have shown promise in clinical trials. The continued development of these agents may establish the true therapeutic potential of P-gp-mediated MDR reversal.

• Steel and Composite Structures
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• 제12권4호
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• pp.325-350
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• 2012

Concrete filled steel hollow structural sections (CFSs) are an efficient, sustainable, and attractive option for both ambient temperature and fire resistance design of columns in multi-storey buildings and are becoming increasingly common in modern construction practice around the world. Whilst the design of these sections at ambient temperatures is reasonably well understood, and models to predict the strength and failure modes of these elements at ambient temperatures correlate well with observations from tests, this appears not to be true in the case of fire resistant design. This paper reviews available data from furnace tests on CFS columns and assesses the statistical confidence in available fire resistance design models/approaches used in North America and Europe. This is done using a meta-analysis comparing the available experimental data from large-scale standard fire tests performed around the world against fire resistance predictions from design codes. It is shown that available design approaches carry a very large uncertainty of prediction, suggesting that they fail to properly account for fundamental aspects of the underlying thermal response and/or structural mechanics during fire. Current North American fire resistance design approaches for CFS columns are shown to be considerably less conservative, on average, than those used in Europe.

• 자연과학논문집
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• 제7권
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• pp.91-101
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• 1995

본 연구는 벼 흰잎마름병 포장저항성 검정방법 체계확립을 위해 25개 품종에 대하여 진성저항성검정, 2차감염검정, 2차전염검정 및 상습지현지검정을 실시한 결과는 다음과 같다. 1. 공시한 25개 품종에 대한 진성저항성 검정결과 (1)섬진벼등 13개 품종은 HB9011균에 저항성인 품종군으로, (2)풍산벼등 5개 품종이 HB9022균에 저항성인 품종으로, (3)삼강벼 등 2품종은 HB9011, HB9022, HB9033균에 저항성인 품종군으로 (4)운봉벼 등 12개 품종이 접종균 모두에 이병성인 품종군으로 각각 분류되었다. 2. 2차감염검정결과 HB9011균에 대해서는 영덕벼 등 3품종이, HB9022에 대해서는 태백벼 등 3품종이, HB9033에 대해서는 태백벼가 진성저항성 검정 결과와 상이한 반응을 보였다. 3. 25개 품종에 대한 2차전염검정 결과와 2차감염검정 결과는 각 균주에 대해 상관계수가 각각 0.972, 0.894, 0.919로 나타나 거의 일치하는 경향이었다. 4. 진성저항성검정 결과와 상습지검정 결과 사이에는 상관계수가 각 균주에 대해 각각 0.203, 0.460, 0.591로 나타났는데 상습지현지검정 결과는 운봉벼, 추청벼, 영덕벼가 진성저항성 검정시는 이병성 품종군으로 분류되었으나 동일 품종군내에서도 품종간 차이가 많았다. 5. 4가지 검정결과는 발병지수로 나타내기 위해 각 검정방법별로 지수 25를 부여하여 전체합이 100이 되도록 하였다. 발병지수가 15이하이면 포장저항성이 있다고 판정할 수 있는데, 각 검정방법을 통해 나타난 결과를 종합해보면 서해벼, 화진벼, 영덕벼, 풍산벼 등 4품종이 발병지수 15 이하로 나타나 포장저항성 품종으로 선발되었다.

• 한국안전학회지
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• 제5권3호
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• pp.3-7
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• 1990

