• Clinical and Experimental Pediatrics
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• 제55권9호
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• pp.309-315
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• 2012

Human respiratory syncytial virus (HRSV) is a major cause of severe respiratory tract illnesses in infants and young children worldwide. Despite its importance as a respiratory pathogen, there is currently no licensed vaccine for HRSV. Following failure of the initial trial of formalin-inactivated virus particle vaccine, continuous efforts have been made for the development of safe and efficacious vaccines against HRSV. However, several obstacles persist that delay the development of HRSV vaccine, such as the immature immune system of newborn infants and the possible Th2-biased immune responses leading to subsequent vaccine-enhanced diseases. Many HRSV vaccine strategies are currently being developed and evaluated, including live-attenuated viruses, subunit-based, and vector-based candidates. In this review, the current HRSV vaccines are overviewed and the safety issues regarding asthma and vaccine-induced pathology are discussed.

• 한국해양공학회지
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• 제19권6호통권67호
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• pp.50-57
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• 2005

Ice resistance on ice-transiting vessels is one of th￡ important issues concerning th￡ design of ships with ice classes. In this study, th￡ development of GUI software for estimation of ice resistance on ice-transiting vessels is discussed. lee resistance estimation equations, based on model tests and full-scale sea trial data from many previous research articles, are studied in conjunction with two ship categories i.e., ,icebreakers/supply/tug vessels and ice-strengthened cargo vessels. lee resistance estimation equations are summarized in common format and are compared with each other. The GUI software 'Ice View,' written in MS Visual Basic language, can calculate ice resistances according to varying ice thickness and ship speed. The software can provide the calculated results, with suitable tables and graphs, for easy comparison of each ice resistance estimation equation.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2006년도 하계학술대회
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• pp.11-14
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• 2006

This paper reviews the optical link technologies which have been developed for gigabit-per-second wavelength-division-multiplexing passive optical networks (WDM-PONs). Similarly to the 100Mb/s WDM-PON systems which have been deployed for trial services by KT, the most important requirement for 1Gb/s WDM-PON is wavelength independence (colorless feature) of its ONU/ONTs, which makes possible convenient operation and cost-effective maintenance with minimum inventory cost. Among various methods to implement such colorless feature, four promising candidates for gigabit WDM-PON are analyzed with their own development issues and their expected performances are compared.

• 한국항행학회논문지
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• 제6권4호
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• pp.312-317
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• 2002

본 논문에서는 스미스 도표 상의 ${\Gamma}_{IN}$ 평면에 도시되는 정합원를 사용한 저잡음 증폭기의 도식적 설계기법을 제시하였다. 입 출력의 각 정합원은 저잡음 증폭기의 최적화된 성능을 위하여 정재파비 등의 설계 파라미터를 결정할 때 발생되는 반복적인 설계작업의 번거로움을 최소화하기 위한 도식적 설계 기법에 이용할 수 있다. 이를 증명하기 위한 방안으로 저잡음 증폭기를 설계하여 제시하였다.

• Journal of Korean Neurosurgical Society
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• 제67권3호
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• pp.299-307
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• 2024

Cerebral cavernous malformation (CCM) is a vascular anomaly commonly found in children and young adults. Common clinical presentations of pediatric patients with CCMs include headache, focal neurological deficits, and seizures. Approximately 40% of pediatric patients are asymptomatic. Understanding the natural history of CCM is crucial and hemorrhagic rates are higher in patients with an initial hemorrhagic presentation, whereas it is low in asymptomatic patients. There is a phenomenon known as temporal clustering in which a higher frequency of symptomatic hemorrhages occurs within a few years following the initial hemorrhagic event. Surgical resection remains the mainstay of treatment for pediatric CCMs. Excision of a hemosiderin-laden rim is controversial regarding its impact on epilepsy outcomes. Stereotactic radiosurgery is an alternative treatment, especially for deep-seated CCMs, but its true efficacy needs to be verified in a clinical trial.

• Korean Journal of Acupuncture
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• 제34권3호
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• pp.116-125
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• 2017

Objectives : The aim of this study was to assess the effectiveness of acupuncture in treating prehypertension and stage 1 hypertension in postmenopausal women. Methods : The study was a multi-center, four-arm, non-blinded, randomized clinical trial. Sixty participants were randomly assigned to experimental or control groups. The experimental groups received 10 acupuncture sessions over 4 weeks(Group A, n=20) or 20 sessions over 8 weeks(Group B, n=20) along with usual care. The acupoints were GB20, LI11, ST36, and SP6, bilaterally. The acupuncture groups were followed-up for an additional 12 weeks after acupuncture treatment. The control groups received usual care for 16 weeks(Group C, n=10) or 20 weeks(Group D, n=10). The outcomes were blood pressure, blood pressure control rates, lipid profile, and high-sensitivity C-reactive protein(hs-CRP). Results : After 4 weeks, DBP in the acupuncture groups(A+B) showed no significant decrease compared to the control group(C+D). However, after 8 weeks of acupuncture treatment, group B showed a significant decrease in DBP after acupuncture treatment and follow-up period compared to control group. Although there was no difference between the acupuncture and control groups in SBP after acupuncture treatment, group B showed a significant decrease in SBP compared to control group after follow-up period. Lipid profiles and hs-CRP did not differ significantly between acupuncture and control groups. Conclusions : Acupuncture treatment for 8 weeks showed the effect on prehypertension and mild hypertension. To verify the effect of acupuncture on blood pressure, rigorous trials including more participants are required.

