• Journal of Advanced Marine Engineering and Technology
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• 제22권6호
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• pp.782-791
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• 1998

This paper presents a computer simulation of five types of triple effect absorption cycles employ-ing the refrigerant absorbent combinations of NH3/LiNO3 low-pressure type NH3/LiNO3+H2O/LiBr binary two-stage type series flow cycle and two types of parallel flow cycle for H2O/LiBr. The absorption systems is investigated through cycle simulation to obtain the system characteristics with the cooling water inlet temperature approach temperature of absorber loss temperature of absorber and chilled water outlet temperature. The most important characteristic temperature of absorber and chilled water outlet temperature. The most important characteristic of NH3/LiNO3 low-pressure type and a NH3/LINO3+H2O/LiBr binary two-stage type is that it obtains a coefficient of performance higher than the sum of the performance coefficients of its part operating independently. As a result of this analysis the optimum designs and operating conditions were determined based on the operating conditions and the coefficient of performance.

• 대한기계학회논문집
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• 제19권1호
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• pp.231-239
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• 1995

This paper describes a computer simulation of the triple effect, water-lithium bromide absorption cooling cycles. The performance of the absorption systems is investigated through cycle simulation to obtain the system characteristics with the cooling water inlet temperature, the working solution concentrations, the ratio of the amount of the weak solution to the high, middle and low temperature generators, and the temperature difference of each solution heat exchanger. The efficiency of different cycles has been studied and the simulation results show that higher coefficient of performance could be obtained for the parallel cycle of constant solution distribution rate. As a result of this analysis, the optimum designs and operating conditions were determined based on the operating conditions and coefficient of performance.

• 설비공학논문집
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• 제10권1호
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• pp.79-87
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• 1998

Basic design of a 50USRT(175㎾) triple effect absorption chiller driven by hot gas has been carried out for both parallel and series flow cycles. Parallel flow cycle showed higher COP, however, the temperature in the generator was also higher than that in series flow cycle. Dynamic operation behavior of a parallel flow system at off-design conditions, such as the change in heat transfer medium temperature or the construction change of the system components, has been investigated in detail. It was found that the cooling capacity was seriously decreased by reducing hot gas flow rate and UA-value in the high temperature generator. However, the system COP was improved, because thermal load in the system components was reduced. The COP and the cooling capacity was found to be improved as cooling water temperature decreased or chilled water temperature increased. The optimum ratio of solution distribution could be suggested by considering the COP, the cooling capacity and the highest temperature in the system, which is critical for corrosion.

• 대한설비공학회지:설비저널
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• 제33권3호
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• pp.43-49
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• 2004

This article reviews R＆D of triple effect cycle developed in Japan. Most of the refrigeration and heat pump technologies are dominated by vapor compressor system. The vapor compressor system, however, is highly concerned with the environmental regulations , as most of the vapor compressor technologies are using CFCs or HCFCs which are known as ozone depleting and global warming gases. As a consequence, refrigeration technologists are trying to invent or to develop an alternative to vapor compressor refrigeration devices. Thermally driven, absorption technology is one of the possible alternatives. At the moment, absorption cycle is most promising technology The paper summarizes briefly the current research and development in advanced technologies of triple effect absorption chiller-heater in Japan.(omitted)

• International Journal of Air-Conditioning and Refrigeration
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• 제15권3호
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• pp.114-121
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• 2007

In this study, a modified reverse flow type, one of the triple effect absorption cycles, is studied for performance improvement. The cycle simulation is carried out by using EES(Engineering Equation Solver) program for the working fluid of $H_2O/LiBr$ solution. The split-ratios of solution flow rate, UA of each component, pumping mass flow rate of solution are considered as key parameters. The results show that the optimal SRH (split ratio of high side) and SRL (split ratio of low side) values are 0.596 and 0.521, respectively. Under these conditions, the COP is maximized to 2.1. The optimal pumping mass flow rate is selected as 3 kg/s and the corresponding UAEV A is 121 kW/K in the present system. The present simulation results are compared to the other literature results from Kaita's (2002) and Cho's (1998) triple effect absorption systems. The present system has a lower solution temperature and a higher COP than the Kaita's modified reverse flow, and it also gives a higher COP than the Cho's parallel flow by adjusting split ratios.

