Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling |
Shakya, Rajina
(College of Pharmacy, Daegu Catholic University)
Park, Gyu Hwan (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) Joo, Sang Hoon (College of Pharmacy, Daegu Catholic University) Shim, Jung-Hyun (College of Pharmacy, Mokpo National University) Choi, Joon-Seok (College of Pharmacy, Daegu Catholic University) |
1 | Wu, K. J., Huang, J. M., Zhong, H. J., Dong, Z. Z., Vellaisamy, K., Lu, J. J., Chen, X. P., Chiu, P., Kwong, D. W. J., Han, Q. B., Ma, D. L. and Leung, C. H. (2017) A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells. PLoS One 12, e0177123. DOI |
2 | Matsumoto, N., Ebihara, M., Oishi, S., Fujimoto, Y., Okada, T. and Imamura, T. (2021) Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Sci. Rep. 11, 1492. DOI |
3 | Park, B. K., Kim, D., Park, S., Maharjan, S., Kim, J., Choi, J. K., Akauliya, M., Lee, Y. and Kwon, H. J. (2021) Differential signaling and virus production in Calu-3 cells and Vero cells upon SARS-CoV-2 infection. Biomol. Ther. (Seoul) 29, 273-281. DOI |
4 | Yun, S., Yun, C. W., Lee, J. H., Kim, S. and Lee, S. H. (2018) Cripto enhances proliferation and survival of mesenchymal stem cells by up-regulating JAK2/STAT3 pathway in a GRP78-dependent manner. Biomol. Ther. (Seoul) 26, 464-473. DOI |
5 | Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C. and Darnell, J. E., Jr. (1999) Stat3 as an oncogene. Cell 98, 295-303. DOI |
6 | Asuaje, A., Martin, P., Enrique, N., Zegarra, L. A. D., Smaldini, P., Docena, G. and Milesi, V. (2018) Diphenhydramine inhibits voltagegated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- new insights into the pro-apoptotic effects of antihistaminic drugs. Channels (Austin) 12, 58-64. DOI |
7 | Bayart, J. (1956) Treatment of nervousness in children with hydroxyzine. Acta Paediatr. Belg. 10, 164-169. |
8 | Bertram, J. S. (2000) The molecular biology of cancer. Mol. Aspects Med. 21, 167-223. DOI |
9 | Buettner, R., Mora, L. B. and Jove, R. (2002) Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8, 945-954. |
10 | Chu, C., Geng, Y., Zhou, Y. and Sicinski, P. (2021) Cyclin E in normal physiology and disease states. Trends Cell Biol. 31, 732-746. DOI |
11 | Nam, S., Xie, J., Perkins, A., Ma, Y., Yang, F., Wu, J., Wang, Y., Xu, R. Z., Huang, W., Horne, D. A. and Jove, R. (2012) Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol. Oncol. 6, 484-493. DOI |
12 | Cleator, S., Heller, W. and Coombes, R. C. (2007) Triple-negative breast cancer: therapeutic options. Lancet Oncol. 8, 235-244. DOI |
13 | Franceschelli, S., Pesce, M., Vinciguerra, I., Ferrone, A., Riccioni, G., Patruno, A., Grilli, A., Felaco, M. and Speranza, L. (2011) Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-interferon-gamma inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules 16, 5720-5734. DOI |
14 | Gibbs, W. W. (2003) Untangling the roots of cancer. Sci. Am. 289, 56-65. DOI |
15 | Baldwin, A. S. (2001) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 107, 241-246. DOI |
16 | Jacobs, A. T., Martinez Castaneda-Cruz, D., Rose, M. M. and Connelly, L. (2022) Targeted therapy for breast cancer: an overview of drug classes and outcomes. Biochem. Pharmacol. 204, 115209. DOI |
17 | Kwapisz, D. (2021) Pembrolizumab and atezolizumab in triple-negative breast cancer. Cancer Immunol. Immunother. 70, 607-617. DOI |