• Asian-Australasian Journal of Animal Sciences
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• 제14권2호
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• pp.224-230
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• 2001

This study was conducted to evaluate the extruding effects of corn and wheat on growth performance and fecal digestibility of amino acids in early-weaned pigs. Ground corn and wheat by a hammer mill (3 mm screen in diameter) were extruded at $130{\pm}2^{\circ}C$ with a moist-type extruder ($Matador^{(R)}$). Treatments were: 1) 3 mm ground corn, 2) extruded corn, 3) 3 mm ground wheat, and 4) extruded wheat. A total of 160 pigs (14 d of age and $4.3{\pm}0.74kg$ BW) were allotted with the dietary treatments for a 21-d feeding trial. All diets were mash and contained 30% corn or wheat products. For a digestibility trial, 16 pigs (14-d old and $4.2{\pm}0.32kg$ BW) were employed in individual metabolic crates. There were no differences (p>0.15) in growth performance between corn-fed and wheat-fed groups. Feeding pigs diets containing extruded corn or wheat did not affect ADG (p>0.15) and ADFI (p>0.15), but it improved feed/gain (p<0.01). Also, feeding pigs diets containing extruded corn or wheat had lower true fecal digestibilities of arginine, histidine, isoleucine, lysine and valine (p<.007) in the pigs. In conclusion, our results suggest that extruding corn and wheat had no benefit on the growth of early-weaned pigs.

• 건축역사연구
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• 제18권5호
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• pp.7-24
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• 2009

This stydy investigates H-shaped houses in 1930s and examines the characters and meanigs of Kim, Jong-Ryang's H-shaped houses as a new trial to urban Hanok of those days. He, who was concerned about the housing problem of Seoul, made an attempt to make various types of dwellings. Among them, this study focuses on Japanese-Korean Style H-shaped houses in Samcheong-dong. As the alternative housing type against other urban Hanok of Seoul in 1930s, the H-shaped houses of Kim, Jong Ryang had characters as follows : 1) H-shaped houses has two special characters. First, the whole space of a single house can be divided into a left region and a right region. Second, it can be divided to a front region and a rear region. In his H-shaped houses, the left/right division was expressed as folding of space-layers in parallel with urban streets. The front/rear division was used as classification of main-living space and sub-living space. 2) KJR's H-shaped Japanese-Korean Style houses were proved to be designed as urban housing against the extreme housing shortage of Seoul in 1930s. 3) His houses however were not accepted broadly as a urban house type because the construction cost of those was higher than an average and the element of Japanese style house was not adapted to Korea. Kim, Jong-Ryang's trial is valuable because it was the rare case of realization of many discourses as defects of existing house type. With more rigorous investigations on KJR's experiment in modern house type, we could understand the housing condition of Seoul in 1930s and modern urban houses more than before.

• 한국항해항만학회지
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• 제45권6호
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• pp.284-297
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• 2021

본 연구에서는 선박의 운항 데이터를 기반으로 조종성능을 모사할 수 있는 단순 운동학 모델을 제안하였다. 수평면 3자유도 각 방향의 속도 성분을 1차 미분방정식의 해 형태의 단순모델로 두고, 계수에 대한 운항데이터 학습을 수행하였다. 실제 선박의 충분한 운항 데이터의 확보는 어렵거나 제한적이므로, 본 연구에서는 실 운항 데이터 대신 공개된 동역학 모델을 활용하여 임의의 제어입력에 대한 시뮬레이션 결과를 얻고, 이를 운항데이터 학습에 활용하였다. 제어입력인 프로펠러 회전수 및 타각을 임의로 부가하여 동역학 시뮬레이션을 수행하고 각 속도 성분 출력을 얻었다. 충분한 시간 동안 동역학 시뮬레이션의 제어 입력과 속도 출력을 학습하여 각 제어 입력에 대한 운동학 모델 내 계수인 시정수 3개, 수렴속도성분 3개의 분포를 도출하였다. 추가로 임의의 제어 입력에 의한 선회 시뮬레이션 결과들과 비교함으로써 단순 운동학 모델의 성능을 검증하였다. 도출된 시정수들의 분포에는 다소 분산이 있으며, 제어 입력 이외의 관련 변수를 더 추가하여 정확도를 높이는 추후 연구가 필요하다.

• 대한한의학회지
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• 제44권3호
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• pp.189-200
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• 2023

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.