• Title/Summary/Keyword: Trial Division

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The Effects of Horticulture Activity Caring Program on Stress, Depression, Blood Glucose, Lipids for Major Company White-Collar Workers.: A Randomized Controlled Trial (대기업 사무직 근로자에게 적용한 원예활동 프로그램이 스트레스, 우울, 혈당, 혈중 지질 등에 미치는 효과: 무작위 대조군 연구)

  • Cha, Hyun-su;Lee, Sook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.10
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    • pp.231-242
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    • 2018
  • This study was performed to determine the effects on psychological and physiological variables of Horticulture Activity Caring Program for major company white-collar workers. Fifty three White-collar Workers participated in study. They were assigned to two groups (experimental group and control group) in random order. Random order is used Excel 2010 program RAND function of Microsoft. During the eight-week trial, the experimental group was treated with Horticulture Activity Caring Program weekly for 90 minute per session. The control group wasn't treated. Measurements of variables (stress, depression, blood glucose, total cholesterol, HDL-C, and LDL-C) were performed at weeks 0 and 8 for all participant. Changes in variables were calculated from baseline to trial completion. The data were collected from July to September 2014. SPSS 21.0 was used for the statistical analysis. : Horticulture Activity Caring Program had positive effects on depression (z=-4.57, p< .000). Conclusion of the study suggest the Horticulture Activity Caring Program may have positive effects on improving depression. We expect that the Horticulture Activity Caring Program will become a complementary and alternative therapy of mental health promotion for the white collar workers.

Continual Reassessment Method in Phase I Clinical Trials for Leukemia Patients (백혈병환자 대상의 제1상임상시험 연속재평가방법)

  • Lee, Joo-Hyoung;Song, Hae-Hiang
    • Communications for Statistical Applications and Methods
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    • v.18 no.5
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    • pp.581-594
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    • 2011
  • The traditional method of 3+3 standard design and model-based Bayesian continual reassessment method (CRM) are commonly used in Phase I clinical trials to identify the maximal tolerated dose(MTD) of a new drug. In this paper we review clinical examples of Phase I trials that were carried out in patients with refractory or relapsed leukemia and myelodysplastic syndrome. The recently proposed 3+1+1 design and rolling-6 design can shorten the trial duration, when a very slow accrual of patients with a simple 3+3 standard design may result in the untimely termination of trials. Too conservative approaches in determining the dose levels in Phase I clinical trials can leave clinical investigators unable to accurately determine the MTD. When determining future patient doses, the designs that use a time-to-event CRM can cooperate late toxicities by accounting for the proportion of the observation period of each enrolled patient. With the CRM design, simulations under different scenarios during the trial are important in detecting the under- or over-estimation of the initial estimate of the dose-limiting toxicity rate for each dose level. We present the advantages and drawbacks of the designs used in Phase I clinical trials for leukemia patients.

Biochemical Overripeness Characterization of Artificially Maturated Japanese Eel Anguilla japonica Egg (인위적으로 성숙시킨 뱀장어 Anguilla japonica 성숙란의 생화학적 과숙 특징)

  • Kwon, O-Nam;Adachi, Shinji
    • Journal of Aquaculture
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    • v.21 no.3
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    • pp.176-180
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    • 2008
  • This study clarified biochemical overripeness characterization of ovulated eggs of Anguilla japonica and suggested a method maintained overripeness after ovulation for high hatching rates. In maturated Japanese eel eggs, the relationships between fertilization rate and hatching rate, and fertilization and survival rates were measured. DNA contents showed the significantly low 0.653 pg/ug protein in 20% downward hatching rate trial with decrease of hatching rate(P<0.05), whereas RNA/DNA ratio showed the significantly high 1.058 in 20% downward hatching rate trial(P<0.05). And activities of total alkaline protease and ACPase according to the hatching rate groups did not show the significant difference(P>0.05). The protein contents were assayed the significantly high 186.16 ug/mg protein in 20% downward hatching rate trial(P<0.05). However, the overripened eggs had lowed hatching rate, because of stimulate the overripening of normal maturated eggs due to the continuous supplement of protein (vitellogenin). We suggested that need to reduce supplement speed or interception of vitellogenin produced in live for prevent overripeness of maturated eggs after ovulation

