• Journal of KIISE
• /
• v.42 no.10
• /
• pp.1195-1206
• /
• 2015

For the management of a knowledge system, systems that automatically infer and manage scalable knowledge are required. Most of these systems use ontologies in order to exchange knowledge between machines and infer new knowledge. Therefore, approaches are needed that infer new knowledge for scalable ontology. In this paper, we propose an approach to perform rule based reasoning for scalable SHIF ontologies in a spark framework which works similarly to MapReduce in distributed memories on a cluster. For performing efficient reasoning in distributed memories, we focus on three areas. First, we define a data structure for splitting scalable ontology triples into small sets according to each reasoning rule and loading these triple sets in distributed memories. Second, a rule execution order and iteration conditions based on dependencies and correlations among the SHIF rules are defined. Finally, we explain the operations that are adapted to execute the rules, and these operations are based on reasoning algorithms. In order to evaluate the suggested methods in this paper, we perform an experiment with WebPie, which is a representative ontology reasoner based on a cluster using the LUBM set, which is formal data used to evaluate ontology inference and search speed. Consequently, the proposed approach shows that the throughput is improved by 28,400% (157k/sec) from WebPie(553/sec) with LUBM.

• Journal of Korean Orthopaedic Sports Medicine
• /
• v.4 no.2
• /
• pp.109-115
• /
• 2005

Purpose: The purpose of this study was to evaluate the effectiveness of three functional performance tests and one-legged hop test and to establish the reference data of the three functional performance tests of the active young Korean men. Materials and methods: We performed five tests on 40 normal subjects such as one-legged hop test (single hop, triple hop) and the three functional performance tests (carioca test, co-contraction test, shuttle run test). The mean age was 28.4 years. The mean score of Tegner activity scale was 6.2 and Lysholm score 98.2 Mean value and standard deviation were obtained. The correlation of age, height and weight with the results, the relationship between FPT and one-legged hop test and the mean difference between dominant and non-dominant limbs were statistically calculated. Results: All data obtained were normally distributed and there were no significant relationship between age, height and weight. The paired t-test of one legged hop test showed no statistical significance between dominant and non-dominant limbs. The results of one legged hop test had strong relationship with functional performance test. Conclusion; The three functional performance tests can be a useful functional test in ACL-insufficient athletes. Our results can be used as normal reference data of the normal active Korean men.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.8 no.1
• /
• pp.12-20
• /
• 2005

Purpose: Helicobacter pylori infection is known to be associated with acute or chronic abdominal pain and upper gastrointestinal bleeding in children. This study was performed to analyze the gastroduodenoscopic findings and the efficacy of triple therapy with omeprazole, amoxicillin and clarithromycin between one and two weeks of duration in children with H. pylori infection. Methods: We have assessed retrospectively 60 patients presented with acute or chronic abdominal pain or upper gastrointestinal bleeding. H. pylori infection was confirmed by endoscopic biopsy and rapid urease test. Out of 60 patients, 30 patients were treated with a combination of omeprazole, amoxicillin, and clarithromycin for one week, and the other 30 patients were treated for two weeks with the same medication. Efficacy of treatment was assessed 4 weeks after the termination of treatment by using the $^{13}C$ urea breath test. Results: The 60 patients with the complaint of diffuse abdominal pain, epigastric pain, vomiting or hematemesis were included in this study. One-week treatment group (group I) consisted of 30 patients (14 male, 16 female) with mean age of $11.6{\pm}2.67years$. Two-week treatment group (group II) consisted of 30 patients (11 male, 19 female) with mean age of $10.7{\pm}4.17years$. In group I, H pylori were eradicated in 26 out of 30 patients (86.7%). In group II, H. pylori were eradicated in 26 out of 30 children (86.7%). Both groups did $^{13}C$ urea breath test after 4 weeks after termination of the triple therapy. The eradication rates were same in both groups as 86.7%, 26 out of 30 patients in each group. The results of endoscopy were nodular gastritis 26 (43.3%), erosive gastritis 10 (16.7%), hemorrhagic gastritis 7 (11.7%), gastric ulcer 2 (3.3%) and normal finding 15 (25.0%). Conclusion: In this study, the nodular gastritis was most common endoscopic findings with H. pylori positive patients. The eradication rate of H. pylori with omeprazole, amoxicillin and clarithromycin was 86.7% and it would be highly effective as primary treatment with no significant differences in the eradication rate between one-week and two-week treatment groups. However, we should need more long-term follow-up data.

