• Title/Summary/Keyword: Trials

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Randomized-Control Screening Trials to Lower Gall Bladder Cancer Mortality in High Risk Populations

  • Krishnatreya, Manigreeva;Kataki, Amal Chandra
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.2325-2327
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    • 2016
  • Gall bladder cancer is generally fatal. The high morbidity and mortality due to gall bladder cancer exerts a significant impact on efforts towards cancer control in high risk populations of the World and a rationale program for control of gall bladder cancer mortality has remained as an unmet need in these populations. Currently there are no effective strategies for controlling gall bladder cancer mortality. This mini review is to highlight the need and feasibility for secondary prevention of gall bladder cancer by screening in high risk populations. A way forward is to assess the role of secondary prevention of gall bladder cancers by conducting randomized-controlled screening trials in high risk populations.

Recent Trends in the Treatment of Voice Disorders: Evidence-based Practice and Translational Biology Research (음성 장애 치료 연구의 최근 동향: 증거에 기초한 임상 치료 및 전이 생물학적 연구)

  • Choi, Seong-Hee
    • Phonetics and Speech Sciences
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    • v.2 no.1
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    • pp.99-112
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    • 2010
  • This study attempted to review the recent, high-quality evidence-based practical research related to the treatment effectiveness of voice disorders which focus on randomized controlled trials (RCTs) and translational research of vocal fold tissue engineering for vocal fold regeneration. Methodology including PICO (P; Populations or Patients, I; Interventions, C; Comparison group (control, placebo, gold standard), O; Outcomes or measures made) information for RCTs and animal models (species), regenerative therapy method, and outcomes of translational research for clinical application was summarized and discussed for future voice disorder research.

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Effect of Storage Temperature, Washing, and Cooking on Postharvest-treated Pesticide Residues in Polished Rice (쌀의 저장온도, 세척 및 취반이 일부 농약잔류의 제거에 미치는 효과)

  • 한선희;조한빈
    • Journal of Food Hygiene and Safety
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    • v.14 no.1
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    • pp.9-16
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    • 1999
  • Effect of storage temperature, washing, and cooking on postharvest-treated pesticide residues in polished rice was investigated. After being treated with each 500 mg/kg of captan, carbaryl, phenthoate, fenthion, fenitrothion, chlorpyriphos-methyl, pirimiphos-methyl, the polished rice was stored for 8 weeks at 4 and 3$0^{\circ}C$, respectively. The penetation rate of carbaryl was the highest as 27.5% and the others, 13 to 18%. The half lives of pesticide residues were estimated as 30 to 230 weeks at 4$^{\circ}C$, but 1 to 12 weeks at 3$0^{\circ}C$. The residues were reduced faster at 3$0^{\circ}C$ than at 4$^{\circ}C$. The half lives of pesticide residues by water washing were estimated as 0.7 to 4.6 trials and the removed with the washing trials. The residues of captan and carbaryl in cooked rice were removed 100 and 98%, respectively, comparing to initial residues concentration in treated rice but those of other 5 pesticides were removed 80%.

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Stamping Analyses of Laser Welded Door Inner and Die Design (레이저 용접 도어 인너의 성형해석과 금형설계)

  • 김헌영;신용승;김관희;조원석
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 1997.10a
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    • pp.65-71
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    • 1997
  • Computer simulations and test trials are carried out to get the optimal conditions about the stamping die design of the tailor laser welded automotive door inner. Firstly, the stamping process including gravity deflection, bead calibration, binder wrap, forming and spring back, are analyzed by the computer simulation. The results of simulation shows good correspondance with those of test trial under the same conditions. The variables of parametric study which will be investigated in the simulation and test trials, are determined form the results of the first run. The formability under the various conditions is evaluated, which are the initial postion of blank, blank holding force, corner radius and the shape of drawbead. Finally, well controled sound product without fracture, wrinkling and excessive weldline movement is obtained.

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A Study on the Comfortable Pesticide-Proof Clothes (농약방제복 개발에 관한 연구)

  • Choi Jeong Wha;Kim Hyun Sik;Jeong Yong Ok
    • Journal of the Korean Society of Clothing and Textiles
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    • v.11 no.2 s.24
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    • pp.91-100
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    • 1987
  • To develop the comfortable pesticid-proof clothes, wearing trials for 7 types of existing pesticide-proof clothes were done measuring skin temperature, pulse rate, humidity and temperature of inside clothing and subjective feeling such as thermal, humid and comfort sensations at $28{\pm}1^{\circ}C$, $75{\pm}5\%$ RH, 2.3 m/sec wind speed. (Experiment 1). On the base of above results, wearing trials of 6 types of new pesticide-proof clothes and 3 types of pesticide-proof clothes as control group were done with the same method as experiment 1. (Experiment 2). The results obtained were as follows 1. Heat stress was lower in newly designed pesticide-proof clothes with mesh running shirts. 2. For the body temperature regulation, it was confirmed that 6 types of new pesticide-proof clothes made of microporous fabric were better than the others.