Effect of Supplementation of Rice Straw with Leucaena leucocephala and Prosopis cineraria Leaves on Nutrient Utilization by Goats

  • Dutta, N.;Sharma, K.;Hasan, Q.Z.
    • Asian-Australasian Journal of Animal Sciences
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    • v.12 no.5
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    • pp.742-746
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    • 1999
  • The potential of Leucaena leucocephala and Prosopis cineraria leaves as nitrogen supplements ($16g/kg\;W^{0.75}/d$) to improve the utilization of a basal diet of rice straw by goats was assessed in a feeding trial. Rice straw supplementation with forage oats (Avena sativa) was fed as a control diet. DMI, $g/kgW^{0.75}$ of rice straw by goats receiving Leucaena was significantly (p<0.05) higher followed by Prosopis and oat fodder. The supplementation of Leucaena improved the digestibility coefficient of DM, OM, CP, NDF and ADF nutrient density. Goats on Prosopis or oat fodder supplemented straw responded similarly in terms of nutrient utilization. The intake ($g/kgW^{0.75}$) of DCP, TDN and nitrogen balance of goats were significantly higher (p<0.05) when Leucaena was fed. It is suggested that the Leucaena may be a useful N-supplement in areas where livestock are fed poor quality crop residues.

Track Initiation and Target Tracking Filter Using LiDAR for Ship Tracking in Marine Environment (해양환경에서 선박 추적을 위한 라이다를 이용한 궤적 초기화 및 표적 추적 필터)

  • Fang, Tae Hyun;Han, Jungwook;Son, Nam-Sun;Kim, Sun Young
    • Journal of Institute of Control, Robotics and Systems
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    • v.22 no.2
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    • pp.133-138
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    • 2016
  • This paper describes the track initiation and target-tracking filter for ship tracking in a marine environment by using Light Detection And Ranging (LiDAR). LiDAR with three-dimensional scanning capability is more useful for target tracking in the short to medium range compared to RADAR. LiDAR has rotating multi-beams that return point clouds reflected from targets. Through preprocessing the cluster of the point cloud, the center point can be obtained from the cloud. Target tracking is carried out by using the center points of targets. The track of the target is initiated by investigating the normalized distance between the center points and connecting the points. The regular track obtained from the track initiation can be maintained by the target-tracking filter, which is commonly used in radar target tracking. The target-tracking filter is constructed to track a maneuvering target in a cluttered environment. The target-tracking algorithm including track initiation is experimentally evaluated in a sea-trial test with several boats.

Development of VR Ship Environment for The Educational Training of Ship Survey (선박 검사 교육훈련을 위한 VR 선박 환경 구축)

  • Kil, WooSung;Son, Myeong-Jo;Lee, Jeong-Youl
    • Journal of the Society of Naval Architects of Korea
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    • v.55 no.4
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    • pp.361-369
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    • 2018
  • The ship surveyor makes a scheme of reasonable ship operation by examining whether the ship has been properly constructed in accordance with the rule of classification societies and international conventions or whether the facilities of the ship in operation meet the standard stipulated by law. Even though the ship surveyors of classification society generally consist of people who have the skill of design or operation of a ship, it takes a long time to train a surveyor to the maturity level. This paper describes the development of survey simulator based on virtual ship environment that enables the surveyor minimize trial and errors to survey the ships. By using VR(Virtual Reality) based survey simulator, surveyors possibly achieve improvement of competence in survey quality by means of safe and immersive training environment. In order to improve the usability and utility of the VR simulator, the ship 3D model has been generated using 3D CAD model for design and production in shipyard. Through this, we suggested the possibility of consistent use of 3D model as the digital twin of a ship.