• 설비공학논문집
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• 제29권7호
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• pp.360-365
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• 2017

Recently, development efforts of triple-effect absorption chiller have been increased in order to improve the efficiency of double-effect absorption chiller. However, triple-effect absorption chiller has some disadvantages, including high corrosion characteristic of LiBr solution at high temperature of $200^{\circ}C$. Moreover, it is necessary to develop new components for operation under high pressure of 2 bars even though COP is increased to 1.6 or 1.7. The objective of this study was to introduce a new system by combining double effect absorption chiller with single effect absorption chiller with multi-generators using bypass flow of LiBr dilute solution to $3^{rd}$ generator to overcome the disadvantages of triple-effect chiller and improve energy efficiency. Results indicate that the new absorption cycle had a much higher efficiency than double-effect chiller system, showing significant improvement when bypass solution flow rate of 25% was applied to the $3^{rd}$ generator using the main dilute solution of the absorber. The COP of the new chiller system was found to be 1.438, which was 21.7% higher than that (1.18) of the present double-effect system. The COP was decreased when solution by-pass rate to the $3^{rd}$ generator was increased. In addition, lower cooling water temperature caused higher COP. Therefore, the multi-generator system with by-pass solution might be an excellent chiller alternative to triple-effect absorption chiller with higher efficiency.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.205-213
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• 2017

Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression. Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.

• Journal of Mechanical Science and Technology
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• 제17권11호
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• pp.1746-1755
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• 2003

Operating characteristics of a triple pressure reheat HRSG are analyzed using a commercial software package (Gate Cycle by GE Enter Software). The calculation routine determines all the design parameters including configuration and area of each heat exchanger. The off-design calculation part has the capability of simulating the effect of any operating parameters such as power load, process requirements, and operating mode, etc., on the transient performance of the plant. The arrangement of high-temperature and intermediate-temperature components of the HRSG is changed, and its effect on the steam turbine performance and HRSG characteristics is examined. It is shown that there could be a significant difference in HRSG sizes even though thermal performance is not in great deviation. From the viewpoint of both economics and steam turbine performance, it should be carefully reviewed whether the optimum design point could exist. Off-design performance could be one of the main factors in arranging components of the HRSG because power plants operate at various off-design conditions such as ambient temperature and gas turbine load, etc. It is shown that different heat exchanger configurations lead to different performances with ambient temperature, even though they have almost the same performances at design points.

• Biomolecules & Therapeutics
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• 제30권6호
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• pp.585-592
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• 2022

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist in human triple-negative breast cancer BT-20 and HCC-70 cells. Hydroxyzine inhibited the growth of cells in dose- and time-dependent manners. The annexin V/propidium iodide double staining assay showed that hydroxyzine induced apoptosis. The hydroxyzine-induced apoptosis was accompanied down-regulation of cyclins and CDKs, as well as the generation of reactive oxygen species (ROS) without cell cycle arrest. The effect of hydroxyzine on the induction of ROS and apoptosis on TNBC cells was prevented by pre-treatment with ROS scavengers, N-acetyl cysteine or Mito-TEMPO, a mitochondria-targeted antioxidant, indicating that an increase in the generation of ROS mediated the apoptosis induced by hydroxyzine. Western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of JAK2 and STAT3 by hydroxyzine treatment. In addition, hydroxyzine induced the phosphorylation of JNK and p38 MAPK. Our results indicate that hydroxyzine induced apoptosis via mitochondrial superoxide generation and the suppression of JAK2/STAT3 signaling.

• 대한기계학회논문집B
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• 제26권3호
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• pp.507-514
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• 2002

A computation routine, capable of performing thermal design analysis of the triple-pressure bottoming system (heat recovery steam generator and steam turbine) of combined cycle power plants, is developed. It is based on thermal analysis of the heat recovery steam generator and estimation of its size and steam turbine power. It can be applied to various parametric analyses including optimized design calculation. This paper presents analysis results for the effects on the design performance of heat exchanger arrangements at intermediate and high temperature parts as well as steam pressures. Also examined is the effect of steam sources for deaeration on design performance.