• Title/Summary/Keyword: Trial Division

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A Systematic Review from the Journals of the Korean Oriental Medical Society. (대한한의학회지 및 대한한의학회 산하 정회원 학회의 학술진흥재단 등재지에 대한 천식 임상연구의 체계적 고찰)

  • Choi, Jun-Yong;Bang, Ji-Hyung;Shen, Feng-Yan;Jung, Hee-Jae;Jung, Sung-Ki
    • The Journal of Korean Medicine
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    • v.31 no.1
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    • pp.14-22
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    • 2010
  • Objectives: This study aimed to evaluate any clinical research regarding asthma published by the Korean Oriental Medical Society and its sub-societies for future rigorous clinical research. Methods: Every article relevant to asthma was initially obtained from journals in the Korean Oriental Medical Society and its sub-societies by electronic search at journal web sites or manual search. Journals were limited to those registered by the Korea Research Foundation. From initial findings, two independent reviewers selected clinical articles and these articles were further analyzed separately into predefined criteria according to prospective and retrospective studies. For prospective studies, quality assessment was also conducted. Results: From 99 articles initially obtained, 19 were finally analyzed. 14 were prospective whereas 5 were retrospective. Among the prospective articles, there were no randomized controlled trials and the non-randomized studies had no control groups, with several problems of quality regarding pre-calculated study size and unbiased assessment. None of the retrospective studies described asthma diagnosis objectively and outcome measures were either non-relevant to asthma or non-validated. Conclusions: Well-designed randomized controlled studies for asthma are needed and more rigorous non-randomized controlled studies should be conducted.

Apical root canal cleaning after preparation with endodontic instruments: a randomized trial in vivo analysis

  • Fornari, Volmir Joao;Hartmann, Mateus Silveira Martins;Vanni, Jose Roberto;Rodriguez, Rubens;Langaro, Marina Canali;Pelepenko, Lauter Eston;Zaia, Alexandre Augusto
    • Restorative Dentistry and Endodontics
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    • v.45 no.3
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    • pp.38.1-38.10
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    • 2020
  • Objectives: This study aimed to evaluate vital pulp tissue removal from different endodontic instrumentation systems from root canal apical third in vivo. Materials and Methods: Thirty mandibular molars were selected and randomly divided into 2 test groups and one control group. Inclusion criteria were a positive response to cold sensibility test, curvature angle between 10 and 20 degrees, and curvature radius lower than 10 mm. Root canals prepared with Hero 642 system (size 45/0.02) (n = 10) and Reciproc R40 (size 40/0.06) (n = 10) and control (n = 10) without instrumentation. Canals were irrigated only with saline solution during root canal preparation. The apical third was evaluated considering the touched/untouched perimeter and area to evaluate the efficacy of root canal wall debridement. Statistical analysis used t-test for comparisons. Results: Untouched root canal at cross-section perimeter, the Hero 642 system showed 41.44% ± 5.62% and Reciproc R40 58.67% ± 12.39% without contact with instruments. Regarding the untouched area, Hero 642 system showed 22.78% ± 6.42% and Reciproc R40 34.35% ± 8.52%. Neither instrument achieved complete cross-sectional root canal debridement. Hero 642 system rotary taper 0.02 instruments achieved significant greater wall contact perimeter and area compared to reciprocate the Reciproc R40 taper 0.06 instrument. Conclusions: Hero 642 achieved higher wall contact perimeter and area but, regardless of instrument size and taper, vital pulp during in vivo instrumentation is not entirely removed.

A review of forest trees micropropagation and its current status in Korea (국내 임목류 기내증식 연구현황 및 전망)

  • Moon, Heung-Kyu;Kim, Yong-Wook;Park, So-Young;Han, Mu-Seok;Yi, Jae-Seon
    • Journal of Plant Biotechnology
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    • v.37 no.4
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    • pp.343-356
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    • 2010
  • Plant micropropagation techniques include bud cultures using apical or axillary buds, organogenesis through callus culture or adventitious bud induction, and somatic embryogenesis. In Korea Forest Research Institute (KFRI), the first tissue culture trial in woody plant was initiated from the bud culture of hybrid poplars (Populus alba x P. glandulosa) in 1978. Since then several mass propagation techniques have developed from conifer and hardwood species, resulting in allowing practical application to Poplars, Birches and some oak species. In addition, useful micropropagation and genetic resources conservation techniques were established in some rare and endangered tree species including Abeliophyllum distichum. Among various in vitro propagation techniques, somatic embryogenesis is known to be the most efficient plant regeneration system. Since the first somatic embryo induction was reported in Tilia amurensis by KFRI in 1986, various protocols for direct or indirect somatic embryogenesis systems have developed in conifer and hardwood species including Larix leptolepis, Pinus rigida x P. taeda F1, Kalopanax septemlobus and Liliodendron tulipifera, etc. However, most of these technologies have been developed using juvenile tissues, i.e. immature zygotic embryos or mature embryos. Therefore it has been difficult to directly application to tree breeding program due to their unproven genetic background. Recently remarkable progresses and new approaches have been achieved in mature tree somatic embryogenesis. In this article we reviewed several micropropagation techniques, which have been mainly developed by KFRI and recent international progresses.