Real Time Monitoring of Energy Efficiency Operation Indicator on Merchant Ships

  • Barro, Ronald Dela Cruz;Kim, Jun-Seong;Lee, Don-Chool
    • Journal of Advanced Marine Engineering and Technology
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    • v.35 no.3
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    • pp.301-308
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    • 2011
  • International Maritime Organization (IMO) proposed the Energy Efficiency Operation Indicator (EEOI) in 2005 and the Energy Efficiency Design Index (EEDI) in 2008 so as to address emission concern and regulation. Likewise, Ship Energy Efficiency Management Plan (SEEMP) and Greenhouse Gas (GHG) monitoring and management are also becoming an issue lately. This paper introduces the energy efficiency design index (operation indicator) monitoring system (EDiMS) software can continuously monitor $CO_2$, $NO_x$, $SO_x$, and PM values emitted from ship. The accurate inventory of ships GHG can be obtained from base of emission result during the engine shop test trial and the actual monitoring of shaft power and ship speed. In addition, the ability to store all exhaust emission and engine operation data can be applied as the useful tool of the inventory work of air pollution and ship energy management plan for the mitigation or reduction of ship emissions.

Standardization of Ice Mechanics Experimental Procedures in a Cold Room (Cold Room을 이용한 얼음 및 동토의 재료특성 계측 실험기법의 표준화)

  • Kim, Jung-Hyun;Choi, Kyung-Sik;Seo, Young-Kyo
    • Journal of Ocean Engineering and Technology
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    • v.21 no.2 s.75
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    • pp.60-66
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    • 2007
  • The first Korean cold room facility for ice mechanics experiments was assembled in 2004. Since then, the $4m{\times}6m$ cold room facility has been used, extensively under various environmental and loading conditions. After reviewing published references on cold room testing methods and also by trial and error, the standard procedures for testing and preparing laboratory ice material were established for the measurement of basic ice properties. In this paper, laboratory experimental techniques with the cold room facility and standard procedures established for ice material properties are introduced. Test specimens include laboratory-grown fresh water ice and frozen soils. Tests are carried out for unconfined compressive strength. Preparation and dimension of the specimen are the most important issues arising in cold room tests. The details of specimen preparation, testing procedure and strength test results are also discussed.

Body Composition of Black Rockfish Sebastes schlegeli Fed on Diets Containing Different Levels of Turmeric Curcuma longa L. (울금(Curcuma longa L.) 첨가 사료 공급이 조피볼락(Sebastes schlegeli) 체성분에 미치는 영향)

  • Hwang, Jae-Ho;Rha, Sung-Ju;Han, Kyeong-Ho;Kim, Seon-Jae
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.46 no.5
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    • pp.540-545
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    • 2013
  • This study investigated the effect of diets supplemented with different levels (0, 1, 3, and 5 %) of turmeric Curcuma longa L. powder (TP) on the body composition of black rockfish Sebastes schlegeli. Fish weighing $10.05{\pm}0.44$ g were fed to apparent satiation twice daily for 8 weeks. Adding TP decreased crude lipid levels and increased crude protein and ash levels. Abundant fatty acids in the TP-added group were C16:0, C18:1 n-9 (cis), and C22:6 n-3. The major amino acids in samples were glutamic acid, aspartic acid, glycine, leucine, alanine, lysine, and arginine.

Analysis of studies on Maekmundong-tang (맥문동탕(麥門冬湯)에 대한 연구 논문 분석)

  • Kim, Hyoung-Won;Yang, Su-Young;Kim, Min-Hee;NamGung, Uk;Park, Yang-Chun
    • Journal of Haehwa Medicine
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    • v.19 no.2
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    • pp.165-171
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    • 2011
  • Objectives: This study analyzed the contents of the research papers of Maekmundong-tang (MMDT). This study was conducted to help development of new clinical application and clinical studies for treating COPD with Oriental medicine. Materials and Methods: We inspected 26 theses and scrutinized their classification, objective diseases, study design, participants, methodological quality of clinical trial. Results: The following results were obtained in this study. 1. The studies of MMDT started in 1989 and have continuously increased, but it decreased recently. 2. The studies were mainly focused on experimental models rather than clinical studies. The topics of studies were mainly relaxation of airway contraction and anti-asthmatic effect. 3. MMDT was showed to have effects on chronic cough and asthma in these papers. Conclusion: MMDT is being used in respiratory disease. However, mechanism study should be conducted at experimental study and more clinical studies on the efficacy of MMDT for chronic respiratory disease are needed.