• Journal of the Korean Geographical Society
• /
• v.47 no.3
• /
• pp.328-346
• /
• 2012

This study provides quantitative constraints on Neogene uplift in the Korean peninsula using onshore paleo-shoreline records and seismic data. The eastern margin of Northeast Asia including Korea sits in the back-arc system behind the Western Pacific Subduction Zone, a complex trench triple junction of the Philippine Sea, Pacific, and Eurasian (Amurian) plates. An analysis of seismic data in the subduction zone shows that the pattern of uplift in the peninsula mirrors the extent of deep seismicity in subducting Pacific plate beneath. Combined with previous tomographic studies it is proposed that uplift is partly driven by asthenospheric upwelling caused by a sinking slab during the Neogene. In addition, the SHmax orientations of E-W and N-S trends in the peninsula are consistent with the prevailing in-situ stress fields in the eastern Eurasian continent generated by various plate boundary forces. The uplift in Korea during the Late Neogene is attributed, in part, to lithospheric failure relating to faulting movements, thus providing a link between dynamic effects of mantle upwelling at sinking slab edge and lithospheric responses driven by plate boundary forces.

• Journal of KIISE:Software and Applications
• /
• v.36 no.11
• /
• pp.960-966
• /
• 2009

A manifold is used to represent a relationship between high-dimensional data samples in low-dimensional space. In human pose estimation, it is created in low-dimensional space for processing image and 3D body configuration data. Manifold learning is to build a manifold. But it is vulnerable to silhouette variations. Such silhouette variations are occurred due to view-change, person-change, distance-change, and noises. Representing silhouette variations in a single manifold is impossible. In this paper, we focus a silhouette variation problem occurred by view-change. In previous view invariant pose estimation methods based on manifold learning, there were two ways. One is modeling manifolds for all view points. The other is to extract view factors from mapping functions. But these methods do not support one by one mapping for silhouettes and corresponding body configurations because of unsupervised learning. Modeling manifold and extracting view factors are very complex. So we propose a method based on triple manifolds. These are view manifold, pose manifold, and body configuration manifold. In order to build manifolds, we employ biased manifold learning. After building manifolds, we learn mapping functions among spaces (2D image space, pose manifold space, view manifold space, body configuration manifold space, 3D body configuration space). In our experiments, we could estimate various body poses from 24 view points.

• Journal of KIISE
• /
• v.42 no.3
• /
• pp.307-319
• /
• 2015

Current ontology studies use the Hadoop distributed storage framework to perform map-reduce algorithm-based reasoning for scalable ontologies. In this paper, however, we propose a novel approach for scalable Web Ontology Language (OWL) Horst Lite ontology reasoning, based on distributed cluster memories. Rule-based reasoning, which is frequently used for scalable ontologies, iteratively executes triple-format ontology rules, until the inferred data no longer exists. Therefore, when the scalable ontology reasoning is performed on computer hard drives, the ontology reasoner suffers from performance limitations. In order to overcome this drawback, we propose an approach that loads the ontologies into distributed cluster memories, using Spark (a memory-based distributed computing framework), which executes the ontology reasoning. In order to implement an appropriate OWL Horst Lite ontology reasoning system on Spark, our method divides the scalable ontologies into blocks, loads each block into the cluster nodes, and subsequently handles the data in the distributed memories. We used the Lehigh University Benchmark, which is used to evaluate ontology inference and search speed, to experimentally evaluate the methods suggested in this paper, which we applied to LUBM8000 (1.1 billion triples, 155 gigabytes). When compared with WebPIE, a representative mapreduce algorithm-based scalable ontology reasoner, the proposed approach showed a throughput improvement of 320% (62k/s) over WebPIE (19k/s).