This study is conducted to experiment on the performance test for 20 types of Filter-integrated Half-masks which could not only protect workers exposed to dusty environment, but also improve workability. Results and conclusions are as follows ： 1) Respirators that removal efficiency of aerosols is 95 percent or more are 11 kinds(55%), and those who are 99.9 percent or more are 4 kinds(20%). Respirators that inhalation resistance is 4 mm in water or less are 13 kinds(65%), and those who are 6 mm in water or less are 17 kinds(85%). Respirators that efficiency of cumulative inhalation resistance is 100 percent or less are 11 kinds(55%) . 2) Respirators that resistance of moisture inhalation is 6 mm in water or less are 11 kinds(55%). and those who are 10 mm in water or less are 13 kinds(65cio), Respira'tors that ratio of removal efficiency for aerosols between dry and wet conditions is 95 percent or more are 9 kinds(45%). 3) Respirators which are not only 95 percent or more for removal efficiency of aersosls and 6 mm in water or less for inhalation resistance, but also 200 percent or less for efficiency of cumulative inhalation resistance, are 8 kinds(40％). Respirators which are not only 99.9 percent or more for removal efficiency and 6 mm in water or less for inhalation resistance, but also 100 percent or less for efficiency of cumulative inhalation resistance, are 3 kinds(15%). Respirators which are not only 95 percent or more for removal efficiency of aerosols and 6 mm in water or less for inhalation resistance, but also 200 percent or less for efficiency of cumulative inhalation resistance and 10 mm in water or less for resistance of moisture inhalation, are 6 kinds(30％) . 4) As standard rrlodel of artificial human head which would be perhaps different from the true one Is used to experiment fitness test, leakage rate is shown to be more or less high. However, artificial human head shall be accurately examined and follow-up studt. would be conducted in the future.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2005년도 하계학술대회
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• pp.259-262
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• 2005

3점전위강하법을 이용한 접지저항을 측정하는데 있어서 관건이 되는 것은 전류전극에까지 이르는 직선 거리상에서 어느 지점에 접지저항의 참값이 존재하는 지를 찾는데 있다. 그러한 전위점 변화에 영향을 미치는 최대의 변수는 토양의 구성 조건이다. 61.8%법칙은 토양이 균일한 경우의 접지저항 참값을 나타내는 전위점(이하 $R_t$)을 말하는 것이다. 이종 토양구성인 경우 $R_t$는 61.8%에 있지 않으며 이에 대하여는 Dawalibi의 논문에 여러 토양 구성의 기본 모델에 대한 실험적 $R_t$를 제시하고 있다. 이러한 것은 토양의 구성 조건을 안다는 전제하에 적용할 수 있는 것이며 실제의 측정 환경에 있어서 특별히 분석을 하지 않는 한, 토양의 구성이 어떠한 특성으로 이루어져 있는 지를 알고 측정한다는 것은 현실적으로 불가능한 일이다. Dawalibi의 논문을 분석하여 보면 $R_t$에 변이를 일으키는 것은 이종 토양 구성에 의한 대지저항률의 차이에 의한 것임을 알 수 있다. 결론적으로 $R_t$는 대지저항률이 낮은 토양 쪽으로 이동하게 되는데 이것이 전위차 특성 그래프의 기울기상에 변화를 준다. 즉 $R_t$는 전위차 곡선의 기울기에 따라 변화하고 전위차 곡선의 기울기는 인근 토양 구성에 의한 영항을 받으므로 이들의 정량적 상관 관계를 분석하여 원리적 변화 규칙을 정형화하면 굳이 토양의 구성 상태를 알지 않고도 $R_t$를 산출할 수 있는 방법을 도출한 수 있으며 역으로 토양의 구성 특성을 감지할 수 있는 측정 방법을 수립할 수도 있다. 본 논문에서는 이러한 취지의 정량 관계 해석을 통한 현실적 측정 방법을 제공한다.분야 별로 아키텍쳐 정도가 다르게 나타나고 있었다(전자 부품은 분야는 오히려 모듈형에 가까웠음). 비단 항공기 개발과정 뿐만 아니라 다른 산업, 제품에도 적용될 수 있는 틀을 마련함으로써, 기존 연구개발기회에서 산업기술 분석을 통한 체계적 기획으로 전환할 수 있는 새로운 대안을 제시한다. 결과적으로 산업기술의 특성과 구조를 반영한 기술개발 방법론으로 아키텍쳐 이론을 적용할 수 있는 단초를 마련했으며, 이것은 본 논문이 기대하는 바이기도 하다.쁖잖⨀쁖잖⨀／ࠐ쁡잖⨀焆덐瀆倆Ā뫫뫫ĀĀĀĀꪛ䂇잖⨀?잖⨀⁅잖⨀耇잖⨀梷熸ጁ庆䌀―?⨀က䀜徾遖洀ᘘ⼄ⴟᠯЭ⠘

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 B
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• pp.423-425
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• 1998

In this paper, a novel Programmable Signal Conditioner(PSC) for Thermo Couple(T/C) without variable-resistance is proposed. It is fabricated by using a fully digitalized error-correction and calibration algorithm. In signal processing of T/C, since the output voltage of T/C is nonlinear and its level is very low, the circuitry become very complicated to reduce the converting error and identify the true thermal voltage signal. The newly proposed PSC has compensation and calibration algorithm not using variable resistor. Moreover structure can be very simple and it has highly precise output characteristics.

