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Toxicity of the Adenoviral Vector Mediated Gene Therapy  

Chung, In-Jae (College of Pharmacy, Duksung Women's University)
Publication Information
Environmental Analysis Health and Toxicology / v.24, no.1, 2009 , pp. 71-77 More about this Journal
Abstract
Adenoviral vector(AdV) has been the most widely used viral vector for delivering an exogenous therapeutic gene to human. As of this date, more clinical trials utilize recombinant AdV to treat cancer and monogenic inherited disease as well as vaccine applications. However, the number of clinical trials had dropped markedly following the tragic death of a patient ongoing an AdV therapy for the treatment of an ornithine transcarbamylase deficiency(OTCD). This review is an attempt to provide the information on toxicity generated by AdVmediated gene transfer. It would serve as a sobering reality to researchers and clinicians exploring the use of AdV, as to the complications involved in human application.
Keywords
adenoviral vector; toxicity; gene therapy; safety;
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1 Markus JV, Vähä-Koskela B, Heikkilä JE and Hinkkanen AE. Oncolytic viruses in cancer therapy, Cancer Letters 2007; 254(2): 178-216   DOI   ScienceOn
2 Raper SE, Yudkoff M, Chirmule N, Gao GP, Nunes F, Haskal ZJ, Furth EE, Propert KJ, Robinson MB, Magosin S, Simoes H, Speicher L, Hughes J, Tazelaar J, Wivel NA, Wilson JM and Batshaw ML. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Human Gene Ther 2002; 13(1): 163-175   DOI   ScienceOn
3 Raper SE. Gene therapy: The good, the bad, and the ugly, Surgery 2005; 137(5): 487-492   DOI   PUBMED   ScienceOn
4 Zhang Y, Chirmule N, Gao GP, Qian R, Croyle M, Joshi B, Tazelaar J and Wilson JM. Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages, Mol Ther 2001; 3(51): 697-707   DOI
5 Krebs P, Scandella E, Odermatt B and Ludewig B. Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus, J Immunol 2005; 174: 4559-4566   DOI   PUBMED
6 Tripathy SK, Goldwasser MM, Lu EB and Leiden JM. Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus, Proc Natl Acad Sci USA 1994; 91: 11557-11561   DOI   ScienceOn
7 Morrissey RE, Horvath C, Snyder EA, Patrick J and Mac- Donald JS. Rodent nonclinical safety evaluation studies of SCH 58500, an adenoviral vector for the p53 gene, Toxicol Sciences 2002b; 65(2): 266-275   DOI   ScienceOn
8 Manickan E, Smith JS, Tian Jie, Eggerman TL, Lozier JN, Muller J and Byrnes AP. Rapid Kupffer cell death after intravenous injection of adenovirus vectors, Mol Ther 2006; 13(1): 108-117   DOI   ScienceOn
9 Morrissey RE, Horvath C, Snyder EA, Patrick J, Collins N, Evans E and MacDonald JS. Porcine toxicology studies of SCH 58500, an adenoviral vector for the p53 gene, Toxicol Sciences 2002a; 65(2): 256-265   DOI   ScienceOn
10 Pearson S, Jia H and Kandachi K. China approves first gene therapy. Nat Biotechnol 2004; 22(1): 3-4   DOI   ScienceOn
11 Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker R, Veghel R, Houtsmuller A, Schultheiss HP, Lamers J and Poller W. Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers, Gene Ther 1999; 6: 1520-1535   DOI   ScienceOn
12 Wickham TJ, Mathias P, Cheresh DA and Nemerow G. Integrins ${\alpha}v{\beta}3$ and ${\alpha}v{\beta}5$ promote adenovirus internalization but not virus attachment, Cell 1993; 73: 309-319   DOI   ScienceOn
13 Boquet MP, Wonganan P, Dekker JD, Croyle MA. Influence of method of systemic administration of adenovirus on virusmediated toxicity: focus on mortality, virus distribution, and drug metabolism, J Pharmacol Toxicol Methods 2008; 58(3): 222-232   DOI   ScienceOn
14 McConnell MJ and Imperiale MJ. Biology of adenovirus and its use as a vector for gene therapy, Human Gene Ther 2004; 15(11): 1022-1033   DOI   ScienceOn
15 Vlachaki MT, Hernandez-Garcia A, Ittmann M, Chhikara M, Aguilar LK, Zhu X, The BS, Butler EB, Woo S, Thompson TC, Barrera-Saldana H and guilar-Cordova E. Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model, Mol Ther 2002; 6: 342-348   DOI   ScienceOn
16 Raki M, Kanerva A, Ristimaki A, Desmond RA, Chen TD, Ranki T, Sarkioja M, Kangasniemi L and Hemminki A. Combination of gemcitabine and Ad5/3-Delta24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer, Gene Ther 2005; 12: 1198-1205   DOI   ScienceOn
17 Su C, Cao H, Tan S, Huang Y, Jia X JL, Wang K, Chen Y, Long J, Liu X, Wu M, Wu X and Qian Q. Toxicology profiles of a novel p53-armed replication-competent oncolytic adenovirus in rodents, felids, and nonhuman primates, Toxicol Sciences 2008; 106(1): 242-250   DOI   ScienceOn
18 Dewey RA, Morrissey G, Cowsill CM, Stone D, Bolognani F, Dodd NJ, Southgate TD, Klatzmann D, Lassmann H, Castro MG and Lowenstein PR. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials, Nat Med 1999; 5: 1256-1263   DOI   ScienceOn
19 Dormond E, Perrier M and Kamen A. From the first to the third generation adenoviral vector: What parameters are governing the production yield? Biotechnol Advances 2009; 27(2): 133-144   DOI   ScienceOn
20 Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL and Finberg RW. Isolation of a common receptor for cosackie B viruses and adenoviruses 2 and 5, Science 1997; 275 (5304): 1320-1323   DOI   PUBMED
21 Thomas CE, Birkett D, Anozie I, Castro MG and Lowenstein PR. Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain, Mol Ther 2001; 3(1): 36-46   DOI   ScienceOn
22 Massari I, Donnini A, Argentati K, Straino S, Mangoni A, Gaetano C, Viticchi C, Capogrossi M and Provinciali M. Age-dependent effects of repeated immunization with a first generation adenovirus vector on the immune response and transgene expression in young and old rats, Exp Gerontol 2002; 37: 823-831   DOI   ScienceOn
23 Driesse MJ, Vincent AJ, Sillevis Smitt PA, Kros JM, Hoogerbrugge PM, Avezaat CJ, Valerio D and Bout A. Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates, Gene Ther 1998; 5: 1122-1129   DOI   ScienceOn
24 Gomez-Manzano C, Yung WK, Alemany R and Fueyo J. Genetically modified adenoviruses against gliomas: from bench to bedside, Neurol 2004; 63: 418-426   DOI   ScienceOn
25 Garcia-Banuelos J, Siller-Lopez F, Miranda A, Aguilar LK, Aguilar-Cordova E and Armendariz-Borunda J. Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion, Gene Ther 2002; 9: 127-134   DOI   ScienceOn
26 Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, Gao G, Wilson JM and Batshaw ML. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer, Mol Genet Met 2003; 80(1-2): 148-158   DOI   ScienceOn