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The Effectso f Textiles Materials and Wearing Type on the Thermal Insulation Value (의복의 소재 및 형태가 보온력에 미치는 영향)

  • 손원교;최정화
    • Journal of the Korean Society of Clothing and Textiles
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    • v.23 no.8
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    • pp.1098-1109
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    • 1999
  • This study was to examine the effects of textiles materials and wearing types on the thermal regulation responses of human, Cotton polyester wool silk and rayon were chosen as outerwears and acetate was selected as a lining. Blouse-skirt suits blouse-slacks suits and one-piece dress made of selected textiles were examined by human trials, Tests results were as follows ; 1 When subjects wore vlouse-slacks suits Tmsk was showed the highest value. There was a significant difference on Tmsk(p<0.05) when they wore one-piece dress. The temperature of microclimate inside clothing when subjects wore blouse-slacks suits showed the highest value and one-piece dress and then blouse-skirt suits in order. For blouse-skirt suits clothing without lining showed higher temperature of the back of microclimate inside clothing than clothing with lining except cotton(p<0.1) 2. There were no significant consistency of the increasing rates of thermal insulation of garment at fabric test and human trials among polyesterand silk.

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Practice of Design Curriculum Aimed for High Attainment Level of Creativity and Perfection

  • Yagi, Hidetsugu;Arimitsu, Yutaka
    • Journal of Engineering Education Research
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    • v.13 no.2
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    • pp.70-73
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    • 2010
  • The practice named "Creative Design and Production" has been given to train the students'ability to find and solve problems. Students are expected to design and fabricate creative artifacts in the practice. The practices focusing on perfection and creativity of the products have been executed for the past few years. We have reviewed the relationships between these abilities and the qualities of products of the students in the practices. It seems that the products lacks of originality and creativity when focused on the perfection. And on the contrary, the perfection of the products is low when focused on the creativity. We have employed the new three trials in order to solve these problems in the practice. Among trials, the cooperation with veterans has been the most useful for students through "Creative Design and Production".

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Treatment Outcomes and Prognosis of Benign Vocal Fold Lesions (양성 성대 병변의 치료 결과 및 예후인자)

  • Lee, Seung Won
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.26 no.2
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    • pp.101-103
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    • 2015
  • There are no standard consensus about treatment results and prognostic factors based on randomized trials for benign vocal fold lesion. Currently, voice therapy is the treatment of choice for vocal nodules, and laryngomicroscopic surgery is for vocal polyps. There are no strong evidences to support it, based on randomized controlled trials, But, it's just a consensus among laryngologist. Considering the pathophysiology of benign vocal cord lesions, cognitive behavioral therapy that corrects the patient's bad voice habits and improves their vocal hygiene could be most important factor for treatment outcomes.

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Toxicity of the Adenoviral Vector Mediated Gene Therapy (아데노바이러스 유전자치료제의 독성)

  • Chung, In-Jae
    • Environmental Analysis Health and Toxicology
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    • v.24 no.1
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    • pp.71-77
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    • 2009
  • Adenoviral vector(AdV) has been the most widely used viral vector for delivering an exogenous therapeutic gene to human. As of this date, more clinical trials utilize recombinant AdV to treat cancer and monogenic inherited disease as well as vaccine applications. However, the number of clinical trials had dropped markedly following the tragic death of a patient ongoing an AdV therapy for the treatment of an ornithine transcarbamylase deficiency(OTCD). This review is an attempt to provide the information on toxicity generated by AdVmediated gene transfer. It would serve as a sobering reality to researchers and clinicians exploring the use of AdV, as to the complications involved in human application.

Evaluation of Herbicides for Management of Weeds in Cultivation of Panax quinquefolius L.

  • B Capell;R.D Reeleder;R Grohs;B Zilkey
    • Journal of Ginseng Research
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    • v.23 no.3 s.55
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    • pp.135-147
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    • 1999
  • Nine herbicide products (fluazifop-p-butyl, clethodim, MCPA-sodium, 2,4-0 amine, chlorthal dimethyl, diquat, glyphosate, ethalfluralin and oryzalin) were evaluated for use on ginseng (Panax quinquefolius). Products varied in their ability to suppress weeds and certain materials were phytotoxic to ginseng in some trials. Chlorthal dimethyl (broadleaf weeds), MCPA-sodium (broadleaf weeds), fluazifop-p-butyl (grass weeds), and clethodim (grass weeds) were found to be effective as weed control agents and did not adversely affect ginseng growth. Other products tested were either not efficacious or were phytotoxic to ginseng in some trials. Weed populations were mainly introduced into the planting sites via the straw mulches used in ginseng cultivation.

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