• 제목/요약/키워드: Triterpene

검색결과 199건 처리시간 0.027초

상륙의 항염증성분 triterpene acid에 관한 연구 (A new triterpene acid from phytolacca esculenta possessing anti-inflammatory action)

  • 우원식
    • 약학회지
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    • 제15권3_4호
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    • pp.99-102
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    • 1971
  • 상륙(Phytolacca esculenta)에서 새로운 물질 trihydroxyolean-12-ene dicarboxylic acid, $C_{30}H_{46}O_{7}$, m.p.318-$320^{\circ}$, [$\alpha$]$_D$$^{6}$ = +113.$7^{\circ}$를 분리하고 jaligonic acid라고 명명하였다. 본물질은 carrageenin으로 유발시킨 edema형성을 강력하게 억제하였다.

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Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root

  • Lee, Dong Gu;Lee, Jaemin;Cho, Ik-Hyun;Kim, Hak-Jae;Lee, Sang-Won;Kim, Young-Ock;Park, Chun-Gun;Lee, Sanghyun
    • Journal of Ginseng Research
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    • 제41권4호
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    • pp.531-533
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    • 2017
  • Background: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. Methods: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. Results and conclusion: New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes.

Two New Antiinflammatory Triterpene Saponins from the Egyptian edicinal Food Black Cumin (Seeds of Nigella sativa)

  • Elbandy, Mohamed;Kang, Ok-Hwa;Kwon, Dong-Yeul;Rho, Jung-Rae
    • Bulletin of the Korean Chemical Society
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    • 제30권8호
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    • pp.1811-1816
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    • 2009
  • An extensive phytochemical investigation of the polar fractions of a methanolic extract of Egyptian medicinal food, black cumin (seeds of Nigella sativa L.) led to the isolation of two new triterpene saponins, named sativosides A and B (1-2), along with four known saponins (3-6). Sativoside A (1) is the first example of saponins containing 18-ene triterpene aglycon not only in this Nigella genus but also in the family Ranunculaceae. The structure of the new saponins was elucidated mainly by a combination of 1D and 2D NMR data, together with HRFABMS and acid hydrolysis. Three compounds (1-3) showed the significant inhibition effect of phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced production of IL-6 in a human mast cell (HMC-1) line.

A New Lupane-Triterpene Glycoside from the Leaves of Acanthopanax gracilistylus

  • Liu, Xiang-Qian;Chang, Seung-Yeup;Park, Sang-Yong;Nohara, Toshihiro;Yook, Chang-Soo
    • Archives of Pharmacal Research
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    • 제25권6호
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    • pp.831-836
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    • 2002
  • A new and two known lupane-triterpene glycosides were isolated from the hot MeOH fraction of the leaves of Acanthopanax gracilistylus W. W. Smith. Based on the physical properties and spectroscopic data, their chemical structures were determined as acankoreoside A (1), acankoreoside D (2), and $3{\alpha}-hydroxy-lup-23-al-20(29)-en-28-oic$ acid $28-O-{\alpha}-L-rhamnopyranosyl-(1{\rightarrow}4)-{$beta}-D-glucopyranosyl-(1{\rightarrow}6)-{\beta}-D-glucopyranosyl$ ester (3), respectively. To our best knowledge, compand 3 appears to be novel, which was named as wujiapioside A.

Fomitoside K, a New Lanostane Triterpene Glycoside from the Fruiting Body of $Fomitopsis$ $nigra$

  • Lee, In-Kyoung;Jung, Jin-Young;Yeom, Ji-Hee;Ki, Dae-Won;Lee, Myeong-Seok;Yeo, Woon-Hyung;Yun, Bong-Sik
    • Mycobiology
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    • 제40권1호
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    • pp.76-78
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    • 2012
  • In an effort to identify the chemical constituents of fruiting bodies of $Fomitopsis$ $nigra$, a new lanostane triterpene glycoside, designated as fomitoside K, has been isolated from its methanolic extract. Its chemical structure was assigned on the basis of various spectroscopic studies.

Synthesis of $^3H$-Labeled dammarane triterpene glycosides of Korean ginseng

  • Han, Byung-Hoon;Woo, Lin-Keun
    • Archives of Pharmacal Research
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    • 제1권1호
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    • pp.27-32
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    • 1978
  • A procedure of $^3H$-radio labeling synthesis for the dammarane triterpene glycosides of Korean ginseng was established by using the ginsenoside $Rg_1$ as starting material. The protons in $C-{11}$ and $C_{13}$ of the aglycone moiety of the glycoside were exchanged with tritium by keto-enol tautomerization of 12-keto-ginsenoside $Rg_1$ which was prepared by partial acetylation, Sarett oxidation and saponification, producing nona-acetate, nonaside $Rg_1$. The acety1-ketone and 12-keto-derivative of ginsenotritated ketone was reduced by metallic sodium and isoproponol to produce the end product $^3H$-ginsenoside $Rg_1$ with 3% radio-chemical recovery in one experiment.

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A New Triterpene Lactone from the Roots of Patrinia scabiosaefolia

  • Yang, Mi-Young;Choi, Young-Hae;Yeo, Ho-Sup;Kim, Jin-Woong
    • Archives of Pharmacal Research
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    • 제24권5호
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    • pp.416-417
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    • 2001
  • A new triterpene lactose named patrinolide A (7) has been isolated from the roots of Patrinia scabiosaefolia (Valerianaceae). Its structure was determined to be 11$\beta$,21$\beta$-dihydroxy-3-oxooleanan-28,13$\beta$-olide on the basis of spectral analysis, including 2D-NMR techniques.

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