• 한국작물학회지
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• 제45권1호
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• pp.59-70
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• 2000

In nature, plant diseases, insects and parasites (hereafter called as "pest") must be co-survived. The most common expression of co-survival of a host crop to the pest can be tolerance. With tolerance, chemical uses can be minimized and it protects environment and sustains host productivity and the minimum pest survival. Tolerance can be applicable in all living organisms including crop plants, lifestocks and even human beings. Tolerant system controls pest about 90 to 95% (this pest control system often be called as horizontal or partial resistance), while the use of chemicals or selection of high resistance controls pest 100% (the most expression of this control system is vertical resistance or true resistance). Controlling or eliminating the pests by either chemicals or vertical resistance create new problems in nature and destroy the co-survial balance of pest and host. Controlling pests through tolerance can only permit co-survive of pests and hosts. Tolerance is durable and environmentally-friend. Crop cultivars based on tolerance system are different from those developed by genetically modified organism (GMO) system. The former stabilizes genetic balance of a pest and a host crop in nature while the latter destabilizes the genetic balance due to 100% control. For three decades, the author has implemented the tolerance system in breeding maize cultivars against various pests in both tropical and temperate environments. Parasitic weed Striga species known as the greatest biological problem in agriculture has even been controlled through this system. The final effect of the tolerance can be an integrated genetic pest management (IGPM) without any chemical uses and it makes co-survival of pests in nature.in nature.

• 조명전기설비학회논문지
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• 제15권2호
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• pp.97-104
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• 2001

본 논문에서는 전위강하법에 의한 접지저항 측정시 전위보조전극 위치의 영향에 대하여 기술하였다. 전위강하법에서 접지저항은 이론적으로 전위보조전극을 피측정 접지전극과 전류보조전극이 이루는 일직선상에 위치시킬때 61.8[%]법칙을 적용하여 측정한다. 하지만 측정현장의 사정상 전위보조전극의 위치를 피측정 접지전극과 전류 보조전극이 이루는 일직선과 어느 정도의 각도를 가지도록 시설하여 접지저항을 측정하게 될 경우에 측정오차가 발생하게 되고 보정이 필요하다. 본 연구에서의 측정대상 전극은 길이 2.4 [m]의 봉형 접지전극으로 하였으며, 피측정 접지전극, 전위보조전극, 전류보조전극이 일직선상에 놓이지 않은 상태에서 접지저항을 측정하면 측정값은 항상 (-)의 오차를 나타내었고, 이들 전극이 이루는 각도가 증가함에 따라 측정 오차도 증가하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 A
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• pp.444-445
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• 2006

The proposed site selection for transmission system construction is applied by KEPCO's regulation of the site selection criteria and it is confirmed through the deliberation of site selection committee and talking with local authority, by means of study on Present status and site survey, to verify impediment of national land use and development plan. Therefore, it is true that KEPCO has difficulty in timely completion of power facility construction because of civil appeals due to insufficiently evaluate resistance factor of stakeholder and stubborn resistance of inhabitants. This paper describes the PEES(power effect estimation system) which contributed to timely completion of transmission system construction to solve the above difficulty by utilizing IT(Information Technology) such as GIS(Geographic Information System) and LiDAR for the proposed site section. PIES evaluates project impacts on commencement of construction and finds out counter measures then makes public construction information after prediction and analysis of stakeholder's resistance factor.

• 조명전기설비학회논문지
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• 제23권7호
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• pp.41-48
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• 2009

Grounding impedance depends on the frequency of current flowing into a grounding system lightning in particular has a broad frequency spectrum from some tens of Hz to a few MHz. So the grounding impedance related to transient currents such as lightning should be measured. In this paper, the grounding impedances of vertically-driven ground rods of 10, 30 and 48[m] long are measured and analyzed as functions of the frequency of injected current and the feeding point. As a result, the longer the ground rod is, the lower the steady-state ground resistance is. However the grounding impedance of a vertically-driven ground rod at a high frequency is significantly increased. It is not always true that low grounding impedance follows from a low steady-state ground resistance. It is important to evaluate the high frequency performance of grounding systems for protection against lightning.