• Title/Summary/Keyword: Trial Division

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Therapeutic Feasibility Study and Clinical Trial of Intrahepatic $I^{-131}-Lipiodol$ on Patients with Hepatocellular Carcinoma ($Lipiodol-I^{-131}$의 경간동맥 주입에 의한 간암치료의 가능성에 관한 연구)

  • Yoo, Hyung-Sik;Suh, Jung-Ho;Lee, Jong-Tae;Kim, Dong-Ik;Park, Chang-Yun;Kim, Byung-Soo;Park, Chan-H.;Thakur, M.
    • The Korean Journal of Nuclear Medicine
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    • v.20 no.2
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    • pp.61-71
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    • 1986
  • An iodized oil such as Ethiodol or Lipiodol was selectively retained in the tumor vessels of the large hepatomas as well as in the small daughter hepatomas for long periods following the intra-arterial hepatic injection of such contrast material. The specific aim of the study is to deliver a high internal radiation dose to hepatocellular carcinoma (HCC) in an attempt to control the disease. We were able to replace a small fraction of the stable iodine (I-127) of the 37% iodine in Lipiodol by the $I^{-131}$ with 100% exchange efficiency. $I^{-131}$ labeled Lipiodol was injected through the super-selected tumor feeding artery under superselection or into the proper hepatic arterial level of patients who have malignant hepatomas confirmed by aspiration cytology serum AFP and various imaging modalities. Clinical traial was performed on 43 cases during recent 6 months and follow-up observation was carried out. No severe complications or other adverse reactions were encountered until nowdays. $I^{-131}-Lipiodol$ was stable in vivo and no significant activity was noted in the thyroid, stomach, blood and urine after the injection. Only small fraction of radioisotope activity was noticed in the both side of lungs. Tumor to normal liver radio was very high. Therefore, $I^{-131}-Lipiodol$ (or P-32-Lipiodol) will be effective delivering high internal radiation dose to the tumor while delivering small radiation doses to normal tissues. Labeling, tumor dose calculation and preliminary findings will be presented.

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Development of Bio-Check Unit and Health Index for Measuring Health Degree through Noninvasive Examination (비침습적 검사를 통한 건강 정도 측정을 위한 바이오체크 유닛과 건강지수의 개발)

  • Lee, Chong-Sun;Yi, Sung-Il;So, Byung-Rok;Park, Byung-Kang;Chung, In-Wook;Lee, Seung-Ju;Park, Seon-Kyun;Han, Cheng-En
    • Journal of the Korean Society for Precision Engineering
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    • v.28 no.7
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    • pp.859-865
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    • 2011
  • A bio-check unit and health index were developed to provide information on personal health state with easily available noninvasive measurements and surveys. Four health indices were defined such as cardiovascular index, stress index, obesity index, and management index. Methods were developed to calculate health index scores from measured physiological signals and answer of survey questions. In order to evaluate effectiveness of the health indices, a clinical trial was conducted for 362 persons who visited general hospital for annual health inspection. The cardiovascular index showed a good correlation coefficient of 0.685 with the cardiovascular health graded by a medical doctor. The stress index showed a good correlation coefficient of 0.638 with the results of stress questionnaires being used in the public health center. Once the health index function is added in the bio-check unit, the unit may provide useful contents for personal health management.