18 | Lopez-Onieva, L., Fernandez-Minan, A. and Gonzalez-Reyes, A. (2008) Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. Development 135, 533-540. DOI |
19 | Lopez, J. and Tait, S. W. (2015) Mitochondrial apoptosis: killing cancer using the enemy within. Br. J. Cancer 112, 957-962. DOI |
20 | McIlwain, D. R., Berger, T. and Mak, T. W. (2013) Caspase functions in cell death and disease. Cold Spring Harb. Perspect. Biol. 5, a008656. |
21 | Haraguchi, K., Ito, K., Kotaki, H., Sawada, Y. and Iga, T. (1997) Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies. Drug Metab. Dispos. 25, 675-684. |
22 | Bollrath, J. and Greten, F. R. (2009) IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep. 10, 1314-1319. DOI |
23 | Cho, T. M., Kim, J. Y., Kim, Y. J., Sung, D., Oh, E., Jang, S., Farrand, L., Hoang, V. H., Nguyen, C. T., Ann, J., Lee, J. and Seo, J. H. (2019) C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition. Cancer Lett. 447, 141-153. DOI |
24 | Dent, R. A., Lindeman, G. J., Clemons, M., Wildiers, H., Chan, A., McCarthy, N. J., Singer, C. F., Lowe, E. S., Watkins, C. L. and Carmichael, J. (2013) Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer. Breast Cancer Res. 15, R88. DOI |
25 | Ling, Y. H., Liebes, L., Zou, Y. and Perez-Soler, R. (2003) Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J. Biol. Chem. 278, 33714-33723. DOI |
26 | Siegel, R. L., Miller, K. D. and Jemal, A. (2020) Cancer statistics, 2020. CA Cancer J. Clin. 70, 7-30. DOI |
27 | Richa, S., Dey, P., Park, C., Yang, J., Son, J. Y., Park, J. H., Lee, S. H., Ahn, M. Y., Kim, I. S., Moon, H. R. and Kim, H. S. (2020) A new histone deacetylase inhibitor, MHY4381, induces apoptosis via generation of reactive oxygen species in human prostate cancer cells. Biomol. Ther. (Seoul) 28, 184-194. DOI |
28 | Richelson, E. (1979) Tricyclic antidepressants and histamine H1 receptors. Mayo Clin. Proc. 54, 669-674. |
29 | Shan, X. L., Zhou, X. Y., Yang, J., Wang, Y. L., Deng, Y. H. and Zhang, M. X. (2010) Inhibitory effect of cucurbitacin E on the proliferation of ovarian cancer cells and its mechanism. Chin. J. Cancer 29, 20-24. DOI |
30 | Stover, D. G., Gil Del Alcazar, C. R., Brock, J., Guo, H., Overmoyer, B., Balko, J., Xu, Q., Bardia, A., Tolaney, S. M., Gelman, R., Lloyd, M., Wang, Y., Xu, Y., Michor, F., Wang, V., Winer, E. P., Polyak, K. and Lin, N. U. (2018) Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer. NPJ Breast Cancer 4, 10. DOI |
31 | Sui, X., Kong, N., Ye, L., Han, W., Zhou, J., Zhang, Q., He, C. and Pan, H. (2014) p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 344, 174-179. DOI |
32 | Wang, S. W. and Sun, Y. M. (2014) The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (review). Int. J. Oncol. 44, 1032-1040. DOI |
33 | Wong, R. S. (2011) Apoptosis in cancer: from pathogenesis to treatment. J. Exp. Clin. Cancer Res. 30, 87. DOI |
34 | Tsukuda, M., Furukawa, S., Kokatsu, T., Enomoto, H., Kubota, A. and Furukawa, M. (1995) Comparison of granisetron alone and granisetron plus hydroxyzine hydrochloride for prophylactic treatment of emesis induced by cisplatin chemotherapy. Eur. J. Cancer 31A, 1647-1649. |
35 | Seo, E. J., Fischer, N. and Efferth, T. (2017) Role of TCTP for cellular differentiation and cancer therapy. Results Probl. Cell Differ. 64, 263-281. DOI |
36 | Smith, E., Narang, P., Enja, M. and Lippmann, S. (2016) Pharmacotherapy for insomnia in primary care. Prim. Care Companion. CNS Disord. 18, doi: 10.4088/PCC.16br01930. DOI |
![]() |