Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root

  • Lee, Dong Gu (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Jaemin (Department of Integrative Plant Science, Chung-Ang University) ;
  • Cho, Ik-Hyun (Department of Convergence Medical Science, Brain Korea 21 Plus Program, and Institute of Korean Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hak-Jae (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Lee, Sang-Won (Department of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Kim, Young-Ock (Department of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Park, Chun-Gun (Department of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
  • Received : 2016.04.15
  • Accepted : 2016.10.06
  • Published : 2017.10.15
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Abstract

Background: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. Methods: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. Results and conclusion: New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes.

Keywords

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