SUPPRESSION OF HYDROGEN CONSUMING BACTERIA IN ANAEROBIC HYDROGEN FERMENTATION

  • Park, Woo-Shin;Jang, Nam-J.;Hyun, Seung-H.;Kim, In-S.
    • Environmental Engineering Research
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    • v.10 no.4
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    • pp.181-190
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    • 2005
  • Severe loss or hydrogen occurred in most anaerobic hydrogen fermentation reactors. Several selected methods were applied to suppress the consumption of hydrogen and increase the potential of production. As the first trial, pH shock was applied. The pH of reactor was dropped nearly to 3.0 by stopping alkalinity supply and on]y feeding glucose (5 g/L-d). As the pH was increase to $4.8{\pm}0.2,$ the degradation pathway was derived to solventogenesis resulting in disappearance of hydrogen in the headspace. In the aspect of bacterial community, methanogens weren't detected after 22 and 35 day, respectively. Even though, however, there was no methanogenic bacterium detected with fluorescence in-situ hybridization (FISH) method, hydrogen loss still occurred in the reactor showing a continuous increase of acetate when the pH was increased to $5.5{\pm}0.2$. This result was suggesting the possibility of the survival of spore fanning acetogenic bacteria enduring the severely acidic pH. As an alternative and additive method, nitrate was added in a batch experiment. It resulted in the increase of maximum hydrogen fraction from 29 (blank) to 61 % $(500\;mg\;NO_3/L)$. However, unfortunately, the loss of hydrogen occurred right after the depletion of nitrate by denitrification. In order to prevent the loss entangled with acetate formation, $CO_2$ scavenging in the headspace was applied to the hydrogen fermentation with heat-treated sludge since it was the primer of acetogenesis. As the $CO_2$ scavenging was applied, the maximum fraction of hydrogen was enhanced from 68 % to 87 %. And the loss of hydrogen could be protected effectively.

A Study on the Roles and Efficient Operations of Urban Regeneration Support Center as Intermediary Organization - Focused on the Chungcheongbuk-do - (중간지원조직으로서 도시재생지원센터의 역할과 운영 방안 - 충청북도 사례를 중심으로 -)

  • Kim, Young-Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.2
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    • pp.448-459
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    • 2020
  • Recently, there has been considerable talk about urban regeneration support centers that are currently promoting urban regeneration projects. The reason is that the role and authority are unclear, and the experience of each local government center is not accumulated, resulting in many trial and error and side effects. This study analyzed the current state of operations of urban regeneration support centers in Chungcheongbuk-do to find desirable ways to operate them in the future. The main findings are as follows. First, the role and division between metropolitan and basic centers and field centers of urban regeneration support centers in Chungcheongbuk-do are unclear. Second, the limitations of the center's operation methods, operational autonomy, and independence are not secured. Third, as a participant in urban regeneration, it has relatively low authority and status compared to administration. Fourth, the lack of professional manpower related to urban regeneration and the instability of staff employment were derived as overall problems.

STUDY ON THE DEVELOPMENT OF A TECHNIQUE FOR PRESERVING STRAW UNDER WET CONDITION IN BANGLADESH

  • Chowdhury, S.A.;Huque, K.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.9 no.1
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    • pp.91-99
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    • 1996
  • About 7.7 million tons of straw dry matter are being rotten during the monsoon. The objective of this trial was to develop a technique to preserve straw under wet condition. To simulate the moisture content of wet straw, a dry straw was deeped overnight in water. After draining the excess water, the wet straw(668 g moisture $kg^{-1}$) was divided into twenty fractions and preserved with 0, 30, 50 ro 70 g urea $kg^{-1}$ dry matter for either of 30, 60, 90, 120 or 180 days in sealed plastic container. Considering the colour, smell, fungal infestation and pH, the wert straw was preserved excellently up to 180 days when 50 or 70 g of urea per kg DM was used. Urea preservation increased the crude protein contents of straw by 3.6 to 6.4 times (174 to $364g{\cdot}kg^{-1}$) over that of the dry straw ($48g{\cdot}kg^{-1}$). Although the NDF content of straw was not effected by the level of urea or by the length of the preservation period, but the ADF content increased (p > 0.05) by 0.086 to $0.889g{\cdot}kg^{-1}$ straw DM for each g increase in the urea level. At 48 hours, the DM degradability of dry straw was $350g{\cdot}kg^{-1}$, which increased to $633g{\cdot}kg^{-1}$ when preserved with 50 g urea $kg^{-1}$ for 180 days. For the same straw, both the rate(0.0388 vs. 0.0136 fraction $h^{-1}$), the extent(717 vs. $631g{\cdot}kg^{-1}$) of straw degradation and the estimated ME(9.55 vs. $6.51MJ{\cdot}kg^{-1}$ straw DM) were higher in the preserved than the dry straw.

