• Title/Summary/Keyword: Trial

Search Result 7,876, Processing Time 0.032 seconds

Studies on the Estimation of Growth Pattern Cut-up Parts in Four Broiler Strain in Growing Body Weight (육용계에 있어서 계통간 산육능력 및 체중증가에 따른 각 부위별 증가양상 추정에 관한 연구)

  • 양봉국;조병욱
    • Korean Journal of Poultry Science
    • /
    • v.17 no.3
    • /
    • pp.141-156
    • /
    • 1990
  • The experiments were conducted to investigate the possibility of improving the effectiveness of the existing method to estimate the edible meat weight in the live broiler chicken. A total of 360 birds, five male and female chicks from each line were sacrificed at Trial 1 (body weight 900-1, 000g), Trial 2 (body weight 1.200-1, 400g), Trial 3(body weight 1, 600-1, 700), and Trial 4(body weight 2, 000g) in order to measure the body weight, edible meat weight of breast, thigh and drumsticks, and various components of body weight. Each line was reared at the Poultry Breeding Farm, Seoul National University from the second of july, 1987 to the thirteenth of September, 1987. The results obtained from this study were summarized as follows : 1. The average body weights of each line( H. T, M, A) were $2150.5\pm$34.9, $2133.0\pm$26.2, $1960.0\pm$23.1, and $2319.3\pm$27.9, respectively. at 7 weeks of age. The feed to body weight eain ratio for each line chicks was 2.55, 2.13, 2.08, and 2.03, respectively, for 0 to 7 weeks of age. The viability of each line was 99.7. 99.7, 100.0, and 100.0%, respectively, for 0 to 7 weeks of age.01 was noticed that A Line chicks grow significantly heavier than did T, H, M line chic ks from 0 to 7 weeks of age. The regression coefficients of growth curves from each line chicks were bA=1.015, bH=0.265, bM=0.950 and bT=0.242, respectively. 2. Among the body weight components, the feather. abdominal fat, breast, and thigh and drumsticks increased in their weight percentage as the birds grew older, while neck. head, giblets and inedible viscera decreased. No difference wat apparent in shank, wings and hack. 3. The weight percentages of breast in edible part for each line thicks were 19.2, 19.0, 19.9 and 19.0% at Trial 4, respectively. The weight percentages of thigh and drumsticks in edible part for each line chicks were 23.1, 23.3, 22.8, and 23.0% at Trial 4. respective1y. 4. The values for the percentage meat yield from breast were 77.2. 78.9 73.5 and 74.8% at Trial 4 in H, T, M and A Line chicks. respectively. For thigh and drumstick, the values of 80.3, 78.4. 79.7 and 80.2% were obtained. These data indicate that the percentage meat yield increase as the birds grow older. 5. The correlation coefficients between body weight and blood. head, shanks. breast. thigh-drumstick were high. The degree if correlation between abdominal fat(%) and percentage of edible meat were extremely low at all times, but those between abdominal fat (%) and inedible viscera were significantly high.

  • PDF

Pharmacokinetic Propertiese of Entecavir 1 mg in Korean Healthy Volunteers (건강한 한국인 피험자에서 Entecavir 1 mg 제제의 약동학적 특성 평가)

  • Jeon, Ji-Young;Hwang, Min-Ho;Im, Yong-Jin;Kim, Yun-Jeong;Han, Su-Mi;Im, Sung-Hyuk;Chae, Soo-Wan;Kim, Min-Gul
    • Korean Journal of Clinical Pharmacy
    • /
    • v.21 no.3
    • /
    • pp.224-227
    • /
    • 2011
  • Entecavir is a potent and selective guanosine analogue that has demonstrated a significant antiviral efficacy against hepatitis B virus (HBV). The aim of this study was to evaluate the safety and pharmacokinetic profile after a single dose of entecavir 1 mg administration in Korean healthy male subjects. Eight volunteers were enrolled. After a single dose of 1 mg entecavir was orally administered, blood samples were collected at specific time intervals from 0-168 hours. The plasma concentrations of entecavir were determined by LC-MS/MS. The pharmacokinetic parameters were determined from the plasma concentration-time profiles. The mean values for $AUC_{last}$ and $AUC_{inf}$ were $14.84{\pm}7.81ng{\cdot}hr/mL$ and $20.71{\pm}8.80ng{\cdot}hr/mL$, respectively. The mean value for $C_{max}$ was $9.19{\pm}4.91ng/ml$ and median value for $t_{max}$ was 0.58 hr. No adverse events were reported by subjects or found on analysis of vital signs or laboratory tests. The results are suggested to be useful in clinical trials of entecavir in Korean subject including bioequivalence study.