Target strength estimation of dominant species in marine ranching ground of Jeju coastal water by KRM model (KRM 모델을 이용한 제주바다목장 해역 주요 우점종의 음향반사강도 추정)

  • Lee, Seung-Jong;Lee, Yoo-Won;Kim, Joo-Il;Oh, Taeg-Yun;Hwang, Bo-Kyu;Kim, Byung-Yeob;Lee, Kyoung-Hoon
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.46 no.2
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    • pp.157-163
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    • 2010
  • The indirect target strength (TS) estimation method which uses the Kirchhoff ray mode model (KRM model) was discussed to apply for a biomass estimation in the water of mixed species. TS of 25 live scorpion fishes for 120kHz were measured by a tethered method and of others dominant 5 species in the marine ranching ground of Jeju coastal water including a scorpion fish were also estimated by KRM model. The measurement TS of scorpion fish well agreed with the theoretical values and the standard formula of scorpion fish was estimated as $TS_{120kHz}=20Log\;(L)-72.9$ ($r^2=0.67$). TScm values estimated on trial to each sample of dominant 5 species were from -69.3dB to -75.1dB at 120kHz and they were in the general range of swimbladdered fish. It was clarified that TS by KRM model can be used to estimate fish biomass estimation by increasing a sample number and is more effective under the condition that there is rare TS information for inhabiting species in mixed-species area.

Review of Regulatory Management System on Side Effects for Veterinary Medical Devices in Korea (국내 동물용의료기기 부작용 관리시스템에 대한 고찰)

  • Kang, Kyoung-Mook;Park, Hee-Myung;Lee, Chang-Min;Kang, Min-Hee;Suh, Tae-Young;Kang, Hwan-Goo;Moon, Jin-San
    • Journal of Veterinary Clinics
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    • v.35 no.1
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    • pp.1-6
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    • 2018
  • This study reviewed the regulatory safety management system for prevention of side effects of veterinary medical devices in Korea based on data obtained through analyses of those medical devices. In order to ensure the safety of medical devices, Ministry of Food and Drug Safety has established the management system include licensing, test inspection (134 designated clinical trial agencies) and post management. In addition, it was introduce the good manufacture practice (GMP) certification system and device tracking requirements. In contrast, it is necessary to establish regulations for side effects report and awareness on veterinary medical devices in Korea. The center for veterinary medicine of FDA in the United States has been operated side effects reporting system of veterinary medical devices from user, manufactures and distributor. Due to increase the use of various kinds of veterinary medical devices for animals, it should be required to improve regulation related to the licensing procedures, GMP system, and the side effects reporting system in our country.

High-level dietary crude protein decreased backfat thickness and increased carcass yield score in finishing Hanwoo beef cattle (Bos taurus coreanae)

  • Jeon, Seoyoung;Lee, Mingyung;Seo, Jakyeom;Kim, Jeong-Hoon;Kam, Dong-Keun;Seo, Seongwon
    • Journal of Animal Science and Technology
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    • v.63 no.5
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    • pp.1064-1075
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    • 2021
  • Recently, a high level of dietary crude protein (CP) has become of interest as a possible practice to improve the carcass quality of beef cattle, and its level has been increasing in the field. However, there is little scientific evidence that supports this. This study was conducted to test whether a high dietary CP level would improve growth performance, body metabolism, and carcass traits in Hanwoo beef cattle. A total of 32 Hanwoo finishing beef cattle (18 multiparous cows, six heifers, and eight steers) participated in a 12-weeks feeding trial. Two kinds of total mixed rations were prepared to contain two different CP; 156 g/kg for the control (CON) and 173 g/kg of CP for the treatment (HCP), while maintaining a similar level of metabolizable energy. The experiment was ended when more than half of the steers reached the target body weight (730 kg). Blood was collected at the end of the experiment. After harvesting, the carcass trait was evaluated at the slaughterhouse according to Korean standards. The carcass yield score and grade were also calculated based on revised criteria. Overall, dry matter intake, average daily gain, blood metabolites concentration, and the carcass traits, except for backfat thickness and the yield score, did not differ between the treatments. The HCP had lower backfat thickness than those of CON. There was no difference in the carcass yield grade, but the yield score was higher in the HCP treatment. According to the newly revised carcass grading criteria, both yield score and grade were higher in HCP than in CON. Increasing CP supply decreased the carcass's backfat thickness without altering growth performance and body metabolism, resulting in improved yield score and grade. Therefore, feeding a high CP diet may be beneficial in the farm income, although it may also increase feed cost and nitrogen excretion to the environment.