• Journal of Korean Society for Atmospheric Environment
• /
• v.25 no.6
• /
• pp.523-538
• /
• 2009

Recently, there has been a keen demand for real-time automatic monitoring of VOCs not only in Korea but other developed countries. We carried out this study to evaluate and to optimize the performance of a continuous automatic monitoring system for hazardous VOCs (HVOCs) in the ambient atmosphere, using an on-line GC system. The online system normally consisted of a Nafion dryer prior to a cold trap of an automatic thermal desorption apparatus and a GC system equipped with two detectors, i.e. PID and ECD. Preliminary tests conducted to check out any contamination of the system revealed an evidence of significant artifact formation of benzene, and it was found that the Nafion dryer (even brand new one) is the source of the benzene artifact. Thus, all the subsequent experiments in this study was carried out inevitably by removing the Nafion dryer. The on-line GC method was investigated with a variety of QC/QA performance criteria such as repeatability, linearity, lower detection limits, and accuracy. In order to find out the best operating condition for the on-line GC system, three different types (in terms of adsorption strength) of cold trap combinations were tested, i.e. (i) Tenax-TA and Carbopack-B combination (weak and hydrophobic); (ii) Tenax-TA, Carbopack-X and Carboxen-1000 combination (strong and hydrophilic); and (iii) Tenax-TA and Carbopack-X combination (medium and hydrophobic/hydrophilic). The USEPA TO-17 manual method was selected as a reference method to evaluate the performance of the on-line method. A series of experiments revealed that the system performance was superior to others when a cold trap packed with hydrophilic adsorbents (Tenax-TA/Carbopack-X/Carboxen-1000 combination) was used and operated at $25^{\circ}C$. However, the system with a cold trap packed with a combination of Tenax-TA and Carbopack-X is more recommended for field applications since the carboxen-1000 adsorbent is too sensitive to water vapor, and hence the performance of the system might be very unstable to humid samples or during rainy days. Furthermore, the precision and accuracy criteria of the Tenax-TA/ Carbopack-X combination were generally compatible with the triple adsorbents cold trap. The continuous automatic monitoring method is, thus, considered very useful to real-time monitoring to understand the variations of VOCs concentrations in ambient air, as it adopts much simpler procedures in sampling, analysis, and data integration steps than manual monitoring methods. However, it should be noted that there is a high possibility of benzene artifacts formation through the Nafion dryer, which is often installed to remove water vapor in air samples before being adsorbed onto the cold trap. Therefore, if a Nafion dryer is used in any studies of monitoring VOCs, the benzene contamination should be carefully examined before carrying out obtaining the data.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.7
• /
• pp.3207-3210
• /
• 2014

Background: Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer characterized by rapidly progressive breast erythema, pain and tenderness, oedema and paeu d'orange appearance. It accounts for 1-3% of all newly diagnosed cases of breast cancer in the west. Data on IBC from India are lacking. The aim of our study was to assess the clinical-pathological parameters and outcome of IBC at, All India Institute of Medical Sciences, a large tertiary care centre. Materials and Methods: We screened 3,650 breast cancer cases registered from January 2004 to December 2012 and found 41 cases of IBC. Data included demographics as well as clinical, radiological and histopathological characteristics, and were collected from clinical case records using the International Classification of Diseases code (C-50). Patients who presented with IBC as a recurrence, or who had a neglected and advanced breast cancer that simulated an IBC were excluded from this study. Results: The median age was 45 years (range 23-66). The median duration of symptoms was 5 months. The American Joint Committee on Cancer stage (AJCC) distribution was Stage III - 26 and IV - 15 patients. Estrogen receptor (ER), progesterone receptor (PR) positivity and human epidermal growth factor receptor 2 (HER2/neu) positivity were 50%, 46% and 60%, respectively. Triple negativity was found in 15% of the cases. All the non metastatic IBC patients received anthracycline and/ or taxane based chemotherapy followed by modified radical mastectomy, radiotherapy and hormonal therapy as indicated. Pathological complete remission rate was 15%. At a median follow-up of 30 months, the 3 year relapse free survival and overall survival were 30% and 40%respectively. Conclusion: IBC constituted 1.1% of all breast cancer patients at our centre. One third of these had metastatic disease at presentation. Hormone positivity and Her2 neu positivity were found in 50% and 60% of the cases, respectively.