Study on the Correction Method of Ice Strength and Thickness Applied to the Sea Trial Condition Based on the Ice Model Test Results (빙두께 및 강도 보정기법을 이용한 모형시험결과의 실선시운전 적용연구)

  • Lee, Seung-Ki;Kim, Moon-Chan;Lee, Won-Jun;Kim, Hyun-Soo;Lee, Chun-Ju
    • Journal of the Society of Naval Architects of Korea
    • /
    • v.48 no.5
    • /
    • pp.457-464
    • /
    • 2011
  • This paper deal with the validation of correction method of ice strength and thickness to the sea trial condition based on the ice model test results. It is very difficult to conduct the model test corresponding to the sea trial condition exactly. In addition, the available sea trial data is not sufficient for the validation of correction method. In the present study, the model test results of Terry-Fox ice breker have been used to compare the corrected results of sea trial test by varying its thickness and strength of model ice. The HSVA and ITTC methods have been applied to the present comparisions and the required power has been also validated by using the HSVA method. There are rather good agreement between the sea trial result and model test corrected by the HSVA and ITTC method. The more comparisons are expected to be carried out in near future.

The Problem and Improvement Plan on Acupuncture Treatment in Clinical Trial Based on EBM (근거 중심 의학(EBM)에 바탕을 둔 임상시험(Clinical Trial)에서 침 치료 문제점과 개선 방안에 대하여)

  • Han, Sung-Soo;Koo, Chang-Mo;Hong, Kweon-Eey;Park, Yang-Chun;Choi, Sun-Mi
    • Journal of Acupuncture Research
    • /
    • v.23 no.6
    • /
    • pp.1-8
    • /
    • 2006
  • Introduction : Even though Acupuncture has been know for its effect for a long time, recently it is required to verifiy its effect. To solve this, clinical trial, based on EBM, has been the way to explain acupuncture's treatment effect. Methods: Last year we had a clinical trial based on acupuncture. From this experience we came to a conclusion mentioned below. Results : 1. To find out acupuncture's effect more certainly, it is needed that Korean medical method or treatment should be connected to diagnosis. 2. We had found out that sham and minimal acupuncture are the most appropriate way in single blinding. 3. It is required for the acupuncturist to practice the right real acupuncture point and sham's point in clinical trial. 4. The most important thing to maintain the subjects from dropping out is to always be concerned to the subjects and management them. Conclusion : The best way to advance clinical trial on acupuncture is to use single blinding system with sham acupuncture together in controlled groups and most of all also needs a standardized acupuncture point and depth.

  • PDF

Effect Analysis of Electronic Clinical Trial Systems (효율성 측정지표를 활용한 전자적 임상시험프로세스 효과분석)

  • Lee, Hyun-Ju;Choi, In-Young
    • The Journal of the Korea Contents Association
    • /
    • v.11 no.1
    • /
    • pp.350-356
    • /
    • 2011
  • The purpose of this study is to empirically examine how much the electronic clinical trial data management system actually enhances its efficiency. While the development of clinical trial markets highlights the significance of data management with increasing rate of adoption of electronic systems, its effects have not been fully supported with rigorous evidences. Particularly, the adoption rate of electronic clinical trial systems is low in domestic clinical trials markets. This study attempts to analyze the effect of the systems for reminding the importance of e-data management in clinical trials. The measurement indicator is experimented with the time related data collected from a multi-center clinical trial case. The result showed that the speed of the electronic clinical trial processes can be improved. The implication of this study lies in its first attempt to empirically analyze the effect of electronic clinical data management systems. Furthermore, application of the indicator in conjunction with electronic clinical trial processes is expected to facilitate strategic data management.