A Response to Postural Response to Sine Curve Vestibular Electric Stimulation during Standing (기립자세동안 전정기관에 인가된 정현파 전류자극에 대한 자세균형 응답)

  • Lee, Ah-Reum;Yu, Mi;Kim, Jin-Ho;Kim, Dong-Wook;Kim, Jung-Ja
    • Journal of Biomedical Engineering Research
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    • v.31 no.3
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    • pp.210-216
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    • 2010
  • This study is vestibular electric stimulation applied between the mastoids during quiet standing elicits postural sway. The aim of this study was to characterize the postural sway response to continuous sinusoidal vestibular electric stimulation across various stimulus frequencies and amplitudes. Binaural bipolar sinusoidal vestibular electric stimulation was applied to the skin overlying the mastoid processes of 10 subjects while they stood on a force plate. The position of the center of pressure(COP) and signals at the feet are obtained on an force plate, while the head and whole body center of mass(COM) was measured with motion analysis system. The stimulus conditions included eight frequencies (1/64, 1/32, 1/16, 1/8, 1/4, 1/2, 1, and 2Hz) and six peak amplitudes (0.1, 0.25, 0.5, 0.7, 1 and 2mA). Each subject experienced one trial at each amplitude-frequency pair. The stimuli elicited sway in lateral plane in all subjects, as evidenced by changes in the stimulus frequency. Our results demonstrate that the vestibular system is sensitive to vestibular electric stimulation intensity changes and responds by altering the magnitude of the response accordingly.

Effects of Manure Additives on pH and Pathogen Populations in Hanwoo (Korean native cattle) Manure (축분 첨가제를 한우분에 첨가시 pH와 유해성 병원균에 미치는 영향에 관한 연구)

  • Kim, Sam-Churl;Amanullah, S.M.;Kim, Dong-Hyeon;Lee, Hyuk-Jun;Choi, Jung-Hoon;Lee, Gee-Dong;Choi, In-Hag
    • Journal of Environmental Science International
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    • v.21 no.12
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    • pp.1529-1533
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    • 2012
  • The objective of this study was to evaluate the effect of applying alum (aluminum sulfate) and aluminum chloride on pH and pathogen populations of Hanwoo manure. A total of 36 steers (8 months old and averaging 300 kg in weight) were used in this trial and allotted to 9 pens (3 replication pens per group with 4 steers per experimental unit, $5{\times}8$ m). Chemical additives were applied as a top dressing with garden rake to a depth of 1 cm of manure with wood shavings in each treatment. The chemical amendments were control (without chemical amendments), 50 g of alum and 50 g of aluminum chloride/kg of Hanwoo manure. The experiment was carried out for 4 weeks. Adding alum and aluminum chloride to Hanwoo manure reduced (P < 0.05) pH compared to untreated controls during the 4-wk period. Both levels of the alum and aluminum chloride treatments tested decreased (P < 0.05) Escherichia coli and Salmonella enterica populations in Hanwoo manure at 2 and 4 weeks. It appears that the reduction in pathogen populations was primarily associated with the lower manure pH. If more strict environmental regulations are put into effect regarding pathogen populations from Hanwoo facilities, treating Hanwoo manure with alum and aluminum chloride may be a good management practice.

