• Journal of Environmental Science International
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• v.12 no.8
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• pp.881-889
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• 2003

Spatial and vertical variations of butyltins(BTs) were investigated in polluted sediments from Jinhae, Busan, Ulsan and Yeongil Bays located in the southeastern part of Korea. Tributyltin(TBT) as a dominant species was detected in 18 of the 20 surficial sediments, and TBT levels were lower that for those in heavily polluted areas worldwide, ranging from 12 to 766 ng Sn/g dry wt. Distribution of TBT levels among bays was not significantly different (p=0.286, ANOVA). The horizontal distributions observed at 20 sites suggests that TBT concentrations are still high in polluted sites around harbors and industrial complexes. The sedimentary records a peak in the early 1990s in Jinhae Bay, in the mid 1980s in Ulsan Bay and in the late 1970s in Yeongil Bay except for Busan Bay which had a homogenous profile. In paricular, TBT at the surface sediments of four core samples still had high levels. From the horizontal and vertical results, it could be assumed that TBT inputs in the sediments were not reduced significantly compared to past levels. The annual accumulation rates estimated using the sedimentation rates and the concentration of surficial sediments exhibited that the accumulation rate of Ulsan Bay was greater than the rates for Jinhae and Yeongil Bays.

• Journal of Environmental Science International
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• v.20 no.2
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• pp.163-174
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• 2011

Butyltin compounds in seawater, sediments and organisms inside Jeju Harbor of Jeju Island, Korea, were quantitatively determined to assess the extent of contamination and to evaluate the bioaccumulation in Thais clavigera (gastropod), Liolophura japonica and Cellana nigrolineata. In addition, imposex in T. clavigera was used to assess the sublethal effect of tributyltin compounds and its usage as a specific biomarker for these compounds was also studied. The main species in seawater was tributyltin (TBT) in March and June, monobutyltin (MBT) in August, but in sediments and organisms it was dibutyltin (DBT) and TBT, respectively, irrespective of survey time. TBT, the most toxic to aquatic organisms among BTs, was found at concentrations which were sufficient to have a serous effect on the sensitive organisms upon chronic exposure. The high correlations (r>0.7) between BTs indicated that DBT and MBT were mainly degraded from TBT based on antifouling paints and their sources were negligible. The sedimentary organic matters have little influence on the distribution of BTs in marine environment and the lipid content in T. clavigera showed a significant correlation with TBT concentrations. Measurement of imposex T. clavigera was expected to be a very helpful tool for preliminary survey of BTs prior to trace analysis of those.

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.645-650
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• 2006

Tributyltin chloride (TBTC) at concentrations of $0.5-1.0\;{\mu}M$ inhibits dopamine biosynthesis in PC12 cells. In this study, the effects of TBTC on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced cytotoxicity in PC12 cells were investigated. TBTC at concentrations up to $1.0\;{\mu}M$ neither affected cell viability, nor induced apoptosis after 24 or 48 h in PC12 cells. However, TBTC at concentrations higher than $2.0\;{\mu}M$ caused cytotoxicity through an apoptotic process. In addition, exposure of PC12 cells to non-cytotoxic (0.5 and $1.0\;{\mu}M$) or cytotoxic $(2.0\;{\mu}M)$ concentrations of TBTC in combination with L-DOPA (20, 50 and $100\;{\mu}M$) resulted in a significant increase in cell loss and the percentage of apoptotic cells after 24 or 48 h compared with TBTC or L-DOPA alone. The enhancing effects of TBTC on L-DOPA-induced cytotoxicity were concentration- and treatment time-dependent. These data demonstrate that TBTC enhances L-DOPA-induced cytotoxicity in PC 12 cells.

• Proceedings of the Korea Society of Environmental Biology Conference
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• 2001.12a
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• pp.107-108
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• 2001

• Bulletin of the Korean Chemical Society
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• v.19 no.1
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• pp.119-120
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• 1998

• Bulletin of the Korean Chemical Society
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• v.15 no.10
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• pp.827-829
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• 1994

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.68-69
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• 2003

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.147-147
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• 2004

• Proceedings of the Korean Society of Life Science Conference
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• 2005.04a
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• pp.229-229
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• 2005

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.6
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• pp.923-928
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• 1997

The occurrence of butyltin compounds in the seawater and sediment of Masan Bay was investigated. The concentrations were in the range of $ND-0.059{\mu}g/\ell$ for tributyltin (TBT), $ND-0.091{\mu}g/\ell$ for dibutyltin (DBT) and $ND-0.720{\mu}g/\ell$ for monobutyltin (MBT) in the seawater, and $ND-0.233{\mu}g\;TBT/g.dry$, $ND-0.197{\mu}g-DBT/g.dry$ and $ND-0.684{\mu}g-MBT/g.dry$ in the sediment. Among the butyltin compounds, the major component in the seawater was MBT, while the predominant species in the sediment changed with time. The tributyltin concentrations in the sediment are approximately three orders of magnitude greater than the associated water column levels. Sediment/water partition coefficients (K) of TBT were between $0.6\times10^3\;and\;5.0\times10^3$.