Study on the effect of Boyanghwanotang on Thrombosis and Elevated Blood Viscosity (혈전증(血栓症) 및 고점도혈증(高粘度血症)에 관(關)한 보양환오탕(補陽還五湯)의 실험적(實驗的) 연구(硏究))

  • Song, Hyo-Jung
    • The Journal of Internal Korean Medicine
    • /
    • v.10 no.1
    • /
    • pp.137-155
    • /
    • 1989
  • In order investigate the effect of Boyanghwanotang (BT) on thrombosis, Sprague-Dawley rats injected endotoxin into the caudal vein were oral administrated solid extract of BT-182. 4mg/200g (Sample A) and 364.8mg/200g (Sample B), and then observed Platelet, fibrinogen, prothrombin time and FDP. Another group injected hydrocortisone acetate into the muscular rump were adopted to observe the effect of BT on elevated blood Viscosity, administrated Sample A and Sample B, thereafter measured body weight, body temperature, whole blood viscosity, plasma viscosity, hematocrit, RBC, WBC, hemoglobin, glucose, albumin, total protein, triglyceride, cholesterol and prothrombin time. 1. Platelet was increased significantly in Sample B compared with the control group. 2. Fibrinogen of the trial groups compared with the control group was increased, and revealed a significance in Sample B. 3. Prothrombin time was decreased significantly in the trial groups compared with the control group. 4. FDP was decreased in the trial groups compared with the control group. 5. Body weight was increased significantly in Sample B after 7 days, body temperature revealed a significance in the trial groups after 5 days. 6. Whole blood viscosity and plasma viscosity of lower shear rates, both were highly decreased in the trial groupn than the control group. 7. The increase of WBC and decrease of hematocrit, RBC and hemoglobin was showed in the trial groups, and Sample B revealed a significance on the increase of WBC and decrease of RBC. 8. The increase of prothrombin time and decrease of glucose, albumin, total protein, triglyceride and cholesterol was showed in the trial group, and Sample B revealed a Significance on the increase of prothrombin time and decrease of albumin, total protein and triglyceride. 9. As compare with Sample A and Sample B, generally Sample B was highly Significant. According to the above results, it was considered that Boyanghwanotang may be the curative effects for thrombosis and elevated blood viscosity.

  • PDF

Development of the Driving Pump for the Super-cavitation & High-speed Cavitation Tunnel (초공동 고속 캐비테이션 터널 구동펌프 개발)

  • Ahn, Jong-Woo;Kim, Gun-Do;Paik, Bu-Geun;Kim, Kyoung-Youl
    • Journal of the Society of Naval Architects of Korea
    • /
    • v.55 no.2
    • /
    • pp.153-160
    • /
    • 2018
  • In order to develop the driving pump for High-speed Cavitation Tunnel(HCT) which can experiment the super-cavitating submerged body, KRISO decided on the pump specification, designed the mixed-flow pump on the basis of the existing pump data and predicted the performance of the design pump using commercial CFD code (CFX-10). After the manufacture and installation of the driving pump, KRISO conducted the trial-test for HCT, analyzed the pump performance and compared trial-test results to those of design stage. The trial-test items for the HCT driving pump are measurements of output current/voltage at the inverter of the driving pump and the flow velocity in the HCT test section. The trial-test results showed the decrease in the flow rate of about 4.6% and the increase in pump head of about 8%, compared with those of the pump prediction. After the trial-test, the performance of the driving pump is predicted using CFX-10 with measured flowrates and pump rotational velocities. Though there is some difference between trial-test and prediction results due to inadequate motor data, it is thought that the tendency is reasonable. It is found that CFX-10 is useful to predict a mixed-flow pump.