A Review of Instrumentation System and Construction of Korea Highway Test Road (시험도로 건설과 계측시스템 구축)

  • 최준성;김도형;김성환
    • Proceedings of the Korean Geotechical Society Conference
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    • 2000.11a
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    • pp.603-606
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    • 2000
  • The cost needed for the construction and management of highways in the whole nation is rapidly growing so the research that can decrease the cost is required. However, most of the highway specs have simply converted from those of other countries, including USA. Therefore, some of our design and construction specs were not the optimum ones based on our own situation, requiring a research under the actual traffic and environment of our nation. The use of test road develops many aspects of highway engineering. Those are evaluation of construction materials, a general overview of korea pavement design and serviceability under the actual traffic and environmental condition of the nation. It is also economical and efficient compared to the trial construction of each item in spreaded form. A test road, 7.7km long with two lanes, is being constructed on the Inner Central Expressway. In this test road, 2.7km is planned for asphalt pavement and 3.4km is planned for concrete pavement. Three test bridges and five earth retaining structures will be included in the test road. Based on the master plan, the major performance was progressing such as detailed research modules of each area, preliminary research for the future research, sensor surveys for the behavior analyses of pavements and structures with installation methods and data acquisition systems, the foundation research of Integrated Instrumentation System and the Management Plan for automated measurement. Some area(structure research division, geotechnical research division) was designed the instrumentation plan because some instrument sensors must be installed during the construction of the test road. And then the instrumentation plan of each area was enforcing because a large majority of the instrument sensors must be installed after the construction of the test road. The field surveys with material property tests and pilot instrumentation test with sensor tests was also performing in accordance with the construction in the field.

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Research Trends on the Clinical Studies of Qigong in the Korean Journal (한국 저널에 게재된 기공관련 대조군 임상연구 현황 분석)

  • Han, Chang-Hyun;Kwon, Young-Kyu;Lee, Sang-Nam;Park, Ji-Ha;Ahn, Sang-Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.2
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    • pp.319-324
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    • 2009
  • Qigong is one energy-healing intervention used to prevent and cure ailments and to improve health through regular practice. Although qigong -neither itself nor its postulated mechanism of action- are within the paradigm of modern Western medical science, effects on the human body could be possible. This study aims to review the bibliography, biological responses and therapeutic effects of Qigong. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. The computerized Korean databases were searched from their respective inceptions up to January 2008. The search terms used were 'qi', 'qigong', 'doin', 'training', 'bioenergy', 'life nurturing' and random or Korean language terms related to qigong. Several specialized journals were also manually searched for relevant articles. Since the 1990s, Qigong papers in the Korean Literature is increased. Clinical research studies are among the most control design study. Research subjects are less patient than the general public. The most common treatment disease was hypertension. The depth study for the each Qigong is needed. Specifically, I think it should be a clinical studies and qualitative research methods for evaluation are needed.

Effects of Replacing Spray Dried Plasma Protein With Spray Dried Porcine Intestine Hydrolysate on Ileal Digestibility of Amino Acids and Growth Performance in Early-Weaned Pigs

  • Kim, J.H.;Chae, B.J.;Kim, Y.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.12
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    • pp.1738-1742
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    • 2000
  • A study was conducted to determine the ileal digestibility (ID) of amino acids and feeding values of spray dried plasma protein (SDPP) and spray dried porcine intestine hydrolysate (SDPI) in early-weaned pigs. Twelve pigs aged 18 days old (Landrace${\times}$Yorkshire${\times}$Duroc; $5.83{\pm}0.51kg$ BW) were cannulated in the terminal ileum for determination of ID of amino acids. Ninety pigs ($6.28{\pm}0.1kg$, 18 days old) were also employed for a feeding trial during phase I period. Treatments were: 1) 6% SDPP, 2) 6% SDPI, and 3) 3% SDPP+3% SDPI. The apparent and true ID values of the essential amino acids except leucine, methionine and valine were lower (p<0.01) in SDPI than in SDPP. The average apparent ID of essential amino acids in SDPP and SDPI were 75.63 and 71.30%, and the average true ID of essential amino acids 84.83 and 80.51%, respectively. The ADG and feed conversion ratio in piglets fed the 6% SDPP diet were better (p<0.01) than in those fed the 6% SDPI diet. When 3% of SDPP was replaced by SDPI, however, the growth rate and efficiency of pigs were comparable to those in pigs fed 6% SDPP. In conclusion, SDPP can be partially replaced by SDPI without any detrimental effect on growth performance in early-weaned pigs.