• The Journal of Korean Society of Virology
• /
• v.30 no.3
• /
• pp.171-178
• /
• 2000

Herpes simplex virus, Varicella zoster virus and Human herpes virus-6 caused central nervous system infections and latent infections but there is no data of the 3 viruses being tested from the same cerebrospinal fluid samples with aseptic meningitis or encephalitis in adults patients. These viruses produced similar neurologic symptoms but difficulties existed in differentiating of etiologic agents and therefore the viruses needed to be detected in the early state. Herpes simplex virus encephalitis (HSVE) in adults, if not treated promptly was fatal. If treated with antiviral drugs in the early phase of encephalitis, neurologic sequales decreased by 65%. Recently, a PCR method for detection of HSVE with CSF was developed. VZV primary and secondary infections caused neurologic symptoms of encephalitis or meningitis. The second frequency of adult encephalitis that caused VZV were reported. HHV-6 caused CNS latent infection that was studied with normal adults brains. But there is no data of HSV, VZV and HHV-6 for aseptic meningitis and encephalitis of Korean adults through etiologic study. We cultured CSFs on HEp-2 cells and simultaneously tested for HSV PCR, VZV nested PCR and HHV-6 PCR with 8 specific primers. The PCR results of CSF from meningitis Korean adults were 13/19 (68.4%) for HSV, 10/19 (52.6%) for VZV and 12/19 (63.2%) for HHV-67/19 (36.8%) cases were triple infected HSV PCR, VZV PCR and HHV-6 PCR positive; 3/19 (15.8%) cases were dual infected HSV PCR and HHV-6 PCR positive; 1119 (0.5%) cases was VZV PCR positive. Strong viral DNA amplification of CSF means a causative virus may be present in aseptic meningitis or encephalitis patients and may cause clinical neurologic symptoms. HSV and HHV-6 viruses detection rate were higher than VZV by PCR with CSFs.

• Journal of Pharmaceutical Investigation
• /
• v.36 no.5
• /
• pp.343-348
• /
• 2006

The purpose of the present study was to evaluate the bioequivalence of two zolpidem tartrate tablets, Stilnox tablet(Sanofi-aventis Korea, reference product) and Zanilo tablet(ChoDang Pharm Co., Ltd., Korea, test product), according to the guidelines of Korea Food and Drug Administration(KFDA). After adding an internal standard(cimetropium), 250 ${\mu}L$ plasma samples were extracted using 1.3 mL of ethyl acetate. Extracted compounds were analyzed by HPLC with triple-quadrupole mass spectrometry. This method for determination of zolpidem is proved accurate and reproducible with the limit of quantitation of 1 ng/mL in human plasma. Twenty-four healthy male Korean volunteers received each medicine at the zolpidem tartrate dose of 10 mg in a $2{\times}2$ crossover study. There was one-week washout period between the doses. Plasma concentrations of zolpidem were monitored for over a period of 8 hr after the administration. $AUC_{0-t}$(the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{0-t}$ and $C_{max}$. No significant sequence effect was found for all of the bio-availability parameters indicating that the crossover design was properly performed. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25(e.g., log 0.92-log 1.06 for $AUC_{0-t}$, log 0.96-log 1.13 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that Zanilo tablet is bioequivalent to Stilnox tablet.