Recruitment and enrollment in a randomized clinical trial of mandibular two-implant overdenture

  • Lee, Jeong-Yol;Kim, Min-Soo;Kim, Ha-Young;Shin, Sang-Wan
    • The Journal of Advanced Prosthodontics
    • /
    • v.5 no.2
    • /
    • pp.204-208
    • /
    • 2013
  • PURPOSE. The purpose of this study was to evaluate the effectiveness of a promotion campaign for subject recruitment and selection, and reasons of withdrawal from a prospective clinical trial of mandibular two-implant supported overdenture. MATERIALS AND METHODS. The subjects of this study were participants in a randomized controlled clinical trial for investigating prognosis of implants and overdentures with attachments. Recruited subjects were classified by gender, age, and participation motives. Withdrawal rate of the participants before and after enrollment were evaluated. RESULTS. 177 patients were recruited and 51 patients were enrolled for the trial. Among them, 40 participants eventually took part in the trial. 116 subjects (65.5%) were recruited by advertisement and 61 (34.5%) were referred by patients of the hospital or local clinics. Regarding recruitment effectiveness, newspaper recruited the largest number of participants. With respect to referral patients, the proportion of our hospital patients was higher (37/61). Subjects in their 70s comprised the largest proportion (22/51). The male to female ratio was similar (25:26). Final withdrawal rate of all subjects were 74.0%. Among the reasons for withdrawal from enrollment (n=126) presence of remaining teeth and lack of motivation were the most common reasons. CONCLUSION. To facilitate recruitment of clinical trial subjects and improve enrollment rate, it is important to obtain a sufficient number of researchers, perform promotion activity with diverse strategies, cooperate with local dentists, increase the research funding, and alleviate subjects' fear against clinical trials by thorough consultation.

An Investigation about the Present States of Clinical Trial for Traditional Medicine in Korea, China, Taiwan and Japan (한국과 중국, 대만, 일본의 전통약 임상시험 현황에 대한 연구)

  • Lee, Kyun-Goo;Bae, Sun-Hee;Shin, Hyeon-Kyoo
    • Korean Journal of Oriental Medicine
    • /
    • v.12 no.1
    • /
    • pp.13-22
    • /
    • 2006
  • Background and Aims: Herbal drugs and traditional medicines have lately attracted considerable attention by global pharmaceutical corporations because the conventional chemical drugs didn't work well for many chronic diseases or intractable diseases. The government of Korea is also supporting to develop the new drug which is high value added product, and the natural medicine including herbal medicine(or Traditional Korean Medicine) have a significant presence in this field. non-clinical pharmacology/toxicology study and clinical trial are the two major criteria which estimate efficacy and safety for registration of new drugs. All of the pharmaceutical companies producing herbal medicine and the academic and the academic world of Tradition Korean Medicine have the will to develop new herbal drugs, but there are obstacles that they have neither experience nor guideline about clinical trial. Therefore for developing new herbal drugs, it is necessary to research the present conditions and comprehensive systems about clinical trial in Northeast Asian countries China, Taiwan and Japan because they have the common background with Korea in traditional medicine fields. Methods : The present state of clinical trial for herbal medicine in Korea was investigated. And then, those in China, Taiwan, Japan was also investigated. Results and conclusions : There are significant differences among 4 Southeast Asian countries Korea, China, Taiwan and Japan each in present condition, purpose, involved comprehensive system including legislation, and actual operation of clinical trial for traditional medicine.

  • PDF

ISDN Field Trial 현황

  • Jo, Pyeong-Dong
    • ETRI Journal
    • /
    • v.9 no.4
    • /
    • pp.162-172
    • /
    • 1987
  • 세계 통신 선진국가에서 이루어지고 었는 ISDN의 동향과 그 field trial 현황에 대해 설명하였다.

  • PDF