The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia

  • Manoppo, Jeanette;Tasiringan, Hilda;Wahani, Audrey;Umboh, Adrian;Mantik, Max
    • Clinical and Experimental Pediatrics
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    • v.62 no.5
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    • pp.173-178
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    • 2019
  • Purpose: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA). Methods: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L. Results: A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from $24.43{\pm}1.64$ to $28.21{\pm}1.72pg/L$ (P=0.000). Mean Ret-He level in group 2 changed from $24.31{\pm}1.42$ to $27.03{\pm}2.14pg/L$ (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05). Conclusion: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

Effect of Feeding Frequency of Commercial Floating and Sinking Pellet Diets on the Growth Performance, Feed Utilization and Body Composition of Sub-adult Starry Flounder Platichthys stellatus (시판용 침강 및 부상 배합사료 공급횟수가 미성어기 강도다리(Platichthys stellatus)의 성장, 사료이용성 및 체조성에 미치는 영향)

  • Byun, Soon-Gyu;Choi, Jin;Lim, Hyun Jeong;Jeong, Min Hwan;Kim, Kyoung-Duck;Kim, Hee Sung
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.52 no.5
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    • pp.468-473
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    • 2019
  • A $2{\times}4$ factorial feeding trial was conducted to examine the effect of feed type and feeding frequency on the performance of sub-adult starry flounder Platichthys stellatus. Two feed types, sinking pellets (SP) and floating pellets (FP), were given to 480 fish housed in tanks. Triplicate groups of fish were fed each feed type at one of four feeding frequencies (one meal every two days, one meal per day, two meals per day, and three meals per day) for nine weeks. Weight gain (WG) and specific growth rate (SGR) of fish were affected by feeding frequency. However, WG and SGR were the same in fish fed SP at two and three meals per day; similarly, there was no difference in WG or SGR of fish fed FP at one meal, two meals, or three meals per day. Feed utilization of fish was affected by both feed type and feeding frequency. These findings suggest that two meals per day of the SP or one meal per day of FP are sufficient for optimum growth performance of sub-adult starry flounder.

A Experimental Research on Stair Ascent Evacuation Support for Vulnerable People (안전약자 상층 대피 지원에 관한 실험적 연구)

  • Lee, Ji Hyang;Lee, Hyo Jeong;Kwon, Jin Suk;Park, Sang Hyun
    • Journal of the Korean Society of Safety
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    • v.34 no.1
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    • pp.90-97
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    • 2019
  • This study is aiming to compare stair ascent transportation speed and physical burden of evacuation supporters according to the types of stair ascent transportation for vulnerable people experimentally. In this study, we measured heart rate of the supporters to indicate physical burden during the transportation. The subjects of this experiment were male students, age of 20-26. Experimental conditions were the ways of stair transportation and the weight of vulnerable people. The types of stair transportation were giving a piggyback ride and carrying a wheelchair. Each experimental trial was video-recorded for measurement of ascent speed and observing supporters movement. As a result of the experiment, as for the ascent transportation speed by piggyback ride from the first floor to the fourth floor, the average speed of the light case is 31 seconds and for the heavy case is 43 seconds. When it comes to the average speed of wheelchair transportation's average speed the light case is 1 minute and 11 seconds and the heavy case is 1 minute and 49 seconds. Therefore, it was indicated that when the weight of a vulnerable people is lighter, the transportation speed is faster. The heart rates of evacuation supporters are different depending on transportation methods or individual's condition but as repetitive transportation increases, they tend to reach the maximum heart rates.

Application of Minimum Commitment Method for Predicting Long-Term Creep Life of Type 316LN Stainless Steel (Type 316LN 스테인리스강의 장시간 크리프 수명 예측을 위한 최소구속법의 적용)

  • Kim, Woo-Gon;Yin, Song-Nan;Ryu, Woo-Seog;Lee, Chan-Bock
    • Korean Journal of Metals and Materials
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    • v.46 no.3
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    • pp.118-124
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    • 2008
  • Abstract: A minimum commitment method(MCM) was applied to predict the long-term creep rupture life for type 316LN stainless steel(SS). Lots of the creep-rupture data for the type 316LN SS were collected through world-wide literature surveys and the experimental data of KAERI. Using these data, the long-term creep rupture life above ${10}^5$ hour was predicted by means of the MCM. In order to obtain the most appropriate value for the constant A being used in the MCM equation, trial and error method was used for the wide ranges from -0.12 to 0.12, and the best value was determined by using the coefficient of determination, $R^2$ which is a statistical parameter. A suitable value for the A in type 316LN stainless steel was found to be at -0.02 ~ -0.05 ranges. It is considered that the MCM will be superior in creep-life prediction to commonly-used timetemperature parametric method, because the P(T) and G($\sigma$) functions are determined from the regression method based on experimental data.